Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
- A2017
Adhesive Capsulitis of the Shoulder Joint: Value of Glenohumeral Distance on Magnetic Resonance Arthrography
Kyu Hong Lee, Hee Jin Park, So Yeon Lee, In Young Youn, Eugene Kim, Jai Hyung Park, Se Jin ParkResearchers investigated a new way to help diagnose adhesive capsulitis (frozen shoulder) using a specific type of MRI called MR arthrography. They measured the distance between the ball and socket of the shoulder joint…
Adhesive capsulitisMR imagingShoulderArthrography - 1A+2017
Emotions in Motion: Myofascial Interoception
B Bordoni, F MarelliIn this perspective piece, the authors argue that the myofascial system is closely linked to our emotional state. They suggest that manual treatment not only affects the body physically but also activates the interocept…
fasciaManual TherapyMyofascialOsteopathicInteroception - A+++2017
Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
Chia-Wei Cheng, Valentina Villani, Roberta Buono, Min Wei, Sanjeev Kumar, Omer H Yilmaz, Pinchas Cohen, Julie B Sneddon…This study, involving mice and human pancreatic cells, explores how cycles of a fasting-mimicking diet (FMD) may influence the pancreas's ability to produce insulin. Researchers found that the diet appears to activate g…
fasting; fasting-mimicking diet; inflammation; intermittent fasting; diabetes - B2017
Mechanical properties of a collagen fibril under simulated degradation
David C Malaspinaa, Igal Szleifera, Yasin DhaheraThis study used computer simulations to investigate how collagen fibrils lose their strength. Researchers modeled three different types of degradation: the removal of cross-links, surface damage, and damage throughout t…
collagenMolecular dynamicsDegradationMMP - A+++2017
Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation
Benoit Chassaing, Tom Van de Wiele, Jana De Bodt, Massimo Marzorati, Andrew T GewirtzThis study investigated how common food additives, specifically the emulsifiers polysorbate 80 (P80) and carboxymethylcellulose (CMC), affect the gut microbiota. Using a laboratory model of the human intestinal ecosyste…
INFLAMMATION; INTESTINAL MICROBIOLOGY - A2017
Art Advancing Science: Filmmaking Leads to Molecular Insights at the Nanoscale
Charles Reilly, Donald E IngberA project that began as an artistic endeavor to create an entertaining short film about fertilization led to the development of a new scientific simulation tool. By integrating physics-based animation software from the…
Tensegritysimulationanimationaxonemedynein - A+++2017
Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease
Min Wei, Sebastian Brandhorst, Mahshid Shelehchi, Hamed Mirzaei, Chia Wei Cheng, Julia Budniak, Susan Groshen, Wendy J…This randomized controlled trial examined the effects of a fasting-mimicking diet (FMD) on risk factors for age-related diseases in 100 healthy participants. For five consecutive days each month over a three-month perio…
fasting; fasting-mimicking diet; inflammation; intermittent fasting; cancer; diabetes; cardiovascular disease - A2017
We are operating too much
Nicola MaffulliIn this editorial, the author, an orthopedic and trauma surgeon, observes a rising number of operations for orthopedic and trauma ailments. He notes that this trend runs counter to the results of high-quality studies, w…
Surgery - A+2017
Effects of the menstrual cycle on lower-limb biomechanics, neuromuscular control, and anterior cruciate ligament injury risk: a systematic review
Vivek Balachandar, Jan-Luigi Marciniak, Owen Wall, Chandrika BalachandarThis systematic review evaluated how the menstrual cycle affects lower-limb biomechanics, neuromuscular control, and anterior cruciate ligament (ACL) injury risk in women. The authors found strong evidence that the risk…
Biomechanicsligamentneuromuscularcruciatemenstrual. - A+2017
The Effect of Menstrual Cycle and Contraceptives on ACL Injuries and Laxity
