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Improvement of skin condition by oral administration of collagen hydrolysates in chronologically aged mice

Zhenbin Wang, Qing Wang, Lin Wang, Weidong Xu, Yuanqing He, Yunliang Li, Song He, Haile Ma
chronological aging; collagen hydrolysates; histological structure; oxidative stress; skin condition; visual appearance
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Key takeaways
  1. 01This animal study found that fish-derived collagen hydrolysates increased skin collagen content in aged mice
  2. 02Supplementation improved the microscopic structure of the skin and collagen fiber density dose-dependently
  3. 03Increased antioxidant enzyme activity suggests enhanced protection against oxidative tissue damage
  4. 04Researchers observed visible improvements in hair quality and luster among the collagen-treated groups

Oral collagen hydrolysates may improve skin structure and collagen density during natural aging, according to this study in mice.

Abstract

Background: Collagen hydrolysates (CHs) have been demonstrated to have positive effects on skin photoaging by topical application or oral ingestion. However, there has been little research on their influence on skin chronological aging. In this study, 9-month-old female ICR mice were given normal AIN-93M diets containing CHs (2.5, 5 and 10% w/w) from Nile tilapia scale.

Results: After 6 months, the collagen content and antioxidant enzyme (superoxide dismutase and glutathione peroxidase) activities increased significantly (P < 0.05), while the survival rate, viscera indices and contents of moisture, fat and non-collagenous protein in skin did not change (P > 0.05). The color, luster and quantity of hair were obviously ameliorated. Moreover, the structure of epidermis and dermis, the density and distribution of collagen fibers and the ratio of type I to type III collagen were improved in a dose-dependent manner as shown by histochemical staining.

Conclusion: Oral ingestion of CHs increased the collagen content and antioxidant enzyme activities and improved the appearance and structure of skin. These results suggest the potential of CHs as an anti-skin-aging ingredient in nutraceuticals or functional foods.

Cite this study
APA
Zhenbin Wang, Qing Wang, Lin Wang, Weidong Xu, Yuanqing He, Yunliang Li, Song He, & Haile Ma (2017). Improvement of skin condition by oral administration of collagen hydrolysates in chronologically aged mice. https://fasciaresearchdatabase.com/improvement-of-skin-condition-by-oral-administration-of-collagen-hydrolysates-in-chronologically-aged-mice/
MLA
Zhenbin Wang, et al. "Improvement of skin condition by oral administration of collagen hydrolysates in chronologically aged mice." 2017, https://fasciaresearchdatabase.com/improvement-of-skin-condition-by-oral-administration-of-collagen-hydrolysates-in-chronologically-aged-mice/.
Chicago
Zhenbin Wang et al. 2017. "Improvement of skin condition by oral administration of collagen hydrolysates in chronologically aged mice.". https://fasciaresearchdatabase.com/improvement-of-skin-condition-by-oral-administration-of-collagen-hydrolysates-in-chronologically-aged-mice/
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