Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+2018
Negative Air Ions and Their Effects on Human Health and Air Quality Improvement
Shu-Ye Jiang, Ali Ma, Srinivasan RamachandranThis review paper examines the research on negative air ions (NAIs) and their effects on human health and air quality. Used for over a century in air cleaning, NAIs are associated with improved psychological health and…
negative air ions; superoxide; particulate matter; pulsed electric field - B2018
Global Expression Profiling Identifies a Novel Hyaluronan Synthases 2 Gene in the Pathogenesis of Lower Extremity Varicose Veins
Chia-Shan Hsieh, Chia-Ti Tsai, Yau-Hung Chen, Sheng-Nan Chang, Juey-Jen Hwang, Eric Y Chuang, I-HuiWuResearchers investigated the genetic factors behind varicose veins by comparing vein tissue from patients with and without the condition. They found that the gene hyaluronan synthase 2 (HAS2) was significantly less acti…
varicose veins; HAS2; RNA seq - A2018
Low Back Pain: The Potential Contribution of Supraspinal Motor Control and Proprioception
Michael Lukas Meier, Andrea Vrana, Petra SchweinhardtThis narrative review explores how motor control—the brain's management of posture and movement—adapts in people with low back pain. While these movement adaptations may reduce pain in the short term, they can sometimes…
proprioceptionlow back painmotor controlchronic painmotor cortex - A+++2018
Resveratrol: A Double-Edged Sword in Health Benefits
Bahare Salehi, Abhay Prakash Mishra, Manisha Nigam, Bilge Sener, Mehtap Kilic, Mehdi Sharifi-Rad, Patrick Valere Tsouh…This narrative review explores resveratrol, a natural polyphenol found in grape skins, red wine, and various plants. Research suggests that this compound possesses significant antioxidant, anti-inflammatory, and cardiop…
anticancer; antimicrobial; antioxidant; pharmacological activity; physiological effects; resveratrol. - A2018
New Proposal to Define the Fascial System
Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Roberto Castagna, Beatrice Sacconi, Paul MazzuccoIn this proposal, the authors suggest a new definition for the fascial system, noting that a universally accepted one does not yet exist. They argue for including the epidermis (the outer layer of skin) based on functio…
fasciaConnective tissuefibroblastMyofascialSkin - B2018
Effectiveness of sodium bicarbonate infusion on mortality in septic patients with metabolic acidosis
Zhongheng Zhang, Carlie Zhu, Lei Mo, Yucai HongThis retrospective database study investigated whether sodium bicarbonate infusion affected mortality in septic patients with metabolic acidosis. The researchers found no overall survival benefit in the general populati…
sepsiscritical careSodium bicarbonateMortalityMarginal structural Cox - A2018
Effectiveness of 3-dimensional shoulder ultrasound in the diagnosis of rotator cuff tears
Aiping Teng, Fanxiao Liu, Dongsheng Zhou, Tao He, Yan Chevalier, Roland M KlarIn this meta-analysis, researchers combined data from seven studies involving 282 patients to evaluate the effectiveness of 3-dimensional (3D) ultrasound in diagnosing rotator cuff tears. The analysis found that 3D ultr…
3-dimensional ultrasounddiagnostic valuemeta-analysisrotator cuff tears - A2018
Variations in Contents of Hyaluronan in the Peritumoral Micro-Environment of Human Chondrosarcoma
Caterina Fede, Carla Stecco, Andrea Angelini, Chenglei Fan, Elisa Belluzzi, Assunta Pozzuoli, Pietro Ruggieri, Raffaele…The micro-environment surrounding a tumor greatly influences its growth and response to therapy. This study focused on chondrosarcoma, a type of bone cancer resistant to both chemotherapy and radiation. Researchers quan…
hyaluronan; chondrosarcoma; peritumoral stroma; fascia; tumor micro-environment; malignant bone tumor; grade - A+++2018
Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin: A Randomized, Double-Blind, Placebo-Controlled Study
Do-Un Kim, Hee-Chul Chung, Jia Choi, Yasuo Sakai, Boo-Yong LeeThis randomized, double-blind, placebo-controlled study evaluated the effects of daily low-molecular-weight collagen peptide (LMWCP) supplementation on the skin of 64 women. Over 12 weeks, researchers measured skin hydr…
collagen hydrolysate; collagen tripeptide; fish collagen; low-molecular-weight collagen peptide; photoaging; skin elasticity; skin hydration; skin wrinkling; type I collagen. - A+2018
Bone turnover markers after the menopause: T-score approach
Fatma Gossiel, Hibatallah Altaher, David M Reid, Christian Roux, Dieter Felsenberg, Claus-C Glüer, Richard EastellThis study investigated how bone turnover changes in women before and after menopause by measuring specific markers for bone formation (PINP) and bone resorption (CTX). The researchers found that bone turnover increases…
Bone mineral density; Bone turnover markers; Menopause; Osteoporosis - A++2018
Low-frequency vibrotherapy considerably improves the effectiveness of manual lymphatic drainage (MLD) in patients with lipedema: A two-armed, randomized, controlled pragmatic trial
Rainer SchneiderThis randomized controlled trial investigated the effect of adding low-frequency vibrotherapy to manual lymphatic drainage (MLD) for 30 women with stage 2–3 lipedema. Participants were randomly assigned to receive eithe…
Lipedema; MLD; quality of life; shock wave vibrotherapy - A2018
The myodural bridges’ existence in the sperm whale
Pei Liu, Chan Li, Nan Zheng, Xiaoying Yuan, Yutong Zhou, Pu Chun, Yanyan Chi, Campbell Gilmore, Shengbo Yu, Hongjin SuiIn this anatomical animal study, researchers examined tissue from a sperm whale to see if it possessed a myodural bridge, a connection between the neck muscles and the dura mater previously identified in humans. The inv…
Myodural Bridge