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Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

2,804
studies
602
top-graded
2,783
with plain-language summary
Showing 121–180 of 213 studies · page 3/4A++With summary
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  1. A++
    2016

    Ultra-weak photon emission of hands in aging prediction

    Xin Zhao, Eduard van Wijk, Yu Yan, Roeland van Wijk, Huanming Yang, Yan Zhang, Jian Wang

    This study, for which a full summary is not yet available, appears to investigate the relationship between ultra-weak photon emissions from the hands and the biological aging process. The title suggests researchers expl…

    AgingbiophotonsUltra-weak photon emissionModel prediction
  2. A++
    2016

    Can fascia’s characteristics be influenced by manual therapy

    Serge Gracovetsky

    This theoretical essay investigates the fundamental properties of collagen, a key component of fascia. The author explores how manual therapy might relate to the necessity of maintaining collagen's strength under load.…

    Collagen; Models; MMP; Water
  3. A++
    2016

    Myofascial triggerpoint release (MTR) for treating chronic shoulder pain: A novel approach

    Christopher-Marc Gordon, Frank Andrasik, Robert Schleip, Niels Birbaumer, Massimiliano Rea

    This study evaluated a specific manual therapy, myofascial trigger point release (MTR), for chronic shoulder pain. Twenty-three participants received four 10-minute sessions over two weeks, applied only to their more pa…

    Algometer; Chronic shoulder pain; Myofascial triggerpoint release; Myometer; Quality of life; Stress.
  4. A++
    2016

    Reduced diversity and altered composition of the gut microbiome in individuals with myalgic encephalomyelitis/chronic fatigue syndrome

    Ludovic Giloteaux, Julia K. Goodrich, William A. Walters, Susan M. Levine, Ruth E. Ley, Maureen R. Hanson

    Researchers investigated the gut microbiome and blood markers of inflammation in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Compared to healthy controls, individuals with ME/CFS had reduced…

    inflammationChronic fatigue syndromeMyalgic encephalomyelitisLipopolysaccharidesMicrobiome
  5. A++
    2016

    Whole-Body and Local Muscle Vibration Immediately Improve Quadriceps Function in Individuals With Anterior Cruciate Ligament Reconstruction

    Derek N Pamukoff, Brian Pietrosimone, Michael D Lewek, Eric D Ryan, Paul S Weinhold, Dustin R Lee, J Troy Blackburn

    This randomized crossover trial investigated the immediate effects of vibration on quadriceps function in individuals with a prior anterior cruciate ligament (ACL) reconstruction. Twenty participants performed isometric…

    Musclevibrationsligament injury
  6. A++
    2016

    Ultra-weak photon emission in healthy subjects and patients with type 2 diabetes: evidence for a non-invasive diagnostic tool

    Meina Yang, Wenyu Ding, Yanli Liu, Hua Fan, Rajendra P Bajpai, Jialei Fu, Jingxiang Pang, Xiaolei Zhao, Jinxiang Han

    All living organisms emit extremely faint light, known as ultra-weak photon emission (UPE). This study investigated whether these light emissions differ between healthy individuals and people with type 2 diabetes. Resea…

    fasciaphoton emissionbiological systemspathological statesUE
  7. A++
    2016

    The effect of an active vibration stimulus according to different shoulder joint angles on functional reach and stability of the shoulder joint

    Eun-Kyung Kim, Seong-Gil Kim

    This study investigated how active vibration exercise with a Flexi-Bar at different shoulder angles affected shoulder joint function and stability in 30 healthy male students. Participants were divided into three groups…

    Active vibration stimulusFlexi-BarShoulder joint angle
  8. A++
    2016

    Effects of matrix rhythm therapy on primary lymphedema: a case report

    Ayse Neriman Narin, Ayse Zengin Alpozgen, Hilal Denizoglu Kulli

    This case report investigated the effects of Matrix Rhythm Therapy on a 36-year-old woman with primary lymphedema in her left leg. She received 20 sessions of the therapy over four weeks, applied to the affected leg, sp…

