Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
- A++2023
The Effect of Craniosacral Therapy on Blood Levels of Stress Hormones in Male Firefighter Cadets: A Randomized Clinical Trial
Małgorzata Wójcik, Bruno Bordoni, Idzi Siatkowski, Ewa ZekanowskaThis randomized clinical trial investigated the effect of craniosacral therapy on blood levels of the stress hormones cortisol and CRH in 57 male firefighter cadets. Participants were assigned to either a treatment grou…
stress; cortisol; corticotropin-releasing hormone - A++2023
What's old is new again: The anatomical studies of Franklin P. Mall and the fascial-interstitial spaces
Carmelo Pirri, Rebecca G Wells, Raffaele De Caro, Carla Stecco, Neil D TheiseFranklin Mall was a pioneering anatomist at the turn of the 19th century whose work is being rediscovered in light of modern fascia research. He studied under Wilhelm His and Carl Ludwig, learning to integrate anatomy w…
His; Mall; Sabin; artery; capillary; fascia; interstitium; liver; lymphatics; reticular network - A++2023
Functional organization of extracellular hyaluronan, CD44 and RHAMM
Mary K Cowman, Eva A TurleyIn this comprehensive review, the authors explore how hyaluronan (HA) and its receptors, CD44 and RHAMM, organize the space immediately surrounding cells. In healthy tissue, these components maintain a stable environmen…
hyaluronanCD44extracellular matrixRHAMMpericellular matrix - A++2023
The Osteopath's Imprint: Osteopathic Medicine Under the Nanoscopic Lens
Bruno Bordoni, Allan R EscherThis theoretical article explores the cellular effects of osteopathic manipulative treatment (OMT) from a new perspective. Traditionally, the benefits of OMT are explained through neurological, vascular, and other physi…
diaphragm; fascia; fascintegrity; myofascial; pain; quantum physics - A++2023
Pain quality patterns in delayed onset muscle soreness of the lower back suggest sensitization of fascia rather than muscle aferents: a secondary analysis study
Andreas Brandl, Jan Wilke, Christoph Egner, Tobias Schmidt, Andreas Schilder, Robert SchleipThis study investigated whether delayed onset muscle soreness (DOMS) in the lower back originates from the muscles or the surrounding connective tissue (fascia). Researchers had participants perform fatiguing back exerc…
Delayed onset muscle soreness; Eccentric exercise; Fascia pain; Lumbar multifidus muscle; Muscle pain; Pain perception; Pain quality; Thoracolumbar fascia - A++2023
Change in gliding properties of the iliotibial tract in hypermobile Ehlers–Danlos Syndrome
Tina J Wang, Antonio Stecco, Robert Schleip, Carla Stecco, Carmelo PirriThis study used ultrasonography to examine the gliding properties of the iliotibial tract (ITT) in individuals with hypermobile Ehlers-Danlos Syndrome (hEDS). Researchers found that the shear strain, which represents ho…
fasciashear strainultrasonographyEhlers–Danlos syndromeIliotibial tract - A++2023
The Cognitive and Emotional Aspect in Fibromyalgia: The Importance of the Orofacial Sphere
Bruno Bordoni, Allan R Escher, Gianmarco Cannadoro, Filippo TobbiThis narrative review explores the link between fibromyalgia and issues in the orofacial region, such as temporomandibular joint (TMJ) disorders and periodontitis. The authors suggest that oral inflammation may contribu…
dental occlusion; fibromyalgia; inflammation; osteopathic; pain; temporomandibular joint - A++2022
The deep fascia and its role in chronic pain and pathological conditions: A review
Flemming Kondrup, Nathaly Gaudreault, Gabriel VenneThis narrative review explores the deep fascia, a three-dimensional continuum of connective tissue surrounding muscles, nerves, and blood vessels. The researchers identified five common conditions associated with fascia…
anatomy; chronic pain; deep fascia; fasciitis; inflammation; innervation. - A++2022
Mechanosensing by Piezo1 and its implications for physiology and various pathologies
Austin Lai, Charles D Cox, Nadia Chandra Sekar, Peter Thurgood, Anthony Jaworowski, Karlheinz Peter, Sara BaratchiThis narrative review explores Piezo1, a specialized ion channel that senses mechanical pressure and converts it into biological signals within the body. These channels are widely distributed in tissues such as blood ve…