Simone D Herzberg, Makalapua L Motu’apuaka, William Lambert, Rongwei Fu, Jacqueline Brady, Jeanne-Marie GuiseThis systematic review and meta-analysis investigated the relationship between the menstrual cycle, hormonal contraceptives, and the risk of anterior cruciate ligament (ACL) injuries. The researchers found that knee lig…
anterior cruciate ligament; knee injury; hormonal contraceptives; female; human; menstrual cycle; systematic review; meta-analysis; sports medicine - A2017
Semimembranosus Muscle Injuries In Sport. A Practical MRI use for Prognosis
Ramon Balius, Mireia Bossy, Carles Pedret, Lluis Capdevila, Xavier Alomar, Bryan Heiderscheit, Gil RodasThis retrospective study investigated whether MRI scans could help predict recovery time for athletes with injuries to the semimembranosus, one of the hamstring muscles. Researchers analyzed MRI scans from 19 athletes,…
MRIreturn to playsemimembranosushamstring injuries - B2017
Sensitivity of ACL Volume and T2* Relaxation Time to Magnetic Resonance Imaging Scan Conditions
Jillian E Beveridge, Edward G Walsh, Martha M Murray, C FlemingThis animal study investigated how different magnetic resonance imaging (MRI) conditions affect measurements of the anterior cruciate ligament (ACL). Researchers in this pig study compared images taken at different reso…
ACL; MRI; T2* relaxometry - A+2017
Hyaluronan as a therapeutic target in human diseases
Jiurong Liang, Dianhua Jiang, Paul W NobleThis narrative review explores the role of hyaluronan, a major component of the extracellular matrix involved in tissue injury and repair. Its function varies significantly with its size; fragmented hyaluronan can promo…
hyaluronan - A+2017
Oxidative Stress and Endometriosis: A Systematic Review of the Literature
Gennaro Scutiero, Piergiorgio Iannone, Giulia Bernardi, Gloria Bonaccorsi, Savino Spadaro, Carlo Alberto Volta, Pantale…This systematic review explores the connection between oxidative stress and endometriosis, a condition where uterine-like tissue grows outside the uterus, causing pain and infertility. Oxidative stress is an imbalance b…
Oxidative stressendometriosisROS - A++2017
Biological effects of direct and indirect manipulation of the fascial system. Narrative review
Giovanni Parravicini, Andrea BergnaThis narrative review explores the biological effects of manual fascial therapies. While osteopathic manipulative treatment (OMT) is clinically effective, its underlying mechanisms are not fully understood. The authors…
fasciaMyofascial releaseManual TherapyMyofascial manipulation - A++2017
Improvement of skin condition by oral administration of collagen hydrolysates in chronologically aged mice
Zhenbin Wang, Qing Wang, Lin Wang, Weidong Xu, Yuanqing He, Yunliang Li, Song He, Haile MaThis animal study investigated how oral supplementation of collagen hydrolysates derived from fish scales affected chronological skin aging in mice over six months. The researchers found that mice receiving collagen in…
chronological aging; collagen hydrolysates; histological structure; oxidative stress; skin condition; visual appearance - A+++2017
Shielding of the geomagnetic field reduces hydrogen peroxide production in human neuroblastoma cell and inhibits the activity of CuZn superoxide dismutase
Hai-Tao Zhang, Zi-Jian Zhang, Wei-Chuan Mo, Ping-Dong Hu, Hai-Min Ding, Ying Liu, Qian Hua, Rong-Qiao HeThis study investigates how an extremely weak magnetic field, similar to conditions in outer space or shielded environments on Earth, affects human cells. Researchers found that shielding the natural geomagnetic field r…
hydrogen peroxide; hypomagnetic field; oxidative stress; reactive oxygen species; superoxide dismutase - A2017
The second terminations of the suboccipital muscles: An assistant pivot for the To Be Named Ligament
Xiao-Ying Yuan, Chan Li, Jia-Ying Sui, Qi-Qi Zhao, Xiao Zhang, Na-Na Mou, Zhao Huang-Fu, Okoye Chukwuemeka Samuel, Nan…In this anatomical dissection study of 35 head-neck specimens, researchers investigated small muscle attachments in the suboccipital region. The scientists confirmed the existence of "second terminations" from several s…
