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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

2,804
studies
602
top-graded
2,783
with plain-language summary
Showing 421–480 of 1,127 studies · page 8/19With summary
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  1. A
    2018

    Therapeutic potentials of superoxide dismutase

    H Younus

    This narrative review explores the therapeutic potential of superoxide dismutases (SODs), a group of enzymes that serve as a crucial antioxidant defense against oxidative stress in the body. The author discusses the rol…

    Oxidative stresssuperoxide dismutasetherapeutic effects
  2. A
    2018

    The infrapatellar fat pad and the synovial membrane: an anatomo-functional unit

    Veronica Macchi, Elena Stocco, Carla Stecco, Elisa Belluzzi, Marta Favero, Andrea Porzionato, Raffaele De Caro

    This descriptive review summarizes evidence on the close relationship between the infrapatellar fat pad and the synovial membrane in the knee. Anatomically, they are linked, as parts of the synovial membrane insert into…

    infrapatellar fat pad; knee plicae; osteoarthritis; synovial membrane.
  3. A+++
    2018

    Applied Myo-Fascial Advances in Veterinary Medicine and Practice

    A P Harrison, V S Elbrønd

    This review article summarizes recent advances in veterinary medicine with a focus on myofascia. It presents findings on the structure and function of these interconnected tissues, highlighting the benefits of treating…

    acoustic myography; kinetic lines; bioimpedance; acupuncture; release therapy
  4. A
    2018

    Mineralization can be an incidental ultrasonographic finding in equine tendons and ligaments

    Etienne J O O'Brien, Roger K W Smith

    In this observational study on horses, researchers investigated the presence of mineralization, or calcium deposits, in tendons and ligaments using ultrasound. They found it was most common in the deep digital flexor te…

    horsecalcificationDopplerossification
  5. A
    2018

    Frontiers in fascia research

    Carla Alessandra Avila Gonzalez, Mark Driscoll, Robert Schleip, Scott Wearing, Eric Jacobson, Thomas Findley, Werner Kl…

    This article reviews recent developments in fascia research, emphasizing new ways to assess this highly variable tissue. Researchers note that fascia differs greatly between individuals in density, stiffness, and metabo…

    fasciaultrasound.Pain therapySport sciencesIndentometry
  6. A+++
    2018

    Effects of Plantar Vibration on Bone and Deep Fascia in a Rat Hindlimb Unloading Model of Disuse

    Yunfei Huang, Yubo Fan, Michele Salanova, Xiao Yang, Lianwen Sun, Dieter Blottner

    This animal study investigated how disuse affects deep fascia and bone, and whether vibration could counteract these effects. Researchers used a rat model where hindlimbs were unloaded for 21 days to simulate disuse, wh…

    extracellular matrixcollagenBonedeep fasciaBiomechanics
  7. 1A+
    2018

    The Fasciacytes- A New Cell Devoted To Fascial Gliding Regulation

    Carla Stecco, Caterina Fede, Veronica Macchi, Andrea Porzionato, Lucia Petrelli, Carlo Biz, Robert Stern, Raffaele De C…

    Researchers have identified a new type of cell within fascia, which they have named "fasciacytes." This study presents evidence that these specialized cells are responsible for producing hyaluronan, a key component of t…

    hyaluronanfasciafasciacytesextracellular matrix
  8. A
    2018

    What Is the Point? The Problem with Acupuncture Research That No One Wants to Talk About

    Helene M Langevin, Peter M Wayne

    In this 2018 commentary, the authors address a persistent criticism of acupuncture research: the unclear scientific basis for "acupuncture points." They argue that the acupuncture research community has not paid enough…

    acupunctureAnatomyacupuncture pointsmethodology
  9. A++
    2018

    Various stem cells in acupuncture meridians and points and their putative roles

    Jeanne Adiwinata Pawitan

    This narrative review explores the connection between acupuncture points and an anatomical network known as the Primo Vascular System (PVS). Formerly called the Bong-Han system, the PVS consists of microscopic vessels a…

