Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
- A+++2024
Ultra-processed foods and food additives in gut health and disease
Kevin Whelan, Aaron S Bancil, James O Lindsay, Benoit ChassaingThis narrative review examines the link between ultra-processed foods (UPFs), food additives, and gastrointestinal health. Research suggests that diets high in UPFs are associated with an increased risk of inflammatory…
gut microbiomfood additives - A+++2024
B-Group Vitamins as Potential Prebiotic Candidates: Their Effects on the Human Gut Microbiome
Raquel Bedani, Ana Clara Candelaria Cucick, Marcela Albuquerque Cavalcanti de Albuquerque, Jean Guy LeBlanc, Susana Mar…This narrative review explores whether B-group vitamins can act as prebiotics by promoting the growth of beneficial gut bacteria. The authors discuss how B-vitamins that are not absorbed in the small intestine can reach…
B-group vitamin bacterial producers; B-group vitamins; intestinal microbiome; microbiome modulators; prebiotic - A+++2024
Therapeutic applications of gut microbes in cardiometabolic diseases: current state and perspectives
Lin Yuan, Ying Li, Moutong Chen, Liang Xue, Juan Wang, Yu Ding, Qihui Gu, Jumei Zhang, Hui Zhao, Xinqiang Xie, Qingping…This narrative review explores the relationship between gut microbiota and cardiometabolic diseases (CMD), such as hypertension, obesity, and type 2 diabetes. The authors describe how gut microbes and their metabolites…
Cardiometabolic disease; Dietary nutrition; Gut microbiome - A+++2024
Gut-Brain Interactions and Their Impact on Astrocytes in the Context of Multiple Sclerosis and Beyond
Julia Zißler, Veit Rothhammer, Mathias LinnerbauerThis narrative review explores how the interaction between the gut microbiome and the brain influences the progression of multiple sclerosis (MS). The researchers describe how imbalances in gut bacteria can lead to bact…
dysbiosis; gut–brain interactions; microbiome; multiple sclerosis; neuroinflammation - A+2023
The Combined Effect of Static Stretching and Foam Rolling With or Without Vibration on the Range of Motion, Muscle Performance, and Tissue Hardness of the Knee Extensor
Masatoshi Nakamura, Andreas Konrad, Kazuki Kasahara, Riku Yoshida, Yuta Murakami, Shigeru Sato, Kodai Aizawa, Ryoma Koi…This study investigated how the order of static stretching (SS) and foam rolling (FR), with or without vibration, affects range of motion, muscle strength, and tissue hardness in the quadriceps. The results showed that…
range of motionFoam rollingPerformancestatic stretching - A++2023
Functional organization of extracellular hyaluronan, CD44 and RHAMM
Mary K Cowman, Eva A TurleyIn this comprehensive review, the authors explore how hyaluronan (HA) and its receptors, CD44 and RHAMM, organize the space immediately surrounding cells. In healthy tissue, these components maintain a stable environmen…
hyaluronanCD44extracellular matrixRHAMMpericellular matrix - A++2023
Pain quality patterns in delayed onset muscle soreness of the lower back suggest sensitization of fascia rather than muscle aferents: a secondary analysis study
Andreas Brandl, Jan Wilke, Christoph Egner, Tobias Schmidt, Andreas Schilder, Robert SchleipThis study investigated whether delayed onset muscle soreness (DOMS) in the lower back originates from the muscles or the surrounding connective tissue (fascia). Researchers had participants perform fatiguing back exerc…
Delayed onset muscle soreness; Eccentric exercise; Fascia pain; Lumbar multifidus muscle; Muscle pain; Pain perception; Pain quality; Thoracolumbar fascia - A+2023
Urinary Incontinence and Other Pelvic Floor Dysfunctions as Underestimated Problems in People under Forty Years: What Is Their Relationship with Sport?
