Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
- A+++2017
Resveratrol Treatment Normalizes the Endothelial Function and Blood Pressure in Ovariectomized Rats
Victor Fabricio, Jorge Camargo Oishi, Bruna Gabriele Biffe, Leandro Dias Gonçalves Ruffoni, Karina Ana da Silva, Keico…This animal study on rats investigated how resveratrol affects blood pressure and vascular function during estrogen deficiency, mimicking post-menopausal conditions. Researchers found that a lack of estrogen led to high…
blood pressureresveratrolPostmenopause - A+++2017
Resveratrol supplementation reduces pain experience by postmenopausal women
Rachel H X Wong, Hamish M Evans, Peter R C HoweThis randomized, double-blind, placebo-controlled study investigated whether resveratrol supplementation could reduce pain and improve well-being in postmenopausal women. Over 14 weeks, participants taking 75 mg of resv…
Resveratrolpolyphenolemenopause - A+++2017
Proinflammatory Cytokines and Oxidative Stress Decrease the Transport of Dopamine Precursor Tyrosine in Human Fibroblasts
Ravi Vumma, Jessica Johansson, Nikolaos VenizelosThis laboratory study investigated how inflammation and oxidative stress affect the transport of the amino acid tyrosine in human fibroblasts, a type of connective tissue cell. Tyrosine is a crucial precursor for the ne…
Dopamine precursor; Human fibroblasts; Neuropsychiatric disorders; Oxidative stress; Proinflammatory cytokines; Tyrosine transport. - 1A+2017
Emotions in Motion: Myofascial Interoception
B Bordoni, F MarelliIn this perspective piece, the authors argue that the myofascial system is closely linked to our emotional state. They suggest that manual treatment not only affects the body physically but also activates the interocept…
fasciaManual TherapyMyofascialOsteopathicInteroception - A++2017
Minimizing Injury and Maximizing Return to Play: Lessons from Engineered Ligaments
Keith BaarMusculoskeletal injuries are a primary reason for time away from sports, partly because our understanding of how training affects tendons and ligaments is limited. This study used engineered ligaments grown in a lab fro…
trainingminimizing injuryreturn to playsupplementation - B2017
The Application of Acoustic Myography in Canine Muscle Function and Performance Testing
Christina Fenger, Adrian P HarrisonThis animal study on 11 Labrador dogs used acoustic myography (AMG) to measure muscle activity during walking and trotting. Researchers focused on two muscles, the m. gluteus superficialis and m. longissimus lumborum, t…
Mechanomyographym.longissimusm.glutealDogMuscle contraction - A+2017
Effects of the menstrual cycle on lower-limb biomechanics, neuromuscular control, and anterior cruciate ligament injury risk: a systematic review
Vivek Balachandar, Jan-Luigi Marciniak, Owen Wall, Chandrika BalachandarThis systematic review evaluated how the menstrual cycle affects lower-limb biomechanics, neuromuscular control, and anterior cruciate ligament (ACL) injury risk in women. The authors found strong evidence that the risk…
Biomechanicsligamentneuromuscularcruciatemenstrual. - A+2017
The Effect of Menstrual Cycle and Contraceptives on ACL Injuries and Laxity
Simone D Herzberg, Makalapua L Motu’apuaka, William Lambert, Rongwei Fu, Jacqueline Brady, Jeanne-Marie GuiseThis systematic review and meta-analysis investigated the relationship between the menstrual cycle, hormonal contraceptives, and the risk of anterior cruciate ligament (ACL) injuries. The researchers found that knee lig…
anterior cruciate ligament; knee injury; hormonal contraceptives; female; human; menstrual cycle; systematic review; meta-analysis; sports medicine - A2017
Correlation between chronic headaches and the rectus capitis posterior minor muscle: A comparative analysis of cross-sectional trail
Xiao-Ying Yuan, Sheng-Bo Yu, Cong Liu, Qiang Xu, Nan Zheng, Jian-Fei Zhang, Yan-Yan Chi, Xu-Gang Wang, Xiang-Tao Lin, H…Researchers investigated the relationship between chronic headaches and a small muscle at the base of the skull, the rectus capitis posterior minor (RCPmi). Using magnetic resonance imaging (MRI), they compared the size…
Myodural Bridgerectus capitis posterior minor musclechronic headacheshypertrophy - A+++2017
Activation of type 2 cannabinoid receptor (CB2R) by selective agonists regulates the deposition and remodelling of the extracellular matrix
