Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
- A+++2020
Endocannabinoids release after Osteopathic Manipulative Treatment. A brief review
Andrea Buscemi, Simona Martino, Santi Scirè Campisi, Alessandro Rapisarda, Marinella CocoThis brief review examines how Osteopathic Manipulative Treatment (OMT) may influence the body's endocannabinoid system, which is crucial for pain regulation and emotional well-being. By analyzing existing research, the…
chronic pain; endocannabinoids; hypothalamic-pituitary-adrenal axis; osteopathic manipulative treatment - A+2020
Tissue Micro-channels Formed by Collagen Fibers and their Internal Components: Cellular Evidence of Proposed Meridian Conduits in Vertebrate Skin
Bai Xuebing, Wu Ruizhi, Zhang Yue, Liang Chunhua, Shi Yonghong, Zhang Yingxin, Ding Baitao, Imran Tarique, Yang Ping, C…This study examined fascia from various vertebrate species using microscopy to search for physical structures that might correspond to the meridian conduits described in Traditional Chinese Medicine (TCM). Researchers i…
Collagen fiberTelocyteChinese traditional medicinemeridian conduittissue micro-channel - A++2020
Therapeutic importance of hydrogen sulfide in age-associated neurodegenerative diseases
Rubaiya Tabassum, Na Young Jeong, Junyang JungThis narrative review explores the potential of molecular hydrogen (H2) as a preventive and therapeutic medical gas for various health conditions. H2 acts as a selective antioxidant, specifically targeting the most harm…
3-mercaptopyruvate sulfurtransferase; aging; antioxidant; cystathionine β-synthase; cystathionine γ-lyase; glutathione; hydrogen sulfide; neurodegenerative disease; oxidative stress; reactive oxygen species - A++2020
The Efficacy of Stretching Exercises on Arterial Stiffness in Middle-Aged and Older Adults: A Meta-Analysis of Randomized and Non-Randomized Controlled Trials
Michitaka Kato, Fumi Nihei Green, Kazuki Hotta, Toshiya Tsukamoto, Yasunari Kurita, Akira Kubo, Hisato TakagiThis meta-analysis reviewed eight studies involving 213 middle-aged and older adults to see how stretching affects arterial stiffness. The combined results suggest that regular stretching can significantly reduce arteri…
stretching exercises; arterial stiffness; endothelial function; middle-aged; older adult - A+++2020
Ascorbate as Prophylaxis and Therapy for COVID-19—Update From Shanghai and U.S. Medical Institutions
Richard Z Cheng, Mikhail Kogan, Devra DavisThis 2020 report describes how a medical panel in Shanghai evaluated the use of intravenous (IV) ascorbate, or vitamin C, for patients with severe COVID-19. The panel reviewed existing studies and preliminary data from…
COVID-19public healthglobal healthintravenous ascorbate - A2020
A Novel Role of Ascorbic Acid in Anti-Inflammatory Pathway and ROS Generation in HEMA Treated Dental Pulp Stem Cells
Francesca Diomede, Guya Diletta Marconi, Simone Guarnieri, Michele D’Attilio, Marcos F X B Cavalcanti, Maria A Mariggiò…Components from common dental resins can sometimes cause inflammation and oxidative stress in the cells of the dental pulp. This laboratory study investigated whether ascorbic acid (Vitamin C) could protect human dental…
human dental pulp stem cells; hema; ascorbic acid; nfkb; erk; perk; inflammatory cytokines - A+++2020
Is the VITAMINS RCT indicating potential redundancy between corticosteroids and vitamin C?
