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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

2,804
studies
602
top-graded
2,783
with plain-language summary
Showing 421–480 of 736 studies · page 8/13Since 2015
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  1. A
    2018

    Treatment for cellulite

    Neil Sadick

    This brief review summarizes the scientific evidence for various treatments for cellulite, a condition present in 80% to 90% of post-pubertal women. The author examines the safety and efficacy of methods ranging from to…

    Cellulite pathophysiology adipocytes radiofrequency lasers
  2. A+++
    2018

    The kinetics of gut microbial community composition in patients with irritable bowel syndrome following fecal microbiota transplantation

    Tarek Mazzawi, Gülen Arslan Lied, Dag André Sangnes, Magdy El-Salhy, Johannes R Hov, Odd Helge Gilja, Jan Gunnar Hatleb…

    This clinical study investigated how fecal microbiota transplantation (FMT) affects gut bacteria and symptoms in patients with irritable bowel syndrome (IBS). Thirteen patients received stool from healthy donors via gas…

    irritable bowel syndromeIBSFecal microbiota transplantation
  3. A+++
    2018

    Applied Myo-Fascial Advances in Veterinary Medicine and Practice

    A P Harrison, V S Elbrønd

    This review article summarizes recent advances in veterinary medicine with a focus on myofascia. It presents findings on the structure and function of these interconnected tissues, highlighting the benefits of treating…

    acoustic myography; kinetic lines; bioimpedance; acupuncture; release therapy
  4. A
    2018

    Non-invasive Assessment of Lameness in Horses with Dorsal Spinous Process Impingement “Kissing spine”: A Case Study.

    Adrian P Harrison, Anja Jensen, Karoline Holst Riis, Kiwa Riis-Olesen

    In this case study, researchers examined a horse with recurring lameness and "kissing spine" using three non-invasive techniques. Acoustic myography was used to assess muscle activity and locate the injury, while bioimp…

    Bioimpedance analysis; Accelerometry; Acoustic myography; lameness
  5. A
    2018

    Mineralization can be an incidental ultrasonographic finding in equine tendons and ligaments

    Etienne J O O'Brien, Roger K W Smith

    In this observational study on horses, researchers investigated the presence of mineralization, or calcium deposits, in tendons and ligaments using ultrasound. They found it was most common in the deep digital flexor te…

    horsecalcificationDopplerossification
  6. A
    2018

    What Is the Point? The Problem with Acupuncture Research That No One Wants to Talk About

    Helene M Langevin, Peter M Wayne

    In this 2018 commentary, the authors address a persistent criticism of acupuncture research: the unclear scientific basis for "acupuncture points." They argue that the acupuncture research community has not paid enough…

    acupunctureAnatomyacupuncture pointsmethodology
  7. A
    2018

    Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas

    Mari Valkonen, Hannu Haapasalo, Kirsi Rilla, Kristiina Tyynelä-Korhonen, Ylermi Soini , Sanna Pasonen-Seppänen

    Astrocytomas are the most common type of brain tumor in adults. In this retrospective study, researchers investigated hyaluronan, a key component of the brain's extracellular matrix, and its related enzymes in 163 tumor…

    hyaluronanHyaluronan synthaseAstrocytomaPrognosisGlioma
  8. A+
    2018

    Endogenous systems involved in exercise-induced analgesia

    R DA SILVA SANTOS, G GALDINO

    This narrative review describes the phenomenon of exercise-induced analgesia, which is the pain-relieving effect of physical activity. Studied since the 1970s, this effect is seen in both endurance and resistance exerci…

    EndocannabinoidspainexerciseNitric oxideanalgesia
  9. B
    2018

    Effectiveness of sodium bicarbonate infusion on mortality in septic patients with metabolic acidosis

