Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious readers.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Researchers behind the studies- A+++2019
Daily oral dosing of vitamin D3 using 5000 TO 50,000 international units a day in long-term hospitalized patients: Insights from a seven year experience
Patrick J McCullough, Douglas S Lehrer, Je!rey AmendThis observational study followed long-term hospitalized patients over seven years to evaluate the safety of high daily doses of vitamin D3. Patients received supplements ranging from 5,000 to 50,000 international units…
vitamin DIntact parathyroid hormoneLong-term supplementationAdverse events - A2019
Hyaluronan/collagen hydrogels containing sulfated hyaluronan improve wound healing by sustained release of heparin-binding EGF-like growth factor
Stephan Thönes, Sandra Rother, Tom Wippold, Joanna Blaszkiewicz, Kanagasabai Balamurugan, Stephanie Moeller, Gloria Rui…This study investigated a new type of hydrogel designed to improve wound healing. Researchers combined collagen and hyaluronan (HA), a natural component of connective tissue, with a growth factor that stimulates skin ce…
Biomimetic material; Extracellular matrix (ECM); Fibroblasts; Heparin-binding epidermal growth factor-like growth factor (HB-EGF); Hyaluronan; Hydrogel; Sulfated hyaluronan; Surface plasmon resonance; Wound healing. - A+++2019
Tentorium Cerebelli: the Bridge Between the Central and Peripheral Nervous System, Part 2
Bruno Bordoni, Marta Simonelli, Maria Marcella LaganaThis article, the second in a series, describes the tentorium cerebelli—a meningeal structure related to the skull, nervous system, and cervical spine. The authors discuss its complex relationships, including its neurol…
fasciapaincraniotentorium cerebellivenous circulation - 1A+2019
The fascial breath
Bruno Bordoni, Marta Simonelli, Bruno MorabitoThis narrative review proposes a new way of understanding the diaphragm muscle, moving beyond a purely mechanical view. The authors argue that the diaphragm is not just covered by fascia but is fundamentally a fascial t…
fasciaMyofascialOsteopathicdiaphragmbreathing - A++2019
Plasma Amino Acid Concentrations After the Ingestion of Dairy and Collagen Proteins, in Healthy Active Males
Rebekah D Alcock, Gregory C Shaw, Nicolin Tee, Louise M BurkeThis study investigated how blood amino acid levels changed in healthy, active men after they consumed either collagen or dairy proteins. Researchers found that the different protein sources led to distinct amino acid p…
Connective tissuetendonligamentprolineleucine - A+++2019
The Endocannabinoid/Endovanilloid System in Bone: From Osteoporosis to Osteosarcoma
Francesca Rossi, Chiara Tortora, Francesca Punzo, Giulia Bellini, Maura Argenziano, Alessandra Di Paola, Marco Torella,…Bone is a dynamic tissue, whose homeostasis is maintained by a fine balance between osteoclast (OC) and osteoblast (OB) activity. The endocannabinoid/endovanilloid (EC/EV) system's receptors are the cannabinoid receptor…
CB1; CB2; TRPV1; bone; osteoblasts; osteoclasts; osteoporosis; osteosarcoma - A+++2019
New Insights of Uterine Leiomyoma Pathogenesis: Endocannabinoid System
Thangesweran Ayakannu, Anthony H Taylor, Timothy H Marczylo, Justin C KonjeThis study investigated the role of the endocannabinoid system in the development of uterine leiomyomas, commonly known as fibroids. Researchers analyzed tissue samples and found that the expression of specific receptor…
CannabinoidsCannabinoid receptorsuterine myomfibroids - A++2019
Development of a biotensegrity focused therapy for the treatment of pelvic organ prolapse: A retrospective case series
Anna Crowle, Clare HarleyThis retrospective case series explores a new biotensegrity-focused therapy for pelvic organ prolapse (POP). Challenging the common view that POP is caused by weak tissue, this approach hypothesizes that the condition i…
Myofascial releasebiotensegrityPelvic organ prolapsePelvic tension - A2019
The diaphragm muscle manual evaluation scale
Bruno Bordoni, Bruno MorabitoThis technical report describes a new method for manually assessing the diaphragm's function, called the Manual Evaluation Diaphragm (MED) scale. The scale is designed to generate a value for the respiratory muscle's mo…
fasciaMyofascialdiaphragmSurgeryphrenic nerve - A2019
Quantifying muscle glycosaminoglycan levels in patients with post-stroke muscle stiffness using T1p MRI
Rajiv G Menon, Preeti Raghavan, Ravinder R RegatteThis study is the first to quantify the amount of hyaluronan, a key component for gliding movements within fascia. Researchers measured hyaluronan in tissue samples from various human anatomical sites and found that the…
hyaluronanStrokestiffnesshyaluronidase - B2019
Modeling and simulation of musculoskeletal system of human lower limb based on tensegrity structure
Zhanxi Wang, Chaoran Yang, Kang Feng, Xiansheng QinResearchers created a computer model of the human lower limb's musculoskeletal system using tensegrity principles, which balance tension and compression. Using an established muscle model (the Hill model), they simulate…
Tensegrity structure; lower limb model; motion analysis; gait simulation - B2019
Photo-crosslinked gelatin-hyaluronic acid methacrylate hydrogel-committed nucleus pulposus-like differentiation of adipose stromal cells for intervertebral disc repair
Pengfei Chen, Lei Ning, Pengcheng Qiu, Jian Mo, Sheng Mei, Chen Xia, Jianfeng Zhang, Xianfeng Lin, Shunwu FanThis animal study on rats investigated a new strategy for repairing degenerated intervertebral discs using stem cells. Researchers combined adipose-derived stromal cells (ASCs) with a special light-activated hydrogel ma…
IntegrinsmicroenvironmentHydrogeladipose stem cellscellular proliferation