Lorenza Bonaldi, Maria Vittoria Mascolini, Martina Todesco, Anna Zara, Camilla Rossato, Caterina Fede, Chiara Giulia Fo…Urinary incontinence is still an underestimated problem due to its anatomical complexity and social taboo. Most of the time, it is believed to affect predominantly the elderly female population, and the literature still…
urinary incontinence; pelvic floor dysfunction; sport; gender; aging - A+++2023
Fasting-mimicking diet synergizes with ferroptosis against quiescent, chemotherapy-resistant cells
Xiaoxia Liu, Shaoyong Peng, Guannan Tang, Gaopo Xu, Yumo Xie, Dingcheng Shen, Mingxuan Zhu, Yaoyi Huang, Xiaolin Wang,…This study investigates how a fasting-mimicking diet (FMD) affects colorectal cancer cells, particularly those resistant to chemotherapy. Researchers found that while fasting slows tumor growth, it can also cause cancer…
Autophagy; Colorectal cancer; Drug-tolerant persister cells; Fasting; Ferroptosis; Metabolomics; Quiescent cells - A++2023
The Cognitive and Emotional Aspect in Fibromyalgia: The Importance of the Orofacial Sphere
Bruno Bordoni, Allan R Escher, Gianmarco Cannadoro, Filippo TobbiThis narrative review explores the link between fibromyalgia and issues in the orofacial region, such as temporomandibular joint (TMJ) disorders and periodontitis. The authors suggest that oral inflammation may contribu…
dental occlusion; fibromyalgia; inflammation; osteopathic; pain; temporomandibular joint - A+2023
A New Player in the Mechanobiology of Deep Fascia: Yes-Associated Protein (YAP)
Carmelo Pirri, Brasilina Caroccia, Andrea Angelini, Maria Piazza, Lucia Petrelli, Ilaria Caputo, Chiara Montemurro, Pie…This study investigated the role of Yes-associated protein (YAP) in the mechanobiology of deep fascia, specifically the thoracolumbar fascia. Researchers analyzed tissue samples from patients and found that YAP acts as…
fascia; thoracolumbar fascia; extracellular matrix; fibroblasts; Yes-associated protein (YAP); remodeling - A++2023
What's old is new again: The anatomical studies of Franklin P. Mall and the fascial-interstitial spaces
Carmelo Pirri, Rebecca G Wells, Raffaele De Caro, Carla Stecco, Neil D TheiseFranklin Mall was a pioneering anatomist at the turn of the 19th century whose work is being rediscovered in light of modern fascia research. He studied under Wilhelm His and Carl Ludwig, learning to integrate anatomy w…
His; Mall; Sabin; artery; capillary; fascia; interstitium; liver; lymphatics; reticular network - A+++2023
Fasting and fasting mimicking diets in cancer prevention and therapy
Olga Blaževitš, Maira Di Tano, Valter D LongoThis review explores how cycles of fasting-mimicking diets (FMD) may aid in cancer prevention and therapy. FMDs are designed to be safer and more manageable than water-only fasting while potentially protecting healthy c…
cancer treatment; differential stress resistance (DSR); differential stress sensitization (DSS); fasting mimicking diet - A+++2023
Immediate Effects of Instrument-Assisted Soft Tissue Mobilization on Hydration Content in Lumbar Myofascial Tissues: A Quasi-Experiment
Andreas Brandl, Christoph Egner, Monique Schwarze, Rüdiger Reer, Tobias Schmidt, Robert SchleipThis quasi-experimental study investigated how instrument-assisted soft tissue mobilization (IASTM) affects the hydration levels of the lumbar fascia in 21 healthy volunteers. Researchers used bioimpedance analysis to t…
bioimpedance analysis; instrument-assisted soft tissue mobilization; thoracolumbar fascia; water content. - A++2023
The Effect of Craniosacral Therapy on Blood Levels of Stress Hormones in Male Firefighter Cadets: A Randomized Clinical Trial
Małgorzata Wójcik, Bruno Bordoni, Idzi Siatkowski, Ewa ZekanowskaThis randomized clinical trial investigated the effect of craniosacral therapy on blood levels of the stress hormones cortisol and CRH in 57 male firefighter cadets. Participants were assigned to either a treatment grou…
stress; cortisol; corticotropin-releasing hormone - A+++2023
Bioelectronic microfluidic wound healing: a platform for investigating direct current stimulation of injured cell collectives
