Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- B2008
Myofascial Force Transmission via Extramuscular Pathways Occurs between Antagonistic Muscles
Peter A Huijing, Guus C BaanIn this experimental study, researchers investigated whether opposing (antagonistic) muscles act independently or influence each other through their fascial connections. By lengthening a lower leg muscle (extensor digit…
Connective tissueProximo-distal force differenceAnterior crural compartmentAnterior tibial muscleExtensor digitorum longus muscle - A2008
Tensegrity-Based Mechanosensing from Macro to Micro
Donald E IngberThis review article, based on a lecture, explores how cells convert mechanical signals into biochemical responses. The author proposes that the body uses "tensegrity" (tensional integrity) principles, where interconnect…
fasciaextracellular matrixTensegritycytoskeletonmechanotransduction - A++2008
Stability, continence and breathing: The role of fascia following pregnancy and delivery
D G Lee, L J Lee, L McLaughlinMany women experience pelvic girdle pain, incontinence, or breathing issues after pregnancy and delivery. This paper explores the role of the trunk's muscles and fascia in stability, continence, and respiration. The aut…
Linea alba; Diastasis rectus abdominis; Pelvic floor; Paravaginal defects; Breathing; Hypocapnia; fascia - 1A+2008
Expression of the endocannabinoid system in fibroblasts and myofascial tissues
J M McPartlandThis narrative review investigates the endocannabinoid (eCB) system, a network in the body similar to the endorphin system that helps regulate pain and inflammation. Using a bioinformatics approach to analyze existing d…
Cannabinoids; Endocannabinoids; Ajulemic acid; Osteopathic medicine; Chiropractic; Myofascial release; Fibromyalgia; Myofascial trigger points; Biodynamics - A++2008
Humoral phototransduction: Light transportation in the blood, and possible biological effects
F Grass, S KasperIn this theoretical paper, researchers propose a model called 'humoral phototransduction' to explain how light might affect the body beyond the eyes. They observed that blood plasma, and particularly the protein albumin…
fasciabiophotonsultraweak photonshumoral phototransduction - B2008
The inflammatory response to cell death
K L Rock, H KonoThis 2008 review article explores how the body responds when cells die from injury rather than infection. Such cell death triggers an inflammatory response that is essential for host defense and tissue repair. However,…
inflammationNecrosisdangertoll-like receptorscytokines - A2008
Mechanotransduction – a field pulling together?
Christopher S ChenIn this 2008 review article, the author discusses mechanotransduction, the process by which cells convert mechanical forces into biochemical signals. Cells are constantly subjected to forces, both from external pressure…
fasciastiffnessmechanobiologycell adhesionmechanical force - A2008
Dorsal horn neurons having input from low back structures in rats
T Taguchi, U Hoheisel, S MenseIn this animal study, researchers in rats investigated how spinal cord nerve cells (dorsal horn neurons) process signals from the low back. They found that these neurons often receive input from several different tissue…
fascialow back painmultifidus muscledorsal horn neuronsnerve growth factor (NGF) - A2008
Magnetic Resonance Imaging of Adhesive Capsulitis: Correlation with Clinical Staging
Carolyn M Sofka, Gina A Ciavarra, Jo A Hannafin, Frank A Cordasco, Hollis G PotterThis study investigated whether standard magnetic resonance imaging (MRI) can be used to diagnose and stage adhesive capsulitis (frozen shoulder). Researchers retrospectively reviewed MRI scans from 46 patients with an…
Adhesive capsulitisShoulderMagnetic resonance imaging - A++2007
Ascorbate in pharmacologic concentrations selectively generates ascorbate radical and hydrogen peroxide in extracellular fluid in vivo
Qi Chen, Michael Graham Espey, Andrew Y Sun, Je-Hyuk Lee, Murali C Krishna, Emily Shacter, Peter L Choyke, Chaya Pooput…High-dose intravenous Vitamin C (ascorbate) can selectively kill some cancer cells without harming normal cells. Researchers have proposed this is because ascorbate acts as a prodrug, creating hydrogen peroxide and othe…
ascorbic acid " cancer " vitamin C " pharmacokinetics - A++2007
A suspensory system for the sacrum in pelvic mechanics: Biotensegrity
Stephen LevinThis 2007 publication by Stephen Levin, available only by title, appears to describe a model for understanding the mechanics of the pelvis. The title suggests a 'suspensory system' for the sacrum, framing its function w…
biotensegrityPelvisKinematicssacrummovement - B2007
Cytokines, Inflammation and Pain
J-M Zhang, J AnThis review chapter describes the role of cytokines—small proteins that cells use for communication—in inflammation and pain. The authors explain that there are both pro-inflammatory and anti-inflammatory types of cytok…
inflammationcytokinepainhyperalgesia