Piezo1; mechanoreceptor; mechanosensitive ion channel; mechanotransduction; shear stress. - A++2022
Lifestyle Factors and Their Influence on Rheumatoid Arthritis: A Narrative Review
Christoph Schäfer, Gernot KeyßerThis narrative review examines how lifestyle factors influence the development and progression of rheumatoid arthritis (RA). Research suggests that smoking, an unhealthy diet, and obesity increase the risk of developing…
Mediterranean diet; diet; lifestyle; physical activity; rheumatoid arthritis; smoking; socioeconomic status - A++2022
Interdisciplinarity and mechanobiology
Donald E Ingber, Dino Di CarloMechanobiology is an interdisciplinary field that studies how cells sense and respond to mechanical forces in their environment. In this article, pioneers Donald Ingber and Dino Di Carlo discuss how physical forces infl…
biotensegrity - A++2022
Piezo1 Channels as Force Sensors in Mechanical Force-Related Chronic Inflammation
Hailin Liu, Jialing Hu, Qingcui Zheng, Xiaojin Feng, Fenfang Zhan, Xifeng Wang, Guohai Xu, Fuzhou HuaThis narrative review explores the role of Piezo1 ion channels as mechanical sensors that link physical force to chronic inflammation. Piezo1 channels open in response to stimuli like pressure, stretch, and tissue stiff…
Ca 2+; MSc; Piezo1; chronic inflammation; mechanical force; pharmacology. - A++2022
Differential Sensitization of Muscle versus Fascia in Individuals with Low Back Pain
Ronen Cozacov, Amir Minerbi, May Haddad, Simon VulfsonsThis clinical study investigated pain sensitivity in both muscle and deep fascia among individuals with low back pain compared to healthy controls. Using ultrasound-guided needling of the quadratus lumborum muscle and i…
fascia; myofascial pain; pain sensitization - A++2022
Blood supply to the superficial fascia of the abdomen:An anatomical study
Carmelo Pirri, Lucia Petrelli, Caterina Fede, Diego Guidolin, Cesare Tiengo, Raffaele De Caro, Carla SteccoThis anatomical study investigated the blood supply to Scarpa's fascia, the superficial fascia of the abdominal wall, using tissue samples from seven volunteers. The researchers demonstrated that this fascia is a highly…
Subcutaneous tissueFlapssuperficial fasciahypodermislymphatics - A++2022
Innervation of human superficial fascia
Caterina Fede, Lucia Petrelli, Carmelo Pirri, Winfried Neuhuber, Cesare Tiengo, Carlo Biz, Raffaele De Caro, Robert Sch…This study examined the superficial fascia, a thin layer of connective tissue within the skin's fat layer, to understand its nerve supply. Researchers found that this tissue is densely packed with nerves, particularly a…
autonomic innervation; hypodermis; innervation; nerve fibers; superficial fascia. - A++2022
The effect of low-intensity whole-body vibration with or without high-intensity resistance and impact training on risk factors for proximal femur fragility fracture in postmenopausal women with low bone mass: study protocol for the VIBMOR randomized controlled trial
Belinda Beck, Clinton Rubin, Amy Harding, Sanjoy Paul, Mark ForwoodThis document outlines the plan for a clinical trial investigating non-drug approaches for low bone mass in postmenopausal women. The study will compare the effects of low-intensity whole-body vibration, high-intensity…
exercisevibrationFractureHiRITOsteoporosis - A++2022
Risk Factors of Postpartum Depression
Iris Agrawal, Ashok M Mehendale, Ritika MalhotraThis literature review examines the risk factors for postpartum depression (PPD), a condition affecting 10–15% of new mothers globally. The research suggests that factors such as a history of psychiatric illness, lack o…
clinical features; history of depression; post-natal mother; postnatal depression; postpartum care; postpartum depression; postpartum mental health; postpartum mothers; risk factors; spousal support. - A++2022
Evidence of Renin-Angiotensin System Receptors in Deep Fascia: A Role in Extracellular Matrix Remodeling and Fibrogenesis?