Sebastian Shaner, Anna Savelyeva, Anja Kvartuh, Nicole Jedrusik, Lukas Matter, José Leal, Maria AsplundThis study investigates how electrical stimulation can accelerate wound healing by mimicking the body's natural electric fields. Researchers developed a bioelectronic microfluidic platform to test the effects of direct…
wound healingDirect current stimulation - A+++2023
Dietary patterns and cardiometabolic health: Clinical evidence and mechanism
Wenting Wang, Yanfei Liu, Yiwen Li, Binyu Luo, Zhixiu Lin, Keji Chen, Yue LiuThis narrative review examines how various dietary patterns influence cardiometabolic health and disease prevention. The researchers emphasize that healthy eating habits, such as the Mediterranean or plant-based diets,…
cardiometabolic disease; clinical evidence; dietary patterns; gut microbiota; mechanism - A+++2023
The Effects of the Mediterranean Diet on Health and Gut Microbiota
Thomas M Barber, Stefan Kabisch, Andreas F H Pfeiffer, Martin O WeickertThis review explores how the Mediterranean Diet, rich in plants, fibers, and olive oil, influences overall health and the gut microbiota. Research suggests that the diet is associated with improved longevity and a reduc…
Mediterranean diet; dietary fibre; gut microbiota; monounsaturated fat - A++2023
The Osteopath's Imprint: Osteopathic Medicine Under the Nanoscopic Lens
Bruno Bordoni, Allan R EscherThis theoretical article explores the cellular effects of osteopathic manipulative treatment (OMT) from a new perspective. Traditionally, the benefits of OMT are explained through neurological, vascular, and other physi…
diaphragm; fascia; fascintegrity; myofascial; pain; quantum physics - A+++2023
Effectiveness of visceral fascial therapy targeting visceral dysfunctions outcome: systematic review of randomized controlled trials
Fabiana C da Silva, Leonardo S Vieira, Lucas V Santos, Nathaly Gaudreault, Ronaldo H Cruvinel-Júnior, Gilmar M SantosThis systematic review evaluated 11 randomized controlled trials to investigate the effectiveness of visceral fascial therapy for various health conditions. The results suggest that the therapy may help reduce long-term…
painFascial therapyVisceral manipulation therapyVisceral disorders - A+++2023
Impact of Vitamin D Deficiency on Mental Health in University Students
Mansour Almuqbil, Moneer E Almadani, Salem Ahmad Albraiki, Ali Musharraf Alamri, Ahmed Alshehri, Adel Alghamdi, Sultan…This cross-sectional study investigated the relationship between vitamin D deficiency and mental health among 480 university students in Saudi Arabia. The findings revealed that nearly 60% of participants were vitamin D…
Riyadh; Saudi Arabia; anxiety; depression; mental health; psychological burden; stress; university students; vitamin D deficiency - A+++2023
The application and trend of ultra-weak photon emission in biology and medicine
Jinxin Du, Tingting Deng, Baorui Cao, Zhiying Wang, Meina Yang, Jinxiang HanThis review article examines ultra-weak photon emission (UPE), a phenomenon where living organisms emit extremely faint light as part of their biological functions. Research has shifted from understanding basic mechanis…
TCM research; oxidative stress; reactive oxygen species (ROS); ultra-weak bioluminescence; ultra-weak photon emission - A+++2023
Regulation of gut microbiota by vitamin C, vitamin E and β-carotene
Xin-Yu Li, Lei Meng, Liang Shen, Hong-Fang JiThis review article summarizes research on how the antioxidants vitamin C, vitamin E, and β-carotene influence the gut microbiota. By analyzing 19 studies, the authors found that these nutrients may alter the compositio…
Gut microbiota; Vitamin C; Vitamin E; β-carotene - A++2023
Change in gliding properties of the iliotibial tract in hypermobile Ehlers–Danlos Syndrome
Tina J Wang, Antonio Stecco, Robert Schleip, Carla Stecco, Carmelo PirriThis study used ultrasonography to examine the gliding properties of the iliotibial tract (ITT) in individuals with hypermobile Ehlers-Danlos Syndrome (hEDS). Researchers found that the shear strain, which represents ho…
fasciashear strainultrasonographyEhlers–Danlos syndromeIliotibial tract - A+++2023
Pulsed Electromagnetic Fields (PEMF)-Physiological Response and Its Potential in Trauma Treatment
