Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A++2016
Ultra-weak photon emission in healthy subjects and patients with type 2 diabetes: evidence for a non-invasive diagnostic tool
Meina Yang, Wenyu Ding, Yanli Liu, Hua Fan, Rajendra P Bajpai, Jialei Fu, Jingxiang Pang, Xiaolei Zhao, Jinxiang HanAll living organisms emit extremely faint light, known as ultra-weak photon emission (UPE). This study investigated whether these light emissions differ between healthy individuals and people with type 2 diabetes. Resea…
fasciaphoton emissionbiological systemspathological statesUE - A2016
Overlapping signatures of chronic pain in the DNA methylation landscape of prefrontal cortex and peripheral T cells
Renaud Massart, Sergiy Dymov, Magali Millecamps, Matthew Suderman, Stephanie Gregoire, Kevin Koenigs, Sebastian Alvarad…In this animal study, researchers investigated how chronic pain might be linked to epigenetic changes, specifically DNA methylation. They compared rats with long-term nerve injury pain to a control group, examining tiss…
immune systemchronic painCentral nervous systemcortexDNA methylation - A2016
Collagen structure: new tricks from a very old dog
Jordi BellaThis narrative review summarizes how our understanding of collagen's triple helix structure has evolved. Initial models from the 1950s provided a general overview, but the development of synthetic collagen-like peptides…
collagen recognitioncollagen stabilitycollagen structurehydrogen bondingprotein design and engineering. - A2016
The Physical Mechanism for Retinal Discrete Dark Noise: Thermal Activation or Cellular Ultraweak Photon Emission?
Vahid Salari, Felix Scholkmann, Istvan Bokkon, Farhad Shahbazi, Jack TuszynskiThe visual 'static' or 'noise' we perceive in complete darkness has long been a puzzle. The conventional explanation is that random thermal energy causes photoreceptor cells in the retina to fire, but this model doesn't…
Biophotons - A++2016
Three Case Reports of Successful Vibration Therapy of the Plantar Fascia for Spasticity Due to Cerebral Palsy-Like Syndrome, Fetal-Type Minamata Disease
Fusako Usuki, Satsuki TohyamaThis series of case reports describes the long-term effects of vibration therapy on lower-limb spasticity in three patients with fetal-type Minamata disease, a condition with symptoms similar to cerebral palsy. Research…
spasticityvibration therapyFDM - A+2016
Comparison of the Hyaluronic Acid Vaginal Cream and Conjugated Estrogen Used in Treatment of Vaginal Atrophy of Menopause Women: A Randomized Controlled Clinical Trial
Azam Jokar, Tayebe Davari, Nasrin Asadi, Fateme Ahmadi, Sedighe ForuhariThis randomized controlled clinical trial compared the effectiveness of hyaluronic acid vaginal cream with conjugated estrogen cream for treating vaginal atrophy in menopausal women. Over an eight-week period, researche…
Atrophic vaginitis; Estrogen; Hyaluronic acid; Menopause - B2016
Internal strain drives spontaneous periodic buckling in collagen and regulates remodeling
Andrew Dittmore, Jonathan Silver, Susanta K Sarkar, Barry Marmer, Gregory I Goldberg, Keir C NeumanThis study investigated how collagen, a key structural protein, is remodeled. Researchers observed that the enzymes responsible for breaking down collagen, called MMPs, bind to specific, vulnerable spots that appear at…
mechanosensingCollagenasematrix metalloproteinasesingle moleculepattern formation - A+++2016
Resveratrol attenuated estrogen-deficient-induced cardiac dysfunction: role of AMPK, SIRT1, and mitochondrial function
Zijun Meng, Hongjiang Jing, Lu Gan, Hua Li, Bingde LuoThis animal study investigated how resveratrol, an antioxidant found in red grapes, affects cardiac function in estrogen-deficient mice. Researchers found that resveratrol supplementation significantly improved heart co…
AMPK; Resveratrol; SIRT1; heart; ischemia; mitochondrion - B2016
Limited mechanical effects of intermuscular myofascial connections within the intact rat anterior crural compartment
Chris Tijs, Jaap H van Dieën, Huub MaasIn this animal study, researchers investigated the connective tissue links between two lower leg muscles in rats, the tibialis anterior and extensor digitorum longus. The goal was to see if these connections significant…
Tibialis anteriorExtensor digitorum longus3D kineticsCo-activationMechanical interaction - A+++2016
Efficacy of an orally administered combination of hyaluronic acid, chondroitin sulfate, curcumin and quercetin for the prevention of recurrent urinary tract infections in postmenopausal women
M Torella, F Del Deo, A Grimaldi, S A Iervolino, M Pezzella, C Tammaro, P Gallo, C Rappa, P De Franciscis, N ColacurciThis prospective study evaluated whether an oral supplement containing hyaluronic acid, chondroitin sulfate, curcumin, and quercetin could prevent recurrent urinary tract infections (UTIs) in postmenopausal women. Resea…
Curcumin; Estrogen; Glycosaminoglycans; Quercetin; Urinary tract infections - C2016
Differential displacement of soft tissue layers from manual therapy loading
Shawn Engell, John J Triano, James R Fox, Helene M Langevin, Elisa E KonofagouTo better understand how manual therapy affects the body, researchers investigated how different layers of soft tissue in the back respond to pressure. They applied a standard preparatory force to the thoracic paraspina…
Spinal manipulationBiomechanicsElastographyCumulative displacementShear displacement - A+++2016
Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells
Brett A Morris, Brian Burkel, Suzanne M Ponik, Jing Fan, John S Condeelis, Julio A Aguirre-Ghiso, James Castracane, Joh…This study used a 3D in vitro model to investigate how the density of the collagen matrix influences the metabolism of breast cancer cells. The researchers observed that a high-density extracellular matrix drives a meta…
Breast cancer; Collagen; Matrix density; Metabolism