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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

2,804
studies
602
top-graded
2,783
with plain-language summary
Showing 661–720 of 1,127 studies · page 12/19With summary
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  1. A
    2015

    New Developments in the Primo Vascular System: Imaging and Functions with regard to Acupuncture

    Richard C Niemtzow, Kwang-Sup Soh, Kyung A Kang, John H Barker, He Sheng Luo, Moriya Ohkuma

    This research entry, for which only the title is available, appears to discuss recent advancements in understanding the primo vascular system. The title suggests a focus on new imaging techniques and the system's functi…

    acupunctureprimo vascular systemeditorial
  2. A+
    2015

    The Heart, the Brain, and the Regulation of Emotion

    Sarah N Garfinkel, Jessica A Eccles, Hugo D Critchley

    This research entry, summarized from its title, appears to explore the relationship between the heart, the brain, and how emotions are managed. It likely discusses how signals from the cardiovascular system, specificall…

    psychology.psychiatryemotionsbody signals
  3. 1A+++
    2015

    Viscoelastic Properties of Hyaluronan in Physiological Conditions

    Mary K Cowman, Tannin A Schmidt, Preeti Raghavan, Antonio Stecco

    Hyaluronan (HA) is a molecule that gives the fluid in our connective tissues its viscous, gel-like quality. This viscosity is crucial for the smooth gliding of fascial layers against muscles and other tissues. Factors l…

    Hyalyronian acidhaviscositylubricationviscoelasticity
  4. C
    2015

    Hyaluronic acid and wound healing

    M G Neuman, R M Nanau, L Oruna-Sanchez, G Coto

    In this systematic review, researchers compiled studies on hyaluronic acid (HA) and wound healing published from 2010–2014. The review found that HA is used for tissue regeneration, either alone or in combination with o…

    hyaluronanwound healing
  5. A
    2015

    Hyaluronan’s Role in Fibrosis: A Pathogenic Factor or a Passive Player?

    S Albeiroti, A Soroosh, C A de la Motte

    This 2015 review article explores the role of hyaluronan (HA) in fibrosis, a condition where excessive connective tissue buildup impairs organ function. HA is a key component of the extracellular matrix, known for its h…

    hyaluronanfasciafibrosis
  6. B
    2015

    The extracellular matrix: Tools and insights for the “omics” era

    A Nabaa, K R Clauser, H Dingd, C A Whittaker, S A Carrc, R O Hynesa

    This narrative review discusses the extracellular matrix (ECM), the complex network of proteins and molecules that provides structural and chemical support to our cells and tissues. Alterations in the ECM are associated…

    extracellular matrixMatrisomeMatrisomeDBECM atlasBioinformatics
  7. C
    2015

    Collagen Crosslinking Does Not Dictate Stiffness in a Transgenic Mouse Model of Skeletal Muscle Fibrosis

    M A Chapman, R Pichika, R L Lieber

    In this animal study on mice, researchers investigated why fibrotic, or scarred, skeletal muscle becomes so stiff. While it is known that fibrosis involves an increase in collagen, the amount of collagen alone does not…

    fibrosisstiffnesscollagen cross-linking
  8. A
    2015

    Innervation Changes Induced by Inflammation of the Thoracolumbar Fascia

    U Hoheisel, J Rosner, S Mense

    This animal study investigated how inflammation affects the nerves in the thoracolumbar fascia (TLF) of rats. Researchers induced inflammation in the TLF and compared its nerve fiber density to that of healthy fascia. W…

    inflammationfasciafasciitisfascia innervationsympathetic fibers
  9. A
    2015

    Evidence for the existence of nociceptors in rat thoracolumbar fascia

    S Mense, U Hoheisel

    This animal study on rats investigated the presence of pain-sensing nerve fibers (nociceptors) in the thoracolumbar fascia. Researchers compared normal fascia with tissue in which they had induced inflammation. The resu…

    inflammationfasciafasciitisnon-specific low back painfascia nociceptors
  10. B
    2015

    Cytokines in rheumatoid arthritis - shaping the immunological landscape

    Iain B McInnes, Christopher D Buckley, John D Isaacs

    In this short opinion article, the authors provide an overview of the central role of cytokines in rheumatoid arthritis (RA). These signaling molecules are involved in the immune responses associated with both the onset…

    cytokinesarthritis
  11. B
    2015

    Manual therapies and hypoalgesia: What are the mechanisms?