Jonas Flatscher, Elizabeth Pavez Loriè, Rainer Mittermayr, Paul Meznik, Paul Slezak, Heinz Redl, Cyrill SlezakThis narrative review examines the use of Pulsed Electromagnetic Fields (PEMF) as a non-invasive method to promote healing in trauma, primarily within orthopedics. Despite decades of research and observed positive clini…
PEMF; biophysical forces; cellular signaling; clinical use; electromagnetic field; regeneration - A++2022
Blood supply to the superficial fascia of the abdomen:An anatomical study
Carmelo Pirri, Lucia Petrelli, Caterina Fede, Diego Guidolin, Cesare Tiengo, Raffaele De Caro, Carla SteccoThis anatomical study investigated the blood supply to Scarpa's fascia, the superficial fascia of the abdominal wall, using tissue samples from seven volunteers. The researchers demonstrated that this fascia is a highly…
Subcutaneous tissueFlapssuperficial fasciahypodermislymphatics - A+++2022
H2 Inhibits the Formation of Neutrophil Extracellular Traps
Kohsuke Shirakawa, Eiji Kobayashi, Genki Ichihara, Hiroki Kitakata, Yoshinori Katsumata, Kazuhisa Sugai, Yoji Hakamata,…This study investigates how molecular hydrogen (H2) may inhibit the formation of neutrophil extracellular traps (NETs), which are web-like DNA structures released by the immune system. While NETs help fight infections,…
BALbronchoalveolar lavage; CVDcardiovascular disease; CitH3citrullinated histone H3; H2; HOClhypochlorous acid; LPS - A+++2022
The Olympic motto through the lens of equestrian sports
Sarah Jane Hobbs, Hilary M ClaytonThis feature article examines the biomechanics of horses across the three Olympic equestrian disciplines: eventing, show jumping, and dressage. The authors describe how the equine body adapts to meet demands for speed,…
horsecentre of massdressageeventingjumping - A++2022
Evidence of Renin-Angiotensin System Receptors in Deep Fascia: A Role in Extracellular Matrix Remodeling and Fibrogenesis?
Carmelo Pirri, Brasilina Caroccia, Andrea Angelini, Lucia Petrelli, Maria Piazza, Carlo Biz, Pietro Ruggieri, Raffaele…This study investigated the presence of renin-angiotensin system (RAS) components in the deep fascia, specifically the thoracolumbar fascia of the lower back. Researchers found that receptors for angiotensin II, particu…
Ang II type 1 receptor (AT1R); angiotensin receptor; angiotensin-converting enzyme 2 (ACE2); fascia; fibrosis; remodeling; renin–angiotensin system; thoracolumbar fascia. - A++2022
Innervation of human superficial fascia
Caterina Fede, Lucia Petrelli, Carmelo Pirri, Winfried Neuhuber, Cesare Tiengo, Carlo Biz, Raffaele De Caro, Robert Sch…This study examined the superficial fascia, a thin layer of connective tissue within the skin's fat layer, to understand its nerve supply. Researchers found that this tissue is densely packed with nerves, particularly a…
autonomic innervation; hypodermis; innervation; nerve fibers; superficial fascia. - A++2022
The effect of low-intensity whole-body vibration with or without high-intensity resistance and impact training on risk factors for proximal femur fragility fracture in postmenopausal women with low bone mass: study protocol for the VIBMOR randomized controlled trial
Belinda Beck, Clinton Rubin, Amy Harding, Sanjoy Paul, Mark ForwoodThis document outlines the plan for a clinical trial investigating non-drug approaches for low bone mass in postmenopausal women. The study will compare the effects of low-intensity whole-body vibration, high-intensity…
exercisevibrationFractureHiRITOsteoporosis - A++2022
Differential Sensitization of Muscle versus Fascia in Individuals with Low Back Pain
Ronen Cozacov, Amir Minerbi, May Haddad, Simon VulfsonsThis clinical study investigated pain sensitivity in both muscle and deep fascia among individuals with low back pain compared to healthy controls. Using ultrasound-guided needling of the quadratus lumborum muscle and i…
fascia; myofascial pain; pain sensitization - A+++2022
Pilot study assessing the effect of Fascial Manipulation on fascial densifications and associated pain
Emmett Hughes, Jessica M Koenig, Robert S Lee, Kena McDermott, Tina Freilicher, Mark H PitcherThis pilot study investigated if Fascial Manipulation (FM) could reduce the thickness of fascial densifications and the acute pain associated with them. Researchers used ultrasound to measure densifications and asked pa…
Fascial manipulation; pain; densification; sex differences; diagnostic ultrasound - A2022