Myodural Bridge - A++2017
Vitamin C–enriched gelatin supplementation before intermittent activity augments collagen synthesis
Gregory Shaw, Ann Lee-Barthel, Megan L R Ross, Bing Wang, Keith BaarIn a small study involving eight healthy men, researchers investigated the effect of vitamin C-enriched gelatin supplementation before exercise. Participants who consumed 15 grams of gelatin one hour before a short, int…
Bonetendonexerciseligamentreturn to play - A++2017
The effect of pre-exercise vibration stimulation on the exercise-induced muscle damage
Ji-Yun Kim, Da-Haeng Kang, Joon-Hee Lee, Se-Min O, Jae-Keun JeonThis study investigated whether vibration stimulation before or after exercise could reduce exercise-induced muscle damage. Thirty healthy men were divided into three groups: one receiving vibration before exercise, one…
pressure pain thresholdmuscle fatiguemuscle damage - A2017
Acute effects of foam rolling on passive tissue stiffness and fascial sliding: study protocol for a randomized controlled trial
Frieder Krause, Jan Wilke, Daniel Niederer, Lutz Vogt, Winfried BanzerThis document is a study protocol, outlining the planned method for a randomized controlled trial, not a report of its results. The researchers intend to investigate the immediate effects of foam rolling on the anterior…
Connective tissue; Cross-correlation; Fascia; Flexibility; Foam rolling; Self-myofascial release; Tissue stiffness; Ultrasound. - B2017
Acoustic wave therapy for cellulite, body shaping and fat reduction
Doris Hexsel, Fernanda Oliveira Camozzato, Aline Flor Silva, Carolina SiegaThis study evaluated the efficacy of acoustic wave therapy (AWT) for cellulite and body shaping. Thirty women with moderate to severe cellulite underwent 12 treatment sessions on the glutes and thighs over six weeks. Th…
Acoustic wave therapy; body shaping; cellulite; Cellulite Severity Scale; subcutaneous fat tissue thickness - A2017
Correlations of magnetic resonance imaging findings with clinical symptom severity and prognosis of frozen shoulder
Jong Pil Yoon, Seok Won Chung, Byung Joo Lee, Hyung Sup Kim, Jae Hyuck Yi, Hyun‑Joo Lee, Won‑Ju Jeong, Sung Gyu Moon, K…Researchers used a specific type of MRI (indirect MR arthrography) to examine the shoulders of 52 people with frozen shoulder and 52 without. They found that certain features, like thickening and inflammation-related ch…
frozen shoulderMR findingIndirect MR arthrogramClinical symptomCorrelation - A+++2017
Role of Magnesium in Vitamin D Activation and Function
Anne Marie Uwitonze, Mohammed S RazzaqueIn this scientific review, the authors discuss how magnesium and vitamin D work together in the body. Magnesium acts as a cofactor, meaning it helps activate the enzymes that metabolize vitamin D in the liver and kidney…
Vitamin D activationmagnesiumcalcidefiolcalcitriol - A++2017
NAD and the aging process: Role in life, death and everything in between
Claudia C S Chini, Mariana G Tarragó, Eduardo N ChiniThis narrative review explores the vital role of the molecule NAD in cellular health and the aging process. Beyond its traditional role in metabolism, NAD is essential for cell signaling and regulating the epigenetic st…
Aging; CD38; Mitochondrial function; NAD(+); PARP; SIRTUINS - A++2017
Telocytes: Connective tissue repair and communication cells
Leon ChaitowThis commentary highlights a newly identified type of connective tissue cell called a telocyte. We already know that other cells, like fibroblasts, respond to mechanical forces from manual therapy, influencing tissue re…
mechanotransductiontelocytesinterstitial cellsregeneration - A+++2017
Activation of type 2 cannabinoid receptor (CB2R) by selective agonists regulates the deposition and remodelling of the extracellular matrix
