Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
- A+++2024
B-Group Vitamins as Potential Prebiotic Candidates: Their Effects on the Human Gut Microbiome
Raquel Bedani, Ana Clara Candelaria Cucick, Marcela Albuquerque Cavalcanti de Albuquerque, Jean Guy LeBlanc, Susana Mar…This narrative review explores whether B-group vitamins can act as prebiotics by promoting the growth of beneficial gut bacteria. The authors discuss how B-vitamins that are not absorbed in the small intestine can reach…
B-group vitamin bacterial producers; B-group vitamins; intestinal microbiome; microbiome modulators; prebiotic - A+++2024
Therapeutic applications of gut microbes in cardiometabolic diseases: current state and perspectives
Lin Yuan, Ying Li, Moutong Chen, Liang Xue, Juan Wang, Yu Ding, Qihui Gu, Jumei Zhang, Hui Zhao, Xinqiang Xie, Qingping…This narrative review explores the relationship between gut microbiota and cardiometabolic diseases (CMD), such as hypertension, obesity, and type 2 diabetes. The authors describe how gut microbes and their metabolites…
Cardiometabolic disease; Dietary nutrition; Gut microbiome - A+++2024
Gut-Brain Interactions and Their Impact on Astrocytes in the Context of Multiple Sclerosis and Beyond
Julia Zißler, Veit Rothhammer, Mathias LinnerbauerThis narrative review explores how the interaction between the gut microbiome and the brain influences the progression of multiple sclerosis (MS). The researchers describe how imbalances in gut bacteria can lead to bact…
dysbiosis; gut–brain interactions; microbiome; multiple sclerosis; neuroinflammation - A+++2024
Ultra-processed foods and food additives in gut health and disease
Kevin Whelan, Aaron S Bancil, James O Lindsay, Benoit ChassaingThis narrative review examines the link between ultra-processed foods (UPFs), food additives, and gastrointestinal health. Research suggests that diets high in UPFs are associated with an increased risk of inflammatory…
gut microbiomfood additives - A+++2023
Immediate Effects of Instrument-Assisted Soft Tissue Mobilization on Hydration Content in Lumbar Myofascial Tissues: A Quasi-Experiment
Andreas Brandl, Christoph Egner, Monique Schwarze, Rüdiger Reer, Tobias Schmidt, Robert SchleipThis quasi-experimental study investigated how instrument-assisted soft tissue mobilization (IASTM) affects the hydration levels of the lumbar fascia in 21 healthy volunteers. Researchers used bioimpedance analysis to t…
bioimpedance analysis; instrument-assisted soft tissue mobilization; thoracolumbar fascia; water content. - A+++2023
Regulation of gut microbiota by vitamin C, vitamin E and β-carotene
Xin-Yu Li, Lei Meng, Liang Shen, Hong-Fang JiThis review article summarizes research on how the antioxidants vitamin C, vitamin E, and β-carotene influence the gut microbiota. By analyzing 19 studies, the authors found that these nutrients may alter the compositio…
Gut microbiota; Vitamin C; Vitamin E; β-carotene - A+++2023
The application and trend of ultra-weak photon emission in biology and medicine
Jinxin Du, Tingting Deng, Baorui Cao, Zhiying Wang, Meina Yang, Jinxiang HanThis review article examines ultra-weak photon emission (UPE), a phenomenon where living organisms emit extremely faint light as part of their biological functions. Research has shifted from understanding basic mechanis…
TCM research; oxidative stress; reactive oxygen species (ROS); ultra-weak bioluminescence; ultra-weak photon emission - A+++2023
Fasting and fasting mimicking diets in cancer prevention and therapy
Olga Blaževitš, Maira Di Tano, Valter D LongoThis review explores how cycles of fasting-mimicking diets (FMD) may aid in cancer prevention and therapy. FMDs are designed to be safer and more manageable than water-only fasting while potentially protecting healthy c…
cancer treatment; differential stress resistance (DSR); differential stress sensitization (DSS); fasting mimicking diet - A+++2023
Fasting-mimicking diet synergizes with ferroptosis against quiescent, chemotherapy-resistant cells
