Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Health E!ects of Alkaline Diet and Water, Reduction of Digestive-tract Bacterial Load, and Earthing
This narrative review discusses how an alkaline diet, alkaline water, reduced digestive-tract bacterial load, and “earthing” might counter chronic low-grade acidosis. The author synthesizes literature suggesting these a…
Fascial hierarchies and the relevance of crossed-helical arrangements of collagen to changes in shape; part II: The proposed effect of blood pressure (Traube-Hering-Mayer) waves on the fascia
Periodic changes in blood pressure, known as Traube-Hering-Mayer waves, are linked to respiration and nervous system activity. While complex and not fully understood, they can provide valuable clinical information. This…
Hyaluronic Acid in Inflammation and Tissue Regeneration
This review article summarizes the role of hyaluronic acid (HA) in tissue healing. As a main component of the extracellular matrix, HA is a key player in tissue regeneration. Interestingly, its effects depend on its mol…
Comparison of the Hyaluronic Acid Vaginal Cream and Conjugated Estrogen Used in Treatment of Vaginal Atrophy of Menopause Women: A Randomized Controlled Clinical Trial
This randomized controlled clinical trial compared the effectiveness of hyaluronic acid vaginal cream with conjugated estrogen cream for treating vaginal atrophy in menopausal women. Over an eight-week period, researche…
Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration
This study investigated how the lubricant hyaluronan in knee joint fluid changes with age and cartilage wear. Researchers analyzed synovial fluid from human donors aged 23 to 91 without diagnosed osteoarthritis. They fo…
Amelioration of estrogen deficiency-induced obesity by collagen hydrolysate
This animal study on rats investigated how collagen hydrolysate supplementation might affect the weight gain often associated with estrogen deficiency, similar to menopause. Researchers found that rats receiving collage…
STRETCHING IMPACTS INFLAMMATION RESOLUTION IN CONNECTIVE TISSUE
In this animal study, researchers investigated the effect of stretching on acute inflammation in the connective tissue of rats. After inducing local inflammation in the rats' backs, one group was subjected to twice-dail…
Fascial Manipulation Associated With Standard Care Compared to Only Standard Postsurgical Care for Total Hip Arthroplasty: A Randomized Controlled Trial
This randomized controlled trial investigated the effects of adding Fascial Manipulation (FM) to standard rehabilitation after total hip replacement surgery. Researchers divided 51 patients into two groups: one received…
Human Recombinant Hyaluronidase Injections For Upper Limb Muscle Stiffness in Individuals With Cerebral Injury: A Case Series
This case series investigated injections of the enzyme hyaluronidase to treat upper limb muscle stiffness in 20 individuals with cerebral injury. The researchers hypothesized that an accumulation of hyaluronan in the mu…
Hyaluronan production and molecular weight is enhanced in pathway-engineered strains of lactate dehydrogenase-deficient Lactococcus lactis
Researchers are exploring ways to use engineered bacteria to produce hyaluronic acid (HA), but the yield and molecular weight have often been limited. Previous work suggested that excessive lactate production might be t…
Effects of whole body vibration exercises on bone mineral density of women with postmenopausal osteoporosis without medications: novel findings and literature review
This systematic review examines the effects of whole-body vibration (WBV) exercises on bone mineral density in postmenopausal women with osteoporosis who are not taking medication. By analyzing twelve studies, researche…
Telocytes in focus
This is a title-only entry, and its contents have not yet been summarized. The title is 'Telocytes in focus', authored by Sandra Maria Cretoiu and published in 2016. Without an abstract or full text, the specific findin…
Protein—glycosaminoglycan interaction networks: Focus on heparan sulfate
This research overview describes a project focused on glycosaminoglycans (GAGs), complex sugars found on the cell surface and in the extracellular matrix. Specifically, it investigates heparan sulfate and how it interac…
Fibromodulin Interacts with Collagen Cross-linking Sites and Activates Lysyl Oxidase
Fibrosis is characterized by a dense and stiff collagen matrix, formed through a cross-linking process driven by the enzyme lysyl oxidase (LOX). This study investigated the role of another protein, fibromodulin, in this…
Can fascia’s characteristics be influenced by manual therapy
