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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

2,804
studies
602
top-graded
2,783
with plain-language summary
Showing 841–900 of 1,127 studies · page 15/19With summary
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  1. A+
    2013

    Exercise training initiated in late middle age attenuates cardiac fibrosis and advanced glycation end-product accumulation in senescent rats

    Kathryn J Wright, Melissa M Thomas, Andrew C Betik, Darrell Belke, Russell T Hepple

    This animal study investigated if exercise started later in life could still benefit the aging heart. Researchers had late middle-aged rats begin treadmill training and continue into old age, comparing them to sedentary…

    %BF; AGE; ANOVA; Advanced glycation end-products; Aging; DXA; ECM; ET; Endurance exercise; F344BNF1; Fibrosis; Fischer 344 Brown Norway F1 hybrid rat; GAPDH; Heart; LV; MMP; Matrix metalloproteinases; RT-PCR; TIMP; TTBS; Tris-buffered saline (+0.5% Tween); WGA; advanced glycation end-product; analysis of variance; dual energy X-ray absorptiometry; exercise training; extracellular matrix; glyceraldehyde 3-phosphate dehydrogenase; left ventricle; matrix metalloproteinase; percent body fat; reverse transcription polymerase chain reaction; tissue inhibitor of matrix metalloproteinase; wheat germ agglutinin.
  2. A+
    2013

    The effect of acute exercise on collagen turnover in human tendons: influence of prior immobilization period

    L Moerch, J Pingel, M Boesen, M Kjaer, Henning Langberg

    Researchers investigated how a period of immobility affects the Achilles tendon's response to exercise. In this study, eight healthy men had one leg immobilized for two weeks while the other was used normally. Afterward…

    Immobilization ! Power Doppler ! Blood flow velocity ! Procollagen type I N-terminal peptide ! Microdialysis
  3. A
    2013

    The Primo Vascular System as a New Anatomical System

    Miroslav Stefanov, Michael Potroz, Jungdae Kim, Jake Lim, Richard Cha, Min-Ho Nam

    This review paper proposes the existence of a "primo vascular system" (PVS) as the physical, anatomical basis for the meridian system of traditional Eastern medicine. According to the authors, this previously unknown sy…

    fasciaEvolutioncirculatory systemnew morphologicalfunctional theory
  4. A
    2013

    Cellulite's aetiology: a review

    M de la Casa Almeida, Suarez Serrano, J Rebollo Roldán, J J Jiménez Rejano

    In this literature review, researchers examined the underlying causes of cellulite. They found that cellulite is a complex phenomenon with many interacting factors, rather than a single cause. The research points to wom…

    Connective tissuecellulites
  5. A
    2013

    A Randomized Steady-State Bioavailability Study of Synthetic versus Natural (Kiwifruit-Derived) Vitamin C

    Anitra C Carr, Stephanie M Bozonet, Juliet M Pullar, Jeremy W Simcock, Margreet C M Vissers

    This randomized study investigated whether the body absorbs vitamin C from kiwifruit as effectively as from a synthetic supplement. Thirty-six young men received either half a kiwifruit or an equivalent dose (50 mg) vit…

    ascorbate; ascorbic acid; human; plasma; urine; semen; leukocytes; skeletal muscle
  6. A
    2013

    Cellular Control of Connective Tissue Matrix Tension

    H M Langevin, M Nedergaard, A Howe

    This review article explores how fibroblasts, the cells within connective tissue, actively help regulate tissue tension. Traditionally, the mechanical properties of connective tissue have been attributed to its passive…

    Connective tissuefibroblastmechanicalatpcytoskeleton
  7. A
    2013

    Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts

    Nanna Goldman, Devin Chandler-Militello, Helene Langevin, Maiken Nedergaard, Takahiro Takano

    This laboratory study investigated how certain molecules, called purines, affect human fibroblast cells. Previous research has shown that acupuncture can trigger the release of purines like ATP. The researchers exposed…

    fasciacytoskeletonacupunctureFibroblastscalcium signaling
  8. A+++
    2013

    The 17-β-oestradiol inhibits osteoclast activity by increasing the cannabinoid CB2 receptor expression