Carmelo Pirri, Brasilina Caroccia, Andrea Angelini, Lucia Petrelli, Maria Piazza, Carlo Biz, Pietro Ruggieri, Raffaele…This study investigated the presence of renin-angiotensin system (RAS) components in the deep fascia, specifically the thoracolumbar fascia of the lower back. Researchers found that receptors for angiotensin II, particu…
Ang II type 1 receptor (AT1R); angiotensin receptor; angiotensin-converting enzyme 2 (ACE2); fascia; fibrosis; remodeling; renin–angiotensin system; thoracolumbar fascia. - A++2021
Physical Agent Modalities in Early Osteoarthritis: A Scoping Review
Giulia Letizia Mauro, Dalila Scaturro, Francesca Gimigliano, Marco Paoletta, Sara Liguori, Giuseppe Toro, Giovanni Iola…This scoping review investigated the role of physical agent modalities in treating early osteoarthritis (EOA). Researchers searched for studies on treatments like TENS, extracorporeal shockwave therapy (ESWT), ultrasoun…
osteoarthritis; early osteoarthritis; rehabilitation; physical therapy modalities; physical agents; electric stimulation therapy; pulsed electromagnetic field; extracorporeal shockwave therapy; vibration therapy - A++2021
Fascia The Universal Singularity Of Biotensegrity The Dark Matter Of Our Inner Cosmos
John SharkeyThis theoretical paper argues that fascia is the body's fundamental and unifying system, analogous to dark matter in the cosmos. The author suggests this continuity is evident from embryology, where the body develops as…
Embryology; Fascia; Biotensegrity; Epigenetics; DNA; Anatomy; Dissection - A++2021
Temporomandibular Myofascial Pain Syndrome-Aetiology and Biopsychosocial Modulation. A Narrative Review
Paulina Golanska, Klara Saczuk, Monika Domarecka, Joanna Kuć, Monika Lukomska-SzymanskaThis case report examined the effectiveness of Global Postural Reeducation (GPR) in treating a 23-year-old woman with temporomandibular disorder (TMD) and postural imbalances. By addressing muscle chains and spinal alig…
biopsychosocial profile modulation; bruxism; limbic system; stress; temporomandibular myofascial pain syndrome - A++2021
Fascia and Tensegrity The Quintessence of a Unified Systems Conception
John SharkeyThis theoretical paper proposes a new way of viewing the human body, moving beyond the traditional mechanical model of parts and levers. The author suggests the body is better understood as a unified system based on ten…
Fascia; Tensegrity; Continuity; Unified Systems; Biotensegrity; Stability; Embryology - A++2021
Beyond bones: The relevance of variants of connective tissue (hypermobility) to fibromyalgia, ME/CFS and controversies surrounding diagnostic classification: an observational study
Jessica A Eccles, Beth Thompson, Kristy Themelis, Marisa L Amato, Robyn Stocks, Amy Pound, Anna-Marie Jones, Zdenka Cip…This observational study investigated the link between hypermobility, fibromyalgia, and ME/CFS. Researchers found a significant overlap in symptoms between fibromyalgia and ME/CFS in the patient group. A large majority…
FibromyalgiapainfatiguehypermobilityME/CFS - A++2021
Altering Dynamics of Autonomic Processing Therapy (ADAPT) trial: a novel, targeted treatment for reducing anxiety in joint hypermobility
Geoff Davies, Jenny L L Csecs, Heather Ball, Jess Dare, Stephen Bremner, Robin Hosking, Hugo D Critchley, Nick Grey, Je…This paper describes the protocol for a clinical trial investigating a new therapy for anxiety in people with joint hypermobility. The proposed therapy, called ADAPT, combines bio-behavioral training with cognitive appr…
InteroceptionhypermobilityAnxietyCBTRCT - A++2021
Is "Delayed Onset Muscle Soreness" a False Friend? The Potential Implication of the Fascial Connective Tissue in Post-Exercise Discomfort
Jan Wilke, Michael BehringerThis narrative review explores the theory that delayed onset muscle soreness (DOMS) may originate in the connective tissue (fascia) rather than the muscle fibers themselves. While traditional explanations like lactic ac…
DOMS; athletes; eccentric exercise; fascia; pain. - A++2021
Therapeutic potential of astaxanthin and superoxide dismutase in Alzheimer's disease
Vyshnavy Balendra, Sandeep Kumar SinghThis narrative review explores how the combination of astaxanthin and the enzyme superoxide dismutase (SOD) may help protect the brain in Alzheimer's disease. Oxidative stress is a key factor in the disease's progressio…