Tao Guan, Guiyang Zhao, Honghui Duan, Yang Liu, Feng ZhaoThis in vitro study investigated how activating the type 2 cannabinoid receptor (CB2R) affects scar formation in eye connective tissue after surgery. Researchers found that human Tenon’s fibroblasts express these recept…
Matrix metalloproteinase 1 (MMP-1); Tenon’s fibroblasts; Transforming growth factor-β1; Type 2 cannabinoid receptor (CB2R); Wound healing - A2017
Implications of immune dysfunction on endometriosis associated infertility
Jessica E Miller, Soo Hyun Ahn, Stephany P Monsanto, Kasra Khalaj, Madhuri Koti, Chandrakant TayadeThis literature review explores the link between endometriosis and infertility, a common issue for which the cause is not fully understood. The authors suggest that dysfunction in the immune system plays a significant r…
cytokines; endometriosis; infertility; inflammation; oxidative stress. - A++2017
Touch, Tension, and Transduction - The Function and Regulation of Piezo Ion Channels
Jason Wu, Amanda H Lewis, Jörg GrandlThis narrative review explores Piezo1 and Piezo2, specialized proteins that act as the body's primary mechanical sensors. These ion channels convert physical forces like touch, tension, and fluid flow into electrical si…
Mechanotransductionpiezo - A2017
Non-contrast MRI diagnosis of adhesive capsulitis of the shoulder
Andrew S Chi, John Kim, Suzanne S Long, William B Morrison, Adam C ZogaThis study investigated whether a standard MRI without contrast dye could be used to reliably diagnose adhesive capsulitis, also known as frozen shoulder. Researchers reviewed MRIs for specific signs, such as a thickene…
MRIfrozen shoulderAdhesive capsulitisNoncontrast - A+2017
Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials
A W Ashor, A D Werner, J Lara, N D Willis, J C Mathers, M SiervoThis systematic review and meta-analysis compiled data from 22 randomized controlled trials to assess the effect of vitamin C supplementation on glycemic control. Overall, the researchers found no significant effect on…
Vitamin Cinsulin resistensglycaemic control - A2017
Amino acid composition in determination of collagen origin and assessment of physical factors effects
Marlena Gauza-Włodarczyk, Leszek Kubisz, Dariusz WłodarczykThis study examines the amino acid composition of collagen derived from various sources, including fish skin, bovine Achilles tendon, and bone tissue. The researchers found that the levels of hydroxyproline, a unique am…
hydroxyprolineBone collagenFish skin collagenIrradiationPolymer - A2017
Effect of MELT method on thoracolumbar connective tissue: The full study
Faria Sanjana, Hans Chaudhry, Thomas FindleyThis study investigated if the MELT method, a self-treatment technique using soft rollers and balls, could affect the thoracolumbar connective tissue in people with chronic low back pain. Researchers used ultrasound ima…
Low back pain; MELT method; Connective tissue; Thickness; Myofascia; Flexibility - C2017
Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface
KA Khan, AJ Naylor, A Khan, PJ Noy, M Mambretti, P Lodhia, J Athwal, A Korzystka, CD Buckley, BE Willcox, F Mohammed ,…Researchers investigated how certain proteins interact to form new blood vessels, a process called angiogenesis that is crucial for tumor growth. This study, which included lab experiments and mouse models, identified a…
fasciaextracellular matrixendotheliumC-type lectintumor angiogenesis - A++2017
Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Severe Sepsis and Septic Shock: A Retrospective Before-After Study
Paul E Marik, Vikramjit Khangoora, Racquel Rivera, Michael H Hooper, John CatravasIn this retrospective before-after study, researchers investigated the effect of a combination therapy of intravenous vitamin C, hydrocortisone, and thiamine for patients with severe sepsis and septic shock. They compar…
corticosteroid; hydrocortisone; septic shock; thiamine; vitamin C - A2017
Does the vaginal wall become thinner as prolapse grade increases?