    Leon Chaitow

    This is a title-only entry, and its contents have not yet been summarized. The title suggests the article explores the possible mechanisms behind hypoalgesia, or a decreased sensitivity to pain, following manual therapi…

    Editorial
  12. A
    2015

    The effects of grounding (earthing) on inflammation, the immune response, wound healing, and prevention and treatment of chronic inflammatory and autoimmune diseases

    James L Oschman, Gaétan Chevalier, Richard Brown

    This report summarizes research on the effects of "grounding" or "earthing," which involves direct electrically conductive contact with the Earth's surface. The research suggests this contact may influence the body's ph…

    fasciachronic inflammationimmune systemwound repairwhite blood cells
  13. A+
    2015

    A unifying neuro-fasciagenic model of somatic dysfunction - Underlying mechanisms and treatment - Part II

    Paolo Tozzi

    This review paper proposes a new, unifying "neuro-fasciagenic" model for understanding somatic dysfunction. The author argues for a shift in perspective, moving from a purely neurological explanation to one where fascia…

    fasciaManual Therapysomatic dysfunctionfascial dysfunctionfascial mechanisms
  14. A
    2015

    Sensory Nerve Fibers Containing Calcitonin Gene-Related Peptide in Gastrocnemius, Latissimus Dorsi and Erector Spinae Muscles and Thoracolumbar Fascia in Mice

    C M Barry, G Kestell, M Gillan, R V Haberberger, I L Gibbins

    In this animal study, researchers investigated sensory nerve fibers containing CGRP, a peptide involved in pain signaling. They compared the presence of these nerve fibers in various muscles (gastrocnemius, latissimus d…

    fasciaBack PainThoracolumbar fasciaimmunohistochemistrysensory innervation
  15. 1A+
    2015

    Electron microscopy of human fascia lata: focus on telocytes

    Joanna Dawidowicz, Sylwia Szotek, Natalia Matysiak, Łukasz Miela!nczyk, Krzysztof Maksymowicz

    This study used an electron microscope to examine the types of cells present in the fascia lata, a sheet of connective tissue in the thigh. For the first time, researchers confirmed the existence of a specific cell type…

    Fibroblastsmyofibroblastshuman fascia latatransmission electron microscopytelocytes
  16. A
    2015

    Reflections on osteopathic fascia treatment in the peripheral nervous system

    Bruno Bordoni, Giovanni Bordoni

    In this reflective article, the authors discuss the fascia of the peripheral nervous system. They explain that nerves are enclosed in several layers of fascia that must be able to slide, and that impeded sliding can be…

    fasciapainfascial treatmentnerve palpation
  17. A
    2015

    The fascial system and exercise intolerance in patients with chronic heart failure: hypothesis of osteopathic treatment

    Bruno Bordoni, F Marelli

    This hypothesis paper proposes a connection between the fascial system and exercise intolerance in people with chronic heart failure. The authors note that heart failure is a complex disease affecting the entire body, l…

    fasciaManual TherapyOsteopathicfatiguechronic heart failure
  18. A
    2015

    Duration and Magnitude of Myofascial Release in 3-Dimensional Bioengineered Tendons: Effects on Wound Healing

    Thanh V Cao, Michael R Hicks, Manal Zein-Hammoud, Paul R Standley

    This laboratory study investigated how myofascial release (MFR) affects wound healing in bioengineered tendons. Researchers created a wound in the tendon models and then applied different magnitudes and durations of str…

    wound healingMyofascial release
  19. A
    2015

    Modes of cancer cell invasion and the role of the microenvironment

    Andrew G Clark, Danijela Matic Vignjevic

    For cancer to spread, or metastasize, tumor cells must first invade the surrounding connective tissue (stroma). This review article describes how cancer cells can move in different ways—either as single cells or in coll…

    fasciaextracellular matrixcancertumor invasionmicroenvironment
  20. A
    2015

    Tracking CNS and systemic sources of oxidative stress during the course of chronic neuroinflammation

