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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

2,804
studies
602
top-graded
2,783
with plain-language summary
Showing 841–900 of 957 studies · page 15/16Since 2010
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  1. B
    2013

    Understanding mechanotransduction and biotensegrity from an adaptation perspective

    Leon Chaitow

    This article, for which only the title is available, appears to be a conceptual exploration of mechanotransduction and biotensegrity. Mechanotransduction is the process by which cells sense and respond to mechanical for…

    Editorial
  2. A
    2013

    Plantar fascia anatomy and its relationship with Achilles tendon and paratenon

    Carla Stecco, Marco Corradin, Veronica Macchi, Aldo Morra, Andrea Porzionato, Carlo Biz, Raffaele De Caro

    This study investigated the detailed anatomy of the plantar fascia and its connection to the Achilles tendon. Dissections of human cadavers revealed that the fascia is more closely linked to the paratenon (the tendon's…

    hyaluronanfasciaFasciacyteachilles tendonparatenon
  3. A
    2013

    Sensory findings after stimulation of the thoracolumbar fascia with hypertonic saline suggest its contribution to low back pain

    Andreas Schilder, Ulrich Hoheisel, Walter Magerl, Justus Benrath, Thomas Klein, Rolf-Detlef Treede

    This experimental study investigated the role of the thoracolumbar fascia as a potential source of low back pain. Researchers injected a pain-inducing saline solution into the fascia, back muscles, and subcutaneous tiss…

    fasciaThoracolumbar fascialow back painhypertonic salineerector spinae muscle
  4. 1A+
    2013

    Fascial Components of the Myofascial Pain Syndrome

    Antonio Stecco, M Gesi, Carla Stecco, R Stern

    Myofascial pain syndrome (MPS) involves muscle pain and other symptoms linked to trigger points, but the role of fascia is often overlooked. This review summarizes recent research into the biology of fascia to better un…

    fasciaHyaluronic aciddensificationMyofascial pain syndrome (MPS)Myofascial trigger
  5. A
    2013

    Nociception originating from the crural fascia in rats

    T Taguchi, M Yasui, A Kubo, M Abe, H Kiyama, A Yamanaka, K Mizumura

    This animal study investigated how the crural fascia, the connective tissue around the lower leg muscles, might be a source of pain signals in rats. Researchers found that this fascia is densely populated with nerve fib…

    fasciacrural fascianociceptorsactivity-dependent change in conduction velocity (ADCCV)twin pulse difference (TPD)
  6. A++
    2013

    Cell-to-cell signaling through light: just a ghost of chance?

    Ondřej Kučera, Michal Cifra

    This paper examines the physical feasibility of cell-to-cell communication via weak light signals, often referred to as biophotons. The researchers analyze whether electromagnetic signaling is possible when considering…

    Cell signalingbiophotonsphoton emission
  7. 1A+
    2013

    Stress and Matrix-Responsive Cytoskeletal Remodeling in Fibroblasts

    R D Abbott, C Koptiuch, J C Iatridis, A K Howe, G J Badger, H M Langevin

    In loose connective tissue, fibroblasts change shape in response to static stretch, which helps the tissue relax. This study investigated whether this response depends on the cell itself or its surrounding environment,…

    Fibroblasts; cytoskeleton; dense connective tissue; areolar connective tissue; mechanotransduction
  8. 1A+
    2013

    Cytoskeletal remodeling of connective tissue fibroblasts in response to static stretch is dependent on matrix material properties

    R D Abbott, C Koptiuch, J C Iatridis, A K Howe, G J Badger, H M Langevin

    This study investigated how fibroblasts, the cells within connective tissue, change shape in response to static stretching. Researchers compared fibroblasts in loose (areolar) and dense connective tissues, as well as ce…

    Fibroblasts; cytoskeleton; dense connective tissue; areolar connective tissue; mechanotransduction
  9. A
    2013

    Complete Obstetric Anal Sphincter Tear and Risk of Long-term Fecal Incontinence: A Cohort Study

    Mette M Soerensen, Steen Buntzen, Karl M Bek, Søren Laurberg

    This cohort study followed women for over 20 years to assess the long-term effects of complete anal sphincter tears during childbirth. Researchers compared 125 women who experienced such a tear with 238 women who gave b…

    Anal sphincter injury; Fecal incontinence; Quality of life.
  10. A+
    2013

    Reduced adipose tissue lymphatic drainage of macromolecules in obese subjects: a possible link between obesity and local tissue inflammation?