Anitra C CarrKnown only by its title, this article appears to be a commentary or analysis of a randomized controlled trial (RCT) known as VITAMINS. The title poses a question about whether there might be a "redundancy," or overlappi…
Vitamin Ccorticosteroidsstress respons - A+++2020
Overview of the possible role of vitamin C in management of COVID-19
Anis Abobaker, Aboubaker Alzwi, Alsalheen Hamed A AlraiedIn this 2020 review, the authors examine the possible role of vitamin C in managing COVID-19. They note that the body's vitamin C levels often drop during an acute infection due to increased metabolic demands. Because v…
Vitamin CCOVID-19SARS-CoV-2Beneficial effectsManagement - A+++2020
Effects of Cesarean Section and Vaginal Delivery on Abdominal Muscles and Fasciae
Chenglei Fan, Diego Guidolin, Serena Ragazzo, Caterina Fede, Carmelo Pirri, Nathaly Gaudreault, Andrea Porzionato, Vero…This study used ultrasound to compare the abdominal muscles and fascia of women who had a C-section, a vaginal delivery, or had never given birth. Researchers found that both types of delivery were associated with chang…
caesarean section; vaginal delivery; fascia; abdominal muscles; pain; ultrasound - A+++2020
Antiviral Mechanisms of Vitamin C: A Short Communication Consensus Report
Michael J Gonzalez, Jorge R Miranda-Massari, Jose R Rodriguez, Victor Marcial-Vega, Miguel J Berdiel, Jorge Duconge, St…This 2020 publication is a consensus report from a large group of authors, summarizing agreed-upon points regarding vitamin C. Based on the title, the report details the various mechanisms by which vitamin C may exert a…
Vitamin CAscorbic acidantiviral effects - A+++2020
Vitamin D insufficiency as a potential culprit in critical COVID-19 patients
Ruhul Munshi, Mohammad H Hussein, Eman A Toraih, Rami M Elshazli, Christina Jardak, Nasrin Sultana, Mohanad R Youssef,…In this systematic review, researchers analyzed data from six studies to explore the association between vitamin D levels and COVID-19 severity. They found that patients with a poor prognosis had significantly lower ser…
meta-analysisCOVID-19SARS-CoV-2vitamin Doutcome - A+2020
Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial
Rachel H X Wong, Jay Jay Thaung Zaw, Cory J Xian, Peter R C HoweThis randomized, placebo-controlled trial investigated how daily resveratrol supplementation affects bone health in postmenopausal women. Over 12 months, participants taking 75 mg of resveratrol twice daily showed incre…
AGING; CLINICAL TRIALS; DXA; MENOPAUSE; NUTRITION - A2020
A new clinical trial to test high-dose vitamin C in patients with COVID-19
Anitra C CarrThis 2020 entry by Anitra C. Carr announces a new clinical trial. The study was designed to investigate the effects of high-dose vitamin C on patients with COVID-19. As this is only a title entry, no details about the s…
Vitamin CCOVID-19corona virushigh-dose C - A2020
Tendon and ligament mechanical loading in the pathogenesis of inflammatory arthritis
Eric Gracey, Arne Burssens, Isabelle Cambré, Georg Schett, Rik Lories, Iain B. McInnes, Hiroshi Asahara, Dirk ElewautThis review article discusses how mechanical loading affects tendons and ligaments. While normal levels of loading are essential for maintaining tissue health, pathological levels of force act as a stressor that can tri…
mechanical stressMechanical loadingtendonrepair of tissueligament - A2020
Feeling Things Out: Bidirectional Signaling of the Cell–ECM Interface, Implications in the Mechanobiology of Cell Spreading, Migration, Proliferation, and Differentiation
Andrew E Miller, Ping Hu, Thomas H BarkerThis narrative review describes how cells and their surrounding environment, the extracellular matrix (ECM), constantly communicate with each other. This communication involves physical cues from the ECM being translate…
extracellular matrixstiffnesscytoskeletonmechanotransduction - A2020
Symptomatology correlations between the diaphragm and irritable bowel syndrome
Bruno Bordoni, Bruno MorabitoThis narrative review explores the potential connection between the diaphragm muscle and Irritable Bowel Syndrome (IBS). The authors propose that an altered contractile ability of the diaphragm and different breathing p…