Alzheimer's disease; astaxanthin; neurodegeneration; nutraceuticals; oxidative stress; superoxide dismutase (SOD) - A++2021
Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration
Bingjin Wang, Wencan Ke, Kun Wang, Gaocai Li, Liang Ma, Saideng Lu, Qian Xiang, Zhiwei Liao, Rongjin Luo, Yu Song, Wenb…This study investigates how the mechanical environment of the intervertebral disc influences cellular health during disc degeneration. Researchers found that as the central part of the disc (nucleus pulposus) becomes st…
mechanotransductionOxidative stressPiezo1Ion channel - A++2021
Fascial or Muscle Stretching? A Narrative Review
Carla Stecco, Carmelo Pirri, Caterina Fede, Can A Yucesoy, Raffaele De Caro, Antonio SteccoIn this narrative review, the authors explore what actually happens in the body during stretching. While it's traditionally been assumed that stretching acts on muscles and tendons, this analysis of tissue mechanics sug…
fascia; biomechanics; exercise; injury and prevention; musculoskeletal; stretching - A++2021
Decoding the silent walk of COVID-19: Halting its spread using old bullets
Mukesh Kumar, Jitender Madan, Rupinder Kaur Sodhi, Shashi Bala Singh, Anju KatyalThis 2021 review article explores the strategy of using existing drugs to combat the rapidly spreading COVID-19 virus. The authors describe how SARS-CoV-2 affects multiple organ systems, creating a significant therapeut…
Chloroquine; Heparin; Noscapine; Remedesivir; Severe acute respiratory syndrome (SARS-CoV2); Vitamin C. - A++2020
Simulation and Modeling of Telocytes Behavior in Signaling and Intercellular Communication Processes
Dragos Cretoiu, Simona Roatesi, Ion Bica, Cezar Plesca, Amado Stefan, Oana Bajenaru, Carmen Elena Condrat, Sanda Maria…Telocytes are a unique type of interstitial cell with long extensions that form networks, thought to be involved in local tissue equilibrium and regeneration. In this study, researchers used computer simulation and math…
content-based image retrieval; image indexation; modeling of living cell behavior; telocyte network tracking and indexing; telocytes; viscoelastic constitutive laws - A++2020
The Efficacy of Stretching Exercises on Arterial Stiffness in Middle-Aged and Older Adults: A Meta-Analysis of Randomized and Non-Randomized Controlled Trials
Michitaka Kato, Fumi Nihei Green, Kazuki Hotta, Toshiya Tsukamoto, Yasunari Kurita, Akira Kubo, Hisato TakagiThis meta-analysis reviewed eight studies involving 213 middle-aged and older adults to see how stretching affects arterial stiffness. The combined results suggest that regular stretching can significantly reduce arteri…
stretching exercises; arterial stiffness; endothelial function; middle-aged; older adult - A++2020
Mesothelial Cells Covering the Surface of Primo Vascular System Tissue
Chae Jeong Lim, Yeo Sung Yoon, Pan Dong RyuIn this study on rats, researchers investigated the cells on the outer surface of the primo vascular system (PVS), a proposed circulatory network. Using various microscopy and staining techniques, they identified these…
HBME-1; hematoxylin and eosin staining (H&E); periductium; primo node; primo vessel; scanning electron microscopy (SEM) - A++2020
The potential role of cannabinoids in dermatology
Tabrez Sheriff, Matthew J Lin, Danielle Dubin, Hooman KhorasaniThis literature review explores how cannabinoids, including both plant-derived and endogenous versions, may affect the skin through the endocannabinoid system. Research suggests that the skin possesses its own receptors…
Cannabinoids in dermatology; cannabidiol; cannabis; endocannabinoids. - A++2020
Optimal Nutritional Status for a Well-Functioning Immune System Is an Important Factor to Protect against Viral Infections
Philip C Calder, Anitra C Carr, Adrian F Gombart, Manfred EggersdorferIn this review, the authors state that optimal nutritional status is crucial for a well-functioning immune system and protection against viral infections. They highlight that many vitamins (A, B6, B12, C, D, E, folate),…
immune system; viral infection; influenza; COVID-19; micronutrients; vitamins; omega-3 fatty acids; minerals; vitamin C; vitamin D - A++2020
Sensitivity of the Fasciae to the Endocannabinoid System: Production of Hyaluronan-Rich Vesicles and Potential Peripheral Effects of Cannabinoids in Fascial Tissue