    Zhongheng Zhang, Carlie Zhu, Lei Mo, Yucai Hong

    This retrospective database study investigated whether sodium bicarbonate infusion affected mortality in septic patients with metabolic acidosis. The researchers found no overall survival benefit in the general populati…

    sepsiscritical careSodium bicarbonateMortalityMarginal structural Cox
  10. C
    2018

    Anatomy of the fasciae and fascial spaces of the maxillofacial and the anterior neck regions

    Seiichiro Kitamura

    This narrative review simplifies the complex anatomy of the fascia in the face, jaw, and front of the neck. The author organizes the region into four distinct portions based on their relationship to a key fascial layer,…

    fasciaFascial spaceGross anatomyMaxillofacial regionAnterior neck
  11. A
    2018

    Metabolic acidosis and the role of unmeasured anions in critical illness and injury

    Tobias Zingg, Bishwajit Bhattacharya, Linda L Maerz

    In this review article, the authors discuss metabolic acidosis, a common condition in critically ill patients that is associated with increased mortality. A significant component of this acidosis can be caused by so-cal…

    Metabolic acidosisUnmeasured anionsStrong ion differenceStrong ion gapAnion gap Base excess
  12. A+
    2018

    Negative Air Ions and Their Effects on Human Health and Air Quality Improvement

    Shu-Ye Jiang, Ali Ma, Srinivasan Ramachandran

    This review paper examines the research on negative air ions (NAIs) and their effects on human health and air quality. Used for over a century in air cleaning, NAIs are associated with improved psychological health and…

    negative air ions; superoxide; particulate matter; pulsed electric field
  13. A
    2018

    Biotensegrity and myofascial chains: A global approach to an integrated kinetic chain

    S L Dischiavi, A A Wright, E J Hegedus, C M Bleakley

    This theoretical paper proposes a holistic way to understand human movement, contrasting it with the traditional approach of studying body parts in isolation. The authors suggest a model based on "biotensegrity," where…

    RehabilitationbiotensegrityMuscular chainsDynamic knee valgusHip
  14. A
    2018

    Fractal fluctuations in muscular activity contribute to judgments of length but not heaviness via dynamic touch

    Madhur Mangalam, James D Conners, Damian G Kelty-Stephen, Tarkeshwar Singh

    COPD (Chronic Obstructive Pulmonary Disease) is a progressive condition that often involves chest pain. This article analyzes the possible causes of this pain, focusing on a less frequently considered source: the fascia…

    Biotensegrity · Effortful touch · Fractality · Haptic perception · Multifractality · Muscular effort · Perceptual invariance · Psychophysics
  15. A
    2018

    A New Concept of Biotensegrity Incorporating Liquid Tissues: Blood and Lymph

    Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Roberto Castagna

    This conceptual article proposes an update to the biotensegrity model, which traditionally focuses on the solid structures of the fascial system. The authors argue that "liquid tissues" like blood and lymph should also…

    fasciaChiropracticManual TherapyMyofascialOsteopathic
  16. A++
    2018

    Release of fascial compartment boundaries reduces muscle force output

    Roy J Ruttiman, David A Sleboda,, Thomas J Roberts

    In this animal study, researchers investigated how the fascial sheets that enclose muscles affect their function. They surgically removed the fascia from a wing muscle in wild turkeys to see how it changed the muscle's…

    Muscletendoncompartmentfasciotomyintramuscular pressure
  17. A
    2018

    Hyaluronan in adipogenesis, adipose tissue physiology and systemic metabolism

    Yi Zhu, llja L Kruglikov, Yucel Akgul, Philipp E Scherer

    This narrative review summarizes research on hyaluronic acid (HA), a sugar molecule abundant in the body's extracellular matrix. The functions of HA are largely dictated by its molecular size, and it is commonly used as…

    HA
  18. A+
    2018

    Bone turnover markers after the menopause: T-score approach

    Fatma Gossiel, Hibatallah Altaher, David M Reid, Christian Roux, Dieter Felsenberg, Claus-C Glüer, Richard Eastell