    Bong-Han system; Kyungrak system; Primo microcell; Primo node; Primo vascular system; Primo vessel; Stem cell.
  10. A
    2018

    Pathobiology of cigarette smoke-induced invasive cancer of the renal pelvis and its prevention by vitamin C

    Shinjini Ganguly, Ayan Chandra, Indu B Chatterjee

    In this animal study, researchers investigated how cigarette smoke might cause invasive cancer of the renal pelvis and if vitamin C could offer protection. They found that when guinea pigs were exposed to cigarette smok…

    Invasive cancer of the renal pelvis Cigarette smoke Vitamin C Oxidative damage Persistent EGFR signaling Cell cycle deregulation
  11. A
    2018

    The influence of breathing on the central nervous system

    Bruno Bordoni, Shahin Purgol, Annalisa Bizzarri, Maddalena Modica, Bruno Morabito

    This narrative review explores the diaphragm's extensive influence on the central nervous system. The authors discuss how the rhythm of our breath can physically move the brain, alter patterns of neural oscillation, and…

    diaphragmbreathingphrenic nervevagus nerveneural oscillation
  12. A
    2018

    Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas

    Mari Valkonen, Hannu Haapasalo, Kirsi Rilla, Kristiina Tyynelä-Korhonen, Ylermi Soini , Sanna Pasonen-Seppänen

    Astrocytomas are the most common type of brain tumor in adults. In this retrospective study, researchers investigated hyaluronan, a key component of the brain's extracellular matrix, and its related enzymes in 163 tumor…

    hyaluronanHyaluronan synthaseAstrocytomaPrognosisGlioma
  13. B
    2018

    The different distribution of enzymatic collagen cross-links found in adult and children bone result in different mechanical behavior of collagen

    B Depalle, A G Duarte, I A K Fiedler, L Pujo-Menjouet, M J Buehler, J-P Berteau

    This computational study explored how molecular bonds called collagen cross-links affect bone mechanics differently in children and adults. Using models based on real bone samples, researchers simulated how collagen fib…

    Cross-linksChildren boneMolecular modelingBiomechanical properties
  14. A+
    2018

    Anatomy of the Superficial Fascia System of the Breast: A Comprehensive Theory of Breast Fascial Anatomy

    Robert D Rehnke, Rachel M Groening, Eric R Van Buskirk, John M Clarke

    This study investigated the three-dimensional fascial structure of the breast through 12 cadaver dissections and clinical observations during surgery. The researchers identified a closed system of fascia and fat that su…

    superficial fasciabreastreconstructive breast surgerycosmetic breast surgery
  15. A
    2018

    Treatment for cellulite

    Neil Sadick

    This brief review summarizes the scientific evidence for various treatments for cellulite, a condition present in 80% to 90% of post-pubertal women. The author examines the safety and efficacy of methods ranging from to…

    Cellulite pathophysiology adipocytes radiofrequency lasers
  16. A+++
    2018

    Exclusion zone and heterogeneous water structure at ambient temperature

    Seong G Hwang, Jun Ki Hong, Abha Sharma, Gerald H Pollack, Gun Woong Bahng

    This study investigates how water interacts with hydrophilic surfaces to form "exclusion zones" (EZ)—regions where water is more structured and dense than bulk water. Researchers found that water can form three-dimensio…

    exclusion zone waterEZ waterstructured water
  17. A
    2018

    Chest pain in patients with COPD: the fascia’s subtle silence

    Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Roberto Castagna

    In this article, the authors discuss potential causes of chest pain in patients with chronic obstructive pulmonary disease (COPD). They highlight that chest pain is common in COPD and propose that an often-overlooked so…

    fasciadiaphragmmuscle painCOPDthoracic pain
  18. C
    2018

    Anatomy of the fasciae and fascial spaces of the maxillofacial and the anterior neck regions

    Seiichiro Kitamura

    This narrative review simplifies the complex anatomy of the fascia in the face, jaw, and front of the neck. The author organizes the region into four distinct portions based on their relationship to a key fascial layer,…

    fasciaFascial spaceGross anatomyMaxillofacial regionAnterior neck
  19. A
    2018

