Modes of cancer cell invasion and the role of the microenvironment
- 01Cancer cells invade surrounding tissue in order to spread
- 02They can move as single cells or in collective groups
- 03The tissue's microenvironment influences how cancer cells move
- 04This interplay is a key focus for future cancer research
How cancer cells invade surrounding tissue depends on the structure and signaling within that local microenvironment.
Metastasis beginswith the invasion oftumor cells into the stroma and migration toward the blood stream. Human pathology studies suggest that tumor cells invade collectively as strands, cords and clusters of cells into the stroma, which is dramatically reorganized during cancer progression. Cancer cells in intravital mouse models and in vitro display many ‘modes’ of migration, from single isolated cells with round or elongated phenotypes to loosely-/non-adherent ‘streams’ of cells or collective migration of cell strands and sheets. The tumor microenvironment, and in particular stroma organization, influences the mode and dynamics of invasion. Future studies will clarify how the combination of stromal network structure, tumor cell signaling and extracellular signaling cues influence cancer cell migration and metastasis.
- APA
- Andrew G Clark, & Danijela Matic Vignjevic (2015). Modes of cancer cell invasion and the role of the microenvironment. https://fasciaresearchdatabase.com/modes-of-cancer-cell-invasion-and-the-role-of-the-microenvironment/
- MLA
- Andrew G Clark, and Danijela Matic Vignjevic. "Modes of cancer cell invasion and the role of the microenvironment." 2015, https://fasciaresearchdatabase.com/modes-of-cancer-cell-invasion-and-the-role-of-the-microenvironment/.
- Chicago
- Andrew G Clark, Danijela Matic Vignjevic. 2015. "Modes of cancer cell invasion and the role of the microenvironment.". https://fasciaresearchdatabase.com/modes-of-cancer-cell-invasion-and-the-role-of-the-microenvironment/
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- A2014Biotensegrity of the extracellular matrix: physiology, dynamic mechanical balance, and implications in oncology and mechanotherapy
- A2011Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer
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