Role of vitamin K 2 in bone metabolism: a point of view and a short reappraisal of the literature
- 01Vitamin K2 activates osteocalcin to effectively bind calcium to bone hydroxyapatite crystals
- 02Low dietary intake of Vitamin K is linked to increased hip fracture risk
- 03Supplementing K2 alongside calcium and Vitamin D may improve bone mineral density
- 04Vitamin K2 appears to inhibit bone-resorbing cells and promote bone-building cells
- 05The ratio of undercarboxylated to carboxylated osteocalcin serves as a marker for K2 status
Vitamin K2 is essential for bone strength as it helps activate the proteins responsible for binding calcium to the skeleton.
Vitamin K2 (vit K2) belongs to a large group of fat-soluble compounds whose formulation is MK (menaquinone) (MK-2 to MK-14), that seem to be involved in different biological functions. In particular, vit K2 has been recently recognized as efficacious and safe in treatment of bone loss, as it contributes to structural integrity of osteocalcin (OC), the major non-collagenous protein typically found in bone matrix. Several studies proved low vit K2 intake is linked to bone loss and to increased fracture risk in both sexes. Nowadays, vit K2 supplementation is considered a significant manner to enhance the association of calcium and vitamin D whose role on bone health is largely recognized. On the other hand, vit K2 may be used alone or with other drugs to preserve bone quality/strength from skeletal degradation after menopause and/or in patients affected by secondary osteoporosis. In this paper, we review the most recent data about vit K2 on skeleton
- APA
- A Capozzi, G Scambia, S Migliaccio, & S Lello (2020). Role of vitamin K 2 in bone metabolism: a point of view and a short reappraisal of the literature. https://fasciaresearchdatabase.com/role-of-vitamin-k-2-in-bone-metabolism-a-point-of-view-and-a-short-reappraisal-of-the-literature/
- MLA
- A Capozzi, et al. "Role of vitamin K 2 in bone metabolism: a point of view and a short reappraisal of the literature." 2020, https://fasciaresearchdatabase.com/role-of-vitamin-k-2-in-bone-metabolism-a-point-of-view-and-a-short-reappraisal-of-the-literature/.
- Chicago
- A Capozzi et al. 2020. "Role of vitamin K 2 in bone metabolism: a point of view and a short reappraisal of the literature.". https://fasciaresearchdatabase.com/role-of-vitamin-k-2-in-bone-metabolism-a-point-of-view-and-a-short-reappraisal-of-the-literature/
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