Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- B2013
The resolution of inflammation
Christopher D Buckley, Derek W Gilroy, Charles N Serhan, Brigitta Stockinger, Paul P TakThis article summarizes a discussion from a scientific conference on how to turn off undesirable inflammation. There is a growing appreciation that the resolution of inflammation, much like its initiation, is an active…
inflammationresolution - A+2013
Local vitamin-C Injection Reduced Tendon Adhesion in a Chicken Model of Flexor Digitorum Profundus Tendon Injury
Leung-Kim Hung, Sai-Chuen Fu, Yuk-Wa Lee, Tsui-Yu Mok, Kai-Ming ChanThis animal study investigated whether vitamin C could reduce scar tissue formation after a tendon injury. Researchers injured a flexor tendon in chickens and then injected either vitamin C or a saline solution at the s…
Vitamin Chealing tendonadhesion - A2013
Helical Structure of the Cardiac Ventricular Anatomy Assessed by Diffusion Tensor Magnetic Resonance Imaging With Multiresolution Tractography
Ferran Poveda, Debora Gil, Enric Marti, Albert,aluz, Manel Ballester, Francesc CarrerasIn this animal study, researchers used advanced magnetic resonance imaging (MRI) and computer modeling to visualize the complex fiber structure of the heart muscle in dogs. They developed an automated method to trace th…
fasciaheartifdfusion magnetic resonance imagingdiffusion tractographyhelical heart - A2013
Heparan sulfate in the nucleus and its control of cellular functions
Mark D Stewart, Ralph D SandersonThis narrative review discusses the roles of heparan sulfate proteoglycans (HSPGs) inside the cell nucleus. These molecules are typically found on the cell surface and in the extracellular matrix, where they help regula…
ProteoglycanSyndecan-1Nuclear localizationChromatin modificationProliferation - A2013
Cellulite's aetiology: a review
M de la Casa Almeida, Suarez Serrano, J Rebollo Roldán, J J Jiménez RejanoIn this literature review, researchers examined the underlying causes of cellulite. They found that cellulite is a complex phenomenon with many interacting factors, rather than a single cause. The research points to wom…
Connective tissuecellulites - 1A+2013
Fascial Components of the Myofascial Pain Syndrome
Antonio Stecco, M Gesi, Carla Stecco, R SternMyofascial pain syndrome (MPS) involves muscle pain and other symptoms linked to trigger points, but the role of fascia is often overlooked. This review summarizes recent research into the biology of fascia to better un…
fasciaHyaluronic aciddensificationMyofascial pain syndrome (MPS)Myofascial trigger - A++2013
Vibration Induced Osteogenic Commitment of Mesenchymal Stem Cells is Enhanced by Cytoskeletal Remodeling but not Fluid Shear
Gunes Uzer, Suphannee Pongkitwitoon, M Ete Chan, Stefan JudexThis laboratory study investigated how mechanical vibrations encourage stem cells to develop into bone cells. Researchers tested two potential mechanisms: the force of fluid moving across the cells (fluid shear) and cha…
fasciaBonedifferentiationProliferationvibrations - B2013
Vitamin C further improves the protective effect of glucagon-like peptide-1 on acute hypoglycemia-induced oxidative stress, inflammation, and endothelial dysfunction in type 1 diabetes
ANTONIO CERIELLO, ANNA NOVIALS, EMILIO ORTEGA, SILVIA CANIVELL, LUCIA LA SALA, GEMMA PUJADAS, LOREDANA BUCCIARELLI, MAU…Acute low blood sugar (hypoglycemia) in people with type 1 diabetes can cause oxidative stress, inflammation, and damage to the lining of blood vessels. This study investigated whether the hormone GLP-1 and vitamin C co…
Oxidative stressdiabetesVitamin C - A+2013
R-Spondin 1 promotes vibration-induced bone formation in mouse models of osteoporosis
Haitao Wang, Tracy A Brennan, Elizabeth Russell, Jung-Hoon Kim, Kevin P Egan, Qijun Chen, Craig Israelite, David C Schu…This animal study on mice investigated how mechanical signals, like vibration, can stimulate bone growth. Researchers identified proteins secreted by mesenchymal progenitor cells (MPCs) in response to vibration. They fo…
Mechanical signals; vibration; R-spondin 1; telomerase; telomere; aging; osteoporosis; mesenchymal stem cells - A2013
Earthing (Grounding) the Human Body Reduces Blood Viscosity—a Major Factor in Cardiovascular Disease
Gaétan Chevalier, Stephen T Sinatra, James L Oschman, Richard M DelanyThis small study investigated how direct physical contact with the earth, known as 'grounding' or 'earthing', affects blood properties. Ten healthy participants were grounded for two hours using conductive patches on th…
fasciaearthinggroundingearth surface electronscardiovasclar disease - A2013
Dosed Myofascial Release in Three-Dimensional Bioengineered Tendons: Effects on Human Fibroblast Hyperplasia, Hypertrophy, and Cytokine Secretion
Thanh V Cao, Michael R Hicks, David Campbell, Paul R StandleyThis laboratory study investigated how different amounts and durations of simulated myofascial release (MFR) affect lab-grown human tendon tissue. Researchers applied varying degrees of stretch for different lengths of…
fasciamusculoskeletal manipulationsFibroblaststendons - A++2013
Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4T1 breast cancer cells in vitamin-C deficient mice
John Cha, M Waheed Roomi, Vadim Ivanov, Tatiana Kalinovsky, Aleksandra Niedzwiecki, Matthias RathThis animal study investigated how Vitamin C (ascorbate) supplementation affects cancer growth in mice that, like humans, cannot produce their own. Researchers injected melanoma or breast cancer cells into two groups of…
Tumor growthinterleukin-6apoptosismetastasisascorbate