Xiaoxia Liu, Shaoyong Peng, Guannan Tang, Gaopo Xu, Yumo Xie, Dingcheng Shen, Mingxuan Zhu, Yaoyi Huang, Xiaolin Wang,…This study investigates how a fasting-mimicking diet (FMD) affects colorectal cancer cells, particularly those resistant to chemotherapy. Researchers found that while fasting slows tumor growth, it can also cause cancer…
Autophagy; Colorectal cancer; Drug-tolerant persister cells; Fasting; Ferroptosis; Metabolomics; Quiescent cells - A+++2023
Effectiveness of visceral fascial therapy targeting visceral dysfunctions outcome: systematic review of randomized controlled trials
Fabiana C da Silva, Leonardo S Vieira, Lucas V Santos, Nathaly Gaudreault, Ronaldo H Cruvinel-Júnior, Gilmar M SantosThis systematic review evaluated 11 randomized controlled trials to investigate the effectiveness of visceral fascial therapy for various health conditions. The results suggest that the therapy may help reduce long-term…
painFascial therapyVisceral manipulation therapyVisceral disorders - A+++2023
Impact of Vitamin D Deficiency on Mental Health in University Students
Mansour Almuqbil, Moneer E Almadani, Salem Ahmad Albraiki, Ali Musharraf Alamri, Ahmed Alshehri, Adel Alghamdi, Sultan…This cross-sectional study investigated the relationship between vitamin D deficiency and mental health among 480 university students in Saudi Arabia. The findings revealed that nearly 60% of participants were vitamin D…
Riyadh; Saudi Arabia; anxiety; depression; mental health; psychological burden; stress; university students; vitamin D deficiency - A+++2023
Pulsed Electromagnetic Fields (PEMF)-Physiological Response and Its Potential in Trauma Treatment
Jonas Flatscher, Elizabeth Pavez Loriè, Rainer Mittermayr, Paul Meznik, Paul Slezak, Heinz Redl, Cyrill SlezakThis narrative review examines the use of Pulsed Electromagnetic Fields (PEMF) as a non-invasive method to promote healing in trauma, primarily within orthopedics. Despite decades of research and observed positive clini…
PEMF; biophysical forces; cellular signaling; clinical use; electromagnetic field; regeneration - A+++2023
Dietary patterns and cardiometabolic health: Clinical evidence and mechanism
Wenting Wang, Yanfei Liu, Yiwen Li, Binyu Luo, Zhixiu Lin, Keji Chen, Yue LiuThis narrative review examines how various dietary patterns influence cardiometabolic health and disease prevention. The researchers emphasize that healthy eating habits, such as the Mediterranean or plant-based diets,…
cardiometabolic disease; clinical evidence; dietary patterns; gut microbiota; mechanism - A+++2023
The Effects of the Mediterranean Diet on Health and Gut Microbiota
Thomas M Barber, Stefan Kabisch, Andreas F H Pfeiffer, Martin O WeickertThis review explores how the Mediterranean Diet, rich in plants, fibers, and olive oil, influences overall health and the gut microbiota. Research suggests that the diet is associated with improved longevity and a reduc…
Mediterranean diet; dietary fibre; gut microbiota; monounsaturated fat - A+++2023
Bioelectronic microfluidic wound healing: a platform for investigating direct current stimulation of injured cell collectives
Sebastian Shaner, Anna Savelyeva, Anja Kvartuh, Nicole Jedrusik, Lukas Matter, José Leal, Maria AsplundThis study investigates how electrical stimulation can accelerate wound healing by mimicking the body's natural electric fields. Researchers developed a bioelectronic microfluidic platform to test the effects of direct…
wound healingDirect current stimulation - A+++2022
Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer
Claudio Vernieri, Giovanni Fucà, Francesca Ligorio, Veronica Huber, Andrea Vingiani, Fabio Iannelli, Alessandra Raimond…This clinical trial investigated the safety and biological effects of a five-day fasting-mimicking diet (FMD) in 101 cancer patients receiving standard treatments. The results suggest that the diet is safe and leads to…
fasting; fasting-mimicking diet; inflammation; intermittent fasting; cancer; antitumor immunity - A+++2022
Making Connections to Improve Health Outcomes
Helene M LangevinIn this editorial, Helene M. Langevin discusses the importance of whole person health, viewing the individual as an interconnected system rather than a collection of isolated organs. She argues that biomedical research…