Caterina Fede , Carmelo Pirri , Lucia Petrelli, Diego Guidolin , Chenglei Fan, Raffaele De Caro, Carla SteccoThis laboratory study investigated how fascial cells respond to cannabinoids. Researchers isolated fibroblast cells from human fascia lata and treated them with a substance that activates cannabinoid receptor 2. The tre…
fascia; hyaluronan; vesicles; endocannabinoid; agonist; antagonist; inflammation; fibrosis; pain; peripheral effect - A++2020
Effect of Low-Intensity Vibration on Bone Strength, Microstructure, and Adiposity in Pre-Osteoporotic Postmenopausal Women: A Randomized Placebo-Controlled Trial
Chamith S Rajapakse, Alyssa J Johncola, Alexandra S Batzdorf, Brandon C Jones, Mona Al Mukaddam, Kelly Sexton, Justine…This randomized, placebo-controlled trial investigated if daily low-intensity vibration could improve bone health in postmenopausal women with pre-osteoporosis. For one year, one group used a vibrating platform for 10 m…
VIBRATION THERAPY; BONE; OSTEOPOROSIS; MRI - A++2020
Ultrasound imaging of a scar on the knee: Sonopalpation for fascia and subcutaneous tissues
Carmelo Pirri, Antonio Stecco, Caterina Fede, Raffaele De Caro, Carla Stecco, Levent ÖzçakarPersistent pain from surgical or trauma-related scars is a common and sometimes debilitating problem. In this article, the authors describe the use of ultrasound imaging to provide an objective diagnosis for debilitatin…
fasciapainscarultrasonographyknee - A++2020
Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
Lijun Wang, Xiuling You, Sutada Lotinun, Lingli Zhang, Nan Wu, Weiguo ZouThis study using mouse models investigates how the protein PIEZO1 acts as a mechanical sensor in the skeleton to regulate bone mass. Researchers found that a deficiency of PIEZO1 in bone-forming cells (osteoblasts) lead…
mechanotransductionpiezobone homeostasis - A++2020
Applicability of Low-intensity Vibrations as a Regulatory Factor on Stem and Progenitor Cell Populations
Oznur Baskan, Ozge Karadas, Gulistan Mese, Engin OzciviciThis narrative review explores how mechanical forces, specifically low-intensity vibrations, can influence stem cells. While high-impact activities like running are known to build tissue, they are not suitable for every…
Stem cell; biomechanics; mechanobiology; progenitor cell populations; tissue engineering; vibrations - A++2020
Telocytes and lymphatic endothelial cells: Two immunophenotypically distinct and spatially close cell entities
Irene Rosa, Mirca Marini, Eleonora Sgambati, Lidia Ibba-Manneschi, Mirko ManettiResearchers have been working to clarify the identity of two cell types, telocytes and lymphatic endothelial cells, which can sometimes look similar in tissue samples. This study used a specific staining technique to lo…
Telocytes and lymphatic endothelial cells: Two immunophenotypically distinct and spatially close cell entities - A++2020
Embryology of the Fascial System
Leonardo VieiraThis review article explores how the fascial system develops in the human embryo, highlighting its role as a continuous network that integrates all body systems. The author describes how different types of fascia—includ…
embryology; fascia; fascial system; human development; neuro-fasciagenic - A++2020
Extracellular Vesicles Released From Articular Chondrocytes Play a Major Role in Cell-Cell Communication
Xiaoming Liu, Claire Shortt, Fenglin Zhang, Mariah Q Bater, Mary K Cowman, Thorsten KirschThis narrative review examines the role of extracellular vesicles (EVs) as crucial mediators in cell-to-cell communication. EVs are small, lipid-enclosed particles that transport proteins, lipids, and genetic material t…
articular chondrocytes; catabolic events; chondrogenesis; extracellular vesicles - A++2020
Integrating mental imagery and fascial tissue: A conceptualization for research into movement and cognition
Amit Abraham, Eric Franklin, Carla Stecco, Robert SchleipThis narrative review explores the connection between mental imagery and fascial tissue, a field that has historically focused on muscles and the nervous system. The authors propose that specific mental visualizations d…
Body schema; Cognition; Dynamic neuro-cognitive imagery; Fascia; Mental imagery; Movement - A++2020
Biotensegrity: What is the big deal?