    N Arngrim, L Simonsen, J J Holst, J Bülow

    Researchers compared lymphatic drainage from abdominal fat tissue in lean and obese men. They measured drainage before and after the men consumed a glucose drink, which mimics the body's response to a meal. In lean men,…

    adipose tissue; lymphatic drainage; blood flow; glucose load; obesity; diabetes
  11. A++
    2013

    Vitamin C in Disease Prevention and Cure: An Overview

    Shailja Chambial, Shailendra Dwivedi, Kamla Kant Shukla, Placheril J John, Praveen Sharma

    This narrative review provides an overview of Vitamin C's many roles in the body. It is essential for developing and maintaining connective tissues, and plays a key part in bone formation, wound healing, and gum health.…

    cancerdiabetesVitamin CImmunityinfertility
  12. A++
    2013

    Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4T1 breast cancer cells in vitamin-C deficient mice

    John Cha, M Waheed Roomi, Vadim Ivanov, Tatiana Kalinovsky, Aleksandra Niedzwiecki, Matthias Rath

    This animal study investigated how Vitamin C (ascorbate) supplementation affects cancer growth in mice that, like humans, cannot produce their own. Researchers injected melanoma or breast cancer cells into two groups of…

    Tumor growthinterleukin-6apoptosismetastasisascorbate
  13. A
    2013

    Telocytes: ultrastructural, immunohistochemical and electrophysiological characteristics in human myometrium

    Sanda M Cretoiu, Dragos Cretoiu, Adela Marin, Beatrice Mihaela Radu, Laurentiu M Popescu

    This study identifies a specific cell type, telocytes, within the muscular wall of both the pregnant and non-pregnant human uterus. Researchers found that these cells have a different structure depending on whether the…

    telocytesuterine
  14. A
    2013

    Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations

    Anitra C Carr, Stephanie M Bozonet, Juliet M Pullar, Jeremy W Simcock, Margreet C M Vissers

    This study investigated how vitamin C intake affects its concentration in human skeletal muscle. Researchers gave 36 men either half a kiwifruit or two kiwifruits daily for six weeks, as kiwifruit is a rich source of vi…

    Vitamin Cascorbate
  15. A
    2013

    A Randomized Steady-State Bioavailability Study of Synthetic versus Natural (Kiwifruit-Derived) Vitamin C

    Anitra C Carr, Stephanie M Bozonet, Juliet M Pullar, Jeremy W Simcock, Margreet C M Vissers

    This randomized study investigated whether the body absorbs vitamin C from kiwifruit as effectively as from a synthetic supplement. Thirty-six young men received either half a kiwifruit or an equivalent dose (50 mg) vit…

    ascorbate; ascorbic acid; human; plasma; urine; semen; leukocytes; skeletal muscle
  16. A+
    2013

    Vitamin C intake, circulating vitamin C and risk of stroke: a meta-analysis of prospective studies

    Guo-Chong Chen, Da-Bing Lu, Zhi Pang, Qing-Fang Liu

    This meta-analysis combined data from multiple prospective studies to investigate the link between vitamin C and stroke risk. The researchers found that people with higher dietary intake of vitamin C had a lower risk of…

    antioxidants • diet • meta-analysis • prevention • stroke
  17. A
    2012

    An MRI Study of Symptomatic Adhesive Capsulitis

    Wen Zhao, Xiaofeng Zheng, Yuying Liu, Wenlu Yang, Vardan Amirbekian, Luis E Diaz, Xudong Huang