complementary and alternative medicine; integrative medicine; treatment and prevention - A+++2022
Magnetic fields induce exclusion zones in water
Valery Shalatonin, Gerald H PollackThis study explores how static magnetic fields influence water by creating "exclusion zones" (EZ), areas where particles are pushed away from the magnet's poles. Researchers observed that these zones form at both the no…
EZ waterfourth phase of waterexclusion zonesmagnetic fields - A+++2022
Myofascial Tissue and Depression
Johannes Michala, Lanre Aranmolate, Antonia Bonn, Karen Grandin, Robert Schleip, Jaqueline Schmiedtke, Svenja Quassowsk…This research investigated the link between myofascial tissue and Major Depressive Disorder (MDD) through two distinct studies. The first study found that patients with depression exhibited significantly higher stiffnes…
Depression; Embodiment; Memory bias; Myofascial tissue. - A+++2022
Fetal Fascial Reinforcement Development: From “a White Tablet” to a Sculpted Precise Organization by Movement
Carmelo Pirri, Lucia Petrelli, Albert Pérez-Bellmunt, Sara Ortiz-Miguel, Caterina Fede, Raffaele De Caro, Maribel Migue…This study examined the development of fascia and retinacula (connective tissue reinforcements) in six human fetuses between 24 and 40 weeks of gestation. The researchers found that deep fascia initially lacks organized…
fetus; fascia development; retinacula; gross functional movements - A+++2022
The Effects of Aging on the Intramuscular Connective Tissue
Caterina Fede, Chenglei Fan, Carmelo Pirri, Lucia Petrelli, Carlo Biz, Andrea Porzionato, Veronica Macchi, Raffaele De…This study investigated how intramuscular connective tissue changes with age in both humans and mice. Researchers found that the amount of stiff collagen (Type I) increases significantly with age, while levels of hyalur…
aging; collagen; extracellular matrix; hyaluronan; intramuscular connective tissue; motor control; muscle - A+++2022
The Olympic motto through the lens of equestrian sports
Sarah Jane Hobbs, Hilary M ClaytonThis feature article examines the biomechanics of horses across the three Olympic equestrian disciplines: eventing, show jumping, and dressage. The authors describe how the equine body adapts to meet demands for speed,…
horsecentre of massdressageeventingjumping - A+++2022
Effect of Ground and Raised Poles on Kinematics of the Walk
Vicki A Walker, Carolyne A Tranquillle, Russell MacKechnie-Guire, Jo Spear, Richard Newton, Rachel C MurrayThis study investigated how horses are affected by walking over ground poles and raised poles compared to walking on flat ground. The results suggest that polework increases joint range of motion through enhanced limb f…
Equine; Gait analysis; IMU; Polework; Rehabilitation - A+++2022
Performance of Swedish Warmblood fragile foal syndrome carriers and breeding prospects
Michela Ablondi, Martin Johnsson, Susanne Eriksson, Alberto Sabbioni, Åsa Gelinder Viklund, Sofia MikkoThis research article investigated the prevalence of Warmblood fragile foal syndrome (WFFS) in Swedish Warmblood horses and its potential link to performance. WFFS is a lethal genetic defect affecting collagen stability…
FFSWFFS - A+++2022
Pilot study assessing the effect of Fascial Manipulation on fascial densifications and associated pain
Emmett Hughes, Jessica M Koenig, Robert S Lee, Kena McDermott, Tina Freilicher, Mark H PitcherThis pilot study investigated if Fascial Manipulation (FM) could reduce the thickness of fascial densifications and the acute pain associated with them. Researchers used ultrasound to measure densifications and asked pa…
Fascial manipulation; pain; densification; sex differences; diagnostic ultrasound - A+++2022
Hyaluronan homeostasis and its role in pain and muscle stiffness
Adam Amir, Soo Kim, Antonio Stecco, Michael P Jankowski, Preeti RaghavanThis narrative review explores the role of hyaluronan (HA) in the musculoskeletal system. HA is a key component of the extracellular matrix in muscles and fascia, where it normally functions as a lubricant and shock abs…