    Matrix Rhythm TherapyLower limbPrimary lymphedema
  9. A++
    2016

    Estrogen and Pelvic Organ Prolapse

    Ling Zhou, Anna Junjie Shangguan, Stacy Ann Kujawa, Katarzyna Bochenska, Lanmei Zhang, Serdar E Bulun, Hong Zhao

    This narrative review explores the relationship between estrogen and pelvic organ prolapse (POP), a condition where pelvic organs descend from their normal positions. Research suggests that low estrogen levels, particul…

    Pelvic organ prolapse; Estrogen; Estrogen receptor; Collagen; Matrix metalloproteinases
  10. A++
    2016

    Microbiota-dependent sequelae of acute infection compromise tissue-specific immunity

    Denise Morais da Fonseca, Timothy W Hand, Seong-Ji Han, Michael Y Gerner, Arielle Glatman Zaretsky, Allyson L Byrd, Oli…

    A single acute infection can have long-term consequences for tissue-specific immunity, even after the pathogen is cleared. This study found that following a gut infection with Yersinia pseudotuberculosis, sustained infl…

    Gut microbiome / Immunity
  11. A++
    2016

    Three Case Reports of Successful Vibration Therapy of the Plantar Fascia for Spasticity Due to Cerebral Palsy-Like Syndrome, Fetal-Type Minamata Disease

    Fusako Usuki, Satsuki Tohyama

    This series of case reports describes the long-term effects of vibration therapy on lower-limb spasticity in three patients with fetal-type Minamata disease, a condition with symptoms similar to cerebral palsy. Research…

    spasticityvibration therapyFDM
  12. A++
    2016

    Amelioration of estrogen deficiency-induced obesity by collagen hydrolysate

    Tsay-I Chiang, I-Chang Chang, Hsueh-Hui Lee, Kuang Hui Hsieh, Yung-Wei Chiu, Te-Jen Lai, Jer-Yuh Liu, Li-Sung Hsu, Shao…

    This animal study on rats investigated how collagen hydrolysate supplementation might affect the weight gain often associated with estrogen deficiency, similar to menopause. Researchers found that rats receiving collage…

    Collagen; Obesity; estrogen deficiency
  13. A++
    2016

    Fascial hierarchies and the relevance of crossed-helical arrangements of collagen to changes in shape; part II: The proposed effect of blood pressure (Traube-Hering-Mayer) waves on the fascia

    Graham Scarr

    Periodic changes in blood pressure, known as Traube-Hering-Mayer waves, are linked to respiration and nervous system activity. While complex and not fully understood, they can provide valuable clinical information. This…

    Arterial pressure waveform; Collagen; Cranial rhythmic impulse; Fascia; Helix; Interstitial fluid flow; Mayer waves; Myofascia; Traube Hering
  14. A++
    2016

    Efficacy and tolerability of an undenatured type II collagen supplement in modulating knee osteoarthritis symptoms: a multicenter randomized, double-blind, placebo-controlled study

    James P Lugo, Zainulabedin M Saiyed, Nancy E Lane

    This randomized, double-blind, placebo-controlled study evaluated the effects of undenatured type II collagen (UC-II) on symptoms of knee osteoarthritis. Over a 180-day period, 191 volunteers received either 40 mg of UC…

    osteoarthritisKnee functionT regulatorycellUndenaturedtype II collagen
  15. A++
    2015

    Telocytes in regenerative medicine

    Yihua Bei, Fei Wang, Changqing Yang, Junjie Xiao

    This 2015 review article summarizes research on telocytes, a distinct type of cell found in the connective tissue of many organs. These cells form a complex 3D network and are thought to play a key role in guiding stem…

    interstitial cells; progenitor cells; regeneration; regenerative medicine; stem cells; telocytes.
  16. A++
    2015

    Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology

    Jaime M Cyphert, Carol S Trempus, Stavros Garantziotis

    This narrative review summarizes current knowledge about hyaluronan, a molecule whose biological effects are dependent on its size. Unlike many other molecules, hyaluronan's signaling properties are determined not by ch…

    hyaluronanCell signalingmolecular size
  17. A++
    2015

    BioTensegrity Fascia and the fallacy of biomechanics, Part 2.