painlow back paindiaphragmirritable bowel syndromechronic headache - A+++2020
Alterations of Extracellular Matrix Mechanical Properties Contribute to Age-Related Functional Impairment of Human Skeletal Muscles
Piero Pavan, Elena Monti, Michela Bondí, Chenglei Fan, Carla Stecco, Marco Narici, Carlo Reggiani, Lorenzo MarcucciThis study investigated why muscles become stiffer with age by comparing individual muscle fibers to bundles of fibers that include the extracellular matrix (ECM). Researchers found that while the stiffness of individua…
aging; collagen; extracellular matrix; resting tension; single muscle fiber; skeletal muscle. - A2020
T1ρ‐Mapping for Musculoskeletal Pain Diagnosis: Case Series of Variation of Water Bound Glycosaminoglycans Quantification before and after Fascial Manipulation® in Subjects with Elbow Pain
Rajiv G Menon, Stephen F Oswald, Preeti Raghavan, Ravinder R Regatte, Antonio SteccoIn this small case series, researchers evaluated five patients with chronic elbow pain. Using an advanced MRI technique (T1ρ-mapping), they measured the concentration of bound and unbound water in the deep fascia before…
T1ρ; fascial manipulation; epicondylitis - A++2020
Fascia and soft tissues innervation in the human hip and their possible role in post-surgical pain
Caterina Fede, Andrea Porzionato, Lucia Petrelli, Chenglei Fan, Carmelo Pirri, Carlo Biz, Raffaele De Caro, Carla SteccoResearchers investigated the nerve supply to various soft tissues in the human hip to better understand persistent pain after hip replacement surgery. Analyzing tissue samples from patients and cadavers, they measured t…
fasciapaininnervationproprioceptionSoft tissue - A2020
A randomized clinical trial for the effect of static stretching and strengthening exercise on pelvic tilt angle in LBP patients
Mohammad Bagher Shamsi, Soodeh Shahsavari, Ameneh Safari, Maryam MirzaeiThis randomized clinical trial investigated whether stretching or strengthening tight hamstrings could change pelvic posture in people with low back pain. Forty-five participants were divided into three groups: static s…
low back painPelvic tiltHamstring - A++2020
Local low-intensity vibration improves healing of muscle injury in mice
Thomas F Corbiere, Timothy J KohIn this animal study, researchers investigated how local low-intensity vibration (LIV) affects muscle injury healing in mice. After lacerating the gastrocnemius (calf) muscle in mice, one group received daily vibration…
skeletal muscle injurycell culturemechanical stimulationmouse modelmuscle repair - A++2020
Telocytes and lymphatic endothelial cells: Two immunophenotypically distinct and spatially close cell entities
Irene Rosa, Mirca Marini, Eleonora Sgambati, Lidia Ibba-Manneschi, Mirko ManettiResearchers have been working to clarify the identity of two cell types, telocytes and lymphatic endothelial cells, which can sometimes look similar in tissue samples. This study used a specific staining technique to lo…
Telocytes and lymphatic endothelial cells: Two immunophenotypically distinct and spatially close cell entities - A2020
Identification of Telocytes in the Pancreas of Turtles—A role in Cellular Communication
Noor Samad Gandahi, Botao Ding, Yonghong Shi, Xuebing Bai, Jameel Ahmed Gandahi, Waseem Ali Vistro, Qiusheng Chen, Ping…In this animal study, researchers examined the pancreas of turtles to look for a specific cell type called telocytes. Using advanced microscopy and other laboratory techniques, they confirmed for the first time that the…
cellular communication; exosomes; pancreas; soft-shelled turtle; telocytes; telopodes. - A+++2020
A Review of the Theoretical Fascial Models: Biotensegrity, Fascintegrity, and Myofascial Chains
Bruno Bordoni, Tom MyersIn this review article, the authors discuss three theoretical models used to understand how fascia functions in the body. The biotensegrity model is mechanical and considers the solid fascia, while the fascintegrity mod…
fasciaMyofascialOsteopathicphysiotherapymyofascial chains - A+++2020
Prevention and treatment of COVID-19 infection by earthing