Rhiannon Bray, Alex Derpapas, Ruwan Fernando, Vik Khullar, Demetri C PanayiThis study investigated the relationship between vaginal wall thickness and the severity of pelvic organ prolapse. Researchers used ultrasound to measure the vaginal walls of 243 women with symptomatic prolapse. They fo…
Prolapse . Ultrasonography . Vaginal wall thickness - A++2017
Decorin and biglycan are necessary for maintaining collagen fibril structure, fiber realignment, and mechanical properties of mature tendons
Kelsey A Robinson, Mei Sun, Carrie E Barnum, Stephanie N Weiss, Julianne Huegel, Snehal S Shetye, Linda Lin, Daniel Sae…This study on mice investigated the role of two molecules, decorin and biglycan, in maintaining healthy adult tendons. Researchers used a genetic model to remove these molecules from mature patellar tendons after they h…
Tendon; Decorin; Biglycan; Collagen fibril; Fiber realignment; Structure; Mechanical properties; Conditional knockout mice - A++2017
Interaction between the gut microbiome and mucosal immune system
Na Shi, Na Li, Xinwang Duan, Haitao NiuIn this narrative review, the authors outline the two-way relationship between the gut microbiome and the mucosal immune system. A balanced microbiome is essential for the proper maturation and function of the immune sy…
inflammationMicrobiomeImmunity - B2017
Mechanical Properties of the Cytoskeleton and Cells
A F Pegoraro, P Janmey, D A WeitzIn this review article, the authors describe the cytoskeleton, which is the cell's main mechanical structure. It is a complex and dynamic network of biopolymers that includes microtubules, actin, and intermediate filame…
cytoskeletonmicrotubulesactin filamentintermediate filament - A++2017
Mitochondrial dysfunction in the APP/PSEN1 mouse model of Alzheimer’s disease and a novel protective role for ascorbate
Shilpy Dixit, Joshua P Fessel, Fiona E HarrisonIn this animal study, researchers examined mitochondrial function in a mouse model of Alzheimer's disease and in mice with low levels of vitamin C (ascorbate). The results indicated that both the presence of amyloid (as…
Alzheimer’s disease; mitochondria; oxidative stress; ascorbate; energy production - A+++2017
Therapeutic effectiveness of instrument-assisted soft tissue mobilization for soft tissue injury: mechanisms and practical application
Jooyoung Kim, Dong Jun Sung, Joohyung LeeThis narrative review explores the mechanisms and practical use of Instrument-Assisted Soft Tissue Mobilization (IASTM) for treating soft tissue injuries. IASTM involves using specialized tools to apply mechanical press…
Injury; Instrument-assisted soft tissue mobilization; Pain; Range of motion; Soft tissue function. - B2017
Complex mechanics of the heterogeneous extracellular matrix in cancer
Andrea Malandrino, Michael Mak, Roger D Kammd, Emad MoeendarbaryThis narrative review explores the complex role of the extracellular matrix (ECM), the non-cellular network that provides structural support to tissues. In solid tumors, the ECM becomes highly altered and complex, as ca…
extracellular matrixCell signalingtumor microenvironment - C2017
Fibronectin in cell adhesion and migration via N-glycosylation
Cheng-Te Hsiao, Hung-Wei Cheng, Chi-Ming Huang, Hao-Ru Li, Meng-Hsin Ou, Jie-Rong Huang, Kay-Hooi Khoo, Helen Wenshin Y…Fibronectin is a protein in blood plasma that helps cells stick together and move, a process essential for wound healing. This study investigated how a specific chemical modification, called N-glycosylation, affects fib…
wound healingcell migrationFibronectincell adhesion - A2017
CT arthrography of adhesive capsulitis of the shoulder: Are MR signs applicable?