    This study used magnetic resonance imaging (MRI) to compare the shoulders of 60 patients with clinically diagnosed adhesive capsulitis (frozen shoulder) to 60 healthy control subjects. Researchers found significant diff…

    Adhesive capsulitisShoulderMagnetic resonance imaging
  18. B
    2012

    Hyaluronan differently modulates TLR-4 and the inflammatory response in mouse chondrocytes

    Giuseppe M Campo, Angela Avenoso, Angela D’Ascola, Vera Prestipino, Michele Scuruchi, Giancarlo Nastasi, Alberto Calatr…

    This study on mouse cartilage cells investigated how different sizes of hyaluronan (HA) affect inflammation. Researchers found that small HA fragments increased the production of several inflammatory markers. In contras…

    hyaluronancytokinesNF-kBtoll-like receptor-4chondrocytes
  19. A+
    2012

    The effect of menopause on the skin and other connective tissues

    J Calleja-Agius, M Brincat

    This narrative review examines how menopause and the resulting decline in estrogen affect the body's connective tissues, particularly the skin. Research suggests that skin collagen levels drop significantly following me…

    collagenageingskin tissuemenopauseoestrogen
  20. B
    2012

    Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism

    Jun Li, Daniel J Gorski, Wendy Anemaet, Jennifer Velasco, Jun Takeuchi, John D Sandy, Anna Plaas

    In this mouse study, researchers investigated how hyaluronan (HA) injections might protect joints in osteoarthritis. They found that even though the injected HA was cleared from the knee joint in under two hours, a sing…

    hyaluronanCD44fibrosisTGF-beta1osteoarthritis
  21. A++
    2012

    Discovering the link between nutrition and skin aging

    Silke K Schagen, Vasiliki A Zampeli, Evgenia Makrantonaki, Christos C Zouboulis

    This narrative review examines the relationship between nutrition and skin aging, focusing on how specific nutrients may protect against damage from ultraviolet (UV) radiation. The authors describe how antioxidants such…

    antioxidants; diet; fatty acids; flavonoids; nutrition; skin aging; ultraviolet protection; vitamins.
  22. A
    2012

    Hyaluronic acid, A key molecule in skin aging

    Eleni Papakonstantinou, Michael Roth, George Karakiulakis

    This review article discusses the role of hyaluronic acid (HA) in skin aging. The authors explain that youthful skin's plumpness and resilience are largely due to its high water content, which HA is uniquely able to ret…

    CD44fasciaHyaluronic acidhyaluronic acid synthaseshyaluronidases
  23. A+++
    2012

    Fascia as a body-wide communication system

    James L Oschman

    This abstract proposes that fascia acts as a body-wide communication system. The author draws an analogy to single-celled organisms, like a paramecium, which can perform complex functions without a nervous system by rel…

    Fascia
  24. A++
    2012

    Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity

    Melody A Swartz, Amanda W Lund

    This review explores how tumors interact with the lymphatic system to grow and spread. Increased fluid flow from a tumor to nearby lymph nodes does more than just transport cancer cells. This flow also creates mechanica…

    fasciacancerstiffnessmechanobiologymicroenvironment
  25. A
    2012

    Massage Therapy Attenuates Inflammatory Signaling After Exercise-Induced Muscle Damage

    Justin D Crane, Daniel I Ogborn, Colleen Cupido, Simon Melov, Alan Hubbard, Jacqueline M Bourgeois, Mark A Tarnopolsky