Haider Abdul-Lateef MousaThis observational study investigated the effects of 'earthing'—direct physical contact with the ground—in 59 people with COVID-19. Participants engaged in earthing for 15 minutes to 3 hours daily. The author reported t…
COVID-19; COVID-19 treatment; COVID-19 prevention; Earthing; Grounding; cytokine storm - A+++2020
Long-term resveratrol supplementation improves pain perception, menopausal symptoms, and overall well-being in postmenopausal women: findings from a 24-month randomized, controlled, crossover trial
Jay Jay Thaung Zaw, Peter R C Howe, Rachel H X WongThis 24-month randomized controlled crossover trial investigated the effects of daily resveratrol supplementation in 125 postmenopausal women. The findings suggest that taking 75 mg of resveratrol twice daily may reduce…
Resveratrolpolyphenolemenopause - A+++2020
Manipulation of the Fascial System Applied During Acute Inflammation of the Connective Tissue of the Thoracolumbar Region Affects Transforming Growth Factor-β1 and Interleukin-4 Levels: Experimental Study in Mice
Maria Elisa Duarte França, Larissa Sinhorim, Daniel Fernandes Martins, Robert Schleip, Nicolas A M M Machado-Pereira, G…This animal study investigated the effects of manual fascial manipulation on acute inflammation in the connective tissue of mice's lower backs. Researchers induced inflammation and then applied a specific manipulation p…
inflammationcytokinesfascial systemManipulationmice - A+++2020
Low-frequency mechanical vibration induces apoptosis of A431 epidermoid carcinoma cells
Wresti L Anggayasti, Chikahiro Imashiro, Taiki Kuribara, Kiichiro Totani, Kenjiro TakemuraResearchers are exploring mechanical vibration as a potential cancer therapy that avoids harming healthy cells. In this lab study, a brief, low-frequency vibration was applied to a line of human skin cancer cells (A431)…
apoptosismechanical vibrationcancer cell modelglucose metabolismhigh-mobility group box 1 - A2020
Calf stretching and plantar fascia-specific stretching for plantar fasciitis: A systematic review and meta-analysis
Akkradate Siriphorn, Sukanya EksakulklaThis systematic review and meta-analysis looked at eight studies to compare two common stretching techniques for plantar fasciitis: calf stretching and plantar fascia-specific stretching. The authors analyzed the data t…
Achilles stretching; Calf stretching; Plantar fascia-specific stretching; Plantar fasciitis; Tendon. - A2020
Day of peak pain reduction by a single session of dry needling in the upper trapezius myofascial trigger points: A 14 daily follow-up study
Phichamon Khanittanuphong, Phichaporn UphoThis study tracked daily pain in people with upper trapezius trigger points following a single dry needling session. Participants received one treatment combined with self-stretching exercises and reported their pain fo…
Dry needling; Myofascial trigger points; Pain; Upper trapezius muscle. - A2020
Iliopsoas muscle thickness and pelvic alignment in pronated and normal foot postures
Zinat Ashnagar, Mohammad-Reza Hadian, Gholamreza Olyaei, Saeed Talebian, Asghar Rezasoltani, Hassan Saeedi, Mir Saeed Y…This study investigated whether chronic foot hyperpronation is linked to changes in pelvic alignment and iliopsoas muscle thickness. Researchers compared a group of women with pronated feet to a group with normal foot p…
Hyperpronation; Iliopsoas; Pelvic angle; Ultrasound imaging. - B2020
Morphological and immunophenotypic characterization of perivascular interstitial cells in human glioma: Telocytes, pericytes, and mixed immunophenotypes
Lubov Mitrofanova, Anton Hazratov, Boris Galkovsky, Andrey Gorshkov, Danila Bobkov, Dmitry Gulyaev, Evgeny ShlyakhtoResearchers investigated two types of cells, telocytes and pericytes, found around blood vessels in brain tumors. The study found that the number of telocytes was ten times higher in the more aggressive glioblastoma tum…
telocytes; pericytes; confocal microscopy; primary culture of glioma telocytes; glioblastoma - B2020
Bicarbonate use and mortality outcome among critically ill patients with metabolic acidosis: A meta analysis
