Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A2015
Effects of non-pharmacological interventions on inflammatory biomarker expression in patients with fibromyalgia: a systematic review
Kenji Sanada, Marta Alda Díez, Montserrat Salas Valero, María Cruz Pérez-Yus, Marcelo M P Demarzo, Mauro García-Toro, J…This systematic review examined how non-drug treatments affect inflammatory markers in people with fibromyalgia. Researchers analyzed 12 studies involving 536 participants who underwent exercise, dietary, or multidiscip…
fasciaFibromyalgiapaincytokinessleep quality - A+2015
Osmotic pressure induced tensile forces in tendon collagen
Admir Masic, Luca Bertinetti, Roman Schuetz, Shu-Wei Chang, Till Hartmut Metzger, Markus J Buehler, Peter FratzlResearchers investigated the role of water in tendon collagen using a combination of experiments and computer modeling. They found that water is a crucial part of the collagen molecule's structure. When water is removed…
collagenOsmotic pressurewater - A+++2015
Swing phase kinematics of horses trotting over poles
S Brown, N C Stubbs, L J Kaiser, M Lavagnino, H M ClaytonThis study investigated how horses are affected by trotting over poles, a common therapeutic exercise used to restore joint range of motion. Researchers aimed to determine if lifting the limbs higher to clear obstacles…
coordination; horse; physiotherapy; rehabilitation - A+++2015
Functional locomotor consequences of uneven forefeet for trot symmetry in individual riding horses
Nathan Wiggers, Sandra L P Nauwelaerts, Sarah Jane Hobbs, Sophie Bool, Claudia F Wolschrijn, Willem BackThis study investigated how horses with uneven forefeet, where the angle differs between left and right, move at a trot. Researchers found that the flatter foot experiences higher loading, including greater braking forc…
asymmetryriding horsesuneven feethoof angle - B2015
Cytokines in rheumatoid arthritis - shaping the immunological landscape
Iain B McInnes, Christopher D Buckley, John D IsaacsIn this short opinion article, the authors provide an overview of the central role of cytokines in rheumatoid arthritis (RA). These signaling molecules are involved in the immune responses associated with both the onset…
cytokinesarthritis - A++2015
Influence of different intensities of vibration on proliferation and differentiation of human periodontal ligament stem cells
Chunxiang Zhang, Yanqin Lu, Linkun Zhang, Yang Liu, Yi Zhou, Yangxi Chen, Haiyang YuIn this laboratory study, researchers investigated how low-magnitude, high-frequency vibration affects stem cells from the human periodontal ligament, the tissue that holds teeth in the jaw. The results suggest that vib…
Proliferationmechanical vibrationperiodontal ligament stem cellsosteogenesismagnitude - A2015
Reflections on osteopathic fascia treatment in the peripheral nervous system
Bruno Bordoni, Giovanni BordoniIn this reflective article, the authors discuss the fascia of the peripheral nervous system. They explain that nerves are enclosed in several layers of fascia that must be able to slide, and that impeded sliding can be…
fasciapainfascial treatmentnerve palpation - A++2015
Glycine improves biochemical and biomechanical properties following inflammation of the achilles tendon
Cristiano Pedrozo Vieira, Letícia Prado De Oliveira, Flávia Da Ré Guerra, Marcos Dos Santos De Almeida, Maria Cristina…This animal study investigated the effect of the amino acid glycine on inflamed Achilles tendons in rats. Researchers induced inflammation and then fed one group of rats a diet supplemented with 5% glycine. After 22 day…
achilles tendon; extracellular matrix; glycine; inflammatory process; tendinopathy. - A2015
Pathophysiology and Immune Dysfunction in Endometriosis
Soo Hyun Ahn, Stephany P Monsanto, Caragh Miller, Sukhbir S Singh, Richard Thomas, Chandrakant TayadeThis narrative review explores the current understanding of endometriosis, a chronic inflammatory condition affecting many women of reproductive age. The authors focus on how endometriosis lesions develop a blood supply…
endometriosis - A+++2015
Efficacy of phytoestrogens for menopausal symptoms: a meta-analysis and systematic review
M-N Chen, C-C Lin, C-F LiuThis systematic review and meta-analysis of 15 randomized controlled trials examined the effectiveness of plant-based estrogens, known as phytoestrogens, for relieving menopausal symptoms. The findings suggest that phyt…
CLIMACTERIC; ESTROGEN; HOT FLUSH; ISOFLAVONE; LIGNAN; MENOPAUSE; META-ANALYSIS. - A2015
Duration and Magnitude of Myofascial Release in 3-Dimensional Bioengineered Tendons: Effects on Wound Healing
Thanh V Cao, Michael R Hicks, Manal Zein-Hammoud, Paul R StandleyThis laboratory study investigated how myofascial release (MFR) affects wound healing in bioengineered tendons. Researchers created a wound in the tendon models and then applied different magnitudes and durations of str…
wound healingMyofascial release - 1A+2015
Electron microscopy of human fascia lata: focus on telocytes
Joanna Dawidowicz, Sylwia Szotek, Natalia Matysiak, Łukasz Miela!nczyk, Krzysztof MaksymowiczThis study used an electron microscope to examine the types of cells present in the fascia lata, a sheet of connective tissue in the thigh. For the first time, researchers confirmed the existence of a specific cell type…
Fibroblastsmyofibroblastshuman fascia latatransmission electron microscopytelocytes