Tao Guan, Guiyang Zhao, Honghui Duan, Yang Liu, Feng ZhaoThis in vitro study investigated how activating the type 2 cannabinoid receptor (CB2R) affects scar formation in eye connective tissue after surgery. Researchers found that human Tenon’s fibroblasts express these recept…
Matrix metalloproteinase 1 (MMP-1); Tenon’s fibroblasts; Transforming growth factor-β1; Type 2 cannabinoid receptor (CB2R); Wound healing - A++2017
A New Definition of an Acupuncture Meridian
Fletcher KovichThis perspective article proposes a new definition of acupuncture meridians, moving away from the idea of dedicated anatomical vessels. The author suggests that meridians are actually tracts of tissue that become affect…
acupunctureelectrical wavesemiconductionsignal propagation - A++2017
A Curious Oversight in Acupuncture Research
Fletcher KovichIn this perspective article, the author argues that current acupuncture hypotheses overlook a crucial factor: the speed at which the treatment takes effect. Observations suggest that communication between acupoints and…
acupunctureelectrical wavesemiconductionsignal propagation - A2017
Art Advancing Science: Filmmaking Leads to Molecular Insights at the Nanoscale
Charles Reilly, Donald E IngberA project that began as an artistic endeavor to create an entertaining short film about fertilization led to the development of a new scientific simulation tool. By integrating physics-based animation software from the…
Tensegritysimulationanimationaxonemedynein - B2017
Sensitivity of ACL Volume and T2* Relaxation Time to Magnetic Resonance Imaging Scan Conditions
Jillian E Beveridge, Edward G Walsh, Martha M Murray, C FlemingThis animal study investigated how different magnetic resonance imaging (MRI) conditions affect measurements of the anterior cruciate ligament (ACL). Researchers in this pig study compared images taken at different reso…
ACL; MRI; T2* relaxometry - 1A++2017
Microscopic anatomy of the visceral fasciae
Carla Stecco, Maria Martina Sfriso, Andrea Porzionato, Anna Rambaldo, Giovanna Albertin, Veronica Macchi, Raffaele De C…Researchers examined the microscopic structure of visceral fascia—the connective tissue surrounding internal organs—from eight cadavers. They analyzed samples from the thorax, abdomen, and around organs like the heart,…
elastic lamina; Gerota fascia; pericardium; peritoneum; serous membrane; visceral fascia; visceral manipulation. - A++2017
Vitamin C–enriched gelatin supplementation before intermittent activity augments collagen synthesis
Gregory Shaw, Ann Lee-Barthel, Megan L R Ross, Bing Wang, Keith BaarIn a small study involving eight healthy men, researchers investigated the effect of vitamin C-enriched gelatin supplementation before exercise. Participants who consumed 15 grams of gelatin one hour before a short, int…
Bonetendonexerciseligamentreturn to play - A2017
The myodural bridge existing in the Nephocaena phocaenoides
Pei Liu, Chan Li, Nan Zheng, Qiang Xu, Sheng-Bo Yu, Hong-Jin SuiThe myodural bridge is a connection between a small neck muscle and the spinal cord's outer covering (the dura mater) previously identified in humans. In this anatomical animal study, researchers investigated whether a…
dura materMyodural Bridge - A++2017
Improvement of skin condition by oral administration of collagen hydrolysates in chronologically aged mice
Zhenbin Wang, Qing Wang, Lin Wang, Weidong Xu, Yuanqing He, Yunliang Li, Song He, Haile MaThis animal study investigated how oral supplementation of collagen hydrolysates derived from fish scales affected chronological skin aging in mice over six months. The researchers found that mice receiving collagen in…
chronological aging; collagen hydrolysates; histological structure; oxidative stress; skin condition; visual appearance - A2017
Acute effects of foam rolling on passive tissue stiffness and fascial sliding: study protocol for a randomized controlled trial
Frieder Krause, Jan Wilke, Daniel Niederer, Lutz Vogt, Winfried BanzerThis document is a study protocol, outlining the planned method for a randomized controlled trial, not a report of its results. The researchers intend to investigate the immediate effects of foam rolling on the anterior…
Connective tissue; Cross-correlation; Fascia; Flexibility; Foam rolling; Self-myofascial release; Tissue stiffness; Ultrasound. - B2017
Acoustic wave therapy for cellulite, body shaping and fat reduction