Kevin Bryan Lo, Veronica Garvia, Jessica M Stempel, Pradhum Ram, Janani RangaswamiThis meta-analysis investigated whether treating critically ill patients with sodium bicarbonate for metabolic acidosis, a condition of excess acid in the blood, affects mortality. The use of bicarbonate in intensive ca…
Bicarbonate; ICU; Meta analysis; Metabolic acidosis; Mortality - A2020
The relaxin family peptide receptor 1 (RXFP1): An emerging player in human health and disease
Ting-Yun Chen, Xiaoyun Li, Ching-Hsia Hung, Harinath Bahudhanapati, Jiangning Tan, Daniel J Kass, Yingze ZhangThis review article explores the relaxin hormone and its receptor, RXFP1, a signaling pathway known for its ability to soften ligaments and connective tissue. While relaxin shows potent antifibrotic potential in laborat…
RXFP1; alternative splicing; fibrosis; relaxin. - A+2020
Narrative review of the epidemiology, diagnosis and pathophysiology of pelvic organ prolapse
Adi Y Weintraub, Hannah Glinter, Naama Marcus-BraunThis narrative review examines the epidemiology and causes of pelvic organ prolapse (POP), a condition affecting many women's quality of life. The authors highlight a discrepancy in prevalence rates, noting that while a…
Epidemiology; Pelvic Organ Prolapse; physiopathology - A+++2020
Cannabinoids in Medicine: Cancer, Immunity, and Microbial Diseases
Paweł Śledziński, Agnieszka Nowak-Terpiłowska, Joanna ZeylandThis narrative review explores how cannabinoids, including those from plants and those produced naturally by the body, influence health through the endocannabinoid system. The authors describe how these compounds intera…
cancer medicine; cannabinoid receptors; cannabinoids; immune medicine - A+2020
Role of vitamin K 2 in bone metabolism: a point of view and a short reappraisal of the literature
A Capozzi, G Scambia, S Migliaccio, S LelloThis narrative review examines the role of Vitamin K2 in bone metabolism and its contribution to maintaining skeletal integrity. Vitamin K2 is essential for activating osteocalcin, a key protein that binds calcium to th…
Vitamin K2; bone; fracture; menaquinone; osteoporosis - A++2020
Is the extent of obstetric anal sphincter injury correlated with the severity of fecal incontinence in the long term?
L Luciano, M. Bouvier, K Baumstarck, V VittonThis retrospective study investigated the relationship between the extent of obstetric anal sphincter injury and the severity of long-term fecal incontinence (FI). Researchers analyzed data from 250 women with a mean ag…
Fecal incontinence · Obstetrical anal sphincter injury · Endoanal ultrasonography · 3D high-resolution anorectal manometry · Delivery - A++2020
The potential of cannabidiol in the COVID-19 pandemic
Giuseppe Esposito, Marcella Pesce, Luisa Seguella, Walter Sanseverino, Jie Lu, Chiara Corpetti, Giovanni SarnelliThis scientific hypothesis explores the potential of cannabidiol (CBD) as a supportive treatment during the COVID-19 pandemic. The authors suggest that CBD may down-regulate the receptors the virus uses for cellular ent…
fibrosisCannabinoidsimmune systemCOVID-19anti-inflammatory - A+++2020
Cannabis and cannabidiol (CBD) for the treatment of fibromyalgia
Amnon A Berger, Joseph Keefe, Ariel Winnick, Elasaf Gilbert, Jonathan P Eskander, Cyrus Yazdi, Alan D Kaye, Omar Viswan…This narrative review examines the use of cannabis and cannabidiol (CBD) for treating fibromyalgia, a complex condition that often responds poorly to standard therapies. The authors note that while high-quality randomiz…
CBT; SNRI; SSRI; chronic pain; depression; myalgia. - A+++2020
Sustained Cerebrovascular and Cognitive Benefits of Resveratrol in Postmenopausal Women
Jay Jay Thaung Zaw, Peter R C Howe, Rachel H X WongThis randomized controlled trial investigated how daily resveratrol supplementation affects brain health in postmenopausal women over a 12-month period. Participants took either 75 mg of trans-resveratrol twice daily or…
ageing; cerebrovascular function; cognitive decline; menopause; neurovascular coupling; nutraceutical; phytoestrogen; resveratrol - A2020
Ageing of the diaphragm muscle
Bruno Bordoni, Bruno Morabito, Marta SimonelliThis narrative review explores how the diaphragm, our main breathing muscle, is affected by aging. Like other muscles, the diaphragm can weaken and lose mass over time, a condition known as sarcopenia. This age-related…
