Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2024
Ultra-processed foods and food additives in gut health and disease
Kevin Whelan, Aaron S Bancil, James O Lindsay, Benoit ChassaingThis narrative review examines the link between ultra-processed foods (UPFs), food additives, and gastrointestinal health. Research suggests that diets high in UPFs are associated with an increased risk of inflammatory…
gut microbiomfood additives - A+++2024
B-Group Vitamins as Potential Prebiotic Candidates: Their Effects on the Human Gut Microbiome
Raquel Bedani, Ana Clara Candelaria Cucick, Marcela Albuquerque Cavalcanti de Albuquerque, Jean Guy LeBlanc, Susana Mar…This narrative review explores whether B-group vitamins can act as prebiotics by promoting the growth of beneficial gut bacteria. The authors discuss how B-vitamins that are not absorbed in the small intestine can reach…
B-group vitamin bacterial producers; B-group vitamins; intestinal microbiome; microbiome modulators; prebiotic - A+++2024
Therapeutic applications of gut microbes in cardiometabolic diseases: current state and perspectives
Lin Yuan, Ying Li, Moutong Chen, Liang Xue, Juan Wang, Yu Ding, Qihui Gu, Jumei Zhang, Hui Zhao, Xinqiang Xie, Qingping…This narrative review explores the relationship between gut microbiota and cardiometabolic diseases (CMD), such as hypertension, obesity, and type 2 diabetes. The authors describe how gut microbes and their metabolites…
Cardiometabolic disease; Dietary nutrition; Gut microbiome - A+++2024
Gut-Brain Interactions and Their Impact on Astrocytes in the Context of Multiple Sclerosis and Beyond
Julia Zißler, Veit Rothhammer, Mathias LinnerbauerThis narrative review explores how the interaction between the gut microbiome and the brain influences the progression of multiple sclerosis (MS). The researchers describe how imbalances in gut bacteria can lead to bact…
dysbiosis; gut–brain interactions; microbiome; multiple sclerosis; neuroinflammation - A+2023
The Combined Effect of Static Stretching and Foam Rolling With or Without Vibration on the Range of Motion, Muscle Performance, and Tissue Hardness of the Knee Extensor
Masatoshi Nakamura, Andreas Konrad, Kazuki Kasahara, Riku Yoshida, Yuta Murakami, Shigeru Sato, Kodai Aizawa, Ryoma Koi…This study investigated how the order of static stretching (SS) and foam rolling (FR), with or without vibration, affects range of motion, muscle strength, and tissue hardness in the quadriceps. The results showed that…
range of motionFoam rollingPerformancestatic stretching - A++2023
Functional organization of extracellular hyaluronan, CD44 and RHAMM
Mary K Cowman, Eva A TurleyIn this comprehensive review, the authors explore how hyaluronan (HA) and its receptors, CD44 and RHAMM, organize the space immediately surrounding cells. In healthy tissue, these components maintain a stable environmen…
hyaluronanCD44extracellular matrixRHAMMpericellular matrix - A++2023
Pain quality patterns in delayed onset muscle soreness of the lower back suggest sensitization of fascia rather than muscle aferents: a secondary analysis study
Andreas Brandl, Jan Wilke, Christoph Egner, Tobias Schmidt, Andreas Schilder, Robert SchleipThis study investigated whether delayed onset muscle soreness (DOMS) in the lower back originates from the muscles or the surrounding connective tissue (fascia). Researchers had participants perform fatiguing back exerc…
Delayed onset muscle soreness; Eccentric exercise; Fascia pain; Lumbar multifidus muscle; Muscle pain; Pain perception; Pain quality; Thoracolumbar fascia - A+2023
Urinary Incontinence and Other Pelvic Floor Dysfunctions as Underestimated Problems in People under Forty Years: What Is Their Relationship with Sport?
Lorenza Bonaldi, Maria Vittoria Mascolini, Martina Todesco, Anna Zara, Camilla Rossato, Caterina Fede, Chiara Giulia Fo…Urinary incontinence is still an underestimated problem due to its anatomical complexity and social taboo. Most of the time, it is believed to affect predominantly the elderly female population, and the literature still…
urinary incontinence; pelvic floor dysfunction; sport; gender; aging - A+++2023
Fasting-mimicking diet synergizes with ferroptosis against quiescent, chemotherapy-resistant cells
Xiaoxia Liu, Shaoyong Peng, Guannan Tang, Gaopo Xu, Yumo Xie, Dingcheng Shen, Mingxuan Zhu, Yaoyi Huang, Xiaolin Wang,…This study investigates how a fasting-mimicking diet (FMD) affects colorectal cancer cells, particularly those resistant to chemotherapy. Researchers found that while fasting slows tumor growth, it can also cause cancer…
Autophagy; Colorectal cancer; Drug-tolerant persister cells; Fasting; Ferroptosis; Metabolomics; Quiescent cells - A++2023
The Cognitive and Emotional Aspect in Fibromyalgia: The Importance of the Orofacial Sphere
Bruno Bordoni, Allan R Escher, Gianmarco Cannadoro, Filippo TobbiThis narrative review explores the link between fibromyalgia and issues in the orofacial region, such as temporomandibular joint (TMJ) disorders and periodontitis. The authors suggest that oral inflammation may contribu…
dental occlusion; fibromyalgia; inflammation; osteopathic; pain; temporomandibular joint - A+2023
A New Player in the Mechanobiology of Deep Fascia: Yes-Associated Protein (YAP)
Carmelo Pirri, Brasilina Caroccia, Andrea Angelini, Maria Piazza, Lucia Petrelli, Ilaria Caputo, Chiara Montemurro, Pie…This study investigated the role of Yes-associated protein (YAP) in the mechanobiology of deep fascia, specifically the thoracolumbar fascia. Researchers analyzed tissue samples from patients and found that YAP acts as…
fascia; thoracolumbar fascia; extracellular matrix; fibroblasts; Yes-associated protein (YAP); remodeling - A++2023
What's old is new again: The anatomical studies of Franklin P. Mall and the fascial-interstitial spaces
Carmelo Pirri, Rebecca G Wells, Raffaele De Caro, Carla Stecco, Neil D TheiseFranklin Mall was a pioneering anatomist at the turn of the 19th century whose work is being rediscovered in light of modern fascia research. He studied under Wilhelm His and Carl Ludwig, learning to integrate anatomy w…
His; Mall; Sabin; artery; capillary; fascia; interstitium; liver; lymphatics; reticular network