    This study investigated how massage therapy affects skeletal muscle at a cellular level after exercise-induced damage. Researchers took muscle biopsies from 11 young men after an intense workout; one leg received 10 min…

    fasciamassage therapyinflammatory cytokinesstretchstrain
  26. A
    2012

    Human myometrium – the ultrastructural 3D network of telocytes

    Sanda M Cretoiu, Dragos Cretoiu, Laurentiu M Popescu

    This study examined a relatively new type of cell, the telocyte, within the human myometrium, the muscular layer of the uterus. Using advanced microscopy, researchers visualized these cells and their very long extension…

    telocytes ! telopodes ! podoms ! podomers ! human uterus ! extracellular vesicles
  27. A
    2012

    Earthing: Health Implications of Reconnecting the Human Body to the Earth’s Surface Electrons

    Gaétan Chevalier, Stephen T Sinatra, James L Oschman, Karol Sokal, Pawel Sokal

    This 2012 review paper explores the concept of 'earthing' or 'grounding,' which involves direct physical contact with the Earth's surface electrons. The authors propose that modern lifestyles separate humans from this c…

    fasciaearthinggroundingearth surface electrons
  28. A+++
    2012

    Brain structure and joint hypermobility: relevance to the expression of psychiatric symptoms

    Jessica A Eccles, Felix D C Beacher, Marcus A Gray, Catherine L Jones, Ludovico Minati, Neil A Harrison, Hugo D Critchl…

    This study investigated the relationship between joint hypermobility and brain structure in 72 healthy volunteers. Using structural brain scans, researchers found that the volume of the amygdala, a brain region importan…

    Fibromyalgiaproprioceptionhypermobilitypsychiatric symptomsbrain structure
  29. A
    2012

    A RHAMM Mimetic Peptide Blocks Hyaluronan Signaling and Reduces Inflammation and Fibrogenesis in Excisional Skin Wounds

    Cornelia Tolg, Sara R Hamilton, Ewa Zalinska, Lori McCulloch, Ripal Amin, Natalia Akentieva, Francoise Winnik, Rashmin…

    In this animal study, researchers investigated how to reduce scarring during skin wound healing. They developed a peptide, P15-1, designed to interfere with signals from fragmented hyaluronan, a molecule involved in inf…

    hyaluronaninflammationfasciaextracellular matrixfibrosis
  30. A+++
    2012

    Total antioxidant capacity of diet and risk of stroke: a population-based prospective cohort of women

    Susanne Rautiainen, Susanna Larsson, Jarmo Virtamo, Alicja Wolk

    This Swedish population-based study examined the relationship between the total antioxidant capacity of the diet and stroke risk in over 36,000 women. By measuring the combined effect of all antioxidants in food rather…

    Antioxidantsstroke
  31. A
    2012

    Mechanical properties of human patellar tendon at the hierarchical levels of tendon and fibril

    René B Svensson, Philip Hansen, Tue Hassenkam, Bjarki T Haraldsson, Per Aagaard, Vuokko Kovanen, Michael Krogsgaard, Mi…

    Researchers investigated how the mechanical properties of the whole human patellar tendon compare to its individual collagen fibrils. They tested whole tendons in living subjects and then tested isolated fibrils from th…

    atomic force microscopy; collagen; fibril dimensions; modulus; toe region
  32. A+
    2012

    Nutritional regulation of muscle protein synthesis with resistance exercise: strategies to enhance anabolism

    Tyler A Churchward-Venne, Nicholas A Burd, Stuart M Phillips

    In this 2012 review article, the authors discuss how nutrition can regulate muscle protein synthesis, especially when combined with resistance exercise. Consuming protein (amino acids) stimulates muscle building, an eff…

    MusclenutritionhypertrophyAnabolic intramuscular signaling
  33. A
    2012

    The thoracolumbar fascia: anatomy, function and clinical considerations

    Frank H Willard, Andry Vleeming, M D Schuenke, L Danneels, Robert Schleip

    This overview paper examines the anatomy and function of the thoracolumbar fascia (TLF), the complex sheet of connective tissue in the lower back. The authors describe its multiple layers, which separate and connect the…

    fasciathoracolumbarfascia
  34. A
    2012

    Primo Vascular System as a New Morphofunctional Integrated System

    Miroslav Stefanov, Jungdae Kim

    This narrative review summarizes research on the primo vascular system (PVS), a proposed anatomical network found throughout the body. The authors describe the methods and instruments used to study this system, primaril…

    fasciacancerphysiologyMorphologyprimo vascular system
  35. A
    2012

    Strain hardening of fascia: Static stretching of dense fibrous connective tissues can induce a temporary stiffness increase accompanied by enhanced matrix hydration