    Agata A Mossakowski, Julian Pohlan, Daniel Bremer, Randall Lindquist, Jason M Millward, Markus Bock, Karolin Pollok, Ro…

    In this animal study, researchers used a mouse model for multiple sclerosis (MS) to track the sources of oxidative stress in the central nervous system. Using an advanced imaging technique, they identified specific immu…

    Multiple sclerosis · Oxidative stress · Neuronal dysfunction · Fluorescence lifetime microscopy · Intravital imaging · Oxidative stress memory
  21. B
    2015

    Fibromyalgia: A Critical and Comprehensive Review

    Andrea T Borchers, M Eric Gershwin

    This comprehensive review discusses fibromyalgia as a complex disorder within a spectrum of medically unexplained syndromes. Characterized by widespread pain, fatigue, and sleep disturbances, it is often associated with…

    FibromyalgiaChronicpainOpiatesPatient supportTrauma
  22. A
    2015

    Effects of non-pharmacological interventions on inflammatory biomarker expression in patients with fibromyalgia: a systematic review

    Kenji Sanada, Marta Alda Díez, Montserrat Salas Valero, María Cruz Pérez-Yus, Marcelo M P Demarzo, Mauro García-Toro, J…

    This systematic review examined how non-drug treatments affect inflammatory markers in people with fibromyalgia. Researchers analyzed 12 studies involving 536 participants who underwent exercise, dietary, or multidiscip…

    fasciaFibromyalgiapaincytokinessleep quality
  23. A
    2015

    Biological electric fields and rate equations for biophotons

    M Alvermann, Y N Srivastava, J Swain, A Widom

    This theoretical paper explores the relationship between biophotons (light emitted by living organisms) and the electric fields within biological systems. The authors note that biophoton intensity is linked to the stren…

    biophotonsElectric fieldsNonlinear rate equations
  24. A
    2015

    Mitochondrial Dysfunction and Disturbed Coherence: Gate to Cancer

    Jirí Pokorný, Jan Pokorný, Alberto Foletti, Jitka Kobilková, Jan Vrba, Jan Vrba Jr

    This theoretical paper explores the link between cellular energy and cancer. Healthy cells maintain a stable, coherent electrical state through continuous energy production in the mitochondria. The authors propose that…

    fasciacancer biophysicsmitochondrial dysfunctionwater orderingmicrotubule oscillations
  25. C
    2015

    Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

    Renato V Iozzo, Liliana Schaefer

    In this review article, the authors propose a new, comprehensive classification system for proteoglycans, a group of molecules important to connective tissue structure and function. The classification is based on three…

    GlycosaminoglycanAngiogenesisProteoglycanCancer growthGrowth factor modulation
  26. A
    2015

    Glycosaminoglycans and Proteoglycans in Palmar Fascia of Patients with Dupuytren

    Priscilla Carneiro Hirai Nascimento, Elsa Yoko Kobayashi, Luiz Guilherme de Saboya Lenzi, João baptista Gomes dos Santo…

    In this experimental study, researchers investigated the role of glycosaminoglycans (GAGs), a type of molecule in connective tissue, in Dupuytren's disease. The team analyzed palmar fascia tissue samples from 23 patient…

    fasciaProteoglycansdupuytren contractureglycosaminoglycans
  27. A
    2015

    The content and size of hyaluronan in biological fluids and tissues

    Mary K Cowman, Hong-Gee Lee, Kathryn L Schwertfeger, James B McCarthy,, Eva A Turley

