The role of stromal cells in the persistence of chronic inflammation

The role of stromal cells in the persistence of chronic inflammation — The Fascia Guide

Key takeaways

01Chronic inflammation often targets specific anatomical sites
02Stromal cells like fibroblasts may be the reason
03These cells could be future therapeutic targets
04Research has been limited by a lack of specific markers

Fibroblasts, the cells that structure our tissues, may be key to why chronic inflammation persists in specific locations.

Abstract

Inflammation is an unstable state; it either resolves or persists. Inflammatory reactions often have a propensity for specific anatomical sites. Why inflammation persists with specific tissue tropism remains obscure. Increasing evidence suggests that stromal cells which define tissue architecture are the key cells involved, and therefore make attractive therapeutic targets. Research on stromal cells in general and fibroblasts in particular has so far been hampered by a lack of fibroblast-specific cell markers. This review highlights our increasing understanding of the role of fibroblasts in inflammation, and suggests that these cells provide the cellular basis for site specific chronic inflammation.

Cite this study

APA: A J Naylor, A Filer, & C D Buckley (2012). The role of stromal cells in the persistence of chronic inflammation. https://fasciaresearchdatabase.com/the-role-of-stromal-cells-in-the-persistence-of-chronic-inflammation/
MLA: A J Naylor, et al. "The role of stromal cells in the persistence of chronic inflammation." 2012, https://fasciaresearchdatabase.com/the-role-of-stromal-cells-in-the-persistence-of-chronic-inflammation/.
Chicago: A J Naylor, A Filer, C D Buckley. 2012. "The role of stromal cells in the persistence of chronic inflammation.". https://fasciaresearchdatabase.com/the-role-of-stromal-cells-in-the-persistence-of-chronic-inflammation/