    Morphological evidence of telocytes in human synovium

    Irene Rosa, Mirca Marini, Daniele Guasti, Lidia Ibba-Manneschi, Mirko Manetti

    A relatively new type of cell, called a telocyte, has been found in many human tissues. This study was the first to look for and find these cells in the synovial membrane, which is the lining of our movable joints. Usin…

    telocytessynovium
  20. 1A+
    2018

    Stretching Reduces Tumor Growth in a Mouse Breast Cancer Model

    L Berrueta, J Bergholz, D Munoz, I Muskaj, G J Badger, A Shukla, H J Kim, J J Zhao, H M Langevin

    In this mouse study, researchers investigated the effect of daily stretching on breast cancer tumors. Mice with implanted tumor cells were divided into two groups, with one group receiving gentle stretching for 10 minut…

    StretchingTumor growthBreast cancer
  21. C
    2018

    Sweet, yet underappreciated: Proteoglycans and extracellular matrix remodeling in heart disease

    Geir Christensen, Kate M Heruma, Ida G Lunde

    In this review article, the authors discuss the role of proteoglycans in heart disease. Remodeling of the heart's extracellular matrix, which is common in several cardiac diseases, can lead to fibrosis and impaired func…

    extracellular matrixHeart failureheartProteoglycansSyndecan
  22. A++
    2018

    The Impedance Profile of Acupuncture Points

    Fletcher Kovich

    This study investigated real-time electrical impedance (resistance) at acupuncture points in a single subject. The researcher observed that when impedance decreased at the center of a point, it often increased at a loca…

    acupunctureacupointsimpedancecommunication
  23. 1A+
    2018

    Effect of Stretching on Thoracolumbar Fascia Injury and Movement Restriction in a Porcine Model

    H M Langevin, J Bishop, R Maple, G J Badger, J R Fox

    In this animal study on pigs, researchers investigated the effect of stretching on the thoracolumbar fascia after injury and movement restriction. An injury combined with restricted movement led to reduced fascial mobil…

    fasciaConnective tissueStretchingManual TherapyMovement Therapy
  24. A
    2018

    Muscle spindles of the rat sternomastoid muscle

    Walter Giuriati, Barbara Ravara, Andrea Porzionato, Giovanna Albertin, Carla Stecco, Veronica Macchi, Raffaele De Caro,…

    This animal study on rats examined the sternomastoid muscle in the neck, which has a unique structure. Researchers found it has two distinct regions: a superficial "white" part with fast-twitch fibers and a deep "red" p…

    ratsternomastoid musclemuscle spindlesfiber typestranslational studies
  25. A
    2018

    Biotensegrity and myofascial chains: A global approach to an integrated kinetic chain

    S L Dischiavi, A A Wright, E J Hegedus, C M Bleakley

    This theoretical paper proposes a holistic way to understand human movement, contrasting it with the traditional approach of studying body parts in isolation. The authors suggest a model based on "biotensegrity," where…

    RehabilitationbiotensegrityMuscular chainsDynamic knee valgusHip
  26. A+++
    2018

    Effect of Health-Promoting Agents on Exclusion-Zone Size

    Abha Sharma, Colby Adams, Benjamin D Cashdollar, Zheng Li, Nam V Nguyen, Himasri Sai, Jiachun Shi, Gautham Velchuru, Ke…

    This experimental study investigated how various health-promoting agents affect the formation of "exclusion zone" (EZ) water, often referred to as the fourth phase of water. Researchers found that substances such as hol…

    dose dependent; dose response; exclusion zone water; health-promoting agents; hydrophilic surface; nutraceuticals
  27. A
    2018

    Fractal fluctuations in muscular activity contribute to judgments of length but not heaviness via dynamic touch