    Hyaluronan is a simple sugar polymer found throughout the body's tissues and fluids. It is typically produced as a very large, high-molecular-mass molecule. This narrative review notes that during processes like inflamm…

    hyaluronanfasciaquantificationassaymolecular mass
  28. B
    2015

    Hyaluronan Controls the Deposition of Fibronectin and Collagen and Modulates TGF-β1 Induction of Lung Myofibroblasts

    Stephen P Evanko, Susan Potter-Perigo, Loreen J Petty, Gail A Workman, Thomas N Wight

    This study investigated how hyaluronan (HA), a key component of the extracellular matrix, influences the formation of myofibroblasts—cells involved in tissue scarring and fibrosis. Researchers observed that while HA lev…

    hyaluronanMyofibroblastTGF-β14-methyl umbelliferonefibronectin; collagen
  29. B
    2015

    Hyaluronan Regulates Bone Morphogenetic Protein-7- dependent Prevention and Reversal of Myofibroblast Phenotype

    Adam C Midgley, Lucy Duggal, Robert Jenkins, Vincent Hascall, Robert Steadman, Aled O Phillips, Soma Meran

    This study on human lung fibroblasts investigated how a protein called BMP7 might counteract fibrosis. Researchers found that BMP7 can prevent and even reverse the formation of myofibroblasts, which are cells that contr…

    hyaluronanMyofibroblastTGF-beta1
  30. B
    2015

    Platelet hyaluronidase-2: an enzyme that translocates to the surface upon activation to function in extracellular matrix degradation

    Sami Albeiroti, Katayoun Ayasoufi, [...], Carol A de la Motte

    Platelets play a key role in responding to tissue injury. This study explores how they interact with hyaluronan, a major component of the extracellular matrix that is involved in inflammation. Researchers demonstrated t…

    hyaluronanextracellular matrixDegradationhyaluronidas-2HYAL2
  31. B
    2015

    Transforming Growth Factor-beta1 (TGF-beta1)-stimulated Fibroblast to Myofibroblast Differentiation Is Mediated by Hyaluronan (HA)-facilitated Epidermal Growth Factor Receptor (EGFR) and CD44 Co-localization in Lipid Rafts

    Adam C Midgley, Mathew Rogers, Maurice B Hallett, Aled Clayton, Timothy Bowen, Aled O Phillips, Robert Steadman

    The transformation of fibroblasts into myofibroblasts is a key part of wound healing, a process largely regulated by the signaling molecule TGF-β1. This study investigated how hyaluronan (HA) and specific receptors (CD4…

    CD44; Epidermal Growth Factor Receptor (EGFR); Hyaluronate; Lipid Raft; Myofibroblast
  32. A
    2015

    Modelling the mechanoreceptor’s dynamic behaviour

    Zhuoyi Song, Robert W Banks, Guy S Bewick

    This study developed a computational model to better understand how mechanoreceptors, our body's stretch and pressure sensors, adapt to stimuli. Researchers adapted a model originally used for vision in flies to simulat…

    fasciabiophysical modelfly photoreceptorrefractory periodsensory adaptation
  33. A
    2015

    Remodelling the extracellular matrix in development and disease

    Caroline Bonnans, Jonathan Chou, Zena Werb

    This narrative review describes the extracellular matrix (ECM), a dynamic network present in all body tissues that undergoes constant remodeling. This remodeling process is crucial for regulating cell functions like pro…

    fasciaextracellular matrixstiffnessmechanotransductionmatrix remodeling
  34. A
    2015

    Hyaluronan, inflammation and breast cancer progression

    Katryn L Schwertfeger, Mary K Cowman, Patrick G Telmer, Eva A Turley, James B McCarthy

    This narrative review explores the link between inflammation, the tissue component hyaluronan (HA), and breast cancer progression. Cancer cells and surrounding host cells can create an inflamed microenvironment that hel…

    hyaluronaninflammationCD44fasciaBreast cancer
  35. A
    2015

    Structural Integration as an Adjunct to Outpatient Rehabilitation for Chronic Nonspecific Low Back Pain: A Randomized Pilot Clinical Trial

