The challenges of chronic pain and fatigue
- 01Chronic pain and fatigue often occur together
- 02Connective tissue variants like hypermobility may be a factor
- 03Other possible contributors include nerve, immune, and inflammatory issues
- 04A multidisciplinary approach to treatment is recommended
This review suggests chronic pain and fatigue may be linked to underlying issues in connective tissue, nerves, and inflammatory processes.
In this review, we explore the challenges of chronic pain and fatigue in clinical practice. Both pain and fatigue are common, troubling and frequently overlapping symptoms, and we describe both the clinical burden and the 'clinical problem'. We explore commonly associated symptoms and possible pathological associations, including variant connective tissue (joint hypermobility), small fibre neuropathy, mast cell activation, dysregulated inflammatory and interoceptive processes, which may inform treatment targets. We suggest a multidisciplinary management approach.
- APA
- Jessica A Eccles, & Kevin A Davies (2021). The challenges of chronic pain and fatigue. https://fasciaresearchdatabase.com/the-challenges-of-chronic-pain-and-fatigue/
- MLA
- Jessica A Eccles, and Kevin A Davies. "The challenges of chronic pain and fatigue." 2021, https://fasciaresearchdatabase.com/the-challenges-of-chronic-pain-and-fatigue/.
- Chicago
- Jessica A Eccles, Kevin A Davies. 2021. "The challenges of chronic pain and fatigue.". https://fasciaresearchdatabase.com/the-challenges-of-chronic-pain-and-fatigue/
- A++2021Beyond bones: The relevance of variants of connective tissue (hypermobility) to fibromyalgia, ME/CFS and controversies surrounding diagnostic classification: an observational study
- A+++2012Brain structure and joint hypermobility: relevance to the expression of psychiatric symptoms
- C2019Involvement of Acid-Sensing Ion Channel 1b in the Development of Acid-Induced Chronic Muscle Pain
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