The Flares of Low back pain with Activity Research Study (FLAReS): study protocol for a case-crossover study nested within a cohort study
Pradeep Suri, Adrienne D Tanus, Nikki Torres, Andrew Timmons, Bianca Irimia, Janna L Friedly, Anna Korpak, Clinton Dani…This study protocol describes the FLAReS project, which aims to clarify the complex relationship between physical activity and low back pain flares. The researchers intend to distinguish between transient, short-term ef…
Disability; Episodes; Exacerbations; Flare-up; Flares; Low back pain; Recurrence. - B2022
Effects of vibration on the expression of mitochondrial fusion and fission genes and ultrastructure of skeletal muscle in rabbits
J X Li, S Y Xie, Z Q Zhang, C Z Zhang, L LinThis animal study explored how different intensities of vibration affect rabbit skeletal muscle at a cellular level. Researchers applied low, medium, or high-intensity vibration to the hind limbs of rabbits for 45 days.…
Mitochondrial fusion and fission genes; Rabbit; Skeletal muscle; Ultrastructure; Vibration - A++2022
Interdisciplinarity and mechanobiology
Donald E Ingber, Dino Di CarloMechanobiology is an interdisciplinary field that studies how cells sense and respond to mechanical forces in their environment. In this article, pioneers Donald Ingber and Dino Di Carlo discuss how physical forces infl…
biotensegrity - A2022
Local Estrogen Therapy for Pelvic Organ Prolapse in Postmenopausal Women: A Systematic Review and Meta-Analysis
Xia Yu, Li He, Yanjun Wang, Li Wang, Zhenglin Yang, Yonghong LinThis systematic review and meta-analysis analyzed seven randomized controlled trials to evaluate the impact of local estrogen therapy on pelvic organ prolapse in postmenopausal women. The findings suggest that while the…
Estrogen; Pelvic organ prolapse; Postmenopausal women; Quality of life; Vaginal health - A+++2022
Fetal Fascial Reinforcement Development: From “a White Tablet” to a Sculpted Precise Organization by Movement
Carmelo Pirri, Lucia Petrelli, Albert Pérez-Bellmunt, Sara Ortiz-Miguel, Caterina Fede, Raffaele De Caro, Maribel Migue…This study examined the development of fascia and retinacula (connective tissue reinforcements) in six human fetuses between 24 and 40 weeks of gestation. The researchers found that deep fascia initially lacks organized…
fetus; fascia development; retinacula; gross functional movements - A++2022
The deep fascia and its role in chronic pain and pathological conditions: A review
Flemming Kondrup, Nathaly Gaudreault, Gabriel VenneThis narrative review explores the deep fascia, a three-dimensional continuum of connective tissue surrounding muscles, nerves, and blood vessels. The researchers identified five common conditions associated with fascia…
anatomy; chronic pain; deep fascia; fasciitis; inflammation; innervation. - A++2022
Risk Factors of Postpartum Depression
Iris Agrawal, Ashok M Mehendale, Ritika MalhotraThis literature review examines the risk factors for postpartum depression (PPD), a condition affecting 10–15% of new mothers globally. The research suggests that factors such as a history of psychiatric illness, lack o…
clinical features; history of depression; post-natal mother; postnatal depression; postpartum care; postpartum depression; postpartum mental health; postpartum mothers; risk factors; spousal support. - A+++2022
Hyaluronan homeostasis and its role in pain and muscle stiffness
Adam Amir, Soo Kim, Antonio Stecco, Michael P Jankowski, Preeti RaghavanThis narrative review explores the role of hyaluronan (HA) in the musculoskeletal system. HA is a key component of the extracellular matrix in muscles and fascia, where it normally functions as a lubricant and shock abs…
hyaluronanpainmuscle stiffness - A+++2022
Performance of Swedish Warmblood fragile foal syndrome carriers and breeding prospects
Michela Ablondi, Martin Johnsson, Susanne Eriksson, Alberto Sabbioni, Åsa Gelinder Viklund, Sofia MikkoThis research article investigated the prevalence of Warmblood fragile foal syndrome (WFFS) in Swedish Warmblood horses and its potential link to performance. WFFS is a lethal genetic defect affecting collagen stability…
FFSWFFS - A++2022
Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation
Hailin Liu, Jialing Hu, Qingcui Zheng, Xiaojin Feng, Fenfang Zhan, Xifeng Wang, Guohai Xu, Fuzhou HuaThis narrative review explores the role of Piezo1 ion channels as mechanical sensors that link physical force to chronic inflammation. Piezo1 channels open in response to stimuli like pressure, stretch, and tissue stiff…
Ca 2+; MSc; Piezo1; chronic inflammation; mechanical force; pharmacology. - A++2022
Mechanosensing by Piezo1 and its implications for physiology and various pathologies
Austin Lai, Charles D Cox, Nadia Chandra Sekar, Peter Thurgood, Anthony Jaworowski, Karlheinz Peter, Sara BaratchiThis narrative review explores Piezo1, a specialized ion channel that senses mechanical pressure and converts it into biological signals within the body. These channels are widely distributed in tissues such as blood ve…
Piezo1; mechanoreceptor; mechanosensitive ion channel; mechanotransduction; shear stress. - A+++2022
The Effects of Aging on the Intramuscular Connective Tissue
Caterina Fede, Chenglei Fan, Carmelo Pirri, Lucia Petrelli, Carlo Biz, Andrea Porzionato, Veronica Macchi, Raffaele De…This study investigated how intramuscular connective tissue changes with age in both humans and mice. Researchers found that the amount of stiff collagen (Type I) increases significantly with age, while levels of hyalur…
aging; collagen; extracellular matrix; hyaluronan; intramuscular connective tissue; motor control; muscle - A+++2022
Fascial Innervation: A Systematic Review of the Literature
Vidina Suarez-Rodriguez, Caterina Fede, Carmelo Pirri, Lucia Petrelli, Juan Francisco Loro-Ferrer, David Rodriguez-Ruiz…This systematic review examines current evidence regarding the innervation of deep fascia and its potential role in myofascial pain. The findings suggest that fascia is not merely an inert wrapping but a sophisticated s…
fascia; innervation; nociceptor; pain - A+++2022
Magnetic fields induce exclusion zones in water
Valery Shalatonin, Gerald H PollackThis study explores how static magnetic fields influence water by creating "exclusion zones" (EZ), areas where particles are pushed away from the magnet's poles. Researchers observed that these zones form at both the no…
EZ waterfourth phase of waterexclusion zonesmagnetic fields - A+++2022
Effect of Ground and Raised Poles on Kinematics of the Walk
Vicki A Walker, Carolyne A Tranquillle, Russell MacKechnie-Guire, Jo Spear, Richard Newton, Rachel C MurrayThis study investigated how horses are affected by walking over ground poles and raised poles compared to walking on flat ground. The results suggest that polework increases joint range of motion through enhanced limb f…
Equine; Gait analysis; IMU; Polework; Rehabilitation - A+++2022
Making Connections to Improve Health Outcomes
Helene M LangevinIn this editorial, Helene M. Langevin discusses the importance of whole person health, viewing the individual as an interconnected system rather than a collection of isolated organs. She argues that biomedical research…
complementary and alternative medicine; integrative medicine; treatment and prevention - A+++2022
Myofascial Tissue and Depression
Johannes Michala, Lanre Aranmolate, Antonia Bonn, Karen Grandin, Robert Schleip, Jaqueline Schmiedtke, Svenja Quassowsk…This research investigated the link between myofascial tissue and Major Depressive Disorder (MDD) through two distinct studies. The first study found that patients with depression exhibited significantly higher stiffnes…
Depression; Embodiment; Memory bias; Myofascial tissue. - A++2022
Lifestyle Factors and Their Influence on Rheumatoid Arthritis: A Narrative Review
Christoph Schäfer, Gernot KeyßerThis narrative review examines how lifestyle factors influence the development and progression of rheumatoid arthritis (RA). Research suggests that smoking, an unhealthy diet, and obesity increase the risk of developing…
Mediterranean diet; diet; lifestyle; physical activity; rheumatoid arthritis; smoking; socioeconomic status - A+++2022
Primo Vascular System: Before the Past, Bizarre Present and Peek After the Future
Miroslav StefanovThis theoretical review explores the Primo Vascular System (PVS), a proposed network of channels suggested to carry information throughout the body via weak electromagnetic radiation. The author discusses the system's h…
