Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology
Jaime M Cyphert, Carol S Trempus, Stavros Garantziotis
Key takeaways
- 01This is a review of hyaluronan signaling
- 02Hyaluronan's function depends on its molecular weight
- 03Different-sized fragments trigger different cellular signals
- 04This leads to diverse biological effects
The biological effects of hyaluronan depend on its molecular size, with different-sized fragments triggering distinct cellular responses.
Abstract
Hyaluronan signaling properties are unique among other biologically active molecules, that they are apparently not influenced by postsynthetic molecular modification, but by hyaluronan fragment size. This review summarizes the current knowledge about the generation of hyaluronan fragments of different size and size-dependent differences in hyaluronan signaling as well as their downstream biological effects.
Cite this study
- APA
- Jaime M Cyphert, Carol S Trempus, & Stavros Garantziotis (2015). Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology. https://fasciaresearchdatabase.com/size-matters-molecular-weight-specificity-of-hyaluronan-effects-in-cell-biology/
- MLA
- Jaime M Cyphert, et al. "Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology." 2015, https://fasciaresearchdatabase.com/size-matters-molecular-weight-specificity-of-hyaluronan-effects-in-cell-biology/.
- Chicago
- Jaime M Cyphert, Carol S Trempus, Stavros Garantziotis. 2015. "Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology.". https://fasciaresearchdatabase.com/size-matters-molecular-weight-specificity-of-hyaluronan-effects-in-cell-biology/