Graham ScarrDetails for this entry have not yet been summarized. The title, "Biotensegrity: What is the big deal?", suggests it is an explanatory or editorial piece about the concept of biotensegrity. Biotensegrity is a model that…
biotensegrity - A++2020
Is the extent of obstetric anal sphincter injury correlated with the severity of fecal incontinence in the long term?
L Luciano, M. Bouvier, K Baumstarck, V VittonThis retrospective study investigated the relationship between the extent of obstetric anal sphincter injury and the severity of long-term fecal incontinence (FI). Researchers analyzed data from 250 women with a mean ag…
Fecal incontinence · Obstetrical anal sphincter injury · Endoanal ultrasonography · 3D high-resolution anorectal manometry · Delivery - A++2020
What is the Intelligent Tissue !eory and How Does it Relate to Acupuncture?
Fletcher KovichThis article introduces the "intelligent tissue theory," which proposes that organ information is transmitted via electromagnetic waves and interpreted by bodily tissues at specific meridians. The author suggests that t…
acupunctureChiintelligent tissueNei Jing - A++2020
Fascia and soft tissues innervation in the human hip and their possible role in post-surgical pain
Caterina Fede, Andrea Porzionato, Lucia Petrelli, Chenglei Fan, Carmelo Pirri, Carlo Biz, Raffaele De Caro, Carla SteccoResearchers investigated the nerve supply to various soft tissues in the human hip to better understand persistent pain after hip replacement surgery. Analyzing tissue samples from patients and cadavers, they measured t…
fasciapaininnervationproprioceptionSoft tissue - A++2020
Therapeutic importance of hydrogen sulfide in age-associated neurodegenerative diseases
Rubaiya Tabassum, Na Young Jeong, Junyang JungThis narrative review explores the potential of molecular hydrogen (H2) as a preventive and therapeutic medical gas for various health conditions. H2 acts as a selective antioxidant, specifically targeting the most harm…
3-mercaptopyruvate sulfurtransferase; aging; antioxidant; cystathionine β-synthase; cystathionine γ-lyase; glutathione; hydrogen sulfide; neurodegenerative disease; oxidative stress; reactive oxygen species - A++2020
Higher Circulating Cortisol in the Follicular vs. Luteal Phase of the Menstrual Cycle: A Meta-Analysis
Ajna Hamidovic, Kristina Karapetyan, Fadila Serdarevic, So Hee Choi, Tory Eisenlohr-Moul, Graziano PinnaThis meta-analysis investigated how levels of the stress hormone cortisol vary across the menstrual cycle in healthy women. By synthesizing data from multiple high-quality studies, researchers found that cortisol levels…
cortisol; follicular; hypothalamic-pituitary-adrenal (HPA) axis; hypothalamic-pituitary-gonadal (HPG) axis; luteal; menstrual cycle - A++2020
Local low-intensity vibration improves healing of muscle injury in mice
Thomas F Corbiere, Timothy J KohIn this animal study, researchers investigated how local low-intensity vibration (LIV) affects muscle injury healing in mice. After lacerating the gastrocnemius (calf) muscle in mice, one group received daily vibration…
skeletal muscle injurycell culturemechanical stimulationmouse modelmuscle repair - A++2020
The potential of cannabidiol in the COVID-19 pandemic
Giuseppe Esposito, Marcella Pesce, Luisa Seguella, Walter Sanseverino, Jie Lu, Chiara Corpetti, Giovanni SarnelliThis scientific hypothesis explores the potential of cannabidiol (CBD) as a supportive treatment during the COVID-19 pandemic. The authors suggest that CBD may down-regulate the receptors the virus uses for cellular ent…
fibrosisCannabinoidsimmune systemCOVID-19anti-inflammatory - A++2020
Nutrition, immunity and COVID-19
Philip C CalderThis review discusses the crucial role of nutrition in supporting the immune system's ability to fight infections. A well-functioning immune response requires a steady supply of energy and specific nutrients derived fro…
immune systemVitamins.nutrientsgut microbiome - A++2020
The Structure and Role of Intramuscular Connective Tissue in Muscle Function