    Robert Schleip, Lutz Duerselen, Andry Vleeming, Ian L Naylor, Frank Lehmann-Horn, Adjo Zorn, Heike Jaeger, Werner Kling…

    This study investigated why fascia sometimes gets stiffer after being stretched and then rested, a phenomenon called strain hardening. Researchers stretched fascia samples from mice and pigs, finding that after a 15-min…

    Lumbar fascia; Paraspinal tissues; Stiffness; Hydration; Stretching
  36. A+
    2012

    The role of stromal cells in the persistence of chronic inflammation

    A J Naylor, A Filer, C D Buckley

    This review article explores why chronic inflammation often persists in specific anatomical locations. The authors highlight that stromal cells, particularly the fibroblasts that define a tissue's architecture, are like…

    inflammationfasciafibroblastchronicpersistence
  37. A++
    2012

    Fluid Flow along Venous Adventitia in Rabbits: Is It a Potential Drainage System Complementary to Vascular Circulations?

    Hong-yi Li, Min Chen, Jie-fu Yang, Chong-qing Yang, Liang Xu, Fang Wang, Jia-bin Tong, You Lv, Caidan Suonan

    In this animal study on rabbits, researchers investigated a potential fluid drainage system within the body's connective tissue. By injecting tracers, they visualized pathways along the loose connective tissue surroundi…

    interstitial fluidacupuncturefluid flow
  38. 1A+
    2012

    Stretching of the Back Improves Gait, Mechanical Sensitivity and Connective Tissue Inflammation in a Rodent Model

    S M Corey, M A Vizzard, N A Bouffard, G J Badger, H M Langevin

    In this rodent study, researchers investigated how stretching affects inflammation in the connective tissue of the low back. They first induced local inflammation, which resulted in altered gait, increased mechanical se…

    fasciaConnective tissueStretchingManual TherapyMovement Therapy
  39. A
    2012

    Myoton Pro: A Novel Tool for the Assessment of Mechanical Properties of Fascial Tissues

    Aleko Peipsi, Ricardas Kerpe, Heike Jäger, Sonja Soeder, Christopher Gordon, Robert Schleip

    This research entry, for which only the title is available, appears to introduce a device called the MyotonPRO. The title suggests its purpose is to assess the mechanical properties of fascial tissues, such as their sti…

    fasciaMyotone Pro
  40. A++
    2012

    INTERSTITIAL FLUID AND LYMPH FORMATION AND TRANSPORT: PHYSIOLOGICAL REGULATION AND ROLES IN INFLAMMATION AND CANCER

    Helge Wiig, Melody A Swartz

    This 2012 review explores the interstitium, the fluid-filled space surrounding our cells that contains interstitial fluid (IF). Formed by filtration from blood capillaries and cleared by lymphatic vessels, IF and its fl…

    ImmunologyLymphTumorinterstitiumfluid
  41. A
    2012

    Mathematical model of fiber orientation in anisotropic fascia layers at large displacements

    Hans Chaudhry, Max Roman, Antonio Stecco, Thomas Findley

    Researchers developed a mathematical model to better understand how collagen fibers within fascia change their orientation when the tissue is stretched. The model suggests that fibers already angled away from the direct…

    Fascial; Reinforcement; Collagen fibers; Re-orientation; Tension
  42. A
    2012

    Real-time imaging of cortical areas involved in the generation of increases in skin sympathetic nerve activity when viewing emotionally charged images