    Madhur Mangalam, James D Conners, Damian G Kelty-Stephen, Tarkeshwar Singh

    COPD (Chronic Obstructive Pulmonary Disease) is a progressive condition that often involves chest pain. This article analyzes the possible causes of this pain, focusing on a less frequently considered source: the fascia…

    Biotensegrity · Effortful touch · Fractality · Haptic perception · Multifractality · Muscular effort · Perceptual invariance · Psychophysics
  28. A
    2018

    A New Concept of Biotensegrity Incorporating Liquid Tissues: Blood and Lymph

    Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Roberto Castagna

    This conceptual article proposes an update to the biotensegrity model, which traditionally focuses on the solid structures of the fascial system. The authors argue that "liquid tissues" like blood and lymph should also…

    fasciaChiropracticManual TherapyMyofascialOsteopathic
  29. A
    2018

    Low Back Pain: The Potential Contribution of Supraspinal Motor Control and Proprioception

    Michael Lukas Meier, Andrea Vrana, Petra Schweinhardt

    This narrative review explores how motor control—the brain's management of posture and movement—adapts in people with low back pain. While these movement adaptations may reduce pain in the short term, they can sometimes…

    proprioceptionlow back painmotor controlchronic painmotor cortex
  30. A
    2018

    Hyaluronan in adipogenesis, adipose tissue physiology and systemic metabolism

    Yi Zhu, llja L Kruglikov, Yucel Akgul, Philipp E Scherer

    This narrative review summarizes research on hyaluronic acid (HA), a sugar molecule abundant in the body's extracellular matrix. The functions of HA are largely dictated by its molecular size, and it is commonly used as…

    HA
  31. B
    2018

    The Receptor for Hyaluronan- Mediated Motility (CD168) promotes inflammation and fibrosis after acute lung injury

    Zheng Cui, Jie Liao, Naeun Cheongb, Christopher Longoria, Gaoyuan Cao, Horace M DeLisser, Rashmin C Savani

    In this animal study, researchers investigated the role of a specific receptor, RHAMM, in the body's response to acute lung injury. Using mouse models, they compared outcomes in mice that lacked the RHAMM receptor to th…

    HA
  32. B
    2018

    Global Expression Profiling Identifies a Novel Hyaluronan Synthases 2 Gene in the Pathogenesis of Lower Extremity Varicose Veins

    Chia-Shan Hsieh, Chia-Ti Tsai, Yau-Hung Chen, Sheng-Nan Chang, Juey-Jen Hwang, Eric Y Chuang, I-HuiWu

    Researchers investigated the genetic factors behind varicose veins by comparing vein tissue from patients with and without the condition. They found that the gene hyaluronan synthase 2 (HAS2) was significantly less acti…

    varicose veins; HAS2; RNA seq
  33. A
    2018

    New Proposal to Define the Fascial System

    Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Roberto Castagna, Beatrice Sacconi, Paul Mazzucco

    In this proposal, the authors suggest a new definition for the fascial system, noting that a universally accepted one does not yet exist. They argue for including the epidermis (the outer layer of skin) based on functio…

    fasciaConnective tissuefibroblastMyofascialSkin
  34. A
    2018

    Combined vitamin C, hydrocortisone, and thiamine therapy for patients with severe pneumonia who were admitted to the intensive care unit: Propensity score-based analysis of a before-after cohort study

    Won-Young Kim, Eun-Jung Jo, Jung Seop Eom, Jeongha Mok, Mi-Hyun Kim, Ki Uk Kim, Hye-Kyung Park, Min Ki Lee, Kwangha Lee

    This cohort study investigated a combination therapy of vitamin C, hydrocortisone, and thiamine for ICU patients with severe pneumonia. Researchers compared a group receiving the treatment to a control group from the pr…

    Ascorbic acidHydrocortisoneIntensive care unitPneumoniaThiamine
  35. A+++
    2018

    Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer

    Federica Pellati, Vittoria Borgonetti, Virginia Brighenti, Marco Biagi, Stefania Benvenuti, Lorenzo Corsi