    Francesca Rossi, Giulia Bellini, Livio Luongo, Silvia Mancusi, Marco Torella, Chiara Tortora, Iolanda Manzo, Francesca…

    This in vitro study investigated how 17-β-oestradiol (estrogen) affects osteoclasts, the cells responsible for bone resorption. The researchers found that estrogen inhibits the formation and activity of these cells by i…

    cannabinoidsosteoporosis
  9. A
    2013

    Heparan sulfate in the nucleus and its control of cellular functions

    Mark D Stewart, Ralph D Sanderson

    This narrative review discusses the roles of heparan sulfate proteoglycans (HSPGs) inside the cell nucleus. These molecules are typically found on the cell surface and in the extracellular matrix, where they help regula…

    ProteoglycanSyndecan-1Nuclear localizationChromatin modificationProliferation
  10. A
    2013

    Molecular assembly and mechanical properties of the extracellular matrix: A fibrous protein perspective

    Lisa D Muiznieks, Fred W Keeley

    This review article examines the extracellular matrix (ECM), the dynamic network of molecules surrounding our cells. The authors focus on fibrous proteins like collagen and elastin, which form the structural backbone of…

    fasciaextracellular matrixcollageneastinself-assembly
  11. C
    2013

    Heparan sulfate proteoglycan as a cell-surface endocytosis receptor

    Helena C Christianson, Mattias Belting

    In this review, the authors discuss how large molecules enter the body's cells. They focus on heparan sulfate proteoglycans (HSPGs), a type of molecule on the cell surface that acts as a receptor or docking station. Man…

    GlycosaminoglycanExosomesDrug deliveryMacromoleculesMembrane transport
  12. A
    2013

    Applications and Emerging Trends of Hyaluronic Acid in Tissue Engineering, as a Dermal Filler, and in Osteoarthritis Treatment

    Amir Fakhari, Cory Berkland

    This narrative review summarizes knowledge about hyaluronic acid (HA), a naturally occurring polymer found in the body's connective tissues and fluids. The authors describe how HA contributes to the structural propertie…

    fasciaHyaluronic acidcrosslinkingdermal fillerviscosupplement
  13. B
    2013

    TGF-β: Guardian of T Cell Function

    Soyoung A Oh, Ming O Li

    In this review article, the authors discuss the role of the cytokine TGF-β (transforming growth factor-beta) in the immune system. TGF-β is critical for regulating T cells, a type of white blood cell central to the adap…

    cytokinesimmune systemTGF-betaT-cells
  14. A
    2012

    Hyaluronic acid, A key molecule in skin aging

    Eleni Papakonstantinou, Michael Roth, George Karakiulakis

    This review article discusses the role of hyaluronic acid (HA) in skin aging. The authors explain that youthful skin's plumpness and resilience are largely due to its high water content, which HA is uniquely able to ret…

    CD44fasciaHyaluronic acidhyaluronic acid synthaseshyaluronidases
  15. B
    2012

    Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism

    Jun Li, Daniel J Gorski, Wendy Anemaet, Jennifer Velasco, Jun Takeuchi, John D Sandy, Anna Plaas

    In this mouse study, researchers investigated how hyaluronan (HA) injections might protect joints in osteoarthritis. They found that even though the injected HA was cleared from the knee joint in under two hours, a sing…

    hyaluronanCD44fibrosisTGF-beta1osteoarthritis
  16. A+
    2012

    The role of stromal cells in the persistence of chronic inflammation

    A J Naylor, A Filer, C D Buckley

    This review article explores why chronic inflammation often persists in specific anatomical locations. The authors highlight that stromal cells, particularly the fibroblasts that define a tissue's architecture, are like…

    inflammationfasciafibroblastchronicpersistence
  17. A
    2012

    A RHAMM Mimetic Peptide Blocks Hyaluronan Signaling and Reduces Inflammation and Fibrogenesis in Excisional Skin Wounds

