Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2022
Making Connections to Improve Health Outcomes
Helene M LangevinIn this editorial, Helene M. Langevin discusses the importance of whole person health, viewing the individual as an interconnected system rather than a collection of isolated organs. She argues that biomedical research…
complementary and alternative medicine; integrative medicine; treatment and prevention - A+++2022
Myofascial Tissue and Depression
Johannes Michala, Lanre Aranmolate, Antonia Bonn, Karen Grandin, Robert Schleip, Jaqueline Schmiedtke, Svenja Quassowsk…This research investigated the link between myofascial tissue and Major Depressive Disorder (MDD) through two distinct studies. The first study found that patients with depression exhibited significantly higher stiffnes…
Depression; Embodiment; Memory bias; Myofascial tissue. - A++2022
Lifestyle Factors and Their Influence on Rheumatoid Arthritis: A Narrative Review
Christoph Schäfer, Gernot KeyßerThis narrative review examines how lifestyle factors influence the development and progression of rheumatoid arthritis (RA). Research suggests that smoking, an unhealthy diet, and obesity increase the risk of developing…
Mediterranean diet; diet; lifestyle; physical activity; rheumatoid arthritis; smoking; socioeconomic status - A+++2022
Primo Vascular System: Before the Past, Bizarre Present and Peek After the Future
Miroslav StefanovThis theoretical review explores the Primo Vascular System (PVS), a proposed network of channels suggested to carry information throughout the body via weak electromagnetic radiation. The author discusses the system's h…
Future; History; Information medicine; PVS; Quantum biology - A+++2022
Intramuscular connective tissue content and mechanical properties: Influence of aging and physical activity in mice
Annesofie T Olesen, Lasse Malchow-Møller, Rune D Bendixen, Michael Kjær, Abigail L Mackey, S Peter Magnusson, Rene B Sv…This animal study on mice investigated how aging and physical activity affect intramuscular connective tissue (IMCT). Researchers found that IMCT became thicker and stiffer with age, accompanied by an increase in advanc…
Collagen; Decellularized muscle; Endomysium; Picrosirius red; Rodent; Wheel running - A+++2022
Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer
Claudio Vernieri, Giovanni Fucà, Francesca Ligorio, Veronica Huber, Andrea Vingiani, Fabio Iannelli, Alessandra Raimond…This clinical trial investigated the safety and biological effects of a five-day fasting-mimicking diet (FMD) in 101 cancer patients receiving standard treatments. The results suggest that the diet is safe and leads to…
fasting; fasting-mimicking diet; inflammation; intermittent fasting; cancer; antitumor immunity - A+++2022
Immediate Effects of Extracorporeal Shock Wave Therapy in Fascial Fibroblasts: An In Vitro Study
Carmelo Pirri, Caterina Fede, Lucia Petrelli, Enrico De Rose, Carlo Biz, Diego Guidolin, Raffaele De Caro, Carla SteccoThis in vitro study investigated how extracorporeal shock wave therapy (ESWT) affects human fascial fibroblasts in a laboratory setting. Researchers found that immediately after treatment, the cells began producing smal…
fascia; hyaluronan; vesicles; myofascial pain; focused extracorporeal shock waves; 3D printer - A+++2021
Resveratrol Enhances the Cytotoxic Activity of Lymphocytes from Menopausal Women
Andrea Di Credico, Giulia Gaggi, Pascal Izzicupo, Ines Bucci, Angela Di BaldassarreThis in vitro study investigated how resveratrol, a natural polyphenol found in grapes and other plants, affects the immune system of postmenopausal women. Researchers isolated lymphocytes from 13 women and co-cultured…
antioxidant effects; cancer; cell-mediated cytotoxicity; immune system; immunomodulatory; menopause; noncommunicable diseases; nutraceuticals; prevention; resveratrol - A+++2021
Osteogenic effect of low-intensity pulsed ultrasound and whole-body vibration on peri-implant bone. An experimental in vivo study
Kenta Shobara, Toru Ogawa, Aya Shibamoto, Makiko Miyashita, Akiyo Ito, Ratri M SitalaksmiThis animal study in rats investigated whether low-intensity pulsed ultrasound (LIPUS) and whole-body vibration (WBV) could improve bone healing around titanium implants. Researchers compared the effects of LIPUS alone,…
low-intensity pulsed ultrasound (LIPUS); low-magnitude high-frequency loading; osseointegration; osteogenesis; prostheses and implants. - A2021
Fascial Nomenclature: Update 2021, Part 2
Bruno Bordoni, Allan R Escher, Filippo Tobbi, Bruno Ducoux, Serge PaolettiThis conceptual article addresses the ongoing debate about how to classify and name fascia. The authors suggest that progress is hindered because the discussion is often limited to a few scientific specialties and can b…
fasciafascial systemOsteopathicfascial continuumfascintegrity - A+++2021
An acupoint-originated human interstitial fluid circulatory network
HongYi Li, Fang Wang, Min Chen, Zhi-Jian Zheng, Ya-Jun Yin, Jun Hu, Hua Li, Andreas Sammer, Georg Feig, Norbert Maurer,…Details from this study have not yet been summarized. The study's title is "An acupoint-originated human interstitial fluid circulatory network". This title suggests the authors are proposing a circulatory network for i…
meridiansacupointsinterstitium - A+++2021
Impaired Lymphatic Drainage and Interstitial Inflammatory Stasis in Chronic Musculoskeletal and Idiopathic Pain Syndromes: Exploring a Novel Mechanism
Brian Tuckey, John Srbely, Grant Rigney, Meena Vythilingam, Jay ShahIn this theoretical paper, the authors propose a potential mechanism for chronic pain syndromes. They hypothesize that impaired lymphatic drainage following trauma or an immune response can trap inflammatory substances…
fasciacytokinesinterstitial inflammatory stasislymphatic dysfunctioncounterstrain techniques