hyaluronanpainmuscle stiffness - A+++2022
Immediate Effects of Extracorporeal Shock Wave Therapy in Fascial Fibroblasts: An In Vitro Study
Carmelo Pirri, Caterina Fede, Lucia Petrelli, Enrico De Rose, Carlo Biz, Diego Guidolin, Raffaele De Caro, Carla SteccoThis in vitro study investigated how extracorporeal shock wave therapy (ESWT) affects human fascial fibroblasts in a laboratory setting. Researchers found that immediately after treatment, the cells began producing smal…
fascia; hyaluronan; vesicles; myofascial pain; focused extracorporeal shock waves; 3D printer - A+++2022
Primo Vascular System: Before the Past, Bizarre Present and Peek After the Future
Miroslav StefanovThis theoretical review explores the Primo Vascular System (PVS), a proposed network of channels suggested to carry information throughout the body via weak electromagnetic radiation. The author discusses the system's h…
Future; History; Information medicine; PVS; Quantum biology - A+++2022
Intramuscular connective tissue content and mechanical properties: Influence of aging and physical activity in mice
Annesofie T Olesen, Lasse Malchow-Møller, Rune D Bendixen, Michael Kjær, Abigail L Mackey, S Peter Magnusson, Rene B Sv…This animal study on mice investigated how aging and physical activity affect intramuscular connective tissue (IMCT). Researchers found that IMCT became thicker and stiffer with age, accompanied by an increase in advanc…
Collagen; Decellularized muscle; Endomysium; Picrosirius red; Rodent; Wheel running - A+++2022
Fascial Innervation: A Systematic Review of the Literature
Vidina Suarez-Rodriguez, Caterina Fede, Carmelo Pirri, Lucia Petrelli, Juan Francisco Loro-Ferrer, David Rodriguez-Ruiz…This systematic review examines current evidence regarding the innervation of deep fascia and its potential role in myofascial pain. The findings suggest that fascia is not merely an inert wrapping but a sophisticated s…
fascia; innervation; nociceptor; pain - A+++2022
H2 Inhibits the Formation of Neutrophil Extracellular Traps
Kohsuke Shirakawa, Eiji Kobayashi, Genki Ichihara, Hiroki Kitakata, Yoshinori Katsumata, Kazuhisa Sugai, Yoji Hakamata,…This study investigates how molecular hydrogen (H2) may inhibit the formation of neutrophil extracellular traps (NETs), which are web-like DNA structures released by the immune system. While NETs help fight infections,…
BALbronchoalveolar lavage; CVDcardiovascular disease; CitH3citrullinated histone H3; H2; HOClhypochlorous acid; LPS - A+++2021
Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression
Harriet Emma Clare Sharp, Hugo D Critchley, Jessica A EcclesThis narrative review explores the growing evidence linking joint hypermobility, a common connective tissue variant, with a range of psychiatric conditions. The authors summarize the well-established connection to anxie…
Hypermobile Ehlers-Danlos syndrome; Joint hypermobility; Mind-body relations; Neurodevelopmental disorders; Psychiatric disorders; Psychopathology. - A+++2021
Cell-to-Cell Communication by Host-Released Extracellular Vesicles in the Gut: Implications in Health and Disease
Natalia Diaz-Garrido, Cecilia Cordero, Yenifer Olivo-Martinez, Josefa Badia, Laura BaldomàThis narrative review explores how small sacs called extracellular vesicles (EVs) act as messengers between cells in the gastrointestinal tract. These vesicles transport proteins, lipids, and genetic material that influ…
exosomes; extracellular vesicles; gut communication; gut immunity; intestinal homeostasis; miRNAs - A+++2021
The multiple effects of fecal microbiota transplantation on diarrhea-predominant irritable bowel syndrome (IBS-D) patients with anxiety and depression behaviors
Hao Lin, Qingqing Guo, Zhiyong Wen, Songlin Tan, Jie Chen, Lijian Lin, Pengcheng Chen, Jianquan He, Jianbo Wen, Ye ChenThis study investigated the effects of fecal microbiota transplantation (FMT) on patients with diarrhea-predominant IBS (IBS-D) who also experience anxiety and depression. The results suggest that FMT may alleviate both…
Anxiety and depression; Fecal microbiota transplantation; Irritable bowel syndrome; Metagenome; Short-chain fatty acids - A+++2021