Doris Hexsel, Fernanda Oliveira Camozzato, Aline Flor Silva, Carolina SiegaThis study evaluated the efficacy of acoustic wave therapy (AWT) for cellulite and body shaping. Thirty women with moderate to severe cellulite underwent 12 treatment sessions on the glutes and thighs over six weeks. Th…
Acoustic wave therapy; body shaping; cellulite; Cellulite Severity Scale; subcutaneous fat tissue thickness - A+++2017
Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation
Benoit Chassaing, Tom Van de Wiele, Jana De Bodt, Massimo Marzorati, Andrew T GewirtzThis study investigated how common food additives, specifically the emulsifiers polysorbate 80 (P80) and carboxymethylcellulose (CMC), affect the gut microbiota. Using a laboratory model of the human intestinal ecosyste…
INFLAMMATION; INTESTINAL MICROBIOLOGY - A2017
The universal existence of myodural bridge in mammals: an indication of a necessary function
Nan Zheng, Xiao-Ying Yuan, Yan-Yan Chi, Pei Liu, Bing Wang, Jia-Ying Sui, Seung-Ho Han, Sheng-Bo Yu, Hong-Jin SuiThe myodural bridge is a connective tissue structure linking one of the deep, upper neck muscles to the spinal dura mater. This anatomical study investigated whether this structure, known in humans, also exists in other…
Myodural Bridge - A++2017
Spontaneous ultra-weak photon emission in correlation to inflammatory metabolism and oxidative stress in a mouse model of collagen-induced arthritis
Min He, Eduard van Wijk, Herman van Wietmarschen, Mei Wang, Mengmeng Sun, Slavik Koval, Roeland van Wijk, Thomas Hankem…In this animal study, researchers investigated a mouse model of rheumatoid arthritis using two techniques: metabolomics (the analysis of metabolic products) and ultra-weak photon emission (UPE), which measures extremely…
biophotonsUltra-weak photon emissionSystems biologyCollagen-induced arthritisCorrelation networks - A2017
Human mesenchymal stem cells secrete hyaluronan-coated extracellular vesicles
Uma Thanigai Arasu, Riikka Kärnä, Kai Härkönen, Sanna Oikari, Arto Koistinen, Heikki Kröger, Chengjuan Qu, Mikko J Lamm…Mesenchymal stem cells (MSCs) are known to help with tissue repair, partly by releasing tiny packages called extracellular vesicles (EVs). This study investigated the connection between these EVs and hyaluronan (HA), a…
Hyaluronan; CD44; Extracellular vesicle; Stem cell; Filopodia; Hyaluronan synthase - A+++2017
Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase
Hai-Tao Zhang, Zi-Jian Zhang, Wei-Chuan Mo, Ping-Dong Hu, Hai-Min Ding, Ying Liu, Qian Hua, Rong-Qiao HeThis study investigates how an extremely weak magnetic field, similar to conditions in outer space or shielded environments on Earth, affects human cells. Researchers found that shielding the natural geomagnetic field r…
hydrogen peroxide; hypomagnetic field; oxidative stress; reactive oxygen species; superoxide dismutase - A2017
The second terminations of the suboccipital muscles: An assistant pivot for the To Be Named Ligament
Xiao-Ying Yuan, Chan Li, Jia-Ying Sui, Qi-Qi Zhao, Xiao Zhang, Na-Na Mou, Zhao Huang-Fu, Okoye Chukwuemeka Samuel, Nan…In this anatomical dissection study of 35 head-neck specimens, researchers investigated small muscle attachments in the suboccipital region. The scientists confirmed the existence of "second terminations" from several s…
Myodural Bridge - B2017
Evaluation of fascial manipulation in carpal tunnel syndrome
Marco Pintucci, Marta Imamura, Aurore Thibaut, Lucas M de Exel Nunes, Mylene Mayumi Nagato, Helena H Kaziyama, Satiko T…Details for this study are not yet available. The research, published in 2017, appears to evaluate the effectiveness of Fascial Manipulation® for treating carpal tunnel syndrome. Without an abstract, further details abo…
Fascial manipulationcarpal tunnel syndrome - A+2017
The nature and biology of basement membranes
Ambra Pozzi, Peter D Yurchenco, Renato V IozzoThis review article discusses the nature and biology of basement membranes. These are thin, flexible sheets of tissue that line and separate different structures in the body. Once thought to be just passive scaffolding,…
Collagen; laminin; heparan sulfate proteoglycan; discoidin domain receptor; integrin - A++2017
Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels
Jason Wu, Amanda H Lewis, Jörg GrandlThis narrative review explores Piezo1 and Piezo2, specialized proteins that act as the body's primary mechanical sensors. These ion channels convert physical forces like touch, tension, and fluid flow into electrical si…
Mechanotransductionpiezo - A2017