Peter P PurslowThis narrative review analyzes the microscopic structure of intramuscular connective tissue—endomysium, perimysium, and epimysium—and its role in muscle function. Rather than acting simply as a container, this connectiv…
extracellular matrixMusclecollagenmechanotransductionperimysium - A++2019
Acute Effects of Static Stretching on Muscle Strength and Power: An Attempt to Clarify Previous Caveats
Helmi Chaabene, David G Behm, Yassine Negra, Urs GranacherThis narrative review examines how static stretching affects subsequent strength and power. While static stretching was once thought to hinder performance, recent evidence suggests the duration of the stretch is the cri…
physiologyrange of motioninjurypassive stretchingphysical fitness - A++2019
Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure
Alpha A Fowler, Jonathon D Truwit, R Duncan Hite, Peter E Morris, Christine DeWilde, Anna Priday, Bernard Fisher, Leroy…This randomized controlled trial investigated whether intravenous vitamin C could help patients with sepsis and severe acute respiratory failure. Researchers gave 167 patients either a high-dose vitamin C infusion or a…
sepsisintravenous vitamin C - A++2019
Effects of season long participation on ACL volume in female intercollegiate soccer athletes
Karen M Myrick, Andreas Voss, Richard S Feinn, Thomas Martin, Bernadette M Mele, Juan C GarbalosaThis study investigated how a competitive season affects the anterior cruciate ligament (ACL) in female collegiate soccer players. Researchers used MRI scans to measure ACL volume in 17 athletes before and after their s…
collagenAnterior cruciate ligamentintense physical trainingvolumetric changes in ligamentpre- to post season changes in ligament - A++2019
Mitochondrial superoxide anions induced by exogenous oxidative stress determine tumor cell fate: an individual cell-based study
Hui PAN, Bao-hui WANG, Zhou-bin LI, Xing-guo GONG, Yong QIN, Yan JIANG, Wei-li HANIn this cell-based study, researchers investigated how external oxidative stress affects individual lung cancer cells. They found that applying a stressor like hydrogen peroxide caused a rapid increase in reactive oxyge…
Individual cell; Superoxide anion; Reactive oxygen species (ROS) dynamics; Intrinsic apoptotic pathway; Ca2+ signaling - A++2019
Inter and Intra operator reliability of motor and palpation evaluation in fascial manipulation in individuals coxarthrosis
Andrea Cotti, Massimiliano Del Corso, Roberto Diana, Luigi Cornale, Alessandra Sudanese, Antonio Stecco, Mirco BranchiniThis study investigated the reliability of assessment methods used in Fascial Manipulation® (FM®) for individuals with hip osteoarthritis (coxarthrosis). Researchers tested whether different therapists, and the same the…
Fascial manipulation; Inter reliability; intra reliability; movement evaluation; motor evaluation; palpation evaluation; coxarthrosis; pain - A++2019
Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis
Harri Hemilä, Elizabeth ChalkerThis meta-analysis reviewed data from 18 controlled trials involving over 2000 patients to assess if vitamin C affects the length of stay in the intensive care unit (ICU). The results suggest that vitamin C supplementat…
antioxidants; burns; artificial respiration; cardiac surgical procedures; cardiovascular system; critical care; dietary supplements; oxidative stress; sepsis; systematic review - A++2019
Oral Supplementation of Specific Collagen Peptides Combined with Calf-Strengthening Exercises Enhances Function and Reduces Pain in Achilles Tendinopathy Patients
Stephan F E Praet, Craig R Purdam, Marijke Welvaert, Nicole Vlahovich, Gregg Lovell, Louise M Burke, Jamie E Gaida, Sil…This pilot study investigated whether supplementing with specific collagen peptides could improve symptoms for patients with chronic Achilles tendinopathy. Participants combined a calf-strengthening program with either…
achilles tendon; microvessels; contrast-enhanced ultrasound; hydrolysed collagen supplementation