fasciadiaphragmskeletal musclephrenic nervevagus nerve - A++2020
Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
Lijun Wang, Xiuling You, Sutada Lotinun, Lingli Zhang, Nan Wu, Weiguo ZouThis study using mouse models investigates how the protein PIEZO1 acts as a mechanical sensor in the skeleton to regulate bone mass. Researchers found that a deficiency of PIEZO1 in bone-forming cells (osteoblasts) lead…
mechanotransductionpiezobone homeostasis - A2020
Muscle Cramps
Bruno Bordoni, Kavin Sugumar, Matthew VaracalloMuscle cramps are involuntary, painful, and localized contractions of a muscle or muscle fibers, often felt as a palpable knot. While common in sports, their exact cause is not fully understood and likely depends on var…
Diagnosiscramp - A+++2020
Fasting-mimicking diet plus chemotherapy in breast cancer treatment
Claudio Vernieri, Francesca Ligorio, Emma Zattarin, Licia Rivoltini, Filippo de BraudThis clinical trial investigated whether a fasting-mimicking diet (FMD) combined with chemotherapy could improve outcomes for breast cancer patients. The overall results were negative, meaning the study did not find a s…
fasting; fasting-mimicking diet; inflammation; intermittent fasting; breast cancer - B2020
Sympathetic activation: a potential link between comorbidities and COVID-19
Andrea Porzionato, Aron Emmi, Silvia Barbon, Rafael Boscolo-Berto, Carla Stecco, Elena Stocco, Veronica Macchi, Raffael…In this perspective article, researchers propose a potential link between common comorbidities and severe COVID-19 outcomes. Conditions like heart disease, hypertension, and diabetes, which are risk factors for severe C…
autonomic nervous system; COVID-19; diabetes; heart failure; hypertension; kidney disease; obesity; SARS-CoV-2; smoking; sympathoactivation - A+++2020
Diet as a Modulator of Intestinal Microbiota in Rheumatoid Arthritis
Eduardo Dourado, Margarida Ferro, Catarina Sousa Guerreiro, João Eurico FonsecaThis narrative review explores how dietary patterns can influence the gut microbiota in individuals with rheumatoid arthritis (RA). Research indicates that RA patients often exhibit significant differences in their inte…
Mediterranean diet; gut microbiota; probiotics; rheumatoid arthritis - A+++2020
Gut Microbiota and Cardiovascular Disease
Marco Witkowski, Taylor L Weeks, Stanley L HazenThis review explores how the gut microbiota influences cardiovascular health through the production of specific metabolic byproducts. Research suggests that the link is not merely associative; certain bacterial metaboli…
atherosclerosis; cardiovascular diseases; gastrointestinal microbiome; thrombosis; vascular diseases - A+2020
Ankle Motion Is Associated With Soft Tissue Displacement in the Dorsal Thigh: An in vivo Investigation Suggesting Myofascial Force Transmission Across the Knee Joint
Jan Wilke, Heloise Debelle, Sarah Tenberg, Andrew Dilley, Constantinos MaganarisThis study investigated how ankle motion affects tissue in the back of the thigh. Researchers passively stretched the calves of healthy participants lying prone with an extended knee. Using ultrasound, they observed tha…
fasciamyofascial chainsultrasound.Myofascial force transmissionrange of motion - A+++2020
Vitamin C-An Adjunctive Therapy for Respiratory Infection, Sepsis and COVID-19
Patrick Holford, Anitra C Carr, Thomas H Jovic, Stephen R Ali, Iain S Whitaker, Paul E Marik, A David SmithIn this literature review, the authors examine vitamin C as a potential adjunctive therapy for respiratory infections, sepsis, and COVID-19. They highlight the vitamin's antioxidant, anti-inflammatory, and immunomodulat…
COVID-19; SARS-CoV-2; coronavirus; vitamin C; ascorbate; colds; pneumonia; sepsis; immunonutrition; supplementation - A+++2020
The Cranial Bowl in the New Millennium and Sutherland's Legacy for Osteopathic Medicine: Part 1
Bruno Bordoni, Stevan Walkowski, Bruno Ducoux, Filippo TobbiIn this review article, the first of a two-part series, the authors examine the foundational assumptions of cranial osteopathy. They argue that a theoretical model must evolve with new scientific information to avoid be…