Milena Cernya, Patrick Omoumia, Ahmed Larbi, Daniel Manicourt, Anne Perozziello, Frédéric Lecouvet, Bruno Vande Berg, B…This retrospective study investigated whether signs of adhesive capsulitis (frozen shoulder) typically seen on MRI could also be identified using CT arthrography (CTA). Researchers compared CTA scans from 22 patients wi…
frozen shoulderAdhesive capsulitisArthrographyRotator intervalCTA - A2017
Correlation between chronic headaches and the rectus capitis posterior minor muscle: A comparative analysis of cross-sectional trail
Xiao-Ying Yuan, Sheng-Bo Yu, Cong Liu, Qiang Xu, Nan Zheng, Jian-Fei Zhang, Yan-Yan Chi, Xu-Gang Wang, Xiang-Tao Lin, H…Researchers investigated the relationship between chronic headaches and a small muscle at the base of the skull, the rectus capitis posterior minor (RCPmi). Using magnetic resonance imaging (MRI), they compared the size…
Myodural Bridgerectus capitis posterior minor musclechronic headacheshypertrophy - A2016
Cystocele and functional anatomy of the pelvic floor: review and update of the various theories
Géry Lamblin, Emmanuel Delorme, Michel Cosson, Chrystèle RubodThis narrative review examines different anatomical theories about how the pelvic floor supports the bladder. The researchers summarize that this support involves a complex interplay of the pubocervical fascia, endopelv…
Pelvic floor . Cystocele . Connective tissue . Anatomy . Endopelvic fascia . Pelvic mobility - A+++2016
Understanding Mechanobiology: Physical Therapists as a Force in Mechanotherapy and Musculoskeletal Regenerative Rehabilitation
William R Thompson, Alexander Scott, M Terry Loghmani, Samuel R Ward, Stuart J WardenThis perspective article explores the field of mechanobiology and how physical therapists use mechanical forces to promote tissue healing. It explains that cells in our muscles, bones, and tendons respond to physical st…
RehabilitationTherapymechantransduction - A+++2016
Clinical applications of vibration therapy in orthopaedic practice
Simone Cerciello, Silvio Rossi, Enrico Vison, Katia Corona, Francesco OlivaThis literature review examines the use of vibration therapy in orthopedic practice. Researchers analyzed 71 studies to understand its effects on bone, muscles, and tendons. The review notes that inconsistencies in appl…
RehabilitationAthletesOsteoporosisphysical therapy modalitieselectric stimulation therapy - A2016
Effect of the Suboccipital Musculature on Symptom Severity and Recovery after Mild Traumatic Brain Injury
S Fakhran, C Qu, L M AlhilaliThis study investigated whether the size of the deep neck muscles at the base of the skull is related to symptoms and recovery after a mild traumatic brain injury (mTBI). Researchers used MRI to measure the cross-sectio…
dura materMyodural BridgeCNS - 1A+2016
STRETCHING IMPACTS INFLAMMATION RESOLUTION IN CONNECTIVE TISSUE
L Berrueta, I Muskaj, S Olenich, T Butler, G J Badger, R A Colas, M Spite, C N Serhan, H M LangevinIn this animal study, researchers investigated the effect of stretching on acute inflammation in the connective tissue of rats. After inducing local inflammation in the rats' backs, one group was subjected to twice-dail…
Stretching; SPM; Resolvin; Inflammation; Connective tissue - A2016
Patterns of attachment of the myodural bridge by the rectus capitis posterior minor muscle
Xiao-Ying Yuan, Sheng-Bo Yu, Yun-Fei Li, Yan-Yan Chi, Nan Zheng, Hai-Bin Gao, Bing-Yi Luan, Zhao-Xi Zhang, Hong-Jin SuiThis anatomical study used dissection and plastination techniques to examine the myodural bridge, a small tissue connection in the upper neck. Researchers focused on the attachments of the rectus capitis posterior minor…
Myodural Bridgerectus capitis posterior minor muscleChronic cervicogenic headacheCirculation of cerebrospinal fluidPlastination technology - A2016
Connection of the Posterior Occipital Muscle and Dura Mater of the Siamese Crocodile
