Implications of immune dysfunction on endometriosis associated infertility
Jessica E Miller, Soo Hyun Ahn, Stephany P Monsanto, Kasra Khalaj, Madhuri Koti, Chandrakant Tayade
Key takeaways
This review suggests immune dysfunction and inflammation may be key drivers of infertility in women with endometriosis.
Endometriosis is a complex, inflammatory disease that affects 6-10% of reproductive-aged women. Almost half of the women with endometriosis experience infertility. Despite the excessive prevalence, the pathogenesis of endometriosis and its associated infertility is unknown and a cure is not available. While many theories have been suggested to link endometriosis and infertility, a consensus among investigators has not emerged. In this extensive review of the literature as well as research from our laboratory, we provide potential insights into the role of immune dysfunction in endometriosis associated infertility. We discuss the implication of the peritoneal inflammatory microenvironment on various factors that contribute to infertility such as hormonal imbalance, oxidative stress and how these could further lead to poor oocyte, sperm and embryo quality, impaired receptivity of the endometrium and implantation failure.
The episode was first published on the Swedish podcast Fasciaguiden on May 27, 2025. What if every chronic disease actually stems from the same root cause — the loss of electrons?…
The episode was first published on The Fascia Guide YouTube channel on February 5, 2025. In this inspiring episode, we meet Deanna Hansen — founder of Block Therapy™ and a pioneer…