Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- C2009
Effect of surgical traumas on microcirculation
Visweswar Bhattacharya, Biswajit Mishra, Binayak Mishra, Umesh Kumar, Siddhartha BhattacharyaThis study observed the live effects of common surgical instruments on the tiny blood vessels within fascia. Researchers used tissue flaps from patients' lower legs and examined them under a microscope. They found that…
Microcirculationsurgical traumacautery traumaclamp traumaforceps trauma - B2009
Protein Crosslinking in Assembly and Remodelling of Extracellular Matrices: The Role of Transglutaminases
Daniel Aeschlimann, Vilmos ThomazyThis review article discusses a family of enzymes called transglutaminases, which help build and remodel the body's extracellular matrix by crosslinking proteins. One specific enzyme, tissue transglutaminase (tTG), is p…
Matrix proteinscrosslinkingtransglutaminaspathology - A2009
Mechanotherapy: how physical therapists’ prescription of exercise promotes tissue repair
K M Khan, A ScottThis review article explains the concept of "mechanotherapy," which is the use of prescribed exercise to promote tissue repair. The underlying biological process is called mechanotransduction, where the body's cells sen…
fasciamechanotherapyechanotransduction - A2009
The treatment of Chronic Low Back Pain following the principles of the Fascial Distortion Modell (FDM)
Rainer EngelThis small study investigated the effect of two Fascial Distortion Model (FDM) treatments on 22 people with chronic low back pain. Researchers measured pain, function, flexibility (finger-floor distance), and use of pai…
Manual Therapyfasciaefascial distortion modelreductionismtypaldos - A++2009
Imaging of Ultraweak Spontaneous Photon Emission from Human Body Displaying Diurnal Rhythm
Masaki Kobayashi, Daisuke Kikuchi, Hitoshi OkamuraThe human body emits an extremely faint light, about 1000 times dimmer than what our naked eyes can detect. This phenomenon, known as ultraweak photon emission, is thought to be linked to the body's energy metabolism. U…
fasciabiophotonsultraweak photonsdiurnal rhythm - A2009
Effect of Loading on the Organization of the Collagen Fibril Network in Juvenile Equine Articular Cartilage
Pieter A J Brama, Jaakko Holopainen, P René van Weeren, Elwyn C Firth, Heikki J Helminen, Mika M HyttinenIn this animal study, researchers investigated how exercise-induced loading affects the collagen network in the articular cartilage of juvenile horses. They compared two sites within a joint: one subjected to high-inten…
cartilage; collagen fibril; loading; parallelism; orientation - A++2009
Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options
Bayani Uttara, Ajay V Singh, Paolo Zamboni, R T MahajanThis review article explores the connection between oxidative stress and neurodegenerative diseases like Alzheimer's and Parkinson's. The authors explain that an imbalance of free radicals, which are normal byproducts o…
Oxidative stressROSantioxidantsneurodegenerative diseasesrns - A+2009
The polyvagal theory: New insights into adaptive reactions of the autonomic nervous system
STEPHEN W PORGESThe Polyvagal Theory describes the autonomic nervous system from an evolutionary perspective. It focuses on a key phylogenetic shift in the vagus nerve that occurred between reptiles and mammals. This change created a l…
vagus nervepolyvagalfighy and flightfreezeparasympathetic system - A2009
Ultrasound evidence of altered lumbar connective tissue structure in human subjects with chronic low back pain
Helene M Langevin, Debbie Stevens-Tuttle, James R Fox, Gary J Badger, Nicole A Bouffard, Martin H Krag, Junru Wu, Sharo…Researchers investigated whether structural differences exist in the low back's connective tissues between people with and without chronic low back pain. Using ultrasound, they measured the thickness and echogenicity (h…
fasciaConnective tissuelow back painlumbar - A2009
Relevance of Collagen Piezoelectricity to “Wolff’s Law”: a Critical Review
Andrew C Ahn, Alan J GrodzinskyThis narrative review explores how bone adapts to mechanical stress, a principle known as Wolff's Law. For decades, scientists have investigated how bone cells sense this stress to trigger remodeling. An early theory pr…
fasciacollagenpiezoelectricwolff's law - B2009
From mechanical loading to collagen synthesis, structural changes and function in human tendon
Michael Kjær, H Langberg, K Heinemeier, M L Bayer, Mette Hansen, L Holm, S Doessing, M Kongsgaard, M R Krogsgaard, S P…This review article outlines how tendons adapt to mechanical loading from exercise. The research indicates that loading increases the synthesis and turnover of collagen, the protein that gives tendons their strength. Th…
fibroblastphysical trainingMechanical loadingtendoncollagen synthesis - A++2009
Structural Behavior of Highly Concentrated Hyaluronan
Paolo Matteini, Luigi Dei, Emiliano Carretti, Nicola Volpi, Andrea Goti, Roberto PiniResearchers investigated the behavior of highly concentrated hyaluronan (HA) in a physiological saline solution. They found that HA molecules can organize into stable, larger "superstructures." When heated, the fluid's…
hyaluronanHA structure