This theoretical essay investigates the fundamental properties of collagen, a key component of fascia. The author explores how manual therapy might relate to the necessity of maintaining collagen's strength under load.…
Expression of the endocannabinoid receptors in human fascial tissue
Researchers investigated whether human fascia contains cannabinoid receptors, which are part of the body's endocannabinoid system. Taking small tissue samples from volunteers during orthopedic surgery, they analyzed the…
Ultra-weak photon emission of hands in aging prediction
This study, for which a full summary is not yet available, appears to investigate the relationship between ultra-weak photon emissions from the hands and the biological aging process. The title suggests researchers expl…
Hormone receptor expression in human fascial tissue
Adult women tend to experience more myofascial pain than men, and this study explored a possible hormonal link. Researchers examined fascial tissue from eight female volunteers, looking for receptors for the hormones es…
Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study
This randomized, double-blind, placebo-controlled study evaluated the effects of undenatured type II collagen (UC-II) on symptoms of knee osteoarthritis. Over a 180-day period, 191 volunteers received either 40 mg of UC…
Ultra-weak photon emission in healthy subjects and patients with type 2 diabetes: evidence for a non-invasive diagnostic tool
All living organisms emit extremely faint light, known as ultra-weak photon emission (UPE). This study investigated whether these light emissions differ between healthy individuals and people with type 2 diabetes. Resea…
Resveratrol attenuated estrogen-deficient-induced cardiac dysfunction: role of AMPK, SIRT1, and mitochondrial function
This animal study investigated how resveratrol, an antioxidant found in red grapes, affects cardiac function in estrogen-deficient mice. Researchers found that resveratrol supplementation significantly improved heart co…
Efficacy of an orally administered combination of hyaluronic acid, chondroitin sulfate, curcumin and quercetin for the prevention of recurrent urinary tract infections in postmenopausal women
This prospective study evaluated whether an oral supplement containing hyaluronic acid, chondroitin sulfate, curcumin, and quercetin could prevent recurrent urinary tract infections (UTIs) in postmenopausal women. Resea…
The Physical Mechanism for Retinal Discrete Dark Noise: Thermal Activation or Cellular Ultraweak Photon Emission?
The visual 'static' or 'noise' we perceive in complete darkness has long been a puzzle. The conventional explanation is that random thermal energy causes photoreceptor cells in the retina to fire, but this model doesn't…
Cystocele and functional anatomy of the pelvic floor: review and update of the various theories
This narrative review examines different anatomical theories about how the pelvic floor supports the bladder. The researchers summarize that this support involves a complex interplay of the pubocervical fascia, endopelv…
Endogenous spontaneous ultraweek photon emission in the formation of eye-specific retinogeniculate projections before birth
It has long been a puzzle how the intricate nerve connections between the eye and brain form so accurately before birth, without any visual input. This theoretical paper proposes a novel explanation for this phenomenon.…
Myofascial triggerpoint release (MTR) for treating chronic shoulder pain: A novel approach
This study evaluated a specific manual therapy, myofascial trigger point release (MTR), for chronic shoulder pain. Twenty-three participants received four 10-minute sessions over two weeks, applied only to their more pa…
Collagen Matrix Density Drives the Metabolic Shift in Breast Cancer Cells
This study used a 3D in vitro model to investigate how the density of the collagen matrix influences the metabolism of breast cancer cells. The researchers observed that a high-density extracellular matrix drives a meta…
Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs
This review article describes matrix metalloproteinases (MMPs), the primary enzymes responsible for breaking down collagen in the extracellular matrix. This breakdown process is normal and necessary for tissue remodelin…
Internal strain drives spontaneous periodic buckling in collagen and regulates remodeling
This study investigated how collagen, a key structural protein, is remodeled. Researchers observed that the enzymes responsible for breaking down collagen, called MMPs, bind to specific, vulnerable spots that appear at…
Effects of matrix rhythm therapy on primary lymphedema: a case report