    Cornelia Tolg, Sara R Hamilton, Ewa Zalinska, Lori McCulloch, Ripal Amin, Natalia Akentieva, Francoise Winnik, Rashmin…

    In this animal study, researchers investigated how to reduce scarring during skin wound healing. They developed a peptide, P15-1, designed to interfere with signals from fragmented hyaluronan, a molecule involved in inf…

    hyaluronaninflammationfasciaextracellular matrixfibrosis
  18. C
    2012

    NGF-evoked sensitization of muscle fascia nociceptors in humans

    Saskia Deising, Benjamin Weinkauf, James Blunk, Otilia Obreja, Martin Schmelz, Roman Rukwied

    This study investigated whether nerve growth factor (NGF) can sensitize pain receptors in muscle fascia. Researchers injected a small amount of NGF into the fascia of the erector spinae muscle in the lower back of 14 ma…

    hyperalgesialow back painmusculoskeletal painPressure pain
  19. A++
    2012

    Fluid Flow along Venous Adventitia in Rabbits: Is It a Potential Drainage System Complementary to Vascular Circulations?

    Hong-yi Li, Min Chen, Jie-fu Yang, Chong-qing Yang, Liang Xu, Fang Wang, Jia-bin Tong, You Lv, Caidan Suonan

    In this animal study on rabbits, researchers investigated a potential fluid drainage system within the body's connective tissue. By injecting tracers, they visualized pathways along the loose connective tissue surroundi…

    interstitial fluidacupuncturefluid flow
  20. A
    2012

    Primo Vascular System as a New Morphofunctional Integrated System

    Miroslav Stefanov, Jungdae Kim

    This narrative review summarizes research on the primo vascular system (PVS), a proposed anatomical network found throughout the body. The authors describe the methods and instruments used to study this system, primaril…

    fasciacancerphysiologyMorphologyprimo vascular system
  21. A
    2012

    An MRI Study of Symptomatic Adhesive Capsulitis

    Wen Zhao, Xiaofeng Zheng, Yuying Liu, Wenlu Yang, Vardan Amirbekian, Luis E Diaz, Xudong Huang

    This study used magnetic resonance imaging (MRI) to compare the shoulders of 60 patients with clinically diagnosed adhesive capsulitis (frozen shoulder) to 60 healthy control subjects. Researchers found significant diff…

    Adhesive capsulitisShoulderMagnetic resonance imaging
  22. A++
    2012

    INTERSTITIAL FLUID AND LYMPH FORMATION AND TRANSPORT: PHYSIOLOGICAL REGULATION AND ROLES IN INFLAMMATION AND CANCER

    Helge Wiig, Melody A Swartz

    This 2012 review explores the interstitium, the fluid-filled space surrounding our cells that contains interstitial fluid (IF). Formed by filtration from blood capillaries and cleared by lymphatic vessels, IF and its fl…

    ImmunologyLymphTumorinterstitiumfluid
  23. A
    2012

    Real-time imaging of cortical areas involved in the generation of increases in skin sympathetic nerve activity when viewing emotionally charged images

    Luke A Henderson, Alexandra Stathis, Cheree James, Rachael Brown, Skye McDonald, Vaughan G Macefield

    This study investigated which brain regions are involved when our bodies react to emotional images. Researchers simultaneously measured brain activity with fMRI and skin sympathetic nerve activity (SSNA), a marker of th…

    fasciaMRIIASP imagesmicroneurographyskin sympathetic nerve activity
  24. A
    2012

    Mathematical model of fiber orientation in anisotropic fascia layers at large displacements

    Hans Chaudhry, Max Roman, Antonio Stecco, Thomas Findley

    Researchers developed a mathematical model to better understand how collagen fibers within fascia change their orientation when the tissue is stretched. The model suggests that fibers already angled away from the direct…

    Fascial; Reinforcement; Collagen fibers; Re-orientation; Tension
  25. A+++
    2012

    Brain structure and joint hypermobility: relevance to the expression of psychiatric symptoms

