Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2020
Prevention and treatment of COVID-19 infection by earthing
Haider Abdul-Lateef MousaThis observational study investigated the effects of 'earthing'—direct physical contact with the ground—in 59 people with COVID-19. Participants engaged in earthing for 15 minutes to 3 hours daily. The author reported t…
COVID-19; COVID-19 treatment; COVID-19 prevention; Earthing; Grounding; cytokine storm - A+++2020
Long-term resveratrol supplementation improves pain perception, menopausal symptoms, and overall well-being in postmenopausal women: findings from a 24-month randomized, controlled, crossover trial
Jay Jay Thaung Zaw, Peter R C Howe, Rachel H X WongThis 24-month randomized controlled crossover trial investigated the effects of daily resveratrol supplementation in 125 postmenopausal women. The findings suggest that taking 75 mg of resveratrol twice daily may reduce…
Resveratrolpolyphenolemenopause - A+++2020
Manipulation of the Fascial System Applied During Acute Inflammation of the Connective Tissue of the Thoracolumbar Region Affects Transforming Growth Factor-β1 and Interleukin-4 Levels: Experimental Study in Mice
Maria Elisa Duarte França, Larissa Sinhorim, Daniel Fernandes Martins, Robert Schleip, Nicolas A M M Machado-Pereira, G…This animal study investigated the effects of manual fascial manipulation on acute inflammation in the connective tissue of mice's lower backs. Researchers induced inflammation and then applied a specific manipulation p…
inflammationcytokinesfascial systemManipulationmice - A+++2020
Low-frequency mechanical vibration induces apoptosis of A431 epidermoid carcinoma cells
Wresti L Anggayasti, Chikahiro Imashiro, Taiki Kuribara, Kiichiro Totani, Kenjiro TakemuraResearchers are exploring mechanical vibration as a potential cancer therapy that avoids harming healthy cells. In this lab study, a brief, low-frequency vibration was applied to a line of human skin cancer cells (A431)…
apoptosismechanical vibrationcancer cell modelglucose metabolismhigh-mobility group box 1 - A2020
Calf stretching and plantar fascia-specific stretching for plantar fasciitis: A systematic review and meta-analysis
Akkradate Siriphorn, Sukanya EksakulklaThis systematic review and meta-analysis looked at eight studies to compare two common stretching techniques for plantar fasciitis: calf stretching and plantar fascia-specific stretching. The authors analyzed the data t…
Achilles stretching; Calf stretching; Plantar fascia-specific stretching; Plantar fasciitis; Tendon. - A2020
Day of peak pain reduction by a single session of dry needling in the upper trapezius myofascial trigger points: A 14 daily follow-up study
Phichamon Khanittanuphong, Phichaporn UphoThis study tracked daily pain in people with upper trapezius trigger points following a single dry needling session. Participants received one treatment combined with self-stretching exercises and reported their pain fo…
Dry needling; Myofascial trigger points; Pain; Upper trapezius muscle. - A2020
Iliopsoas muscle thickness and pelvic alignment in pronated and normal foot postures
Zinat Ashnagar, Mohammad-Reza Hadian, Gholamreza Olyaei, Saeed Talebian, Asghar Rezasoltani, Hassan Saeedi, Mir Saeed Y…This study investigated whether chronic foot hyperpronation is linked to changes in pelvic alignment and iliopsoas muscle thickness. Researchers compared a group of women with pronated feet to a group with normal foot p…
Hyperpronation; Iliopsoas; Pelvic angle; Ultrasound imaging. - B2020
Morphological and immunophenotypic characterization of perivascular interstitial cells in human glioma: Telocytes, pericytes, and mixed immunophenotypes
Lubov Mitrofanova, Anton Hazratov, Boris Galkovsky, Andrey Gorshkov, Danila Bobkov, Dmitry Gulyaev, Evgeny ShlyakhtoResearchers investigated two types of cells, telocytes and pericytes, found around blood vessels in brain tumors. The study found that the number of telocytes was ten times higher in the more aggressive glioblastoma tum…
telocytes; pericytes; confocal microscopy; primary culture of glioma telocytes; glioblastoma - B2020
Bicarbonate use and mortality outcome among critically ill patients with metabolic acidosis: A meta analysis
Kevin Bryan Lo, Veronica Garvia, Jessica M Stempel, Pradhum Ram, Janani RangaswamiThis meta-analysis investigated whether treating critically ill patients with sodium bicarbonate for metabolic acidosis, a condition of excess acid in the blood, affects mortality. The use of bicarbonate in intensive ca…
Bicarbonate; ICU; Meta analysis; Metabolic acidosis; Mortality - A2020
The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease
Ting-Yun Chen, Xiaoyun Li, Ching-Hsia Hung, Harinath Bahudhanapati, Jiangning Tan, Daniel J Kass, Yingze ZhangThis review article explores the relaxin hormone and its receptor, RXFP1, a signaling pathway known for its ability to soften ligaments and connective tissue. While relaxin shows potent antifibrotic potential in laborat…
RXFP1; alternative splicing; fibrosis; relaxin. - A+2020
Narrative review of the epidemiology, diagnosis and pathophysiology of pelvic organ prolapse
Adi Y Weintraub, Hannah Glinter, Naama Marcus-BraunThis narrative review examines the epidemiology and causes of pelvic organ prolapse (POP), a condition affecting many women's quality of life. The authors highlight a discrepancy in prevalence rates, noting that while a…
Epidemiology; Pelvic Organ Prolapse; physiopathology - A+++2020
Cannabinoids in Medicine: Cancer, Immunity, and Microbial Diseases
Paweł Śledziński, Agnieszka Nowak-Terpiłowska, Joanna ZeylandThis narrative review explores how cannabinoids, including those from plants and those produced naturally by the body, influence health through the endocannabinoid system. The authors describe how these compounds intera…
cancer medicine; cannabinoid receptors; cannabinoids; immune medicine