Telocytes and Their Extracellular Vesicles—Evidence and Hypotheses
Dragos Cretoiu, Jiahong Xu, Junjie Xiao, Sanda M Cretoiu
Key takeaways
- 01
Telocytes, a cell type found in connective tissue, communicate with other cells by releasing vesicles, suggesting a potential role in regeneration.
Entering the new millennium, nobody believed that there was the possibility of discovering a new cellular type. Nevertheless, telocytes (TCs) were described as a novel kind of interstitial cell. Ubiquitously distributed in the extracellular matrix of any tissue, TCs are regarded as cells with telopodes involved in intercellular communication by direct homo- and heterocellular junctions or by extracellular vesicle (EVs) release. Their discovery has aroused the interest of many research groups worldwide, and many researchers regard them as potentially regenerative cells. Given the experience of our laboratory, where these cells were first described, we review the evidence supporting the fact that TCs release EVs, and discuss alternative hypotheses about their future implications.
The episode was first published on The Fascia Guide YouTube channel on February 5, 2025. In this inspiring episode, we meet Deanna Hansen — founder of Block Therapy™ and a pioneer…
The episode was first published on the Swedish podcast Fasciaguiden on May 26, 2025. In this episode, we meet the French surgeon Jean-Claude Guimberteau, who has spent more than 3…