    This study investigated how bone turnover changes in women before and after menopause by measuring specific markers for bone formation (PINP) and bone resorption (CTX). The researchers found that bone turnover increases…

    Bone mineral density; Bone turnover markers; Menopause; Osteoporosis
  19. B
    2018

    The Receptor for Hyaluronan- Mediated Motility (CD168) promotes inflammation and fibrosis after acute lung injury

    Zheng Cui, Jie Liao, Naeun Cheongb, Christopher Longoria, Gaoyuan Cao, Horace M DeLisser, Rashmin C Savani

    In this animal study, researchers investigated the role of a specific receptor, RHAMM, in the body's response to acute lung injury. Using mouse models, they compared outcomes in mice that lacked the RHAMM receptor to th…

    HA
  20. B
    2018

    Global Expression Profiling Identifies a Novel Hyaluronan Synthases 2 Gene in the Pathogenesis of Lower Extremity Varicose Veins

    Chia-Shan Hsieh, Chia-Ti Tsai, Yau-Hung Chen, Sheng-Nan Chang, Juey-Jen Hwang, Eric Y Chuang, I-HuiWu

    Researchers investigated the genetic factors behind varicose veins by comparing vein tissue from patients with and without the condition. They found that the gene hyaluronan synthase 2 (HAS2) was significantly less acti…

    varicose veins; HAS2; RNA seq
  21. A++
    2018

    Female hormones: do they influence muscle and tendon protein metabolism?

    Mette Hansen

    This narrative review examines how female sex hormones, particularly estrogen, influence the metabolism of proteins in muscles and tendons. After menopause, declining hormone levels are associated with accelerated muscl…

    ACL anterior cruciate ligament; ER oestrogen receptors; ERT oestrogen replacement therapy; HRT hormone replacement therapy; IGF-I insulin-like growth factor-I; OC oral contraceptive; Collagen; Hormone replacement therapy; Muscle strength; Oestrogen; Sarcopenia.
  22. A+++
    2018

    Effects of local vibration therapy on various performance parameters: a narrative literature review

    Darrin Germann, Amr El Bouse, Jordan Shnier, Nader Abdelkader, Mohsen Kazemi

    This narrative literature review examines how local muscle vibration (LMV) affects performance parameters such as strength, power, and range of motion. By applying vibrations directly to a specific muscle or tendon, LMV…

    chiropractic; local muscle vibration; performance; vibration.
  23. A+++
    2018

    Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer

    Federica Pellati, Vittoria Borgonetti, Virginia Brighenti, Marco Biagi, Stefania Benvenuti, Lorenzo Corsi

    This narrative review explores the chemical properties and health effects of non-psychoactive compounds found in hemp (Cannabis sativa L.), focusing primarily on cannabidiol (CBD). The research suggests that CBD acts as…

    cancerCannabinoidsOxidative stressiflammation
  24. A
    2018

    Variations in Contents of Hyaluronan in the Peritumoral Micro-Environment of Human Chondrosarcoma

    Caterina Fede, Carla Stecco, Andrea Angelini, Chenglei Fan, Elisa Belluzzi, Assunta Pozzuoli, Pietro Ruggieri, Raffaele…

    The micro-environment surrounding a tumor greatly influences its growth and response to therapy. This study focused on chondrosarcoma, a type of bone cancer resistant to both chemotherapy and radiation. Researchers quan…

    hyaluronan; chondrosarcoma; peritumoral stroma; fascia; tumor micro-environment; malignant bone tumor; grade
  25. A++
    2018

    Bone is fascia

    Stephen Levin

    This entry, based on its title alone, proposes a conceptual link between bone and fascia. Without an abstract or full text, the specific arguments made by the author remain unclear. The title 'Bone is fascia' suggests a…

    fascia
  26. C
    2018

    Small leucine-rich proteoglycans and matrix metalloproteinase-14: Key partners?

