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The Fascia Guide
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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

Researchers behind the studies
2,806
studies
602
top-graded
2,783
with plain-language summary
TopicAllfascia233extracellular matrix51hyaluronan46inflammation40Connective tissue39mechanotransduction36collagen32Vitamin C31Manual Therapy30acupuncture24
GradeAll1A+++41A++21A+42A++++1A+++317A++236A+84A435
YearAll yearsSince 2020Since 2015Since 2010With summary
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Showing 733–744 of 1,131 studies · page 62/95
  1. B
    2015

    Hyaluronan Controls the Deposition of Fibronectin and Collagen and Modulates TGF-β1 Induction of Lung Myofibroblasts

    Stephen P Evanko, Susan Potter-Perigo, Loreen J Petty, Gail A Workman, Thomas N Wight

    This study investigated how hyaluronan (HA), a key component of the extracellular matrix, influences the formation of myofibroblasts—cells involved in tissue scarring and fibrosis. Researchers observed that while HA lev…

    hyaluronanMyofibroblastTGF-β14-methyl umbelliferonefibronectin; collagen
  2. A
    2015

    Remodelling the extracellular matrix in development and disease

    Caroline Bonnans, Jonathan Chou, Zena Werb

    This narrative review describes the extracellular matrix (ECM), a dynamic network present in all body tissues that undergoes constant remodeling. This remodeling process is crucial for regulating cell functions like pro…

    fasciaextracellular matrixstiffnessmechanotransductionmatrix remodeling
  3. A
    2015

    Hyaluronan, inflammation and breast cancer progression

    Katryn L Schwertfeger, Mary K Cowman, Patrick G Telmer, Eva A Turley, James B McCarthy

    This narrative review explores the link between inflammation, the tissue component hyaluronan (HA), and breast cancer progression. Cancer cells and surrounding host cells can create an inflamed microenvironment that hel…

    hyaluronaninflammationCD44fasciaBreast cancer
  4. A+
    2015

    The Heart, the Brain, and the Regulation of Emotion

    Sarah N Garfinkel, Jessica A Eccles, Hugo D Critchley

    This research entry, summarized from its title, appears to explore the relationship between the heart, the brain, and how emotions are managed. It likely discusses how signals from the cardiovascular system, specificall…

    psychology.psychiatryemotionsbody signals
  5. A++
    2014

    Highly sensitive imaging for ultra-weak photon emission from living organisms

    Masaki Kobayashi

    This review article describes research on ultra-weak photon emission (UPE), also known as biophotons, which is faint light spontaneously emitted from living organisms. This light emission is associated with metabolic pr…

    biophotonsUltra-weak photon emissionCCDReactive oxygen speciesImaging
  6. 1A+
    2014

    The Medium of Haptic Perception: A Tensegrity Hypothesis

    Michael T Turvey, Sérgio T Fonseca

    In this theoretical paper, the authors propose a new hypothesis for how our sense of touch, or haptic perception, works. Unlike other senses that have a clear medium (like air for sound), the haptic system lacks one. Th…

    fasciaConnective tissuecytoskeletonhaptic systemmultifractal tensegrity
  7. A++
    2014

    Antioxidants, inflammation and cardiovascular disease

    Harald Mangge, Kathrin Becker, Dietmar Fuchs, Johanna M Gostner

    This narrative review explores the links between inflammation, oxidative stress, and cardiovascular disease (CVD). The authors explain that chronic immune activation in CVD leads to high levels of reactive oxygen specie…

    Antioxidative therapy; Atherogenesis; Cardiovascular disease; Homocysteine; Neopterin; Nitric oxide; Oxidative stress; Tetrahydrobiopterin; Tryptophan; Vitamins.
  8. A
    2014

    Vitamin C in the Treatment and/or Prevention of Obesity

    Diego Fernando GARCIA-DIAZ, Patricia LOPEZ-LEGARREA, Pablo QUINTERO, Jose Alfredo MARTINEZ

    In this 2014 narrative review, the authors examine the relationship between vitamin C and obesity. Obesity is often linked to oxidative stress, which can lead to other health issues like diabetes and cardiovascular dise…

    Oxidative stressAscorbic acidantioxidantbody weight
  9. A
    2014

    Clinical Relevance of Fascial Tissue and Dysfunctions

    Werner Klingler, M Velders, K Hoppe, M Pedro, Robert Schleip

    Fascia is a continuous network of connective tissue that supports the entire body. Traditionally seen as a passive structure, recent research shows it plays a more active role. Fascia contains contractile elements that…

    fasciaMyofascial painlumbar fasciadysfunction
  10. A++
    2014

    Ingested hyaluronan moisturizes dry skin

    Chinatsu Kawada, Takushi Yoshida, Hideto Yoshida, Ryosuke Matsuoka, Wakako Sakamoto, Wataru Odanaka, Toshihide Sato, Ta…

    This review article summarizes research on how oral hyaluronan (HA) supplements may influence skin hydration levels. Studies suggest that a daily intake of 120–240 mg of hyaluronic acid can contribute to increased moist…

    hyaluronanhaHyaluronic acidSkinsupplementation
  11. B
    2014

    Mechanisms of Myofascial Pain

    M Saleet Jafri

    This 2014 narrative review discusses the potential causes of myofascial pain. Myofascial pain syndrome is a common condition involving painful trigger points in muscle, but its precise mechanisms are not well understood…

    fasciaMyofascial painMyofascial trigger points
  12. A
    2014

    Hyaluronan Synthase 2 Protects Skin Fibroblasts against Apoptosis Induced by Environmental Stress

    Yan Wang, Mark E Lauer, Sanjay Anand, Judith A Mack, Edward V Maytin

    Skin fibroblasts need to manage environmental stress, such as UV radiation. This study on mouse cells investigated how hyaluronan (HA) and the enzymes that produce it help fibroblasts survive. Researchers found that cel…

    Apoptosis; Caspase; Extracellular Matrix; Fibroblast; Hyaluronan; Skin; Stress.