This case report investigated the effects of Matrix Rhythm Therapy on a 36-year-old woman with primary lymphedema in her left leg. She received 20 sessions of the therapy over four weeks, applied to the affected leg, sp…
Acute effects of muscle stretching on physical performance, range of motion, and injury incidence in healthy active individuals: a systematic review
This systematic review examines how different types of stretching (static, dynamic, and PNF) affect performance, range of motion (ROM), and injury risk in healthy individuals. The findings suggest that static stretching…
A five year follow-up of women with obstetric anal sphincter rupture at their first delivery
This study followed 82 women for five years after they experienced an obstetric anal sphincter rupture (OASR) during their first delivery. Researchers investigated long-term outcomes like incontinence and sexual functio…
Estrogen and Pelvic Organ Prolapse
This narrative review explores the relationship between estrogen and pelvic organ prolapse (POP), a condition where pelvic organs descend from their normal positions. Research suggests that low estrogen levels, particul…
The relationship between pelvic alignment and dysmenorrhea
This study investigated the relationship between pelvic alignment and dysmenorrhea (menstrual pain). Researchers compared 102 women, divided into a group with menstrual pain and a group without, using 4D imaging to meas…
Piezo2 is the principal mechanotransduction channel for proprioception
Proprioception is the sense of where our body parts are in space. In this animal study, researchers investigated the molecular sensor responsible for this ability in mice. They found that an ion channel called Piezo2 wa…
Limited mechanical effects of intermuscular myofascial connections within the intact rat anterior crural compartment
In this animal study, researchers investigated the connective tissue links between two lower leg muscles in rats, the tibialis anterior and extensor digitorum longus. The goal was to see if these connections significant…
Microbiota-dependent sequelae of acute infection compromise tissue-specific immunity
A single acute infection can have long-term consequences for tissue-specific immunity, even after the pathogen is cleared. This study found that following a gut infection with Yersinia pseudotuberculosis, sustained infl…
Differential displacement of soft tissue layers from manual therapy loading
To better understand how manual therapy affects the body, researchers investigated how different layers of soft tissue in the back respond to pressure. They applied a standard preparatory force to the thoracic paraspina…
Nutraceutical supplement in the management of tendinopathies: a systematic review
This systematic review examines the effects of various nutraceuticals, such as glucosamine, chondroitin, vitamin C, and curcumin, in managing tendon disorders. While preclinical research on cells and animals shows promi…
Connecting (T)issues: How Research in Fascia Biology Can Impact Integrative Oncology
Many cancer patients use complementary therapies like massage, acupuncture, and yoga to improve their quality of life. This review article suggests these treatments may have further benefits by affecting the body's conn…
Understanding Mechanobiology: Physical Therapists as a Force in Mechanotherapy and Musculoskeletal Regenerative Rehabilitation
This perspective article explores the field of mechanobiology and how physical therapists use mechanical forces to promote tissue healing. It explains that cells in our muscles, bones, and tendons respond to physical st…
Telocytes and Their Extracellular Vesicles—Evidence and Hypotheses
This narrative review discusses telocytes, a relatively new type of interstitial cell found throughout the body's connective tissues. These cells are characterized by long projections and are involved in communication b…
Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
This narrative review explores the link between oxidative stress and inflammation, focusing on how plant-derived polyphenols may mitigate these processes. Oxidative stress occurs when reactive oxygen species overwhelm t…
Functional in vitro tension measurements of fascial tissue – a novel modified superfusion approach
In this laboratory study on rat tissue, researchers compared two techniques for measuring tension changes in fascia. The traditional method involves immersing the tissue in a fluid bath, but the team also tested a modif…
Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies
This review examines the relationship between vitamin C and heart health by analyzing data from epidemiological studies and clinical trials. Research suggests that vitamin C may protect blood vessels by preventing the o…