    Eric E Jacobson, Alec L Meleger, Paolo Bonato, Peter M Wayne, Helene M Langevin, Ted J Kaptchuk, Roger B Davis

    This randomized pilot clinical trial investigated if adding Structural Integration (SI) to standard outpatient rehabilitation could help people with chronic non-specific low back pain. Researchers assigned 46 participan…

    fascia
  36. 1A+
    2015

    Fascia and Primo Vascular System

    Chun Yang, Yi-kuan Du, Jian-bin Wu, JunWang, Ping Luan, Qin-lao Yang, Lin Yuan

    In this review article, the authors explore the idea that the body's network of fascia may be the physical structure corresponding to acupuncture meridians in Traditional Chinese Medicine (TCM). They also discuss the pr…

    fasciamechanotransductionprimo vascular systemBonghan systemfasciology
  37. A
    2015

    Essential Experimental Methods for Identifying Bonghan Systems as a Basis for Korean Medicine: Focusing on Visual Materials from Original Papers and Modern Outcomes

    Hoon-Gi Kim, Byung-Cheon Lee, Ki-Bog Lee

    This narrative review examines methods for identifying the so-called Bonghan system, also known as the primo vascular system (PVS). This system was originally proposed in the 1960s as the anatomical basis for acupunctur…

    fasciaacupunctureprimo vascular systembongan system
  38. A
    2015

    Primo Vascular System: A Unique Biological System Shifting a Medical Paradigm

    Bruno Chikly, Paul Roberts, Jörgen Quaghebeur

    This article describes the primo vascular system (PVS), a unique biological system distinct from the arteriovenous and lymphatic systems. Research suggests the PVS has immune and endocrine functions and plays a role in…

    fasciaprimo vascular system
  39. A
    2015

    Primo Vascular System: An Endothelial-to-Mesenchymal Potential Transitional Tissue Involved in Gastric Cancer Metastasis

    An Ping, Su Zhendong, Qu Rongmei, Dai Jingxing, Chen Wei, Zhou Zhongyin, Luo Hesheng, Kwang-Sup Soh

    The primo vascular system (PVS) is described as a distinct circulatory network beyond the blood and lymphatic systems. This study investigated the role this system might play in the spread of gastric cancer. The researc…

    fasciacancermetastasisprimo vascular system
  40. A
    2015

    Primo-Vascular System as Presented by Bong Han Kim

    Vitaly Vodyanoy, Oleg Pustovyy, Ludmila Globa, Iryna Sorokulova

    In the 1960s, researcher Bong Han Kim described a new vascular system, distinct from the blood and lymph systems, which he proposed was involved in tissue regeneration. However, his work was difficult for later scientis…

    fasciaprimo vascular system
  41. A
    2015

    Investigation of meningomyovertebral structures within the upper cervical epidural space: a sheet plastination study with clinical implications

    Frank Scali, Matthew E Pontell, Lance G Nash, Dennis E Enix

    This cadaver study investigated soft-tissue connections within the epidural space of the upper cervical spine using dissection and a technique called sheet plastination. The researchers found consistent connections wher…

    fasciacervical spineMyodural Bridgedural lacerationsepidural space
  42. A++
    2015

    Influence of different intensities of vibration on proliferation and differentiation of human periodontal ligament stem cells

    Chunxiang Zhang, Yanqin Lu, Linkun Zhang, Yang Liu, Yi Zhou, Yangxi Chen, Haiyang Yu

    In this laboratory study, researchers investigated how low-magnitude, high-frequency vibration affects stem cells from the human periodontal ligament, the tissue that holds teeth in the jaw. The results suggest that vib…

    Proliferationmechanical vibrationperiodontal ligament stem cellsosteogenesismagnitude
  43. A++
    2015

    The Effects of Vibration and Muscle Fatigue on Trunk Sensorimotor Control in Low Back Pain Patients

    Jean-Alexandre Boucher, Jacques Abboud, François Nougarou, Martin C Normand, Martin Descarreaux

