Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2012
Mathematical model of fiber orientation in anisotropic fascia layers at large displacements
Hans Chaudhry, Max Roman, Antonio Stecco, Thomas FindleyResearchers developed a mathematical model to better understand how collagen fibers within fascia change their orientation when the tissue is stretched. The model suggests that fibers already angled away from the direct…
Fascial; Reinforcement; Collagen fibers; Re-orientation; Tension - A+++2012
Total antioxidant capacity of diet and risk of stroke: a population-based prospective cohort of women
Susanne Rautiainen, Susanna Larsson, Jarmo Virtamo, Alicja WolkThis Swedish population-based study examined the relationship between the total antioxidant capacity of the diet and stroke risk in over 36,000 women. By measuring the combined effect of all antioxidants in food rather…
Antioxidantsstroke - B2012
Recent Developments in Myofibroblast Biology
Boris Hinz, Sem H Phan, Victor J Thannickal, Marco Prunotto, Alexis Desmoulière, John Varga, Olivier De Wever, Marc Mar…This 2012 narrative review summarizes advances in understanding the myofibroblast, a specialized cell crucial for both normal wound healing and the development of fibrotic diseases. The authors discuss how these cells g…
fibrosisMyofibroblast - A2012
Hyaluronic acid, A key molecule in skin aging
Eleni Papakonstantinou, Michael Roth, George KarakiulakisThis review article discusses the role of hyaluronic acid (HA) in skin aging. The authors explain that youthful skin's plumpness and resilience are largely due to its high water content, which HA is uniquely able to ret…
CD44fasciaHyaluronic acidhyaluronic acid synthaseshyaluronidases - A+++2012
Fascia as a body-wide communication system
James L OschmanThis abstract proposes that fascia acts as a body-wide communication system. The author draws an analogy to single-celled organisms, like a paramecium, which can perform complex functions without a nervous system by rel…
Fascia - A+2012
Nutritional regulation of muscle protein synthesis with resistance exercise: strategies to enhance anabolism
Tyler A Churchward-Venne, Nicholas A Burd, Stuart M PhillipsIn this 2012 review article, the authors discuss how nutrition can regulate muscle protein synthesis, especially when combined with resistance exercise. Consuming protein (amino acids) stimulates muscle building, an eff…
MusclenutritionhypertrophyAnabolic intramuscular signaling - A2012
Primo Vascular System as a New Morphofunctional Integrated System
Miroslav Stefanov, Jungdae KimThis narrative review summarizes research on the primo vascular system (PVS), a proposed anatomical network found throughout the body. The authors describe the methods and instruments used to study this system, primaril…
fasciacancerphysiologyMorphologyprimo vascular system - A2012
Mechanical properties of human patellar tendon at the hierarchical levels of tendon and fibril
René B Svensson, Philip Hansen, Tue Hassenkam, Bjarki T Haraldsson, Per Aagaard, Vuokko Kovanen, Michael Krogsgaard, Mi…Researchers investigated how the mechanical properties of the whole human patellar tendon compare to its individual collagen fibrils. They tested whole tendons in living subjects and then tested isolated fibrils from th…
atomic force microscopy; collagen; fibril dimensions; modulus; toe region - A++2012
Diet-Induced Dysbiosis of the Intestinal Microbiota and the Effects on Immunity and Disease
Kirsty Brown, Daniella DeCoffe, Erin Molcan, Deanna L GibsonThis 2012 narrative review explores the connection between diet, gut microbes, and the immune system. The gastrointestinal tract must balance tolerance for harmless bacteria and food with responsiveness to pathogens. An…
inflammationnutritionintestinal microbiotadisease susceptibility - A2012
Real-time imaging of cortical areas involved in the generation of increases in skin sympathetic nerve activity when viewing emotionally charged images
Luke A Henderson, Alexandra Stathis, Cheree James, Rachael Brown, Skye McDonald, Vaughan G MacefieldThis study investigated which brain regions are involved when our bodies react to emotional images. Researchers simultaneously measured brain activity with fMRI and skin sympathetic nerve activity (SSNA), a marker of th…
fasciaMRIIASP imagesmicroneurographyskin sympathetic nerve activity - A++2012
Vitamin C transport and its role in the central nervous system
James M MayThis review article explores the critical role of vitamin C in the central nervous system. Although it circulates in the blood at low concentrations, neurons in the brain and spinal cord maintain very high levels of the…
ascorbate transport; brain; dehydroascorbate; glutamate; neurons; SVCT2 - B2012
Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism
Jun Li, Daniel J Gorski, Wendy Anemaet, Jennifer Velasco, Jun Takeuchi, John D Sandy, Anna PlaasIn this mouse study, researchers investigated how hyaluronan (HA) injections might protect joints in osteoarthritis. They found that even though the injected HA was cleared from the knee joint in under two hours, a sing…
hyaluronanCD44fibrosisTGF-beta1osteoarthritis