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The Fascia Guide
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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

Researchers behind the studies
2,806
studies
602
top-graded
2,783
with plain-language summary
TopicAllfascia233extracellular matrix51hyaluronan46inflammation40Connective tissue39mechanotransduction36collagen32Vitamin C31Manual Therapy30acupuncture24
GradeAll1A+++41A++21A+42A++++1A+++317A++236A+84A435
YearAll yearsSince 2020Since 2015Since 2010With summary
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Showing 1,105–1,116 of 1,131 studies · page 93/95
  1. A
    2001

    Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture

    Helene M Langevin, David L Churchill, Marilyn J Cipolla

    This paper proposes a hypothesis for how acupuncture might work. The authors focus on the "de qi" sensation, which includes the acupuncturist feeling a "needle grasp" in the tissue. They suggest that when an acupuncture…

    collagenmechanotransductionmeridian
  2. A
    2000

    Effect of Mechanical Load on Articular Cartilage Collagen Structure: A Scanning Electron-Microscopic Study

    Max J Kääb, Keita Ito, Berton Rahn, John M Clark, Hubert P Nötzli

    This study on rabbit knees examined how static mechanical loads affect the collagen structure of articular cartilage. Researchers applied varying levels of force for different durations to simulate muscle activity, then…

    rabbit.Morphology; Loadingmechanical; Collagen fibers; Scanning electron microscopy; Cryofixation; Freeze substitution
  3. A
    2000

    Adhesive Capsulitis

    Jo A Hannafin, Theresa A Chiaia

    In this 2000 review article, the authors examine adhesive capsulitis, or frozen shoulder, a condition of unknown cause that restricts shoulder motion. They review what is known about its etiology and critically evaluate…

    frozen shoulderAdhesive capsulitisstages
  4. A+
    2000

    Role of collagen hydrolysate in bone and joint disease

    R W Moskowitz

    This narrative review examines the role of collagen hydrolysate in the management of osteoarthritis and osteoporosis. Research suggests that a daily intake of 10 grams of pharmaceutical-grade collagen hydrolysate may he…

    supplementationOsteoporosishydrolysate collagenosteartrithis
  5. A
    1999

    Tensegrity and mechanoregulation: from skeleton to cytoskeleton

    Christopher S Chen, Donald E Ingber

    This review article explores how mechanical forces are transmitted from the whole body down to individual cells. The authors propose that a design principle called "tensegrity," which uses continuous tension and local c…

    extracellular matrixTensegritycytoskeletonmechanotransductionIntegrins
  6. A
    1999

    Oral Administration of 14C Labeled Gelatin Hydrolysate Leads to an Accumulation of Radioactivity in Cartilage of Mice (C57/BL)

    Steffen Oesser, Milan Adam, Wilfried Babel, Jürgen Seifert

    In this animal study, researchers investigated how gelatin hydrolysate is absorbed and distributed in the bodies of mice. Using a radioactive label, they tracked the gelatin after it was administered orally. The results…

    gelatin hydrolysate; peptide absorption; organ distribution; cartilage; mice (C57/BL)
  7. C
    1998

    Thyroid hormone-induced upregulation of Na channels and Na-K pumps: implications for contractility

    Adrian P Harrison, T Clausen

    In this animal study, researchers investigated how thyroid hormone affects muscle endurance in rats. They treated rats with the hormone T3, which increased the concentration of both sodium (Na+) channels and sodium-pota…

    NaKThyroid hormone
  8. A+++
    1998

    The Architecture of Life

    Donald E Ingber

    As this is a title-only entry, the full text has not yet been reviewed. The title, "The Architecture of Life," suggests a focus on the structural principles governing biological systems, possibly involving concepts like…

    Tensegritycytoskeleton
  9. A+
    1997

    Mechanical Loading and TGF-b Regulate Proteoglycan Synthesis in Tendon

    James R Robbins, Stephen P Evanko, Kathryn G Vogel

    Tendons can develop cartilage-like properties in areas subjected to compressive loading. In this study on fetal bovine tendon tissue, researchers investigated how mechanical compression affects the cells. They found tha…

    load forcetissue transition
  10. A
    1997

    Tensegrity: The Architectural Basis of Cellular Mechanotransduction

    D E Ingber

    This 1997 review article proposes a model for how cells sense and respond to physical forces, a process called mechanotransduction. The author suggests that cells are built using 'tensegrity' architecture, a system of b…

    extracellular matrixsignal transductioncytoskeletonIntegrinsmechanoreceptor
  11. A++
    1997

    Functional morphology of serially linked skeletal muscle fibers

    T Hijikata, H Ishikawa

    Skeletal muscle fibers don't always run the full length of a muscle; they often link together in series. This study describes two main ways these connections occur: end-to-end via connective tissue plates, or by overlap…

    EndomysiumMuscle fiber morphologyLinked muscle fiber
  12. C
    1997

    Biophoton emission of the human body

    S Cohen, F A Popp

    Researchers measured "ultraweak" photon emissions, or biophotons, from the human body using a sensitive light detector. The study, involving about 200 individuals, found that these emissions are not random. They appear…

    BiophotonBiological regulationBiological rhythmsHuman body measurmentLeft right symmetry