Fasting and fasting mimicking diets in cancer prevention and therapy
- 01Fasting-mimicking diets offer a safer alternative to water-only fasting for patients
- 02FMD cycles may protect healthy cells through differential stress resistance
Fasting-mimicking diets may enhance cancer treatment by protecting healthy tissue while making tumors more vulnerable to therapy.
Fasting mimicking diets (FMDs) are emerging as effective dietary interventions with the potential to improve healthspan and decrease the incidence of cancer and other age-related diseases. Unlike chronic dietary restrictions or water-only fasting, FMDs represent safer and less challenging options for cancer patients. FMD cycles increase protection in healthy cells while sensitizing cancer cells to various therapies, partly by generating complex environments that promote differential stress resistance (DSR) and differential stress sensitization (DSS), respectively. More recent data indicate that FMD cycles enhance the efficacy of a range of drugs targeting different cancers in mice by stimulating antitumor immunity. Here, we report on the effects of FMD cycles on cancer prevention and treatment and the mechanisms implicated in these effects.
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