fasciaOsteopathicdiaphragmcraniocraniosacral - A+++2020
Repositioning Vitamin C as a Promising Option to Alleviate Complications associated with COVID-19
Mithila Farjana, Akhi Moni, Abdullah Al Mamun Sohag, Adeba Hasan, Abdul Hannan, Golzar Hossain, Jamal UddinThis narrative review explores the potential of Vitamin C (L-ascorbic acid) for managing complications associated with COVID-19. The authors highlight its known functions, including antioxidant, anti-inflammatory, and i…
COVID-19; SARS-CoV-2; Vitamin C; Immune response; In!ammation - A++2020
Nutrition, immunity and COVID-19
Philip C CalderThis review discusses the crucial role of nutrition in supporting the immune system's ability to fight infections. A well-functioning immune response requires a steady supply of energy and specific nutrients derived fro…
immune systemVitamins.nutrientsgut microbiome - A+++2020
The Five Diaphragms in Osteopathic Manipulative Medicine: Myofascial Relationships, Part 1
Bruno BordoniThis review article outlines the osteopathic concept of the body's "five diaphragms": the tentorium cerebelli, tongue, thoracic outlet, respiratory diaphragm, and pelvic floor. According to the osteopathic respiratory-c…
fasciaMyofascialOsteopathicdiaphragmphysiotherapy - A+++2020
The Five Diaphragms in Osteopathic Manipulative Medicine: Myofascial Relationships, Part 2
Bruno BordoniThis conceptual review article continues an examination of the "five diaphragms" concept within osteopathic manipulative medicine. The paper focuses on the myofascial connections along the front and sides of the body, e…
fasciaMyofascialOsteopathicdiaphragmphysiotherapy - A++2020
Effect of Low-Intensity Vibration on Bone Strength, Microstructure, and Adiposity in Pre-Osteoporotic Postmenopausal Women: A Randomized Placebo-Controlled Trial
Chamith S Rajapakse, Alyssa J Johncola, Alexandra S Batzdorf, Brandon C Jones, Mona Al Mukaddam, Kelly Sexton, Justine…This randomized, placebo-controlled trial investigated if daily low-intensity vibration could improve bone health in postmenopausal women with pre-osteoporosis. For one year, one group used a vibrating platform for 10 m…
VIBRATION THERAPY; BONE; OSTEOPOROSIS; MRI - A+++2020
Mini-Review on the Roles of Vitamin C, Vitamin D, and Selenium in the Immune System against COVID-19
Minkyung Bae, Hyeyoung KimThis mini-review discusses how vitamin C, vitamin D, and selenium may affect the immune system in relation to COVID-19. Research suggests that deficiencies in these micronutrients are common in patients with acute respi…
COVID-19; infectious disease; selenium; virus; vitamin C; vitamin D - A+++2020
A Closer Look at Anandamide Interaction With TRPV1
Chante Muller, Diane L Lynch, Dow P Hurst, Patricia H ReggioThis study used advanced molecular dynamics simulations to investigate how anandamide, an endocannabinoid, interacts with the TRPV1 ion channel, which is central to pain perception. The researchers observed that anandam…
TRP channels; TRPV1; anandamide; cannabinoids; molecular dynamics - A+2020
The Rolf Method of Structural Integration and Pelvic Floor Muscle Facilitation: Preliminary Results of a Randomized, Interventional Study
Martyna Kasper-Jedrzejewska, Grzegorz Jedrzejewski, Lucyna Ptaszkowska, Kuba Ptaszkowski, Robert Schleip, Tomasz HalskiThis randomized, interventional study investigated how the Rolf Method of Structural Integration (SI) affects pelvic floor muscle function in healthy women. Thirty-three women were divided into two groups; one received…
pelvic floor muscles; Structural Integration; surface electromyography - A+++2020
Do Interventions with Diet or Dietary Supplements Reduce the Disease Activity Score in Rheumatoid Arthritis? A Systematic Review of Randomized Controlled Trials
Josefine Nelson, Helen Sjöblom, Inger Gjertsson, Stine M Ulven, Helen M Lindqvist, Linnea BärebringThis systematic review examined randomized controlled trials to determine if diet or dietary supplements can reduce disease activity in adults with rheumatoid arthritis. The researchers found moderate-strength evidence…
DAS28; Rheumatoid Arthritis; diet