Don’t Forget the Abdominal Wall: Imaging Spectrum of Abdominal Wall Injuries after Nonpenetrating Trauma
Shanna A Matalon, Reza Askari, Jonathan D Gates, Ketan Patel, Aaron D Sodickson, Bharti KhuranaAbdominal wall injuries from non-penetrating trauma are relatively common but are often overlooked in the emergency department. This can happen because more severe, distracting injuries draw attention away, or because t…
abdominal wallabdominal wall injuriesabdominal wall herniaabdominal wall muscle injurycostochondral rib injury - A+2017
Quantitative tissue parameters of Achilles tendon and plantar fascia in healthy subjects using a handheld myotonometer
Sarah Orner, Wolfgang Kratzer, Julian Schmidberger, Beate GrünerThis study examined the mechanical properties of the Achilles tendon and plantar fascia in over 150 healthy adults using a handheld device called a MyotonPRO. The goal was to establish baseline normal values for tissue…
fasciaachilles tendonplantar fasciaMyotonePRO - B2017
Mechanical properties of a collagen fibril under simulated degradation
David C Malaspinaa, Igal Szleifera, Yasin DhaheraThis study used computer simulations to investigate how collagen fibrils lose their strength. Researchers modeled three different types of degradation: the removal of cross-links, surface damage, and damage throughout t…
collagenMolecular dynamicsDegradationMMP - A++2017
Massage therapy research review
Tiffany FieldThis review summarizes research showing beneficial effects of massage therapy for a wide range of conditions, including prenatal depression, pain syndromes, autoimmune conditions, and issues related to aging. The author…
Massage therapy research review - A2017
Amino acid composition in determination of collagen origin and assessment of physical factors effects
Marlena Gauza-Włodarczyk, Leszek Kubisz, Dariusz WłodarczykThis study examines the amino acid composition of collagen derived from various sources, including fish skin, bovine Achilles tendon, and bone tissue. The researchers found that the levels of hydroxyproline, a unique am…
hydroxyprolineBone collagenFish skin collagenIrradiationPolymer - A2017
Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease
Rutger A F Gjaltema, Ruud A BankThis narrative review provides an updated overview of the complex process of creating mature collagen. The formation of collagen fibrils from precursor molecules involves many enzymes and chaperones in a series of steps…
Bruck syndrome; Collagen; Ehlers–Danlos syndrome; connective tissue disorders; fibrosis; lysyl hydroxylation; osteogenesis imperfecta; prolyl hydroxylation. - A2017
Reconnecting the Body in Eastern and Western Medicine
Helene M Langevin, Rosa N SchnyerDetails for this 2017 publication, titled 'Reconnecting the Body in Eastern and Western Medicine' by Helene M. Langevin and Rosa N. Schnyer, have not yet been summarized. The title suggests a discussion comparing and in…
acupunctureTCM - A++2017
Interaction between the gut microbiome and mucosal immune system
Na Shi, Na Li, Xinwang Duan, Haitao NiuIn this narrative review, the authors outline the two-way relationship between the gut microbiome and the mucosal immune system. A balanced microbiome is essential for the proper maturation and function of the immune sy…
inflammationMicrobiomeImmunity - A2017
Effect of MELT method on thoracolumbar connective tissue: The full study
Faria Sanjana, Hans Chaudhry, Thomas FindleyThis study investigated if the MELT method, a self-treatment technique using soft rollers and balls, could affect the thoracolumbar connective tissue in people with chronic low back pain. Researchers used ultrasound ima…
Low back pain; MELT method; Connective tissue; Thickness; Myofascia; Flexibility - A++2017
Biological effects of direct and indirect manipulation of the fascial system. Narrative review
Giovanni Parravicini, Andrea BergnaThis narrative review explores the biological effects of manual fascial therapies. While osteopathic manipulative treatment (OMT) is clinically effective, its underlying mechanisms are not fully understood. The authors…
fasciaMyofascial releaseManual TherapyMyofascial manipulation - A++2017
Telocytes: Connective tissue repair and communication cells
Leon ChaitowThis commentary highlights a newly identified type of connective tissue cell called a telocyte. We already know that other cells, like fibroblasts, respond to mechanical forces from manual therapy, influencing tissue re…
mechanotransductiontelocytesinterstitial cellsregeneration - C2017
Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface
KA Khan, AJ Naylor, A Khan, PJ Noy, M Mambretti, P Lodhia, J Athwal, A Korzystka, CD Buckley, BE Willcox, F Mohammed ,…Researchers investigated how certain proteins interact to form new blood vessels, a process called angiogenesis that is crucial for tumor growth. This study, which included lab experiments and mouse models, identified a…
fasciaextracellular matrixendotheliumC-type lectintumor angiogenesis - A2017
Semimembranosus Muscle Injuries In Sport. A Practical MRI use for Prognosis
Ramon Balius, Mireia Bossy, Carles Pedret, Lluis Capdevila, Xavier Alomar, Bryan Heiderscheit, Gil RodasThis retrospective study investigated whether MRI scans could help predict recovery time for athletes with injuries to the semimembranosus, one of the hamstring muscles. Researchers analyzed MRI scans from 19 athletes,…
MRIreturn to playsemimembranosushamstring injuries - A++2017
EFFECT OF MATRIX RHYTHM THERAPY (MRT) COMBINED WITH PHYSIOTHERAPY INTERVENTION IN FROZEN SHOULDER – A CASE REPORT
Vijay Bhartiya, Shrikant Darade, Sandip Bhagwat, Manjumala RoyThis case report describes the treatment of a 52-year-old man with a painful and stiff right shoulder, diagnosed as frozen shoulder. His condition also involved tendinosis, bursitis, and osteoarthritic changes. The pati…
exercisesfrozen shoulderMRT - A2017
We are operating too much
Nicola MaffulliIn this editorial, the author, an orthopedic and trauma surgeon, observes a rising number of operations for orthopedic and trauma ailments. He notes that this trend runs counter to the results of high-quality studies, w…
Surgery - B2017
Ultra-weak photon emission as a dynamic tool for monitoring oxidative stress metabolism
Rosilene Cristina Rossetto Burgos, Johannes Cornelius Schoeman, Lennart Jan van Winden, Kateřina Červinková, Rawi Ramau…This laboratory study investigated a method for measuring oxidative stress, a process linked to many diseases. Researchers used a technique called ultra-weak photon emission (UPE) to monitor human cells in a dish after…
Ultra-weak photon emission - A2016
Endogenous spontaneous ultraweek photon emission in the formation of eye-specific retinogeniculate projections before birth
István Bókkon, Felix Scholkmann, Vahid Salari, Noémi Császár, Gábor KapócsIt has long been a puzzle how the intricate nerve connections between the eye and brain form so accurately before birth, without any visual input. This theoretical paper proposes a novel explanation for this phenomenon.…
discrete retinal noise; intrinsically photosensitive retinal ganglion cells; retinogeniculate pathways; spontaneous ultraweak photon emission - A2016
Monitoring the primo vascular system in lymphatic vessels by using window chambers
Jungdae Kim, Dong-Hyun Kim, Sharon Jiyoon Jung, Hyun-Ji Gil, Seung Zhoo Yoon, Young-Il Kim, Kwang-Sup SohIn this animal study, researchers developed a method for observing the primo vascular system (PVS) inside the lymphatic vessels of rats over an extended period. By implanting a "window chamber" into the skin and injecti…
primo vascular systemlymphatic vessels - A2016
Telocytes and Their Extracellular Vesicles—Evidence and Hypotheses
Dragos Cretoiu, Jiahong Xu, Junjie Xiao, Sanda M CretoiuThis narrative review discusses telocytes, a relatively new type of interstitial cell found throughout the body's connective tissues. These cells are characterized by long projections and are involved in communication b…
telocytes; telopodes; extracellular vesicles; exosomes; ectosomes - A++2016
Three Case Reports of Successful Vibration Therapy of the Plantar Fascia for Spasticity Due to Cerebral Palsy-Like Syndrome, Fetal-Type Minamata Disease
Fusako Usuki, Satsuki TohyamaThis series of case reports describes the long-term effects of vibration therapy on lower-limb spasticity in three patients with fetal-type Minamata disease, a condition with symptoms similar to cerebral palsy. Research…
spasticityvibration therapyFDM - A+2016
Health E!ects of Alkaline Diet and Water, Reduction of Digestive-tract Bacterial Load, and Earthing
Haider Abdul-Lateef MousaThis narrative review discusses how an alkaline diet, alkaline water, reduced digestive-tract bacterial load, and “earthing” might counter chronic low-grade acidosis. The author synthesizes literature suggesting these a…
chronic inflammationearthinghypertensionMetabolic acidosisalkaline diet - A++2016