    John Sharkey

    In this conceptual article, the second in a series, the author introduces BioTensegrity as an alternative to classical biomechanics. He argues that traditional models of animal and human movement, which date back to the…

    biotensegrityBiomechanics
  18. A++
    2015

    BioTensegrity Fascia and the fallacy of biomechanics. Part 1

    John Sharkey

    This conceptual article introduces Biotensegrity as an emerging model for understanding human anatomy. It challenges traditional biomechanics by viewing the body as a continuous tensional network in which fascia plays a…

    biotensegrityBiomechanics
  19. A++
    2015

    Glycine improves biochemical and biomechanical properties following inflammation of the achilles tendon

    Cristiano Pedrozo Vieira, Letícia Prado De Oliveira, Flávia Da Ré Guerra, Marcos Dos Santos De Almeida, Maria Cristina…

    This animal study investigated the effect of the amino acid glycine on inflamed Achilles tendons in rats. Researchers induced inflammation and then fed one group of rats a diet supplemented with 5% glycine. After 22 day…

    achilles tendon; extracellular matrix; glycine; inflammatory process; tendinopathy.
  20. A++
    2015

    Influence of different intensities of vibration on proliferation and differentiation of human periodontal ligament stem cells

    Chunxiang Zhang, Yanqin Lu, Linkun Zhang, Yang Liu, Yi Zhou, Yangxi Chen, Haiyang Yu

    In this laboratory study, researchers investigated how low-magnitude, high-frequency vibration affects stem cells from the human periodontal ligament, the tissue that holds teeth in the jaw. The results suggest that vib…

    Proliferationmechanical vibrationperiodontal ligament stem cellsosteogenesismagnitude
  21. A++
    2015

    Meralgia paresthetica caused by entrapment of the lateral femoral subcutaneous nerve at the fascia lata of the thigh: a case report and literature review

    Yasuyuki Omichi, Ichiro Tonogai, Shinsuke Kaji, Teruaki Sangawa, Koichi Sairyo

    This case report and literature review describe an unusual presentation of meralgia paresthetica, a condition causing numbness and pain in the outer thigh. While the condition typically involves nerve entrapment at the…

    nerve entrapment
  22. A++
    2015

    Neurovisceral phenotypes in the expression of psychiatric symptoms

    Jessica A Eccles, Andrew P Owens, Christopher J Mathias, Satoshi Umeda, Hugo D Critchley

    This narrative review explores the idea that vulnerability to anxiety may be rooted in inherent physical differences in how the body is regulated. The authors focus on conditions like joint hypermobility, Postural Tachy…

    joint hypermobilityAnxietypostural tachycardia syndromevasovagal syncopepsychiatry
  23. A++
    2015

    The Effects of Vibration and Muscle Fatigue on Trunk Sensorimotor Control in Low Back Pain Patients

    Jean-Alexandre Boucher, Jacques Abboud, François Nougarou, Martin C Normand, Martin Descarreaux

    This study compared trunk muscle control between people with chronic low back pain (cLBP) and healthy individuals. Researchers found that the cLBP group was less accurate at reproducing a specific amount of force with t…

    fascialow back painmuscle fatiguevibration
  24. A++
    2015

    Effects of plant sterols derived from Aloe vera gel on human dermal fibroblasts in vitro and on skin condition in Japanese women

    Miyuki Tanaka, Eriko Misawa, Koji Yamauchi, Fumiaki Abe, Chiaki Ishizaki

    This study investigated how plant sterols from Aloe vera gel affect the skin, using both laboratory tests on human skin cells (fibroblasts) and a clinical trial with women. In the lab, these sterols were found to stimul…

    oral supplementationaloe sterol; collagen; wrinkle
  25. A++
    2015

    Estrogen inhibits lysyl oxidase and decreases mechanical function in engineered ligaments

    Cassandra A Lee, Ann Lee-Barthel, Louise Marquino, Natalie Sandoval, George R Marcotte, Keith Baar