    Katarzyna Pietraszek-Gremplewicz, Konstantina Karamanou, Aïchata Niang, Manuel Dauchez, Nicolas Belloy, François-Xavier…

    This narrative review summarizes research on a family of proteins called small leucine-rich proteoglycans (SLRPs). These proteins are important regulators of the extracellular matrix and have been identified as potentia…

    fibromodulinSLRPsLumicanDecorinBiglycan
  27. A+++
    2018

    Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis

    Jing Li

    This commentary presents a meta-analysis of research on using vitamin C to treat sepsis. It builds upon two previous reviews by pooling their data for a combined statistical analysis. The aggregated results indicated a…

    meta-analysisVitamin CAscorbic acidsepsisSevere sepsis
  28. A
    2018

    Measuring the Human Ultra-Weak Photon Emission Distribution Using an Electron-Multiplying, Charge-Coupled Device as a Sensor

    Fernando Ortega-Ojeda, Matías Calcerrada, Alejandro Ferrero, Joaquín Campos, Carmen Garcia-Ruiz

    Living systems, including humans, emit an extremely faint light called ultra-weak photon emission (UPE). This light is thought to be a byproduct of metabolic processes, particularly those involving reactive oxygen speci…

    ultra-weak photon emission; spectrometer; measurement; electron multiplying charge coupled device sensor; liquid crystal tunable filter
  29. A+++
    2018

    Sagittal plane fore hoof unevenness is associated with fore and hindlimb asymmetrical force vectors in the sagittal and frontal planes

    Sarah Jane Hobbs, Sandra Nauwelaerts, Jonathan Sinclair, Hilary M Clayton, Willem Back

    Unevenness in a horse's fore hooves, defined by differences in the dorsal hoof wall angle, affects how force is distributed across both the fore and hindlimbs. This study of 34 riding horses found that hooves with a ste…

    asymmetryriding horsesuneven feethoof angleforce
  30. A++
    2018

    Biomechanical findings in horses showing asymmetrical vertical excursions of the withers at walk

    Anna Byström, Agneta Egenvall, Lars Roepstorff, Marie Rhodin, Filipe S Bragança, Elin Hernlund, René van Weeren, Michae…

    This study investigated movement patterns in seven sound high-level dressage horses to understand why the withers move asymmetrically at a walk. Researchers found that vertical asymmetry in the withers was not caused by…

    asymmetry
  31. A+++
    2018

    The laterality of the gallop gait in Thoroughbred racehorses

    Paulette Cully, Brian Nielsen, Bryony Lancaster, Jessica Martin, Paul McGreevy

    This observational study investigated whether Thoroughbred racehorses have a preferred leading leg when transitioning from a halt to a gallop in starting stalls. Analyzing over 2,000 horses, researchers found no overall…

    asymmetryrace horses
  32. A+
    2018

    Lymphatic System Flows

    James E Moore Jr, Christopher D Bertram

    The lymphatic system plays a crucial role in the body's fluid balance by collecting fluid that has leaked from blood vessels and returning it to the bloodstream. This process works against an adverse pressure gradient,…

    Physiology; Oedema; Cancer; Immunology; Lymph
  33. A
    2018

    The infrapatellar fat pad and the synovial membrane: an anatomo-functional unit

    Veronica Macchi, Elena Stocco, Carla Stecco, Elisa Belluzzi, Marta Favero, Andrea Porzionato, Raffaele De Caro

    This descriptive review summarizes evidence on the close relationship between the infrapatellar fat pad and the synovial membrane in the knee. Anatomically, they are linked, as parts of the synovial membrane insert into…

    infrapatellar fat pad; knee plicae; osteoarthritis; synovial membrane.
  34. A+++
    2018

    Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study

    Do-Un Kim, Hee-Chul Chung, Jia Choi, Yasuo Sakai, Boo-Yong Lee

    This randomized, double-blind, placebo-controlled study evaluated the effects of daily low-molecular-weight collagen peptide (LMWCP) supplementation on the skin of 64 women. Over 12 weeks, researchers measured skin hydr…

    collagen hydrolysate; collagen tripeptide; fish collagen; low-molecular-weight collagen peptide; photoaging; skin elasticity; skin hydration; skin wrinkling; type I collagen.
  35. A
    2018

    Not merely a protective packing organ? A review of fascia and its force transmission capacity

    Jan Wilke, Robert Schleip, Can A Yucesoy, Winfried Banzer

    This review article examines fascia's role in transmitting force throughout the body. Traditionally seen as just a "packing" material, research now suggests fascia is an active tissue that connects muscles into a body-w…

    epimuscular; fascia; force transmission; myofascial chains
  36. A
    2018

    Chest pain in patients with COPD: the fascia’s subtle silence

    Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Roberto Castagna

    In this article, the authors discuss potential causes of chest pain in patients with chronic obstructive pulmonary disease (COPD). They highlight that chest pain is common in COPD and propose that an often-overlooked so…

    fasciadiaphragmmuscle painCOPDthoracic pain
  37. A
    2018

    Muscle spindles of the rat sternomastoid muscle

    Walter Giuriati, Barbara Ravara, Andrea Porzionato, Giovanna Albertin, Carla Stecco, Veronica Macchi, Raffaele De Caro,…

    This animal study on rats examined the sternomastoid muscle in the neck, which has a unique structure. Researchers found it has two distinct regions: a superficial "white" part with fast-twitch fibers and a deep "red" p…

    ratsternomastoid musclemuscle spindlesfiber typestranslational studies
  38. A+++
    2018

    Effect of Health-Promoting Agents on Exclusion-Zone Size

    Abha Sharma, Colby Adams, Benjamin D Cashdollar, Zheng Li, Nam V Nguyen, Himasri Sai, Jiachun Shi, Gautham Velchuru, Ke…

    This experimental study investigated how various health-promoting agents affect the formation of "exclusion zone" (EZ) water, often referred to as the fourth phase of water. Researchers found that substances such as hol…

    dose dependent; dose response; exclusion zone water; health-promoting agents; hydrophilic surface; nutraceuticals
  39. A
    2018

    Low Back Pain: The Potential Contribution of Supraspinal Motor Control and Proprioception

    Michael Lukas Meier, Andrea Vrana, Petra Schweinhardt

    This narrative review explores how motor control—the brain's management of posture and movement—adapts in people with low back pain. While these movement adaptations may reduce pain in the short term, they can sometimes…

    proprioceptionlow back painmotor controlchronic painmotor cortex
  40. A
    2018

    New Proposal to Define the Fascial System

    Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Roberto Castagna, Beatrice Sacconi, Paul Mazzucco

    In this proposal, the authors suggest a new definition for the fascial system, noting that a universally accepted one does not yet exist. They argue for including the epidermis (the outer layer of skin) based on functio…

    fasciaConnective tissuefibroblastMyofascialSkin
  41. A
    2018

    Fascial well-being: Mechanotransduction in manual and movement therapies

    Leon Chaitow

    This article discusses mechanotransduction, the process by which cells in connective tissue sense and respond to mechanical forces like stretch, compression, and shear. Specialized cells such as fibroblasts communicate…

    mechanotransduction
  42. 1A+
    2018

    From mechanobiology to developmentally inspired engineering

    Donald Ingber

    This review article, based on a lecture, explores the field of mechanobiology, which studies the central role of physical forces in development and physiology. The author reviews 40 years of his laboratory's foundationa…