    Jessica A Eccles, Felix D C Beacher, Marcus A Gray, Catherine L Jones, Ludovico Minati, Neil A Harrison, Hugo D Critchl…

    This study investigated the relationship between joint hypermobility and brain structure in 72 healthy volunteers. Using structural brain scans, researchers found that the volume of the amygdala, a brain region importan…

    Fibromyalgiaproprioceptionhypermobilitypsychiatric symptomsbrain structure
  26. A++
    2012

    Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease

    Kirsty Brown, Daniella DeCoffe, Erin Molcan, Deanna L Gibson

    This 2012 narrative review explores the connection between diet, gut microbes, and the immune system. The gastrointestinal tract must balance tolerance for harmless bacteria and food with responsiveness to pathogens. An…

    inflammationnutritionintestinal microbiotadisease susceptibility
  27. B
    2012

    Mechanical strain applied to human fibroblasts differentially regulates skeletal myoblast differentiation

    Michael R Hicks, Thanh V Cao, David H Campbell, Paul R Standley

    This laboratory study investigated how different types of stretching affect muscle repair at a cellular level. Researchers applied two types of strain to human fibroblasts (connective tissue cells) and observed the effe…

    myotubescocultureinterleukin-6
  28. 1A+
    2012

    Stretching of the Back Improves Gait, Mechanical Sensitivity and Connective Tissue Inflammation in a Rodent Model

    S M Corey, M A Vizzard, N A Bouffard, G J Badger, H M Langevin

    In this rodent study, researchers investigated how stretching affects inflammation in the connective tissue of the low back. They first induced local inflammation, which resulted in altered gait, increased mechanical se…

    fasciaConnective tissueStretchingManual TherapyMovement Therapy
  29. A
    2012

    CTGF is a central mediator of tissue remodeling and fibrosis and its inhibition can reverse the process of fibrosis

    Kenneth E Lipson, Carol Wong, Yuchin Teng, Suzanne Spong

    Fibrosis is a process of excessive connective tissue formation, leading to scarring and stiffness in organs. A protein called Connective Tissue Growth Factor (CTGF) plays a central role in driving this process. This res…

    extracellular matrixfibrosisfascia CTGFtissue remodeling
  30. A
    2012

    Myoton Pro: A Novel Tool for the Assessment of Mechanical Properties of Fascial Tissues

    Aleko Peipsi, Ricardas Kerpe, Heike Jäger, Sonja Soeder, Christopher Gordon, Robert Schleip

    This research entry, for which only the title is available, appears to introduce a device called the MyotonPRO. The title suggests its purpose is to assess the mechanical properties of fascial tissues, such as their sti…

    fasciaMyotone Pro
  31. B
    2012

    Fascia: a morphological description and classification system based on a literature review

    Myroslava Kumka, Jason Bonar

    In this literature review, the authors address the historical problem of ambiguous and inconsistent terminology for fascia. Based on a review of existing research, they propose a new system for classifying fascia accord…

    fasciaConnective tissueManual TherapyterminologyAnatomy
  32. A++
    2012

    Discovering the link between nutrition and skin aging

    Silke K Schagen, Vasiliki A Zampeli, Evgenia Makrantonaki, Christos C Zouboulis

    This narrative review examines the relationship between nutrition and skin aging, focusing on how specific nutrients may protect against damage from ultraviolet (UV) radiation. The authors describe how antioxidants such…

    antioxidants; diet; fatty acids; flavonoids; nutrition; skin aging; ultraviolet protection; vitamins.
  33. A
    2012

    A theoretical framework for the role of fascia in manual therapy

    Nigel Simmonds, Peter Miller, Hugh Gemmell

    This theoretical paper explores why different types of manual therapy, such as soft tissue work and joint manipulation, often seem to produce similar results. The authors compare these approaches based on their effects…

    fasciaManual TherapyMyofascialManipulationautonomic nervous system
  34. A
    2012