    This study compared trunk muscle control between people with chronic low back pain (cLBP) and healthy individuals. Researchers found that the cLBP group was less accurate at reproducing a specific amount of force with t…

    fascialow back painmuscle fatiguevibration
  44. A
    2015

    A multidisciplinary approach to scars: a narrative review

    Emiliano Zanier, Bruno Bordoni

    This narrative review examines complementary and alternative medicine approaches to treating scar tissue. The authors survey literature on osteopathy, naturopathy, and manual therapies like physiotherapy. They also disc…

    fasciaosteopathyscarwoundcomplementary and alternative medicine
  45. A
    2015

    Modeled Osteopathic Manipulative Treatments: A Review of Their in Vitro Effects on Fibroblast Tissue Preparations

    Manal Zein-Hammoud, Paul R Standley

    This narrative review summarizes lab-based (in vitro) studies investigating how simulated osteopathic treatments, like myofascial release, affect fibroblasts. The authors found that applying mechanical strain to these c…

    fasciaFibroblastsManual TherapyOsteopathic
  46. 1A+
    2015

    Gymnastic Training and Dynamic Mobilization Exercises Improve Stride Quality and Increase Epaxial Muscle Size in Therapy Horses

    Kátia de Oliveira, Ricardo V G Soutello, Ricardo da Fonseca, Ciniro Costa, Paulo R de L Meirelles, Daniele F Fachiolli,…

    This study on therapy horses investigated how specific exercises affect stride and back muscles. Over three months, nine horses were divided into three groups: a control group, one doing dynamic mobilization exercises,…

    Hippotherapytherapeutic exercisedynamic mobilization exercisephysical trainingthree-dimensional movement
  47. A++
    2015

    Estrogen inhibits lysyl oxidase and decreases mechanical function in engineered ligaments

    Cassandra A Lee, Ann Lee-Barthel, Louise Marquino, Natalie Sandoval, George R Marcotte, Keith Baar

    This lab study investigated why women are more likely to rupture their anterior cruciate ligament (ACL) than men, focusing on the role of estrogen. Researchers used human ACL cells to create engineered ligaments in a la…

    ACL; exercise; tendon; ultimate tensile strength
  48. A+
    2015

    Chondroprotection and the Prevention of Osteoarthritis Progression of the Knee

    Brian Gallagher, Fotios P Tjoumakaris, Marc I Harwood, Robert P Good, Michael G Ciccotti, Kevin B Freedman

    In this systematic review, researchers evaluated whether certain medications and supplements could protect joint cartilage and slow the progression of knee osteoarthritis. By analyzing randomized controlled trials, they…

    knee; articular cartilage; chondroprotection; nutraceutical
  49. A
    2015

    Comparative effects of vitamin C on the effects of local anesthetics ropivacaine, bupivacaine, and lidocaine on human chondrocytes

    Jun Tian, Yan Li

    Local anesthetics injected into joints can sometimes be harmful to cartilage cells (chondrocytes). This laboratory study investigated the effects of three common anesthetics—ropivacaine, bupivacaine, and lidocaine—on hu…

    Chondrocytes; Vitamin C; Local anesthetics; Ropivacaine; Bupivacaine; Lidocaine
  50. A+
    2015

    Osmotic pressure induced tensile forces in tendon collagen

    Admir Masic, Luca Bertinetti, Roman Schuetz, Shu-Wei Chang, Till Hartmut Metzger, Markus J Buehler, Peter Fratzl

    Researchers investigated the role of water in tendon collagen using a combination of experiments and computer modeling. They found that water is a crucial part of the collagen molecule's structure. When water is removed…

    collagenOsmotic pressurewater
  51. A
    2015

    Collagen network strengthening following cyclic tensile loading

    Monica E Susilo, Jeffrey A Paten, Edward A Sander, Thao D Nguyen, Jeffrey W Ruberti