    Luke A Henderson, Alexandra Stathis, Cheree James, Rachael Brown, Skye McDonald, Vaughan G Macefield

    This study investigated which brain regions are involved when our bodies react to emotional images. Researchers simultaneously measured brain activity with fMRI and skin sympathetic nerve activity (SSNA), a marker of th…

    fasciaMRIIASP imagesmicroneurographyskin sympathetic nerve activity
  43. B
    2012

    Mechanical strain applied to human fibroblasts differentially regulates skeletal myoblast differentiation

    Michael R Hicks, Thanh V Cao, David H Campbell, Paul R Standley

    This laboratory study investigated how different types of stretching affect muscle repair at a cellular level. Researchers applied two types of strain to human fibroblasts (connective tissue cells) and observed the effe…

    myotubescocultureinterleukin-6
  44. A
    2012

    CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis

    Kenneth E Lipson, Carol Wong, Yuchin Teng, Suzanne Spong

    Fibrosis is a process of excessive connective tissue formation, leading to scarring and stiffness in organs. A protein called Connective Tissue Growth Factor (CTGF) plays a central role in driving this process. This res…

    extracellular matrixfibrosisfascia CTGFtissue remodeling
  45. B
    2012

    Fascia: a morphological description and classification system based on a literature review

    Myroslava Kumka, Jason Bonar

    In this literature review, the authors address the historical problem of ambiguous and inconsistent terminology for fascia. Based on a review of existing research, they propose a new system for classifying fascia accord…

    fasciaConnective tissueManual TherapyterminologyAnatomy
  46. A++
    2012

    Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease

    Kirsty Brown, Daniella DeCoffe, Erin Molcan, Deanna L Gibson

    This 2012 narrative review explores the connection between diet, gut microbes, and the immune system. The gastrointestinal tract must balance tolerance for harmless bacteria and food with responsiveness to pathogens. An…

    inflammationnutritionintestinal microbiotadisease susceptibility
  47. A
    2012

    A theoretical framework for the role of fascia in manual therapy

    Nigel Simmonds, Peter Miller, Hugh Gemmell

    This theoretical paper explores why different types of manual therapy, such as soft tissue work and joint manipulation, often seem to produce similar results. The authors compare these approaches based on their effects…

    fasciaManual TherapyMyofascialManipulationautonomic nervous system
  48. C
    2012

    NGF-evoked sensitization of muscle fascia nociceptors in humans

    Saskia Deising, Benjamin Weinkauf, James Blunk, Otilia Obreja, Martin Schmelz, Roman Rukwied

    This study investigated whether nerve growth factor (NGF) can sensitize pain receptors in muscle fascia. Researchers injected a small amount of NGF into the fascia of the erector spinae muscle in the lower back of 14 ma…

    hyperalgesialow back painmusculoskeletal painPressure pain
  49. B
    2012

    Recent Developments in Myofibroblast Biology

    Boris Hinz, Sem H Phan, Victor J Thannickal, Marco Prunotto, Alexis Desmoulière, John Varga, Olivier De Wever, Marc Mar…

    This 2012 narrative review summarizes advances in understanding the myofibroblast, a specialized cell crucial for both normal wound healing and the development of fibrotic diseases. The authors discuss how these cells g…

    fibrosisMyofibroblast
  50. A++
    2012

    Vitamin C transport and its role in the central nervous system

    James M May

    This review article explores the critical role of vitamin C in the central nervous system. Although it circulates in the blood at low concentrations, neurons in the brain and spinal cord maintain very high levels of the…

    ascorbate transport; brain; dehydroascorbate; glutamate; neurons; SVCT2
  51. B
    2011

    Adhesive capsulitis of the shoulder

    Andrew S Neviase, Robert J Neviaser

    This clinical overview describes adhesive capsulitis, or "frozen shoulder," a condition marked by painful, progressive loss of shoulder movement due to fibrosis of the joint capsule. The authors note that diagnosis requ…

    frozen shoulderAdhesive capsulitis
  52. A
    2011

    Dynamic fascial release and the role of mechanical/vibrational assist devices in manual therapies