    Human myometrium – the ultrastructural 3D network of telocytes

    Sanda M Cretoiu, Dragos Cretoiu, Laurentiu M Popescu

    This study examined a relatively new type of cell, the telocyte, within the human myometrium, the muscular layer of the uterus. Using advanced microscopy, researchers visualized these cells and their very long extension…

    telocytes ! telopodes ! podoms ! podomers ! human uterus ! extracellular vesicles
  35. A+++
    2012

    Fascia as a body-wide communication system

    James L Oschman

    This abstract proposes that fascia acts as a body-wide communication system. The author draws an analogy to single-celled organisms, like a paramecium, which can perform complex functions without a nervous system by rel…

    Fascia
  36. A++
    2012

    Vitamin C transport and its role in the central nervous system

    James M May

    This review article explores the critical role of vitamin C in the central nervous system. Although it circulates in the blood at low concentrations, neurons in the brain and spinal cord maintain very high levels of the…

    ascorbate transport; brain; dehydroascorbate; glutamate; neurons; SVCT2
  37. B
    2012

    Hyaluronan differently modulates TLR-4 and the inflammatory response in mouse chondrocytes

    Giuseppe M Campo, Angela Avenoso, Angela D’Ascola, Vera Prestipino, Michele Scuruchi, Giancarlo Nastasi, Alberto Calatr…

    This study on mouse cartilage cells investigated how different sizes of hyaluronan (HA) affect inflammation. Researchers found that small HA fragments increased the production of several inflammatory markers. In contras…

    hyaluronancytokinesNF-kBtoll-like receptor-4chondrocytes
  38. A
    2012

    Massage Therapy Attenuates Inflammatory Signaling After Exercise-Induced Muscle Damage

    Justin D Crane, Daniel I Ogborn, Colleen Cupido, Simon Melov, Alan Hubbard, Jacqueline M Bourgeois, Mark A Tarnopolsky

    This study investigated how massage therapy affects skeletal muscle at a cellular level after exercise-induced damage. Researchers took muscle biopsies from 11 young men after an intense workout; one leg received 10 min…

    fasciamassage therapyinflammatory cytokinesstretchstrain
  39. A++
    2012

    Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity

    Melody A Swartz, Amanda W Lund

    This review explores how tumors interact with the lymphatic system to grow and spread. Increased fluid flow from a tumor to nearby lymph nodes does more than just transport cancer cells. This flow also creates mechanica…

    fasciacancerstiffnessmechanobiologymicroenvironment
  40. A
    2012

    Mechanical properties of human patellar tendon at the hierarchical levels of tendon and fibril

    René B Svensson, Philip Hansen, Tue Hassenkam, Bjarki T Haraldsson, Per Aagaard, Vuokko Kovanen, Michael Krogsgaard, Mi…

    Researchers investigated how the mechanical properties of the whole human patellar tendon compare to its individual collagen fibrils. They tested whole tendons in living subjects and then tested isolated fibrils from th…

    atomic force microscopy; collagen; fibril dimensions; modulus; toe region
  41. A
    2012

    Earthing: Health Implications of Reconnecting the Human Body to the Earth’s Surface Electrons

    Gaétan Chevalier, Stephen T Sinatra, James L Oschman, Karol Sokal, Pawel Sokal

    This 2012 review paper explores the concept of 'earthing' or 'grounding,' which involves direct physical contact with the Earth's surface electrons. The authors propose that modern lifestyles separate humans from this c…

    fasciaearthinggroundingearth surface electrons
  42. A
    2012

    Strain hardening of fascia: Static stretching of dense fibrous connective tissues can induce a temporary stiffness increase accompanied by enhanced matrix hydration

    Robert Schleip, Lutz Duerselen, Andry Vleeming, Ian L Naylor, Frank Lehmann-Horn, Adjo Zorn, Heike Jaeger, Werner Kling…

    This study investigated why fascia sometimes gets stiffer after being stretched and then rested, a phenomenon called strain hardening. Researchers stretched fascia samples from mice and pigs, finding that after a 15-min…

    Lumbar fascia; Paraspinal tissues; Stiffness; Hydration; Stretching
  43. A+
    2012

