Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+2013
Vitamin C intake, circulating vitamin C and risk of stroke: a meta-analysis of prospective studies
Guo-Chong Chen, Da-Bing Lu, Zhi Pang, Qing-Fang LiuThis meta-analysis combined data from multiple prospective studies to investigate the link between vitamin C and stroke risk. The researchers found that people with higher dietary intake of vitamin C had a lower risk of…
antioxidants • diet • meta-analysis • prevention • stroke - A2013
Molecular assembly and mechanical properties of the extracellular matrix: A fibrous protein perspective
Lisa D Muiznieks, Fred W KeeleyThis review article examines the extracellular matrix (ECM), the dynamic network of molecules surrounding our cells. The authors focus on fibrous proteins like collagen and elastin, which form the structural backbone of…
fasciaextracellular matrixcollageneastinself-assembly - A+++2013
Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection
Yejin Kim, Hyemin Kim, Seyeon Bae, Jiwon Choi, Sun Young Lim, Naeun Lee, Joo Myung Kong, Young-il Hwang, Jae Seung Kang…This animal study investigated how vitamin C affects the immune response to influenza A virus (H3N2). Researchers used mice that, like humans, cannot synthesize their own vitamin C. When these mice were made vitamin C-d…
immune responseVitamin Cantiviralinfluenza Ainterferon alfa/beta - A2013
Complete Obstetric Anal Sphincter Tear and Risk of Long-term Fecal Incontinence: A Cohort Study
Mette M Soerensen, Steen Buntzen, Karl M Bek, Søren LaurbergThis cohort study followed women for over 20 years to assess the long-term effects of complete anal sphincter tears during childbirth. Researchers compared 125 women who experienced such a tear with 238 women who gave b…
Anal sphincter injury; Fecal incontinence; Quality of life. - A++2013
Cell-to-cell signaling through light: just a ghost of chance?
Ondřej Kučera, Michal CifraThis paper examines the physical feasibility of cell-to-cell communication via weak light signals, often referred to as biophotons. The researchers analyze whether electromagnetic signaling is possible when considering…
Cell signalingbiophotonsphoton emission - B2013
TGF-β: Guardian of T Cell Function
Soyoung A Oh, Ming O LiIn this review article, the authors discuss the role of the cytokine TGF-β (transforming growth factor-beta) in the immune system. TGF-β is critical for regulating T cells, a type of white blood cell central to the adap…
cytokinesimmune systemTGF-betaT-cells - A2013
Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts
Nanna Goldman, Devin Chandler-Militello, Helene Langevin, Maiken Nedergaard, Takahiro TakanoThis laboratory study investigated how certain molecules, called purines, affect human fibroblast cells. Previous research has shown that acupuncture can trigger the release of purines like ATP. The researchers exposed…
fasciacytoskeletonacupunctureFibroblastscalcium signaling - A++2013
Air ions and mood outcomes: a review and meta-analysis
Vanessa Perez, Dominik D Alexander, William H BaileyThis review and meta-analysis examined 33 studies to investigate how air ions affect human psychological states. The authors found no consistent effects of positive or negative ionization on anxiety, general mood, relax…
systematic reviewepidemiologyMood disordersDepressionAir ionization - C2013
What Lies Beneath: Sub-Articular Long Bone Shape Scaling in Eutherian Mammals and Saurischian Dinosaurs Suggests Different Locomotor Adaptations for Gigantism
Matthew F Bonnan, D Ray Wilhite, Simon L Masters, Adam M Yates, Christine K Gardner, Adam AguiarThis study explored why giant dinosaurs were more common than giant mammals by examining their joint structures. Researchers compared the long bones of large mammals like elephants and rhinos with those of saurischian d…
fasciaeutherian mammalsdinosaursherbivoresgiant mammals - A2013
Anatomic connections of the diaphragm: influence of respiration on the body system
Bruno Bordoni, Emiliano ZanierThis review article explains why the diaphragm muscle is a critical crossroads of information for the entire body. The authors describe its extensive anatomical, fascial, and neurological connections, which link it to s…
fasciadiaphragmPelvisphrenic nervevagus nerve - A++2013
Mathematical Analysis of the Flow of Hyaluronic Acid Around Fascia During Manual Therapy Motions
Max Roman, Hans Chaudhry, Bruce Bukiet, Antonio Stecco,Thomas FindleyThis study used a mathematical model to simulate how different manual therapy techniques affect the flow of hyaluronic acid (HA) within fascia. The researchers compared constant sliding, perpendicular vibration, and tan…
hyaluronanfasciaManual Therapyfluid flowvibration - A+2013
Reduced adipose tissue lymphatic drainage of macromolecules in obese subjects: a possible link between obesity and local tissue inflammation?
N Arngrim, L Simonsen, J J Holst, J BülowResearchers compared lymphatic drainage from abdominal fat tissue in lean and obese men. They measured drainage before and after the men consumed a glucose drink, which mimics the body's response to a meal. In lean men,…
adipose tissue; lymphatic drainage; blood flow; glucose load; obesity; diabetes