    Tensegritymechanicalorgans-on-chipstissue engineering
  43. A+++
    2018

    Exclusion zone and heterogeneous water structure at ambient temperature

    Seong G Hwang, Jun Ki Hong, Abha Sharma, Gerald H Pollack, Gun Woong Bahng

    This study investigates how water interacts with hydrophilic surfaces to form "exclusion zones" (EZ)—regions where water is more structured and dense than bulk water. Researchers found that water can form three-dimensio…

    exclusion zone waterEZ waterstructured water
  44. A
    2018

    Meaning of the Solid and Liquid Fascia to Reconsider the Model of Biotensegrity

    Bruno Bordoni, David Lintonbon, Bruno Morabito

    This theoretical article proposes a reconsideration of the traditional biotensegrity model. The authors argue that fascia should be viewed as a system with both solid and liquid components, where blood and lymph constit…

    fasciaChiropracticManual TherapyMyofascialOsteopathic
  45. A
    2018

    Morphometric and dynamic measurements of muscular fascia in healthy individuals using ultrasound imaging: a!summary of the discrepancies and gaps in the current literature

    Caterina Fede, Nathaly Gaudreault, Chenglei Fan, Veronica Macchi, Raffaele De Caro, Carla Stecco

    This narrative review examined existing research on using ultrasound to measure muscular fascia in healthy people. The authors found that while ultrasound is a useful tool, the research is concentrated on a few specific…

    Fascia · Ultrasound imaging · Thickness · Strain · Motion
  46. 1A+++
    2018

    Emission of Biophotons and Adjustable Sounds by the Fascial System: Review and Reflections for Manual Therapy

    Bruno Bordoni, F Marelli, B Morabito, B Sacconi

    In this narrative review, the authors explore how fascia, the web of connective tissue enveloping everything in the body, might communicate. They discuss research suggesting the fascial system may emit faint light parti…

    fasciaMuscleManual TherapyMyofascialOsteopathic
  47. B
    2018

    Cellular Mechanotransduction: From Tension to Function

    F Martino, A R Perestrelo, V Vinarský, S Pagliari, G Forte

    In this review article, the authors describe mechanotransduction—the process by which cells sense and respond to physical forces from their environment, such as the extracellular matrix. These mechanical cues are conver…

    mechanotransductionnucleoskeletonfocal adhesionmechanobiologymechanosensor
  48. A++
    2018

    The Impedance Profile of Acupuncture Points

    Fletcher Kovich

    This study investigated real-time electrical impedance (resistance) at acupuncture points in a single subject. The researcher observed that when impedance decreased at the center of a point, it often increased at a loca…

    acupunctureacupointsimpedancecommunication
  49. A++
    2018

    Various stem cells in acupuncture meridians and points and their putative roles

    Jeanne Adiwinata Pawitan

    This narrative review explores the connection between acupuncture points and an anatomical network known as the Primo Vascular System (PVS). Formerly called the Bong-Han system, the PVS consists of microscopic vessels a…

    Bong-Han system; Kyungrak system; Primo microcell; Primo node; Primo vascular system; Primo vessel; Stem cell.
  50. A
    2018

    Combined vitamin C, hydrocortisone, and thiamine therapy for patients with severe pneumonia who were admitted to the intensive care unit: Propensity score-based analysis of a before-after cohort study

    Won-Young Kim, Eun-Jung Jo, Jung Seop Eom, Jeongha Mok, Mi-Hyun Kim, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee, Kwangha Lee

    This cohort study investigated a combination therapy of vitamin C, hydrocortisone, and thiamine for ICU patients with severe pneumonia. Researchers compared a group receiving the treatment to a control group from the pr…

    Ascorbic acidHydrocortisoneIntensive care unitPneumoniaThiamine
  51. A
    2018

    Morphological evidence of telocytes in human synovium

    Irene Rosa, Mirca Marini, Daniele Guasti, Lidia Ibba-Manneschi, Mirko Manetti

    A relatively new type of cell, called a telocyte, has been found in many human tissues. This study was the first to look for and find these cells in the synovial membrane, which is the lining of our movable joints. Usin…

    telocytessynovium
  52. A
    2018

    Comparison of vibration rolling, nonvibration rolling, and static stretching as a warm-up exercise on flexibility, joint proprioception, muscle strength, and balance in young adults