    The effect of menopause on the skin and other connective tissues

    J Calleja-Agius, M Brincat

    This narrative review examines how menopause and the resulting decline in estrogen affect the body's connective tissues, particularly the skin. Research suggests that skin collagen levels drop significantly following me…

    collagenageingskin tissuemenopauseoestrogen
  44. A+
    2012

    Nutritional regulation of muscle protein synthesis with resistance exercise: strategies to enhance anabolism

    Tyler A Churchward-Venne, Nicholas A Burd, Stuart M Phillips

    In this 2012 review article, the authors discuss how nutrition can regulate muscle protein synthesis, especially when combined with resistance exercise. Consuming protein (amino acids) stimulates muscle building, an eff…

    MusclenutritionhypertrophyAnabolic intramuscular signaling
  45. A+++
    2012

    Total antioxidant capacity of diet and risk of stroke: a population-based prospective cohort of women

    Susanne Rautiainen, Susanna Larsson, Jarmo Virtamo, Alicja Wolk

    This Swedish population-based study examined the relationship between the total antioxidant capacity of the diet and stroke risk in over 36,000 women. By measuring the combined effect of all antioxidants in food rather…

    Antioxidantsstroke
  46. B
    2012

    Recent Developments in Myofibroblast Biology

    Boris Hinz, Sem H Phan, Victor J Thannickal, Marco Prunotto, Alexis Desmoulière, John Varga, Olivier De Wever, Marc Mar…

    This 2012 narrative review summarizes advances in understanding the myofibroblast, a specialized cell crucial for both normal wound healing and the development of fibrotic diseases. The authors discuss how these cells g…

    fibrosisMyofibroblast
  47. A
    2012

    The thoracolumbar fascia: anatomy, function and clinical considerations

    Frank H Willard, Andry Vleeming, M D Schuenke, L Danneels, Robert Schleip

    This overview paper examines the anatomy and function of the thoracolumbar fascia (TLF), the complex sheet of connective tissue in the lower back. The authors describe its multiple layers, which separate and connect the…

    fasciathoracolumbarfascia
  48. A
    2011

    Correlation of MR Arthrographic Findings and Range of Shoulder Motions in Patients With Frozen Shoulder

    So-Yeon Lee, Jeongmi Park, Seok-Whan Song

    This study investigated the relationship between findings on MR arthrography (a type of MRI) and range of motion in people with frozen shoulder. Researchers measured the thickness of two structures: the coracohumeral li…

    MRIfrozen shoulderAdhesive capsulitiscoracohumeral ligament
  49. A
    2011

    The Genetics of Vitamin C Loss in Vertebrates

    Guy Drouin, Jean-Rémi Godin, Benoît Pagé

    This narrative review explores why some vertebrate species, including humans, cannot produce their own Vitamin C. The inability to synthesize this crucial nutrient, important for collagen and antioxidant functions, stem…

    BiosynthesisVitamin CAscorbic acidGLO geneL-gulono-gamma-lactone oxidase
  50. A+
    2011

    The presence of physiological stress shielding in the degenerative cycle of musculoskeletal disorders

    Mark Driscoll, L Blyum

    This theoretical paper discusses how mechanical stimulation is essential for tissue health, a concept known as mechanical homeostasis. When this process is flawed, it can contribute to the development of musculoskeletal…

    Fascia; Musculoskeletal; Cerebral palsy; Remodeling; Stress shielding
  51. A
    2011

    Hyaluronan: From Extracellular Glue to Pericellular Cue

    B P Toole

    Hyaluronan is traditionally seen as a biological 'goo' that lubricates joints and holds connective tissues together. This review describes how hyaluronan also functions as an important signaling molecule, or cue, in the…

    hyaluronanfasciasignal transductioncancer
  52. 1A+++
    2011

    Hyaluronan within fascia in the etiology of myofascial pain

    Carla Stecco, R Stern, A Porzionato, V Macchi, S Masiero, Antonio Stecco, R De Caro