Stretch-induced network reconfiguration of collagen fibres in the human facet capsular ligament
The facet capsular ligament in the neck is a common source of chronic pain, often resulting from excessive stretching. This study investigated how the collagen fibers within this ligament reorganize when it is stretched…
Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome
Researchers investigated the gut microbiome and blood markers of inflammation in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Compared to healthy controls, individuals with ME/CFS had reduced…
The tongue after whiplash: case report and osteopathic treatment
This case report describes a 30-year-old man who experienced neck pain during swallowing and had a reduced ability to open his mouth following a whiplash injury. He was treated with osteopathic manual techniques directe…
Oxidative stress and oocyte quality: ethiopathogenic mechanisms of minimal/mild endometriosis-related infertility
In this review article, the authors explore the connection between mild endometriosis and infertility. Although the link is known, the exact mechanisms are not fully understood. The researchers suggest that poor oocyte…
Ultrasound Evaluation of the Combined Effects of Thoracolumbar Fascia Injury and Movement Restriction in a Porcine Model
This animal study used pigs to investigate how back fascia responds to injury and restricted movement. Researchers created a small injury in the thoracolumbar fascia and also limited movement in some of the pigs for eig…
A long-distance fluid transport pathway within fibrous connective tissues in patients with ankle edema
This anatomical study investigated how fluid might drain from swollen ankles. Researchers injected a fluorescent dye into the skin of four lower legs scheduled for amputation to trace fluid movement. They observed that…
Restoration of Full Shoulder Range of Motion After Application of the Fascial Distortion Model
This case report describes a 28-year-old man with chronic shoulder pain and severely limited movement, 18 months after an injury. His condition, similar to a frozen shoulder, involved significant pain and an inability t…
Vitamin C Protects Chondrocytes against Monosodium Iodoacetate-Induced Osteoarthritis by Multiple Pathways
In this study using rat and cell models, researchers investigated if vitamin C could protect cartilage cells against osteoarthritis-like damage. The results showed that vitamin C reduced oxidative stress, inflammation,…
Fascial Manipulation® for chronic aspecific low back pain: a single blinded randomized controlledtrial.
This randomized controlled trial compared Fascial Manipulation® combined with standard physiotherapy to physiotherapy alone for patients with chronic non-specific low back pain. The group receiving Fascial Manipulation®…
New evidence of a dynamic fascial maintenance and self-repair process
This 2016 publication by Leon Chaitow has not yet been summarized in detail. Based on its title, the article appears to present new findings that highlight the dynamic processes of fascial maintenance and self-repair. W…
Whole-Body and Local Muscle Vibration Immediately Improve Quadriceps Function in Individuals With Anterior Cruciate Ligament Reconstruction
This randomized crossover trial investigated the immediate effects of vibration on quadriceps function in individuals with a prior anterior cruciate ligament (ACL) reconstruction. Twenty participants performed isometric…
Clinical applications of vibration therapy in orthopaedic practice
This literature review examines the use of vibration therapy in orthopedic practice. Researchers analyzed 71 studies to understand its effects on bone, muscles, and tendons. The review notes that inconsistencies in appl…
A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms
This study investigates how a periodic fasting-mimicking diet (FMD) affects symptoms of multiple sclerosis (MS) using mouse models and preliminary human trials. In animal models, the diet reduced inflammation and promot…
The effect of an active vibration stimulus according to different shoulder joint angles on functional reach and stability of the shoulder joint
This study investigated how active vibration exercise with a Flexi-Bar at different shoulder angles affected shoulder joint function and stability in 30 healthy male students. Participants were divided into three groups…
Understanding Fibroblasts in Order to Comprehend the Osteopathic Treatment of the Fascia
In this review paper, the authors argue that understanding fibroblasts is essential for comprehending and applying osteopathic treatment of the fascia. As the foundational cells of connective tissue, fibroblasts have ma…