    Zachary Comeaux

    This review article explores the use of mechanical vibration devices in manual therapy. The author examines several such tools, including percussion vibrators, vibrational platforms, and deep tissue oscillation. The art…

    fasciaConnective tissuevibrationpercussion vibrationtonic vibratory reflex
  53. A
    2011

    Sensory Innervation of the Nonspecialized Connective Tissues in the Low Back of the Rat

    Sarah M Corey, Margaret A Vizzard, Gary J Badger, Helene M Langevin

    In this animal study, researchers investigated the sensory nerves in the nonspecialized connective tissue of the rat low back, an area where knowledge is limited. Using 3D reconstruction and dye-labeling techniques, the…

    fasciaConnective tissueinnervationlow back painmusculoskeletal pain
  54. A+
    2011

    The Alkaline Diet: Is There Evidence That an Alkaline pH Diet Benefits Health

    Gerry K Schwalfenberg

    This 2011 review examined the published medical literature to evaluate the health benefits of an alkaline diet. The author looked at studies on the body's pH and its connection to bone health, muscle function, back pain…

    Metabolic acidosisalkaline dietmetabolic syndrom
  55. A
    2011

    Hyaluronan in intestinal homeostasis and inflammation: implications for fibrosis

    Carol A de la Motte

    This narrative review explores the role of hyaluronan (HA) in intestinal health and disease. Chronic intestinal inflammation can lead to fibrosis, or scarring, a process driven by inflammatory signals and specialized ce…

    hafasciaextracellular matrixfibrosismesenchymal cells
  56. A+
    2011

    Diet-induced metabolic acidosis

    María M Adeva, Gema Souto

    The typical Western diet, high in animal products and low in fruits and vegetables, can lead to a state of chronic, low-grade metabolic acidosis. This means the body becomes slightly more acidic, a situation that can wo…

    Metabolic acidosisAmmonium ionsCitrateInsulin resistance
  57. A
    2011

    A questionnaire survey of UK physiotherapists on the diagnosis and management of contracted (frozen) shoulder

    Nigel C A Hanchard, Lorna Goodchild, Jackie Thompson, Tracey O’Brien, Dot Davison, Chris Richardson

    This survey of 289 UK physiotherapists explored how they diagnose and manage frozen shoulder. The results showed that diagnosis typically relies on assessing movement restriction, particularly passive external rotation.…

    frozen shoulderAdhesive capsulitisShoulder painDiagnosisTherapy
  58. 1A+++
    2011

    Hyaluronan within fascia in the etiology of myofascial pain

    Carla Stecco, R Stern, A Porzionato, V Macchi, S Masiero, Antonio Stecco, R De Caro

    In this cadaver and ultrasound study, researchers examined the composition of deep fascia. They identified layers of hyaluronan (HA), a lubricating substance, between the fascia and muscle, as well as between the fascia…

    fasciaHyaluronic acidSliding systemLoose connective tissueFasciacyte
  59. A
    2011

    Pandiculation: Nature’s way of maintaining the functional integrity of the myofascial system?

    Luiz Fernando Bertolucci

    This paper explores the hypothesis that pandiculation—the involuntary stretching and yawning most animals do upon waking—serves a key role for the locomotor system. Beyond preparing the nervous system for wakefulness, t…

    fasciaConnective tissuemyofasciayawningsleep-wake rhythm
  60. A
    2011

    Fascia and the mechanism of acupuncture

    Steven Finando, Donna Finando

    This theoretical paper re-evaluates the mechanisms of acupuncture. The authors propose that fascia, the body's connective tissue network, is the structure that explains how acupuncture works. They argue for this model b…

    fasciaacupunctureShamPlaceboMechanism