collagen
32 studies, 5 episodes on collagen — reviewed, translated, woven together.
Articles
Nothing here yet.
Research
- 2020
The Structure and Role of Intramuscular Connective Tissue in Muscle Function
Peter P PurslowThis narrative review analyzes the microscopic structure of intramuscular connective tissue—endomysium, perimysium, and epimysium—and its role in muscle function. Rather than acting simply as a container, this connectiv…
- 2020
Alterations of Extracellular Matrix Mechanical Properties Contribute to Age-Related Functional Impairment of Human Skeletal Muscles
Piero Pavan, Elena Monti, Michela Bond, Chenglei Fan, Carla Stecco, Marco Narici, Carlo Reggiani, Lorenzo MarcucciMuscles tend to get stiffer with age, and this study investigated why. Researchers compared muscle tissue from young and elderly individuals, testing the passive resistance of both individual muscle fibers and bundles o…
- 2019
Oral Collagen Supplementation: A Systematic Review of Dermatological Applications
Franchesca D Choi, Calvin T Sung, Margit L W Juhasz, Natasha Atanaskova MesinkovskThis systematic review examined eleven clinical trials investigating the impact of oral collagen supplements on skin health. The findings suggest that collagen hydrolysates and peptides may improve skin elasticity, hydr…
- 2019
Collagen changes in pelvic support tissues in women with pelvic organ prolapse
Runqi Gong, Zhijun XiaThis narrative review summarizes research on how changes in collagen are linked to pelvic organ prolapse in women. Collagen is a critical component of the pelvic floor, providing essential supportive functions. Studies…
- 2019
Mechanics and structural stability of the collagen triple helix
Michael W H Kirkness, Kathrin Lehmann, Nancy R FordeThis narrative review explores the mechanical properties of collagen, the body's primary structural protein. Collagen's unique triple helix structure is believed to be the source of its stability and resilience in tissu…
- 2019
Rehabilitation and nutrition protocols for optimising return to play from traditional ACL reconstruction in elite rugby union players: A case study
Gregory Shaw, Ben Serpell, Keith BaarThis case report followed two professional rugby players undergoing rehabilitation after an anterior cruciate ligament (ACL) reconstruction. In addition to a standard rehabilitation program, they received specific suppl…
- 2019
Effects of season long participation on ACL volume in female intercollegiate soccer athletes
Karen M Myrick, Andreas Voss, Richard S Feinn, Thomas Martin, Bernadette M Mele, Juan C GarbalosaThis study investigated how a competitive season affects the anterior cruciate ligament (ACL) in female collegiate soccer players. Researchers used MRI scans to measure ACL volume in 17 athletes before and after their s…
- 2018
Improvement of Functional Ankle Properties Following Supplementation with Specific Collagen Peptides in Athletes with Chronic Ankle Instability
Patrick Dressler, Dominic Gehring, Denise Zdzieblik, Steffen Oesser, Albert Gollhofer, Daniel KönigThis randomized, placebo-controlled study investigated the effect of specific collagen peptides on athletes with chronic ankle instability (CAI). Fifty athletes received either a daily collagen supplement or a placebo f…
- 2018
Effects of Plantar Vibration on Bone and Deep Fascia in a Rat Hindlimb Unloading Model of Disuse
Yunfei Huang, Yubo Fan, Michele Salanova, Xiao Yang, Lianwen Sun, Dieter BlottnerThis animal study investigated how disuse affects deep fascia and bone, and whether vibration could counteract these effects. Researchers used a rat model where hindlimbs were unloaded for 21 days to simulate disuse, wh…