Low frequency weak electric fields can induce structural changes in water
Iman Rad, Rainer Stahlberg, Kurt Kung, Gerald H PollackThis study investigated how weak, low-frequency electric fields affect the structure of different types of water, including "exclusion zone" (EZ) water. Researchers found that exposure to these fields, even without dire…
EZ waterfourth phase of water - A+++2021
A Closer Look at the Cellular and Molecular Components of the Deep/Muscular Fasciae
Caterina Fede, Carmelo Pirri, Chenglei Fan, Lucia Petrelli, Diego Guidolin, Raffaele De Caro, Carla SteccoThis narrative review describes fascia as a complex and dynamic connective tissue network. This network is composed of different cell types, an extracellular matrix, and nerve fibers. Each component plays a specific rol…
fascia; cells; extracellular matrix; nerve - A+++2021
Changes in fecal short-chain fatty acids following fecal microbiota transplantation in patients with irritable bowel syndrome
Magdy El-Salhy, Jørgen Valeur, Trygve Hausken, Jan Gunnar HatlebakkThis clinical study investigated how fecal microbiota transplantation (FMT) affects short-chain fatty acids (SCFAs) in patients with irritable bowel syndrome (IBS). Researchers found that levels of butyric acid increase…
Fecal microbiota transplantationshort chain fatty acidsbutyric acidIrritable Bowel Syndrom - A+++2021
Fascia Focused Manual Therapy Interventions-Proposed Treatment for Post-COVID Syndrome
John SharkeyThis report proposes that fascia-focused manual therapies may be an appropriate treatment for patients with post-COVID syndrome. The author suggests that many of the long-term symptoms following COVID-19, such as soft t…
Coronavirus. Fascia. Post-COVID Syndrome. Long-term COVIDpost-COVID-19 syndrome. Hyaluronan. Angiotensin-converting enzyme 2 [ACE2]. Cytokines - A+++2021
Endocannabinoids and the Gut-Brain Control of Food Intake and Obesity
Nicholas V DiPatrizioThis narrative review explores how the endocannabinoid system in the upper gastrointestinal tract regulates gut-brain communication to control food intake and energy balance. Research suggests that these lipid-derived s…
CB1 receptor; endocannabinoid; food intake; gut-brain; intestine; reward - A+++2021
Intermittent and periodic fasting, longevity and disease
Valter D Longo, Maira Di Tano, Mark P Mattson, Novella GuidiThis narrative review explores how intermittent fasting (IF) and periodic fasting (PF) may influence longevity and healthspan by acting on cellular aging processes. The authors describe how fasting periods ranging from…
fasting; fasting-mimicking diet; inflammation; intermittent fasting - A+++2021
Impaired Lymphatic Drainage and Interstitial Inflammatory Stasis in Chronic Musculoskeletal and Idiopathic Pain Syndromes: Exploring a Novel Mechanism
Brian Tuckey, John Srbely, Grant Rigney, Meena Vythilingam, Jay ShahIn this theoretical paper, the authors propose a potential mechanism for chronic pain syndromes. They hypothesize that impaired lymphatic drainage following trauma or an immune response can trap inflammatory substances…
fasciacytokinesinterstitial inflammatory stasislymphatic dysfunctioncounterstrain techniques - A+++2021
Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
Giulia Salvadori, Federica Zanardi, Fabio Iannelli, Riccardo Lobefaro, Claudio Vernieri, Valter D LongoThis study investigates how a fasting-mimicking diet (FMD) affects triple-negative breast cancer and its stem cells. Researchers found that FMD lowers blood glucose and inhibits growth signaling in cancer stem cells, wh…
CDK4/6; PI3K/AKT; PKA; cancer stem cells; fasting; fasting-mimicking diet; glucose; mTOR; starvation escape pathways; triple-negative breast cancer - A+++2021
The challenges of chronic pain and fatigue
Jessica A Eccles, Kevin A DaviesIn this review article, the authors explore the challenges of chronic pain and fatigue, two common and frequently overlapping symptoms. They discuss possible underlying biological associations, including connective tiss…
Fibromyalgiapainfatiguehypermobilityrheumatology - A+++2021
