Hyaluronan in adipogenesis, adipose tissue physiology and systemic metabolism
Yi Zhu, llja L Kruglikov, Yucel Akgul, Philipp E Scherer
HA
Key takeaways
- 01This is a review of existing research
This review explores hyaluronic acid's role in fat tissue, noting its effects on fat cell formation in the body remain unclear.
Hyaluronic acid (HA, also known as hyaluronan), is a non-sulfated linear glycosaminoglycan polymer consisting of repeating disaccharide units of o-glucuronic acid and N-acetyl-o-glucosamine abundantly present in the extracellular matrix. The sizes of hyaluronic acid polymers range from 5000 to 20,000,000 Da in vivo, and the functions of HA are largely dictated by its size. Due to its high biocompatibility, HA has been commonly used as soft tissue filler as well as a major component of biomaterial scaffolds in tissue engineering. Several studies have implicated that HA may promote differentiation of adipose tissue derived stem cells in vitro or in vivo when used as a supporting scaffold. However, whether HA actually promotes adipogenesis in vivo and the subsequent metabolic effects of this process are unclear. This reviewsummarizes some recent publications in the field and discusses the possible directions and approaches for future studies, focusing on the role of HA in the adipose tissue.
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