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The Fascia Guide
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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

Researchers behind the studies
2,806
studies
602
top-graded
2,783
with plain-language summary
TopicAllfascia233extracellular matrix51hyaluronan46inflammation40Connective tissue39mechanotransduction36collagen32Vitamin C31Manual Therapy30acupuncture24
GradeAll1A+++41A++21A+42A++++1A+++317A++236A+84A435
YearAll yearsSince 2020Since 2015Since 2010With summary
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Showing 529–540 of 1,131 studies · page 45/95
  1. A
    2017

    Rectus Capitis Posterior Minor

    Gabriel Venne, Brian J Rasquinha, Manuela Kunz, Randy E Ellis

    This cadaver study investigated the connection between a small neck muscle (Rectus Capitis Posterior Minor, RCPMi) and the spinal dura mater. Researchers used both microscopic analysis and biomechanical testing to clari…

    biomechanical testingcervical dura matermechanical influence of musclesmechanical influence of soft tissuerectus capitis posterior minor
  2. A++
    2017

    Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons

    Kelsey A Robinson, Mei Sun, Carrie E Barnum, Stephanie N Weiss, Julianne Huegel, Snehal S Shetye, Linda Lin, Daniel Sae…

    This study on mice investigated the role of two molecules, decorin and biglycan, in maintaining healthy adult tendons. Researchers used a genetic model to remove these molecules from mature patellar tendons after they h…

    Tendon; Decorin; Biglycan; Collagen fibril; Fiber realignment; Structure; Mechanical properties; Conditional knockout mice
  3. A
    2017

    Muscle strength and stiffness in resistance exercise: Force transmission in tissues

    Hans Chaudhry, Bruce Bukiet, Ellen Z Anderson, Jared Burch, Thomas Findley

    Researchers used a mathematical model to estimate how forces are transmitted through the quadriceps muscle during isometric resistance exercises. They specifically looked at how knee angle affects muscle stiffness, stre…

    Knee muscle strength; Stiffness; Mathematical modeling; Resistance exercise
  4. A
    2017

    We are operating too much

    Nicola Maffulli

    In this editorial, the author, an orthopedic and trauma surgeon, observes a rising number of operations for orthopedic and trauma ailments. He notes that this trend runs counter to the results of high-quality studies, w…

    Surgery
  5. A
    2017

    The indeterminable resilience of the fascial system

    Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Beatrice Sacconi

    This commentary proposes a model of fascia not as layers, but as a network of polyhedral microvacuoles of connective tissue. These structures connect the body's systems and can change shape in response to tension, allow…

    fasciafibroblastManual TherapyOsteopathicfascial continuum
  6. A
    2017

    Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease

    Rutger A F Gjaltema, Ruud A Bank

    This narrative review provides an updated overview of the complex process of creating mature collagen. The formation of collagen fibrils from precursor molecules involves many enzymes and chaperones in a series of steps…

    Bruck syndrome; Collagen; Ehlers–Danlos syndrome; connective tissue disorders; fibrosis; lysyl hydroxylation; osteogenesis imperfecta; prolyl hydroxylation.
  7. A
    2017

    The significance of closed kinematic chains to biological movement and dynamic stability

    Stephen Levin, Susan Lowell de Sol!orzano, Graham Scarr

    Biomechanical research has long focused on the body as a system of levers, but this review highlights the importance of "closed kinematic chains" (CKCs). These are continuous mechanical loops that couple multiple parts…

    biotensegrityBiomechanicsClosed-chainDevelopmentEvolution
  8. A
    2017

    What's in a name: Myofascial Release or Myofascial Induction?

    Leon Chaitow

    This commentary discusses two terms for a similar manual therapy technique: Myofascial Release (MFR) and Myofascial Induction Therapy (MIT). The author notes that while the techniques are virtually identical, the names…

    Myofascial releaseMyofascial Induction therapy
  9. A+
    2017

    Hyaluronan as a therapeutic target in human diseases

    Jiurong Liang, Dianhua Jiang, Paul W Noble

    This narrative review explores the role of hyaluronan, a major component of the extracellular matrix involved in tissue injury and repair. Its function varies significantly with its size; fragmented hyaluronan can promo…

    hyaluronan
  10. A++
    2017

    Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels

    Jason Wu, Amanda H Lewis, Jörg Grandl

    This narrative review explores Piezo1 and Piezo2, specialized proteins that act as the body's primary mechanical sensors. These ion channels convert physical forces like touch, tension, and fluid flow into electrical si…

    Mechanotransductionpiezo
  11. C
    2017

    S100A4 in cancer progression and metastasis: A systematic review

    Fei Fei, Jie Qu, Mingqing Zhang, Yuwei Li, Shiwu Zhang

    This systematic review examines the role of the protein S100A4 in cancer progression and metastasis. S100A4 is involved in the epithelial-mesenchymal transition, a key process that allows cancer cells to spread. The aut…

    metastasisS100A4malignant tumorepithelial-mesenchymal transition
  12. B
    2017

    All you need to know about the AIP diet

    Lana Burgess

    This article reviews the Autoimmune Protocol (AIP) diet, which aims to reduce inflammation and relieve symptoms of autoimmune disorders. The diet is based on the idea that problems with the gut wall, sometimes called 'l…

    inflammationAutoimmune protocolautoimmune disease