Myofascial pain in females and personalized care: The key role played by sex hormones
Caterina Fede, Carmelo Pirri, Raffaele De Caro, Carla SteccoBased on its title, this publication appears to explore the relationship between sex hormones and myofascial pain specifically in females. The authors suggest that hormonal factors play a key role in this type of pain.…
Myofascial painsex hormonesfemales - A+++2021
Soft Tissue Manipulation May Attenuate Inflammation, Modulate Pain, and Improve Gait in Conscious Rodents With Induced Low Back Pain
M Terry Loghmani, Carolyn Tobin, Colleen Quigley, Alanna FennimoreThis animal study on rodents explored how instrument-assisted soft tissue manipulation (IASTM) affects pain, gait, and inflammation in cases of low back pain. The researchers found that the treatment suggests an ability…
rehabilitation - A+++2021
Cannabinoids in the landscape of cancer
Nagina Mangal, Simon Erridge, Nagy Habib, Anguraj Sadanandam, Vikash Reebye, Mikael Hans SodergrenThis narrative review explores how cannabinoids—including plant-derived, endogenous, and synthetic versions—interact with cancer in laboratory and animal models. The research suggests that these compounds may inhibit tu…
Cancer; Cannabidiol; Cannabinoid receptors; Cannabinoids; Endocannabinoid system; Tetrahydrocannabinol - A+++2021
Osteogenic effect of low-intensity pulsed ultrasound and whole-body vibration on peri-implant bone. An experimental in vivo study
Kenta Shobara, Toru Ogawa, Aya Shibamoto, Makiko Miyashita, Akiyo Ito, Ratri M SitalaksmiThis animal study in rats investigated whether low-intensity pulsed ultrasound (LIPUS) and whole-body vibration (WBV) could improve bone healing around titanium implants. Researchers compared the effects of LIPUS alone,…
low-intensity pulsed ultrasound (LIPUS); low-magnitude high-frequency loading; osseointegration; osteogenesis; prostheses and implants. - A+++2021
An acupoint-originated human interstitial fluid circulatory network
HongYi Li, Fang Wang, Min Chen, Zhi-Jian Zheng, Ya-Jun Yin, Jun Hu, Hua Li, Andreas Sammer, Georg Feig, Norbert Maurer,…Details from this study have not yet been summarized. The study's title is "An acupoint-originated human interstitial fluid circulatory network". This title suggests the authors are proposing a circulatory network for i…
meridiansacupointsinterstitium - A+++2021
The effects of collagen peptide supplementation on body composition, collagen synthesis, and recovery from joint injury and exercise: a systematic review
Mishti Khatri, Robert J Naughton, Tom Clifford, Liam D Harper, Liam CorrThis systematic review evaluated 15 randomized controlled trials on how collagen peptide supplementation interacts with exercise to affect joint health and recovery. The findings suggest that collagen may be most effect…
Fat free mass; Gelatin; Joint health; Joint pain; Muscle damage; Protein - A+++2021
Cannabinoids in Breast Cancer: Differential Susceptibility According to Subtype
Cristina Ferreira Almeida, Natércia Teixeira, Georgina Correia-da-Silva, Cristina AmaralThis narrative review explores how different subtypes of breast cancer respond to cannabinoids like THC and CBD. Research suggests that estrogen receptor-negative cells may be more susceptible to these compounds than ho…
Cannabis sativa; anandamide; breast cancer; cannabidiol; cannabidivarin; cannabigerol; cannabinoids; cannabinol; Δ9-tetrahydrocannabinol - A+++2021
Resveratrol Enhances the Cytotoxic Activity of Lymphocytes from Menopausal Women
Andrea Di Credico, Giulia Gaggi, Pascal Izzicupo, Ines Bucci, Angela Di BaldassarreThis in vitro study investigated how resveratrol, a natural polyphenol found in grapes and other plants, affects the immune system of postmenopausal women. Researchers isolated lymphocytes from 13 women and co-cultured…
antioxidant effects; cancer; cell-mediated cytotoxicity; immune system; immunomodulatory; menopause; noncommunicable diseases; nutraceuticals; prevention; resveratrol - A+++2021
Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin
Edwin D Lephart, Frederick NaftolinThis narrative review explores how the decline in estrogen levels during menopause significantly impacts skin health and structural integrity. The loss of estrogen leads to reduced collagen and elastin production, along…
4′-Acetoxy resveratrol; Aging; Cosmeceuticals; Equol; Estrogen; Estrogen deficient skin; Hormone therapy; Menopause; Polyphenols; Skin - A+++2021
The Molecular Targets of Cannabinoids in the Treatment of Cancer and Inflammation
Alenabi Aylar, Malekinejad HassanThis narrative review examines how cannabinoids influence inflammation and cancer by interacting with the body's endocannabinoid system. The researchers describe how endogenous, plant-derived, and synthetic compounds ta…
Cannabinoids; anti-proliferative effects; apoptosis; cancer; cell proliferation; inflammation - A+++2021
The Emerging Science of Interoception: Sensing, Integrating, Interpreting, and Regulating Signals within the Self
Wen G Chen, Dana Schloesser, Angela M Arensdorf, Janine M Simmons, Changhai Cui, Rita Valentino, James W Gnadt, Lisbeth…This review article presents a unified framework for interoception, the process by which the body senses, interprets, and regulates its internal signals. The authors propose an expanded definition that includes bidirect…
autonomic; insula; parasympathetic; spinal; sympathetic; vagal - A+++2021
Resveratrol Ameliorates Aortic Calcification in Ovariectomized Rats via SIRT1 Signaling
Sally K Hammad, Rana G Eissa, Mohamed A Shaheen, Nahla N YounisThis animal study on rats investigated how the phytoestrogen resveratrol affects aortic calcification following menopause. Researchers found that resveratrol, similar to estrogen, reduced calcium deposition in arterial…
SIRT1; estrogen; menopause; phytoestrogen; polyphenol; resveratrol; vascular calcification - A+++2021
Parameter-Dependency of Low-Intensity Vibration for Wound Healing in Diabetic Mice
Rita E Roberts, Onur Bilgen, Rhonda D Kineman, Timothy J KohIn this animal study on diabetic mice, researchers investigated how different settings of low-intensity vibration affect wound healing. The mice were exposed to various combinations of vibration frequency and accelerati…
wound healingAngiogenesisgrowth factorsdiabeteslow-intensity vibration - A+++2021
Evidence for continuity of interstitial spaces across tissue and organ boundaries in humans
Odise Cenaj, Douglas H R Allison, Rami Imam, Briana Zeck, Lilly M Drohan, Luis Chiriboga, Jessica Llewellyn, Cheng Z Li…Researchers investigated whether the fluid-filled spaces within our connective tissues, known as the interstitium, are isolated within organs or form a continuous network throughout the body. By tracking particles like…
continuityinterstitiumfluid - A+++2021
Fascial thickness and stiffness in hypermobile Ehlers-Danlos syndrome
Tina J Wang, Antonio SteccoResearchers investigated fascial changes in people with hypermobile Ehlers-Danlos Syndrome (hEDS), a condition often associated with widespread pain. They used ultrasound and elastography to compare fascial thickness an…
deep fasciaconnective tissue disorderhypermobile Ehlers-Danlos syndromeultrasound elastography - A+++2021
Effect of vibration therapy on physical function in critically ill adults (VTICIA trial): protocol for a single-blinded randomised controlled trial
Nobuto Nakanishi, Satoshi Doi, Yoshimi Kawahara, Mie Shiraishi, Jun OtoThis is a protocol for a randomized controlled trial designed to investigate the effect of vibration therapy for critically ill adults. The researchers plan to enroll 188 intensive care unit (ICU) patients and randomly…
vibration therapydeliriummuscle atrophy - A+++2021
Variant connective tissue (joint hypermobility) and dysautonomia are associated with multimorbidity at the intersection between physical and psychological health
Jenny L L Csecs, Nicholas G Dowell, Georgia K Savage, Valeria Iodice, Christopher J Mathias, Hugo D Critchley, Jessica…This study investigated the links between joint hypermobility, autonomic nervous system dysfunction (dysautonomia), and anxiety in adults with mental health or neurodevelopmental conditions. Researchers found that this…
joint hypermobilityAnxietyautonomic dysfunctionmultimorbidity