    This lab study investigated why women are more likely to rupture their anterior cruciate ligament (ACL) than men, focusing on the role of estrogen. Researchers used human ACL cells to create engineered ligaments in a la…

    ACL; exercise; tendon; ultimate tensile strength
  26. A++
    2015

    Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin resistance and glycaemia in 9-10 year-old children

    A S Donin, J E Dent, C M Nightingale, N Sattar, C G Owen, A R Rudnicka, M R Perkin, A M Stephen, S A Jebb, D G Cook, P…

    This cross-sectional study of over 2000 children in the UK examined the relationship between vitamin C and risk factors for type 2 diabetes. Researchers found that higher levels of vitamin C in the blood were associated…

    Vitamin Cinsulin resistensglycaemiadiabetes type 2
  27. A++
    2014

    Vibration therapy: clinical applications in bone

    William R Thompson, Sherwin S Yen, Janet Rubin

    This review article explores vibration therapy as a way to mimic the positive effects of physical activity on bone and muscle, especially for frail individuals who cannot exercise. Animal and human studies suggest that…

    low-intensity vibration; mesenchymal stem cells; osteocyte; osteoporosis
  28. A++
    2014

    Role of reactive oxygen species in ultra-weak photon emission in biological systems

    Pavel Pospíšil, Ankush Prasad, Marek Rác

    This narrative review explores the connection between reactive oxygen species (ROS) and the faint light, or ultra-weak photon emission, that living organisms naturally produce. The authors explain that normal metabolic…

    biophotonsChemiluminescenceReactive oxygen specieslipid peroxidationHydroxyl radical
  29. A++
    2014

    Ultraweak photon emission as a non-invasive health assessment: a systematic review

    John A Ives, Eduard P A van Wijk, Namuun Bat, Cindy Crawford, Avi Walter, Wayne B Jonas, Roeland van Wijk, Jan van der…

    This systematic review explores the use of ultraweak photon emission (UPE) as a non-invasive tool for assessing human health. By analyzing 56 studies, researchers found that measuring light particles emitted by the body…

    Ultra-weak photon emissionultra-weak bioluminescencehealt assessment
  30. A++
    2014

    Low-intensity vibration improves angiogenesis and wound healing in diabetic mice

    Eileen M Weinheimer-Haus, Stefan Judex, William J Ennis, Timothy J Koh

    This animal study investigated if whole-body low-intensity vibration (LIV) could improve chronic wound healing in diabetic mice. Mice with surgical wounds received either 30 minutes of daily vibration or a sham treatmen…

    wound healingvibrationsdiabetic wounds
  31. A++
    2014

    Ingested hyaluronan moisturizes dry skin

    Chinatsu Kawada, Takushi Yoshida, Hideto Yoshida, Ryosuke Matsuoka, Wakako Sakamoto, Wataru Odanaka, Toshihide Sato, Ta…

    This review article summarizes research on how oral hyaluronan (HA) supplements may influence skin hydration levels. Studies suggest that a daily intake of 120–240 mg of hyaluronic acid can contribute to increased moist…

    hyaluronanhaHyaluronic acidSkinsupplementation
  32. A++
    2014

    Towards whole-body ultra-weak photon counting and imaging with a focus on human beings: A review

    Roeland Van Wijk, Eduard P A Van Wijk, Herman A van Wietmarschen, Jan van der Greef

    In this review article, the authors describe the history and development of research into ultra-weak photon emission (UPE), the faint light naturally emitted by the human body. The scientific understanding of this pheno…

    Ultra-weak photon emissionBiophotonReactive oxygen speciesSystems biologyHuman
  33. A++
    2014

    Biophoton signal transmission and processing in the brain

    Rendong Tang, Jiapei Dai

    This narrative review explores an alternative theory of how brain cells communicate. The traditional view is that the nervous system uses bioelectrical and chemical signals, but these models struggle to explain higher b…

    biophotonsUltra-weak photon emissionsBiophotonic transmissionNeural signal transmission and processingNeural circuits
  34. A++
    2014

