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The challenges of chronic pain and fatigue

Jessica A Eccles, Kevin A Davies

Fibromyalgia pain fatigue hypermobility rheumatology

Key takeaways

01Chronic pain and fatigue often occur together
02Connective tissue variants like hypermobility may be a factor
03Other possible contributors include nerve, immune, and inflammatory issues
04A multidisciplinary approach to treatment is recommended

This review suggests chronic pain and fatigue may be linked to underlying issues in connective tissue, nerves, and inflammatory processes.

Abstract

In this review, we explore the challenges of chronic pain and fatigue in clinical practice. Both pain and fatigue are common, troubling and frequently overlapping symptoms, and we describe both the clinical burden and the 'clinical problem'. We explore commonly associated symptoms and possible pathological associations, including variant connective tissue (joint hypermobility), small fibre neuropathy, mast cell activation, dysregulated inflammatory and interoceptive processes, which may inform treatment targets. We suggest a multidisciplinary management approach.

Cite this study

APA: Jessica A Eccles, & Kevin A Davies (2021). The challenges of chronic pain and fatigue. https://fasciaresearchdatabase.com/the-challenges-of-chronic-pain-and-fatigue/
MLA: Jessica A Eccles, and Kevin A Davies. "The challenges of chronic pain and fatigue." 2021, https://fasciaresearchdatabase.com/the-challenges-of-chronic-pain-and-fatigue/.
Chicago: Jessica A Eccles, Kevin A Davies. 2021. "The challenges of chronic pain and fatigue.". https://fasciaresearchdatabase.com/the-challenges-of-chronic-pain-and-fatigue/