    Chia-Lun Lee, I-Hua Chu, Bo-Jhang Lyu, Wen-Dien Chang, Nai-Jen Chang

    This study compared the immediate effects of three warm-up techniques in young adults: vibration rolling, non-vibration rolling, and static stretching. Researchers measured changes in lower-body flexibility, joint posit…

    Vibration; self-myofascial release; foam rolling; exercise; performance
  53. A
    2018

    Immediate effects of self-myofascial release on latent trigger point sensitivity: a randomized, placebo-controlled trial

    Jan Wilke, Lutz Vogt, Winfried Banzer

    This randomized, placebo-controlled trial examined whether foam rolling could immediately reduce sensitivity in latent trigger points. Researchers compared 90 seconds of static compression, dynamic rolling, and a placeb…

    fasciaMyofascial painFoam rollingSelf-masage
  54. A
    2018

    Lipedema

    Caitriona Canning, John R Bartholomew

    A detailed summary of this 2018 publication by Caitriona Canning and John R. Bartholomew is not yet available. The work is titled simply 'Lipedema,' suggesting it may be a general overview or review of the condition. Wi…

    lipedemalipoedemalipolymphedemavascular medicine
  55. A++
    2018

    Low-frequency vibrotherapy considerably improves the effectiveness of manual lymphatic drainage (MLD) in patients with lipedema: A two-armed, randomized, controlled pragmatic trial

    Rainer Schneider

    This randomized controlled trial investigated the effect of adding low-frequency vibrotherapy to manual lymphatic drainage (MLD) for 30 women with stage 2–3 lipedema. Participants were randomly assigned to receive eithe…

    Lipedema; MLD; quality of life; shock wave vibrotherapy
  56. C
    2018

    Sweet, yet underappreciated: Proteoglycans and extracellular matrix remodeling in heart disease

    Geir Christensen, Kate M Heruma, Ida G Lunde

    In this review article, the authors discuss the role of proteoglycans in heart disease. Remodeling of the heart's extracellular matrix, which is common in several cardiac diseases, can lead to fibrosis and impaired func…

    extracellular matrixHeart failureheartProteoglycansSyndecan
  57. A++
    2018

    Subcutaneous adipose tissue therapy reduces fat by dual X-ray absorptiometry scan and improves tissue structure by ultrasound in women with lipoedema and Dercum disease

    M Ibarra, A Eekema, C Ussery, D Neuhardt, K Garby, K L Herbst

    This small study investigated a non-surgical therapy for subcutaneous adipose tissue in seven women with lipoedema or Dercum disease. Over four weeks of treatment, participants experienced significant reductions in weig…

    lipoedemaDercum diseasesubcutaneous adipose tissue.
  58. A
    2018

    Lipedema—An update

    Uwe Wollina

    This review provides an update on lipedema, a chronic condition affecting subcutaneous fat tissue in the limbs, almost exclusively in women. It typically appears during or after puberty and is characterized by symmetric…

    painEdemaobesitylipedemalymphedema
  59. A
    2018

    Fascial preadipocytes: another missing piece of the puzzle to understand fibromyalgia?

    Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Francesca Cavallaro, David Lintonbon

    In this review paper, the authors discuss fibromyalgia, a chronic pain condition whose cause remains uncertain. While often linked to changes in the central nervous system, research also points to peripheral nerve damag…

    fasciaFibromyalgiapainMyofascialneuropathic pain
  60. A+
    2018

    Anatomy of the Superficial Fascia System of the Breast: A Comprehensive Theory of Breast Fascial Anatomy

    Robert D Rehnke, Rachel M Groening, Eric R Van Buskirk, John M Clarke

    This study investigated the three-dimensional fascial structure of the breast through 12 cadaver dissections and clinical observations during surgery. The researchers identified a closed system of fascia and fat that su…

    superficial fasciabreastreconstructive breast surgerycosmetic breast surgery