Can fascia’s characteristics be influenced by manual therapy
Serge GracovetskyThis theoretical essay investigates the fundamental properties of collagen, a key component of fascia. The author explores how manual therapy might relate to the necessity of maintaining collagen's strength under load.…
Collagen; Models; MMP; Water - A2016
Is remote stretching based on myofascial chains as effective as local exercise? A randomised-controlled trial
Jan Wilke, L Vogt, D Niederer, W BanzerThis randomized controlled trial investigated whether stretching the lower limbs could improve neck mobility as effectively as direct neck stretching. Researchers divided 63 healthy participants into three groups: one s…
Myofascial chains; force transmission; fascia; meridians; MiSpEx - A2016
Intermuscular force transmission along myofascial chains: a systematic review
Frieder Krause, Jan Wilke, Lutz Vogt, Winfried BanzerThis systematic review examined evidence for force transmission along continuous lines of muscle and fascia, often called myofascial chains. Researchers analyzed nine studies of moderate to excellent quality that invest…
anatomy trains; fascia; myofascial continuity; tension transfer - A+++2016
Understanding Mechanobiology: Physical Therapists as a Force in Mechanotherapy and Musculoskeletal Regenerative Rehabilitation
William R Thompson, Alexander Scott, M Terry Loghmani, Samuel R Ward, Stuart J WardenThis perspective article explores the field of mechanobiology and how physical therapists use mechanical forces to promote tissue healing. It explains that cells in our muscles, bones, and tendons respond to physical st…
RehabilitationTherapymechantransduction - A2016
What Is Evidence-Based About Myofascial Chains: A Systematic Review
Jan Wilke, Frieder Krause, Lutz Vogt, Winfried BanzerThis systematic review evaluated anatomical dissection studies to find evidence for six proposed myofascial meridians. Researchers analyzed 62 studies and found strong evidence for the anatomical continuity of three lin…
fasciaForce transmissionmyofascial chainsmeridians - A2016
Remote effects of lower limb stretching: preliminary evidence for myofascial connectivity?
Jan Wilke, Daniel Niederer, Lutz Vogt, Winfried BanzerThis study investigated whether stretching the lower body could affect neck mobility. Twenty-six healthy participants were divided into two groups, with one group performing static stretches for the calf and hamstring m…
Myofascial chains; force transmission; fascia; meridians - B2016
Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs
Agata Jabłońska-Trypuć, Marzena Matejczyk, Stanisław RosochackiThis review article describes matrix metalloproteinases (MMPs), the primary enzymes responsible for breaking down collagen in the extracellular matrix. This breakdown process is normal and necessary for tissue remodelin…
cancercollagenAngiogenesisapoptosismetalloproteinase - A+2016
Piezo2 is the principal mechanotransduction channel for proprioception
Seung-Hyun Woo, Viktor Lukacs, Joriene C de Nooij, Dasha Zaytseva, Connor R Criddle, Allain Francisco, Thomas M Jessell…Proprioception is the sense of where our body parts are in space. In this animal study, researchers investigated the molecular sensor responsible for this ability in mice. They found that an ion channel called Piezo2 wa…
proprioceptionmuscle spindlespiezomechanotranductiiongolgi tendon organ - A+++2016
Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells
Brett A Morris, Brian Burkel, Suzanne M Ponik, Jing Fan, John S Condeelis, Julio A Aguirre-Ghiso, James Castracane, Joh…This study used a 3D in vitro model to investigate how the density of the collagen matrix influences the metabolism of breast cancer cells. The researchers observed that a high-density extracellular matrix drives a meta…
Breast cancer; Collagen; Matrix density; Metabolism - A+2016
Acute effects of muscle stretching on physical performance, range of motion, and injury incidence in healthy active individuals: a systematic review
David G Behm, Anthony J Blazevich, Anthony D Kay, Malachy McHughThis systematic review examines how different types of stretching (static, dynamic, and PNF) affect performance, range of motion (ROM), and injury risk in healthy individuals. The findings suggest that static stretching…
ballistic stretch; dynamic stretch; facilitation neuromusculaire proprioceptive; flexibility; flexibilité; proprioceptive neuromuscular facilitation; static stretch; warm-up