Future; History; Information medicine; PVS; Quantum biology - A+++2022
Intramuscular connective tissue content and mechanical properties: Influence of aging and physical activity in mice
Annesofie T Olesen, Lasse Malchow-Møller, Rune D Bendixen, Michael Kjær, Abigail L Mackey, S Peter Magnusson, Rene B Sv…This animal study on mice investigated how aging and physical activity affect intramuscular connective tissue (IMCT). Researchers found that IMCT became thicker and stiffer with age, accompanied by an increase in advanc…
Collagen; Decellularized muscle; Endomysium; Picrosirius red; Rodent; Wheel running - A+++2022
Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer
Claudio Vernieri, Giovanni Fucà, Francesca Ligorio, Veronica Huber, Andrea Vingiani, Fabio Iannelli, Alessandra Raimond…This clinical trial investigated the safety and biological effects of a five-day fasting-mimicking diet (FMD) in 101 cancer patients receiving standard treatments. The results suggest that the diet is safe and leads to…
fasting; fasting-mimicking diet; inflammation; intermittent fasting; cancer; antitumor immunity - A+++2022
Immediate Effects of Extracorporeal Shock Wave Therapy in Fascial Fibroblasts: An In Vitro Study
Carmelo Pirri, Caterina Fede, Lucia Petrelli, Enrico De Rose, Carlo Biz, Diego Guidolin, Raffaele De Caro, Carla SteccoThis in vitro study investigated how extracorporeal shock wave therapy (ESWT) affects human fascial fibroblasts in a laboratory setting. Researchers found that immediately after treatment, the cells began producing smal…
fascia; hyaluronan; vesicles; myofascial pain; focused extracorporeal shock waves; 3D printer - A+++2021
Resveratrol Enhances the Cytotoxic Activity of Lymphocytes from Menopausal Women
Andrea Di Credico, Giulia Gaggi, Pascal Izzicupo, Ines Bucci, Angela Di BaldassarreThis in vitro study investigated how resveratrol, a natural polyphenol found in grapes and other plants, affects the immune system of postmenopausal women. Researchers isolated lymphocytes from 13 women and co-cultured…
antioxidant effects; cancer; cell-mediated cytotoxicity; immune system; immunomodulatory; menopause; noncommunicable diseases; nutraceuticals; prevention; resveratrol - A+++2021
Osteogenic effect of low-intensity pulsed ultrasound and whole-body vibration on peri-implant bone. An experimental in vivo study
Kenta Shobara, Toru Ogawa, Aya Shibamoto, Makiko Miyashita, Akiyo Ito, Ratri M SitalaksmiThis animal study in rats investigated whether low-intensity pulsed ultrasound (LIPUS) and whole-body vibration (WBV) could improve bone healing around titanium implants. Researchers compared the effects of LIPUS alone,…
low-intensity pulsed ultrasound (LIPUS); low-magnitude high-frequency loading; osseointegration; osteogenesis; prostheses and implants. - A2021
Fascial Nomenclature: Update 2021, Part 2
Bruno Bordoni, Allan R Escher, Filippo Tobbi, Bruno Ducoux, Serge PaolettiThis conceptual article addresses the ongoing debate about how to classify and name fascia. The authors suggest that progress is hindered because the discussion is often limited to a few scientific specialties and can b…
fasciafascial systemOsteopathicfascial continuumfascintegrity - A+++2021
An acupoint-originated human interstitial fluid circulatory network
HongYi Li, Fang Wang, Min Chen, Zhi-Jian Zheng, Ya-Jun Yin, Jun Hu, Hua Li, Andreas Sammer, Georg Feig, Norbert Maurer,…Details from this study have not yet been summarized. The study's title is "An acupoint-originated human interstitial fluid circulatory network". This title suggests the authors are proposing a circulatory network for i…
meridiansacupointsinterstitium - A+++2021
Impaired Lymphatic Drainage and Interstitial Inflammatory Stasis in Chronic Musculoskeletal and Idiopathic Pain Syndromes: Exploring a Novel Mechanism
Brian Tuckey, John Srbely, Grant Rigney, Meena Vythilingam, Jay ShahIn this theoretical paper, the authors propose a potential mechanism for chronic pain syndromes. They hypothesize that impaired lymphatic drainage following trauma or an immune response can trap inflammatory substances…
fasciacytokinesinterstitial inflammatory stasislymphatic dysfunctioncounterstrain techniques