Ascorbic acid in cancer treatment: let the phoenix fly
Niraj Shenoy, Edward Creagan, Thomas Witzig, Mark Levine
Intravenous Vitamin C is being reinvestigated as a promising anti-cancer agent due to newly understood mechanisms of action.
Vitamin C (ascorbic acid, ascorbate), despite controversy, has re-emerged as a promising anti-cancer agent. Recent knowledge of intravenous ascorbate pharmacokinetics and discovery of unexpected mechanisms of ascorbate action have spawned many investigations. Two mechanisms of anti-cancer activity with ascorbate have gained prominence: hydrogen peroxide-induced oxidative stress and DNA demethylation mediated by ten-eleven translocation enzyme activation. Here, we highlight salient aspects of the evolution of ascorbate in cancer treatment, provide insights into the pharmacokinetics of ascorbate, describe mechanisms of its anti-cancer activity in relation to the pharmacokinetics, outline promising preclinical and clinical evidence, and recommend future directions.
The episode was first published on the Swedish podcast Fasciaguiden on May 27, 2025. What if every chronic disease actually stems from the same root cause — the loss of electrons?…
The episode was first published on the Swedish podcast Fasciaguiden on May 26, 2025. In this episode, we meet the French surgeon Jean-Claude Guimberteau, who has spent more than 3…