    Tissues adapt to the mechanical loads they experience, with collagen being the primary load-bearing component. In this study, researchers investigated how a collagen-based material responded to repeated, cyclic tensile…

    collagen networkmechanical adaptationtissue remodelling
  52. B
    2015

    Myofascial Trigger Points Then and Now: A Historical and Scientific Perspective

    Jay P Shah, Nikki Thaker, Juliana Heimur, Jacqueline V Aredo, Siddhartha Sikdar, Lynn H Gerber

    This narrative review explores the historical and scientific understanding of myofascial trigger points (MTrPs) and their role in myofascial pain syndrome (MPS). MTrPs are palpable nodules in taut muscle bands, long con…

    fasciaMyofascial trigger points
  53. A++
    2015

    Telocytes in regenerative medicine

    Yihua Bei, Fei Wang, Changqing Yang, Junjie Xiao

    This 2015 review article summarizes research on telocytes, a distinct type of cell found in the connective tissue of many organs. These cells form a complex 3D network and are thought to play a key role in guiding stem…

    interstitial cells; progenitor cells; regeneration; regenerative medicine; stem cells; telocytes.
  54. A
    2015

    Isolated human uterine telocytes: immunocytochemistry and electrophysiology of T-type calcium channels

    Sanda Maria Cretoiu, Beatrice Mihaela Radu, Adela Banciu, Daniel Dumitru Banciu, Dragos Cretoiu, Laura Cristina Ceafala…

    Telocytes are a relatively newly described cell type found in the muscular wall of the uterus, thought to play a role in cell-to-cell signaling. In this laboratory study, researchers examined telocytes from both pregnan…

    Telocytes · Human myometrium · T-type calcium channels · CaV3.1 · CaV3.2
  55. A
    2015

    Pathophysiology and Immune Dysfunction in Endometriosis

    Soo Hyun Ahn, Stephany P Monsanto, Caragh Miller, Sukhbir S Singh, Richard Thomas, Chandrakant Tayade

    This narrative review explores the current understanding of endometriosis, a chronic inflammatory condition affecting many women of reproductive age. The authors focus on how endometriosis lesions develop a blood supply…

    endometriosis
  56. A++
    2015

    Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin resistance and glycaemia in 9-10 year-old children

    A S Donin, J E Dent, C M Nightingale, N Sattar, C G Owen, A R Rudnicka, M R Perkin, A M Stephen, S A Jebb, D G Cook, P…

    This cross-sectional study of over 2000 children in the UK examined the relationship between vitamin C and risk factors for type 2 diabetes. Researchers found that higher levels of vitamin C in the blood were associated…

    Vitamin Cinsulin resistensglycaemiadiabetes type 2
  57. A++
    2015

    Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology

    Jaime M Cyphert, Carol S Trempus, Stavros Garantziotis

    This narrative review summarizes current knowledge about hyaluronan, a molecule whose biological effects are dependent on its size. Unlike many other molecules, hyaluronan's signaling properties are determined not by ch…

    hyaluronanCell signalingmolecular size
  58. A+++
    2015

    Optimal Vitamin D Supplementation Levels for Cardiovascular Disease Protection

    Sebastian T Lugg, Phillip A Howells, David R Thickett

    This narrative review explores the growing body of evidence linking vitamin D to cardiovascular health. While traditionally associated with bone health, data suggests vitamin D status may be a marker for, and possibly a…

    vitamin DCardiovascular disease25-hydroxyvitamin D3
  59. A++
    2015

    BioTensegrity Fascia and the fallacy of biomechanics, Part 2.

    John Sharkey

    In this conceptual article, the second in a series, the author introduces BioTensegrity as an alternative to classical biomechanics. He argues that traditional models of animal and human movement, which date back to the…

    biotensegrityBiomechanics
  60. A++
    2015

    BioTensegrity Fascia and the fallacy of biomechanics. Part 1

    John Sharkey

    This conceptual article introduces Biotensegrity as an emerging model for understanding human anatomy. It challenges traditional biomechanics by viewing the body as a continuous tensional network in which fascia plays a…

    biotensegrityBiomechanics