    In this cadaver and ultrasound study, researchers examined the composition of deep fascia. They identified layers of hyaluronan (HA), a lubricating substance, between the fascia and muscle, as well as between the fascia…

    fasciaHyaluronic acidSliding systemLoose connective tissueFasciacyte
  53. A++
    2011

    Optimizing an Intermittent Stretch Paradigm Using ERK1/2 Phosphorylation Results in Increased Collagen Synthesis in Engineered Ligaments

    Jennifer Z Paxton, Paul Hagerty, Jonathan J Andrick, Keith Baar

    This study on engineered ligaments explored how different stretching patterns affect tissue development. Researchers used a bioreactor to apply cyclic stretch, measuring cellular responses by tracking a key protein call…

    collagen synthesisERK 1/2 phosphorylationintermittent stretch
  54. A+
    2011

    Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate: a pilot randomized controlled trial

    T E McAlindon, M Nuite, N Krishnan, R Ruthazer, L L Price, D Burstein, J Grif!th, K Flechsenhar

    This pilot randomized controlled trial investigated if collagen hydrolysate supplements could affect knee cartilage in people with mild osteoarthritis. Using a specialized MRI technique (dGEMRIC), researchers tracked ch…

    MRIosteoarthritisMagnetic resonance imagingCartilageDelayed gadolinium enhanced
  55. A++
    2011

    Acne vulgaris, probiotics and the gut-brain-skin axis - back to the future?

    Whitney P Bowe, Alan C Logan

    This review article discusses a theory first proposed over 70 years ago connecting the gastrointestinal tract, the brain, and the skin. Researchers Stokes and Pillsbury hypothesized that emotional states like anxiety an…

    acneprobioticsintestinal microfloragut-brain-skinbacteriotherapy
  56. A
    2011

    Structure and function of the skeletal muscle extracellular matrix

    Allison R Gillies, Richard L Lieber

    This narrative review explores the extracellular matrix (ECM), the connective tissue network within skeletal muscle. The authors describe the ECM's crucial roles in transmitting force and in muscle maintenance and repai…

    Skeletal muscle; extracellular matrix; collagen; biomechanics; fibrosis
  57. A
    2011

    Management of the stiff shoulder. A prospective multicenter comparative study of the six main techniques in use: 235 cases

    P Gleyzea, P Clavert, P-H Flurin, E Laprelle, D Katz, B Toussaint, T Benkalfate, C Charousset, T Joudet, T Georges, L H…

    This prospective study compared six different therapeutic techniques for stiff shoulder in 235 patients. Researchers evaluated conventional rehabilitation below the pain threshold against self-rehabilitation pushing pas…

    frozen shoulderAdhesive capsulitisPain managementAlgodystrophyTherapeutic education
  58. A
    2011

    A questionnaire survey of UK physiotherapists on the diagnosis and management of contracted (frozen) shoulder

    Nigel C A Hanchard, Lorna Goodchild, Jackie Thompson, Tracey O’Brien, Dot Davison, Chris Richardson

    This survey of 289 UK physiotherapists explored how they diagnose and manage frozen shoulder. The results showed that diagnosis typically relies on assessing movement restriction, particularly passive external rotation.…

    frozen shoulderAdhesive capsulitisShoulder painDiagnosisTherapy
  59. B
    2011

    Adhesive capsulitis of the shoulder

    Andrew S Neviase, Robert J Neviaser

    This clinical overview describes adhesive capsulitis, or "frozen shoulder," a condition marked by painful, progressive loss of shoulder movement due to fibrosis of the joint capsule. The authors note that diagnosis requ…

    frozen shoulderAdhesive capsulitis
  60. A++
    2011

    Vibration therapy of the plantar fascia improves spasticity of the lower limbs of a patient with fetal-type Minamata disease in the chronic stage

    Fusako Usuki, Satsuki Tohyama

    This case report describes a treatment for spasticity in a patient with fetal-type Minamata disease. Researchers used a hand-held vibration massager applied directly to the patient's plantar fascia and hamstrings. After…

    spasticityvibration therapy