    Antioxidants, inflammation and cardiovascular disease

    Harald Mangge, Kathrin Becker, Dietmar Fuchs, Johanna M Gostner

    This narrative review explores the links between inflammation, oxidative stress, and cardiovascular disease (CVD). The authors explain that chronic immune activation in CVD leads to high levels of reactive oxygen specie…

    Antioxidative therapy; Atherogenesis; Cardiovascular disease; Homocysteine; Neopterin; Nitric oxide; Oxidative stress; Tetrahydrobiopterin; Tryptophan; Vitamins.
  35. A++
    2014

    Highly sensitive imaging for ultra-weak photon emission from living organisms

    Masaki Kobayashi

    This review article describes research on ultra-weak photon emission (UPE), also known as biophotons, which is faint light spontaneously emitted from living organisms. This light emission is associated with metabolic pr…

    biophotonsUltra-weak photon emissionCCDReactive oxygen speciesImaging
  36. A++
    2014

    The role of collagen crosslinks in ageing and diabetes - the good, the bad, and the ugly

    Jess G Snedeker, Alfonso Gautieri

    This narrative review explores how glucose in the body can bind to proteins like collagen, a process called glycation. This process creates crosslinks that can change the mechanical properties and function of connective…

    collagenCrosslinksageingadvanced glycation endproductstendon mechanics
  37. A++
    2014

    Ultra-weak photon emission from biological samples: Definition, mechanisms, properties, detection and applications

    Michal Cifra, Pavel Pospíšil

    This review article summarizes the current understanding of ultra-weak photon emission (UPE), a faint light naturally produced by living organisms. This light, a form of chemiluminescence, is generated during normal met…

    biophotonsChemiluminescenceOxidative stressSinglet oxygenCharge coupled device
  38. A++
    2014

    The Role of Functional Foods in Cutaneous Anti-aging

    Soyun Cho

    This narrative review examines how functional foods and oral supplements may influence skin aging by addressing oxidative stress and inflammation. Research suggests that compounds such as carotenoids, aloe vera, red gin…

    Anti-oxidant; Collagen; Functional foods; Photoaging
  39. A++
    2014

    Age- and diabetes-related nonenzymatic crosslinks in collagen fibrils: Candidate amino acids involved in Advanced Glycation End-products

    Alfonso Gautieri, Alberto Redaelli, Markus J Buehler, Simone Vesentini

    Advanced Glycation End-products (AGEs) are harmful crosslinks that form in collagen with aging and in diabetes, making tissues stiffer. However, the exact location of these crosslinks has been unclear. In this theoretic…

    Advanced glycation end-products; Ageing; Atomistic simulations; Collagen; Crosslinks; Diabetes.
  40. A++
    2014

    Spatiotemporal Imaging of Glutamate-Induced Biophotonic Activities and Transmission in Neural Circuits

    Rendong Tang, Jiapei Dai

    This study on mouse brain tissue investigated biophotons, which are ultra-weak light emissions from biological systems. Researchers found that applying the neurotransmitter glutamate caused a significant and long-lastin…

    fasciabiophotonsultraweak photons
  41. A++
    2014

    New perspective in cell communication: Potential role of ultra-weak photon emission

    Ankush Prasad, Claudio Rossi, Stefania Lamponi, Pavel Pospíšil, Alberto Foletti

    This 2014 narrative review explores how cells might communicate with each other. Beyond chemical signals and direct contact, the authors discuss evidence for communication via electromagnetic radiation, specifically ult…

    fasciabiophotonsUltra-weak photon emissioncellular interactionbiocommunication
  42. A++
    2014

    Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study

    E Proksch, D Segger, J Degwert, M Schunck, V Zague, S Oesser

    This double-blind, placebo-controlled study investigated the effects of daily collagen peptide supplementation in individuals with knee osteoarthritis. Participants received either porcine or bovine collagen, or a place…

    skin agingCollagen hydrolysatecollagen peptidesskin health.
  43. A++
    2013

    Squeeze film lubrication for non-Newtonian fluids with application to manual medicine

