Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology
Jaime M Cyphert, Carol S Trempus, Stavros Garantziotis
The biological effects of hyaluronan depend on its molecular size, with different-sized fragments triggering distinct cellular responses.
Hyaluronan signaling properties are unique among other biologically active molecules, that they are apparently not influenced by postsynthetic molecular modification, but by hyaluronan fragment size. This review summarizes the current knowledge about the generation of hyaluronan fragments of different size and size-dependent differences in hyaluronan signaling as well as their downstream biological effects.
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