    This narrative review explores the chemical properties and health effects of non-psychoactive compounds found in hemp (Cannabis sativa L.), focusing primarily on cannabidiol (CBD). The research suggests that CBD acts as…

    cancerCannabinoidsOxidative stressiflammation
  36. A+++
    2018

    Resveratrol: A Double-Edged Sword in Health Benefits

    Bahare Salehi, Abhay Prakash Mishra, Manisha Nigam, Bilge Sener, Mehtap Kilic, Mehdi Sharifi-Rad, Patrick Valere Tsouh…

    This narrative review explores resveratrol, a natural polyphenol found in grape skins, red wine, and various plants. Research suggests that this compound possesses significant antioxidant, anti-inflammatory, and cardiop…

    anticancer; antimicrobial; antioxidant; pharmacological activity; physiological effects; resveratrol.
  37. A+++
    2018

    Depression and anxiety in patients with chronic heart failure

    Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Beatrice Sacconi

    In this review article, the authors discuss the connection between chronic heart failure (CHF), mental health, and diaphragm function. CHF is a serious, progressive condition often accompanied by depression and anxiety.…

    anxiety • baroreceptors • chronic heart failure • diaphragm • depression • inflammatory cytokines • phrenic nerve • psychiatric disorders • rehabilitation • vagus nerve
  38. A++
    2018

    Female hormones: do they influence muscle and tendon protein metabolism?

    Mette Hansen

    This narrative review examines how female sex hormones, particularly estrogen, influence the metabolism of proteins in muscles and tendons. After menopause, declining hormone levels are associated with accelerated muscl…

    ACL anterior cruciate ligament; ER oestrogen receptors; ERT oestrogen replacement therapy; HRT hormone replacement therapy; IGF-I insulin-like growth factor-I; OC oral contraceptive; Collagen; Hormone replacement therapy; Muscle strength; Oestrogen; Sarcopenia.
  39. 1A+
    2018

    Equine Manual Therapies in Sport Horse Practice

    Kevin K Haussler

    Manual therapies can provide diagnostic and therapeutic approaches for assessing and managing neuromuscular coordination and strength in sport horses. This review describes various techniques, including active and passi…

    osteopathyManual Therapyproprioceptionmassage therapyNeuromuscular control
  40. A
    2018

    Variations in Contents of Hyaluronan in the Peritumoral Micro-Environment of Human Chondrosarcoma

    Caterina Fede, Carla Stecco, Andrea Angelini, Chenglei Fan, Elisa Belluzzi, Assunta Pozzuoli, Pietro Ruggieri, Raffaele…

    The micro-environment surrounding a tumor greatly influences its growth and response to therapy. This study focused on chondrosarcoma, a type of bone cancer resistant to both chemotherapy and radiation. Researchers quan…

    hyaluronan; chondrosarcoma; peritumoral stroma; fascia; tumor micro-environment; malignant bone tumor; grade
  41. A++
    2018

    Ascorbic acid in cancer treatment: let the phoenix fly

    Niraj Shenoy, Edward Creagan, Thomas Witzig, Mark Levine

    This review article discusses the renewed interest in Vitamin C (ascorbic acid) as a potential anti-cancer agent. When administered intravenously, Vitamin C can reach much higher concentrations in the body than when tak…

    cancerVitamin Cascorbatepharmacokinetics
  42. A++
    2018

    Biotensegrity-Anatomy for the 21st Century Informing Yoga and Physiotherapy Concerning New Findings in Fascia Research

    John Sharkey

    This short article discusses how a new view of anatomy, called biotensegrity, is changing our understanding of the human body. This perspective focuses on fascia as a continuous, interconnected network that creates a un…

    biotensegrityyogahuman anatomy
  43. A++
    2018

    Low intensity vibration increases cartilage thickness in obese mice

    Tee Pamon, Vincent Bhandal, Benjamin J Adler, M Ete Chan, Clinton T Rubin

    This animal study investigated if a high-fat diet affected cartilage thickness in mice and if low-intensity vibration (LIV) could offer protection. Contrary to expectations, the high-fat diet alone did not significantly…

    osteoarthritis; chondrocytes; exercise; biomechanics; adaptation; stem cell
  44. A+
    2018