- 2017
Mechanical properties of a collagen fibril under simulated degradation
David C Malaspinaa, Igal Szleifera, Yasin DhaheraThis study used computer simulations to investigate how collagen fibrils lose their strength. Researchers modeled three different types of degradation: the removal of cross-links, surface damage, and damage throughout t…
- 2016
Stretch-induced network reconfiguration of collagen fibres in the human facet capsular ligament
Sijia Zhang, Danielle S Bassett, Beth A WinkelsteinThe facet capsular ligament in the neck is a common source of chronic pain, often resulting from excessive stretching. This study investigated how the collagen fibers within this ligament reorganize when it is stretched…
- 2016
Fascial hierarchies and the relevance of crossed-helical arrangements of collagen to changes in the shape of muscles
Graham ScarrMuscles are complex structures wrapped in layers of fascia reinforced with collagen fibers. This article describes how these collagen fibers are often arranged in a specific crisscrossing, spiral-like pattern known as a…
- 2016
Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs
Agata Jabłońska-Trypuć, Marzena Matejczyk, Stanisław RosochackiThis review article describes matrix metalloproteinases (MMPs), the primary enzymes responsible for breaking down collagen in the extracellular matrix. This breakdown process is normal and necessary for tissue remodelin…
- 2015
Osmotic pressure induced tensile forces in tendon collagen
Admir Masic, Luca Bertinetti, Roman Schuetz, Shu-Wei Chang, Till Hartmut Metzger, Markus J Buehler, Peter FratzlResearchers investigated the role of water in tendon collagen using a combination of experiments and computer modeling. They found that water is a crucial part of the collagen molecule's structure. When water is removed…
- 2014
The role of collagen crosslinks in ageing and diabetes - the good, the bad, and the ugly
Jess G Snedeker, Alfonso GautieriThis narrative review explores how glucose in the body can bind to proteins like collagen, a process called glycation. This process creates crosslinks that can change the mechanical properties and function of connective…
- 2013
Molecular assembly and mechanical properties of the extracellular matrix: A fibrous protein perspective
Lisa D Muiznieks, Fred W KeeleyThis review article examines the extracellular matrix (ECM), the dynamic network of molecules surrounding our cells. The authors focus on fibrous proteins like collagen and elastin, which form the structural backbone of…
- 2012
The effect of menopause on the skin and other connective tissues
J Calleja-Agius, M BrincatThis narrative review examines how menopause and the resulting decline in estrogen affect the body's connective tissues, particularly the skin. Research suggests that skin collagen levels drop significantly following me…
- 2011
Exercise training reduces fibrosis and matrix metalloproteinase dysregulation in the aging rat heart
Hyo-Bum Kwak, Jong-hee Kim, Kumar Joshi, Alvin Yeh, Daniel A Martinez, John M LawlerIn this animal study, researchers investigated how exercise affects age-related fibrosis (scarring) in the rat heart. They found that aging was associated with an increase in collagen and a dysregulation of enzymes call…
- 2011
Fascia Research from a Clinician/Scientist’s Perspective
Thomas W FindleyIn this perspective piece, a clinician-scientist summarizes exciting areas in fascia research. The article describes the fascial network as a body-wide system that connects individual cells and shares loads with muscles…
- 2011
The extracellular matrix: an active or passive player in fibrosis?