    Hans Chaudhry, Bruce Bukiet, Max Roman, Antonio Stecco, Thomas Findley

    Researchers used a mathematical model to investigate how manual therapy affects the fluid in and around fascia. The model focused on hyaluronic acid (HA), a natural lubricant in connective tissue. The results suggest th…

    fasciaHyaluronic acidmassage therapyvibrationsmanual manipulation
  44. A++
    2013

    Mathematical Analysis of the Flow of Hyaluronic Acid Around Fascia During Manual Therapy Motions

    Max Roman, Hans Chaudhry, Bruce Bukiet, Antonio Stecco,Thomas Findley

    This study used a mathematical model to simulate how different manual therapy techniques affect the flow of hyaluronic acid (HA) within fascia. The researchers compared constant sliding, perpendicular vibration, and tan…

    hyaluronanfasciaManual Therapyfluid flowvibration
  45. A++
    2013

    Vitamin C in Disease Prevention and Cure: An Overview

    Shailja Chambial, Shailendra Dwivedi, Kamla Kant Shukla, Placheril J John, Praveen Sharma

    This narrative review provides an overview of Vitamin C's many roles in the body. It is essential for developing and maintaining connective tissues, and plays a key part in bone formation, wound healing, and gum health.…

    cancerdiabetesVitamin CImmunityinfertility
  46. A++
    2013

    Vibration Induced Osteogenic Commitment of Mesenchymal Stem Cells is Enhanced by Cytoskeletal Remodeling but not Fluid Shear

    Gunes Uzer, Suphannee Pongkitwitoon, M Ete Chan, Stefan Judex

    This laboratory study investigated how mechanical vibrations encourage stem cells to develop into bone cells. Researchers tested two potential mechanisms: the force of fluid moving across the cells (fluid shear) and cha…

    fasciaBonedifferentiationProliferationvibrations
  47. A++
    2013

    Ascorbate supplementation inhibits growth and metastasis of B16FO melanoma and 4T1 breast cancer cells in vitamin-C deficient mice

    John Cha, M Waheed Roomi, Vadim Ivanov, Tatiana Kalinovsky, Aleksandra Niedzwiecki, Matthias Rath

    This animal study investigated how Vitamin C (ascorbate) supplementation affects cancer growth in mice that, like humans, cannot produce their own. Researchers injected melanoma or breast cancer cells into two groups of…

    Tumor growthinterleukin-6apoptosismetastasisascorbate
  48. A++
    2013

    The application of matrix rhythm therapy as a new clinical modality in burn physiotherapy programmes

    Zübeyir Sarı, Mine Gülden Polat, Bahar Özgül, Onur Aydogdu, Burcu Camcıoglu, Ahmet Hakan Acar, Saadet Ufuk Yurdalan

    This study investigated the use of Matrix Rhythm Therapy (MRT) as part of a physiotherapy program for patients with upper extremity burn injuries. A group of patients received a treatment protocol that included whirlpoo…

    Matrix Rhythm TherapyBurnsPhysiotherapy and rehabilitation
  49. A++
    2013

    Implementation of Matrix Rhythm Therapy and Conventional Massage in Young Females and Comparison of Their Acute Effects on Circulation

    Ferruh Taspinar, Ummuhan Bas Aslan, Nuran Sabir, Ugur Cavlak

    This randomized controlled trial compared the acute effects of Matrix Rhythm Therapy and conventional massage on lower leg blood circulation in young, healthy women. Fifteen participants received a single 30-minute sess…

    fascia
  50. A++
    2013

    Cell-to-cell signaling through light: just a ghost of chance?

    Ondřej Kučera, Michal Cifra

    This paper examines the physical feasibility of cell-to-cell communication via weak light signals, often referred to as biophotons. The researchers analyze whether electromagnetic signaling is possible when considering…

    Cell signalingbiophotonsphoton emission
  51. A++
    2013

    Air ions and mood outcomes: a review and meta-analysis

    Vanessa Perez, Dominik D Alexander, William H Bailey

    This review and meta-analysis examined 33 studies to investigate how air ions affect human psychological states. The authors found no consistent effects of positive or negative ionization on anxiety, general mood, relax…

    systematic reviewepidemiologyMood disordersDepressionAir ionization
  52. A++
    2012