    Bone turnover markers after the menopause: T-score approach

    Fatma Gossiel, Hibatallah Altaher, David M Reid, Christian Roux, Dieter Felsenberg, Claus-C Glüer, Richard Eastell

    This study investigated how bone turnover changes in women before and after menopause by measuring specific markers for bone formation (PINP) and bone resorption (CTX). The researchers found that bone turnover increases…

    Bone mineral density; Bone turnover markers; Menopause; Osteoporosis
  45. A
    2018

    Lipedema—An update

    Uwe Wollina

    This review provides an update on lipedema, a chronic condition affecting subcutaneous fat tissue in the limbs, almost exclusively in women. It typically appears during or after puberty and is characterized by symmetric…

    painEdemaobesitylipedemalymphedema
  46. A+++
    2018

    Low-Intensity Vibration Improves Muscle Healing in a Mouse Model of Laceration Injury

    Thomas F Corbiere, Eileen M Weinheimer-Haus, Stefan Judex, Timothy J Koh

    In this animal study, researchers investigated if low-intensity vibration (LIV) could improve healing of lacerated calf muscles in mice. The mice were divided into groups that received daily vibration treatment and a co…

    skeletal muscle injury; laceration; low-intensity vibration; muscle regeneration; fibrosis
  47. C
    2018

    Small leucine-rich proteoglycans and matrix metalloproteinase-14: Key partners?

    Katarzyna Pietraszek-Gremplewicz, Konstantina Karamanou, Aïchata Niang, Manuel Dauchez, Nicolas Belloy, François-Xavier…

    This narrative review summarizes research on a family of proteins called small leucine-rich proteoglycans (SLRPs). These proteins are important regulators of the extracellular matrix and have been identified as potentia…

    fibromodulinSLRPsLumicanDecorinBiglycan
  48. A+++
    2018

    Sagittal plane fore hoof unevenness is associated with fore and hindlimb asymmetrical force vectors in the sagittal and frontal planes

    Sarah Jane Hobbs, Sandra Nauwelaerts, Jonathan Sinclair, Hilary M Clayton, Willem Back

    Unevenness in a horse's fore hooves, defined by differences in the dorsal hoof wall angle, affects how force is distributed across both the fore and hindlimbs. This study of 34 riding horses found that hooves with a ste…

    asymmetryriding horsesuneven feethoof angleforce
  49. A
    2018

    Fascial preadipocytes: another missing piece of the puzzle to understand fibromyalgia?

    Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Francesca Cavallaro, David Lintonbon

    In this review paper, the authors discuss fibromyalgia, a chronic pain condition whose cause remains uncertain. While often linked to changes in the central nervous system, research also points to peripheral nerve damag…

    fasciaFibromyalgiapainMyofascialneuropathic pain
  50. A+++
    2018

    Anatomical and Functional Relationships Between External Abdominal Oblique Muscle and Posterior Layer of Thoracolumbar Fascia

    Chenglei Fan, Caterina Fede, Nathaly Gaudreault, Andrea Porzionato, Veronica Macchi, Raffaele de Caro, Carla Stecco

    This study investigated the anatomical connection between the external abdominal oblique muscle (EO) and the thoracolumbar fascia (TLF) in the low back. Using both cadaveric dissection and CT scans, researchers found a…

    external abdominal oblique muscle; fascia; lumbar; computed tomography
  51. A
    2018

    The anatomical relationships of the tongue with the body system

    Bruno Bordoni, Bruno Morabito, Roberto Mitrano, Marta Simonelli, Anastasia Toccafondi