T N Wight, S Potter-PerigoFibrosis, the excessive buildup of scar tissue, can be understood as a wound healing process that has gone awry. Normally, specialized cells called myofibroblasts help repair tissue and then disappear, but in fibrosis,…
- 2010
3D reconstruction of the crural and thoracolumbar fasciae
L Benetazzo, A Bizzego, R De Caro, G Frigo, D Guidolin, Carla SteccoResearchers created detailed 3D computer models to visualize the structure of the crural fascia in the lower leg and the superficial layer of the thoracolumbar fascia in the lower back. They found the crural fascia is c…
- 2010
Mechanical Strain Stabilizes Reconstituted Collagen Fibrils against Enzymatic Degradation by Mammalian Collagenase Matrix Metalloproteinase 8 (MMP-8)
Brendan P Flynn, Amit P Bhole, Nima Saeidi, Melody Liles, Charles A DiMarzio, Jeffrey W RubertiThis laboratory study investigated how mechanical tension affects collagen's resistance to breakdown. Researchers created small networks of type I collagen fibers, gently stretching some while leaving others unloaded. B…
- 2010
A new lock-step mechanism of matrix remodelling based on subcellular contractile events
Lysianne Follonier Castella, Lara Buscemi, Charles Godbout, Jean-Jacques Meister, Boris HinzMyofibroblasts are cells that contribute to tissue contracture in fibrotic conditions like scarring. This study investigated how these cells contract to remodel tissue. The researchers identified two separate contractio…
- 2009
Relevance of Collagen Piezoelectricity to “Wolff’s Law”: a Critical Review
Andrew C Ahn, Alan J GrodzinskyThis narrative review explores how bone adapts to mechanical stress, a principle known as Wolff's Law. For decades, scientists have investigated how bone cells sense this stress to trigger remodeling. An early theory pr…
- 2008
Differential effects of hyaluronan and its fragments on fibroblasts: Relation to wound healing
Maha David-Raoudi, Frederic Tranchepain, Brigitte Deschrevel, Jean-Claude Vincent, Patrick Bogdanowicz, Karim Boumedien…This lab study investigated how hyaluronan (HA) of different molecular sizes affects human fibroblast cells, which are key to wound healing. Researchers exposed fibroblasts to native HA and two smaller fragments. All th…
- 2006
Subcutaneous Tissue Fibroblast Cytoskeletal Remodeling Induced by Acupuncture: Evidence for a Mechanotransduction-Based Mechanism
Helene M Langevin, Nicole A Bouffard, Gary J Badger, David L Churchill, Alan K HoweIn this mouse tissue study, researchers investigated how rotating an acupuncture needle affects fibroblasts in the connective tissue under the skin. They found that rotation caused the fibroblasts to actively change sha…
- 2004
Role of Extracellular Matrix in Adaptation of Tendon and Skeletal Muscle to Mechanical Loading
MICHAEL KJÆRThis review discusses how the extracellular matrix (ECM), particularly collagen, adapts to mechanical loading in tendons and muscles. Physical activity stimulates both the creation and breakdown of collagen, a process e…
- 2002
Age-related Changes in the Collagen Network and Toughness of Bone
X Wang, X Shen, X Li, C Mauli AgrawalThis study investigated how the collagen network in bone tissue changes with age and how this affects bone toughness. Researchers analyzed 30 femurs from human cadavers, with donors ranging from 19 to 89 years of age. T…
- 2001
Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture
Helene M Langevin, David L Churchill, Marilyn J CipollaThis paper proposes a hypothesis for how acupuncture might work. The authors focus on the "de qi" sensation, which includes the acupuncturist feeling a "needle grasp" in the tissue. They suggest that when an acupuncture…
- 2001
Collagen accumulation in muscles of children with cerebral palsy and correlation with severity of spasticity
Booth, Cortina-Borja, TheologisThis study investigated the link between connective tissue and muscle function in children with cerebral palsy (CP). Researchers analyzed muscle samples from 26 children, comparing collagen content to clinical measures…
Podcast
- Ep. 117
117. Back Pain
Back pain is the third most common diagnosis for long-term sick leave, and for a long time, it has been difficult to explain why people get it. In the last 15-20 years, a wealth of new research has s…
- Ep. 114
114. What happens to the Fascia as we get older
As we get older, the body's production of collagen changes – which affects the network of Fascia that surrounds every single cell in the entire body. At the same time, the flow itself decreases, as d…
- Ep. 089
89. How is Fascia affected by ovulation, movement and exercise?
Did you know that the female body rebuilds itself twice a month? Carla Stecco, professor of anatomy, presented two major discoveries at the Fascia Research Congress 2018. The first was the discovery…
- Ep. 061
61. How menopause affects the Fascia
Menopause. Something completely natural that about half the world's population experiences, and which therefore indirectly affects practically the entire world's population, yet is talked about incre…
- Ep. 036
36. Osteoarthritis, Herniated Discs & Chronic Back Pain
A deep dive into research on topics including collagen & hyaluronic acid Why do people get osteoarthritis? What causes herniated discs? Can you get rid of chronic back pain and, if so, how? In recent…