JING-HUI ZHANG, WEI TANG, ZHAO-XI ZHANG, BING-YI LUAN, SHENG-BO YU, HONG-JIN SUIIn this animal study, researchers investigated a connective tissue structure called the myodural bridge in six Siamese crocodiles. This bridge connects deep muscles in the suboccipital region to the dura mater, the oute…
myodural bridge; rectus capitis posterior major muscle; rectus capitis posterior minor muscle;proatlas; spinal dura mater; Siamese crocodile; cerebrospinal fluid circulation - A2016
A Systematic Review of the Soft-Tissue Connections Between Neck Muscles and Dura Mater
Luis Palomeque-del-Cerro, Luis A Arráez-Aybar, Cleofás Rodriguez-Blanco, Rafael Guzmán-Garcia, Mar Menendez-Aparicio, Á…In this systematic review, researchers compiled data from 26 studies to investigate direct soft-tissue connections between neck muscles and the dura mater, the outermost membrane surrounding the spinal cord. The analysi…
fasciaConnective tissueproprioceptionSpineAnatomy - A2016
Monitoring the primo vascular system in lymphatic vessels by using window chambers
Jungdae Kim, Dong-Hyun Kim, Sharon Jiyoon Jung, Hyun-Ji Gil, Seung Zhoo Yoon, Young-Il Kim, Kwang-Sup SohIn this animal study, researchers developed a method for observing the primo vascular system (PVS) inside the lymphatic vessels of rats over an extended period. By implanting a "window chamber" into the skin and injecti…
primo vascular systemlymphatic vessels - A+++2016
Manual evaluation of the diaphragm muscle
Bruno Bordoni, F Marelli, B Morabito, B SacconiThe diaphragm is a vital muscle for breathing, but it also plays a key role in posture, organ function, and even emotional states. Despite its importance, there is little scientific literature on how to manually assess…
ChiropracticManual Therapydiaphragmphysiotherapyosteopathic evaluation - A2016
Overlapping signatures of chronic pain in the DNA methylation landscape of prefrontal cortex and peripheral T cells
Renaud Massart, Sergiy Dymov, Magali Millecamps, Matthew Suderman, Stephanie Gregoire, Kevin Koenigs, Sebastian Alvarad…In this animal study, researchers investigated how chronic pain might be linked to epigenetic changes, specifically DNA methylation. They compared rats with long-term nerve injury pain to a control group, examining tiss…
immune systemchronic painCentral nervous systemcortexDNA methylation - B2016
Thermographic mapping of the skin surface in biometric evaluation of cellulite treatment effectiveness
S Wilczynski, R Koprowski, A Deda, M Janiczek, N Kuleczka, B Błonska-FajfrowskaThis study explored a new way to objectively measure the effectiveness of cellulite treatments using thermal imaging (thermography). Researchers followed ten women undergoing a series of treatments, taking thermal image…
cellulite – thermography – Alidya – biomedical imaging – GLCM contrast – gynoid lipodystrophy - A2016
Collagen structure: new tricks from a very old dog
Jordi BellaThis narrative review summarizes how our understanding of collagen's triple helix structure has evolved. Initial models from the 1950s provided a general overview, but the development of synthetic collagen-like peptides…
collagen recognitioncollagen stabilitycollagen structurehydrogen bondingprotein design and engineering. - A2016
Human Recombinant Hyaluronidase Injections For Upper Limb Muscle Stiffness in Individuals With Cerebral Injury: A Case Series
Preeti Raghavan, Ying Lu, Mona Mirchandani, Antonio SteccoThis case series investigated injections of the enzyme hyaluronidase to treat upper limb muscle stiffness in 20 individuals with cerebral injury. The researchers hypothesized that an accumulation of hyaluronan in the mu…
fasciaConnective tissueStrokeHypertoniaspasticity - C2016
Functional in vitro tension measurements of fascial tissue – a novel modified superfusion approach
Robert Schleip, Werner Klingler, S Wearing, I Naylor, M Zuegel, K HoppeIn this laboratory study on rat tissue, researchers compared two techniques for measuring tension changes in fascia. The traditional method involves immersing the tissue in a fluid bath, but the team also tested a modif…
fasciaOrgan BathMechanographic RegistrationSuperfusionImmersionmized Mice