    In this review article, the authors examine the tongue's functions and its anatomical connections to the rest of the body. The tongue is not only essential for swallowing, breathing, and speaking, but it also affects po…

    fasciadiaphragmphysiotherapytonguespeech therapy
  52. A
    2018

    Fascial well-being: Mechanotransduction in manual and movement therapies

    Leon Chaitow

    This article discusses mechanotransduction, the process by which cells in connective tissue sense and respond to mechanical forces like stretch, compression, and shear. Specialized cells such as fibroblasts communicate…

    mechanotransduction
  53. A
    2018

    Fasciae of the musculoskeletal system: normal anatomy and MR patterns of involvement in autoimmune diseases

    Thomas Kirchgesner, Xavier Demondion, Maria Stoenoiu, Patrick Durez, Adrien Nzeusseu Toukap, Frédéric Houssiau, Christi…

    This review article describes the fascial system as a three-dimensional continuum of connective tissue found throughout the body. The authors review the normal anatomy of fascia and its appearance on magnetic resonance…

    fasciaMusculoskeletalAnatomyAutoimmuneMRI
  54. A++
    2018

    Vitamin C – A new player in regulation of the cancer epigenome

    Linn Gillberg, Andreas D Ørskov, Minmin Liu, Laurine B S Harsløf, Peter A Jones, Kirsten Grønbæk

    This narrative review explores the emerging role of vitamin C in cancer treatment, particularly in relation to epigenetics. The authors note that vitamin C is crucial for enzymes that help regulate gene expression, and…

    Ascorbic acid; Cancer treatment; Epigenetics; Hematological malignancies; Vitamin C
  55. A+++
    2018

    Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study

    Do-Un Kim, Hee-Chul Chung, Jia Choi, Yasuo Sakai, Boo-Yong Lee

    This randomized, double-blind, placebo-controlled study evaluated the effects of daily low-molecular-weight collagen peptide (LMWCP) supplementation on the skin of 64 women. Over 12 weeks, researchers measured skin hydr…

    collagen hydrolysate; collagen tripeptide; fish collagen; low-molecular-weight collagen peptide; photoaging; skin elasticity; skin hydration; skin wrinkling; type I collagen.
  56. 1A+
    2018

    From mechanobiology to developmentally inspired engineering

    Donald Ingber

    This review article, based on a lecture, explores the field of mechanobiology, which studies the central role of physical forces in development and physiology. The author reviews 40 years of his laboratory's foundationa…

    Tensegritymechanicalorgans-on-chipstissue engineering
  57. A+++
    2018

    Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis

    Jing Li

    This commentary presents a meta-analysis of research on using vitamin C to treat sepsis. It builds upon two previous reviews by pooling their data for a combined statistical analysis. The aggregated results indicated a…

    meta-analysisVitamin CAscorbic acidsepsisSevere sepsis
  58. A
    2018

    Meaning of the Solid and Liquid Fascia to Reconsider the Model of Biotensegrity

    Bruno Bordoni, David Lintonbon, Bruno Morabito

    This theoretical article proposes a reconsideration of the traditional biotensegrity model. The authors argue that fascia should be viewed as a system with both solid and liquid components, where blood and lymph constit…

    fasciaChiropracticManual TherapyMyofascialOsteopathic
  59. A
    2018

    Effectiveness of Physiotherapy Treatment for Urinary Incontinence in Women: A Systematic Review

    Remedios López-Liria, María de los Ángeles Varverde-Martínez, David Padilla-Góngora, Patricia Rocamora-Pérez

    This systematic review evaluated the effectiveness of different physiotherapy techniques for treating urinary incontinence in women. Researchers analyzed 16 studies covering methods such as pelvic floor exercises, vagin…

    physiotherapywomenurinary incontinencepelvic floor muscle
  60. A
    2018

    Morphometric and dynamic measurements of muscular fascia in healthy individuals using ultrasound imaging: a!summary of the discrepancies and gaps in the current literature

    Caterina Fede, Nathaly Gaudreault, Chenglei Fan, Veronica Macchi, Raffaele De Caro, Carla Stecco

    This narrative review examined existing research on using ultrasound to measure muscular fascia in healthy people. The authors found that while ultrasound is a useful tool, the research is concentrated on a few specific…

    Fascia · Ultrasound imaging · Thickness · Strain · Motion