    INTERSTITIAL FLUID AND LYMPH FORMATION AND TRANSPORT: PHYSIOLOGICAL REGULATION AND ROLES IN INFLAMMATION AND CANCER

    Helge Wiig, Melody A Swartz

    This 2012 review explores the interstitium, the fluid-filled space surrounding our cells that contains interstitial fluid (IF). Formed by filtration from blood capillaries and cleared by lymphatic vessels, IF and its fl…

    ImmunologyLymphTumorinterstitiumfluid
  53. A++
    2012

    Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity

    Melody A Swartz, Amanda W Lund

    This review explores how tumors interact with the lymphatic system to grow and spread. Increased fluid flow from a tumor to nearby lymph nodes does more than just transport cancer cells. This flow also creates mechanica…

    fasciacancerstiffnessmechanobiologymicroenvironment
  54. A++
    2012

    Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease

    Kirsty Brown, Daniella DeCoffe, Erin Molcan, Deanna L Gibson

    This 2012 narrative review explores the connection between diet, gut microbes, and the immune system. The gastrointestinal tract must balance tolerance for harmless bacteria and food with responsiveness to pathogens. An…

    inflammationnutritionintestinal microbiotadisease susceptibility
  55. A++
    2012

    Vitamin C transport and its role in the central nervous system

    James M May

    This review article explores the critical role of vitamin C in the central nervous system. Although it circulates in the blood at low concentrations, neurons in the brain and spinal cord maintain very high levels of the…

    ascorbate transport; brain; dehydroascorbate; glutamate; neurons; SVCT2
  56. A++
    2012

    Fluid Flow along Venous Adventitia in Rabbits: Is It a Potential Drainage System Complementary to Vascular Circulations?

    Hong-yi Li, Min Chen, Jie-fu Yang, Chong-qing Yang, Liang Xu, Fang Wang, Jia-bin Tong, You Lv, Caidan Suonan

    In this animal study on rabbits, researchers investigated a potential fluid drainage system within the body's connective tissue. By injecting tracers, they visualized pathways along the loose connective tissue surroundi…

    interstitial fluidacupuncturefluid flow
  57. A++
    2012

    Discovering the link between nutrition and skin aging

    Silke K Schagen, Vasiliki A Zampeli, Evgenia Makrantonaki, Christos C Zouboulis

    This narrative review examines the relationship between nutrition and skin aging, focusing on how specific nutrients may protect against damage from ultraviolet (UV) radiation. The authors describe how antioxidants such…

    antioxidants; diet; fatty acids; flavonoids; nutrition; skin aging; ultraviolet protection; vitamins.
  58. A++
    2011

    Review of Evidence Suggesting That the Fascia Network Could Be the Anatomical Basis for Acupoints and Meridians in the Human Body

    Yu Bai, Jun Wang, Jin-Peng Wu, Jing-Xing Dai, Ou Sha, David Tai Wai Yew, Lin Yuan, Qiu-Ni Liang

    This narrative review explores the idea that the body's fascia network could be the physical structure behind traditional Chinese medicine's (TCM) meridians and acupoints. The authors examine anatomical, physiological,…

    fasciaacupunctureacupoints
  59. A++
    2011

    Vibration therapy of the plantar fascia improves spasticity of the lower limbs of a patient with fetal-type Minamata disease in the chronic stage

    Fusako Usuki, Satsuki Tohyama

    This case report describes a treatment for spasticity in a patient with fetal-type Minamata disease. Researchers used a hand-held vibration massager applied directly to the patient's plantar fascia and hamstrings. After…

    spasticityvibration therapy
  60. A++
    2011

    Optimizing an Intermittent Stretch Paradigm Using ERK1/2 Phosphorylation Results in Increased Collagen Synthesis in Engineered Ligaments

    Jennifer Z Paxton, Paul Hagerty, Jonathan J Andrick, Keith Baar

    This study on engineered ligaments explored how different stretching patterns affect tissue development. Researchers used a bioreactor to apply cyclic stretch, measuring cellular responses by tracking a key protein call…

    collagen synthesisERK 1/2 phosphorylationintermittent stretch