mechanotransduction
36 studies, 2 episodes on mechanotransduction — reviewed, translated, woven together.
Articles
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Research
- 2021
Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration
Bingjin Wang, Wencan Ke, Kun Wang, Gaocai Li, Liang Ma, Saideng Lu, Qian Xiang, Zhiwei Liao, Rongjin Luo, Yu Song, Wenb…This study investigates how the mechanical environment of the intervertebral disc influences cellular health during disc degeneration. Researchers found that as the central part of the disc (nucleus pulposus) becomes st…
- 2020
The Structure and Role of Intramuscular Connective Tissue in Muscle Function
Peter P PurslowThis narrative review analyzes the microscopic structure of intramuscular connective tissue—endomysium, perimysium, and epimysium—and its role in muscle function. Rather than acting simply as a container, this connectiv…
- 2020
Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
Lijun Wang, Xiuling You, Sutada Lotinun, Lingli Zhang, Nan Wu, Weiguo ZouThis study using mouse models investigates how the protein PIEZO1 acts as a mechanical sensor in the skeleton to regulate bone mass. Researchers found that a deficiency of PIEZO1 in bone-forming cells (osteoblasts) lead…
- 2020
Feeling Things Out: Bidirectional Signaling of the Cell–ECM Interface, Implications in the Mechanobiology of Cell Spreading, Migration, Proliferation, and Differentiation
Andrew E Miller, Ping Hu, Thomas H BarkerThis narrative review describes how cells and their surrounding environment, the extracellular matrix (ECM), constantly communicate with each other. This communication involves physical cues from the ECM being translate…
- 2020
Endothelial mechanobiology
Ming He, Marcy Martin, Traci Marin, Zhen Chen, Brendan GongolThis narrative review explores how the cells lining our blood vessels, called endothelial cells, respond to the mechanical forces of blood flow. It describes two main patterns: smooth, pulsatile flow in straight vessels…
- 2019
Tissue Regeneration from Mechanical Stretching of Cell–Cell Adhesion
Amir Monemian Esfahani, Jordan Rosenbohm, Keerthana Reddy, Xiaowei Jin, Tasneem Bouzid, Brandon Riehl, Eunju Kim, Jung…This narrative review explores how mechanical stretching can stimulate tissue regeneration and wound healing. Researchers have long known that cells respond to mechanical forces, but much of the focus has been on the co…
- 2019
Mechanobiology of cells and cell systems, such as organoids
Ece Bayir, Aylin Sendemir, Yannis F MissirlisThis review discusses organoids, which are three-dimensional tissues grown in a lab that self-organize to mimic organ development. While organoids offer great potential for disease modeling and drug development, little…
- 2019
Biophysics of Cell-Substrate Interactions Under Shear
Neha Paddillaya, Ashish Mishra, Paturu Kondaiah, Pramod Pullarkat, Gautam I Menon, Namrata GundiahIn this review article, the authors examine how cells adhere to surfaces and respond to mechanical forces. Cells use complex structures called focal adhesions to sense and react to their environment, including forces fr…
- 2019
The plasma membrane as a mechanochemical transducer
Anabel-Lise Le Roux, Xarxa Quiroga, Nikhil Walani, Marino Arroyo, Pere Roca-CusachsIn this review article, researchers describe how the plasma membrane, the cell's outer boundary, acts as a key sensor for mechanical forces. The membrane senses and responds to physical stresses from its environment, su…
- 2019
Cell Biology: Function Guides Form of Auditory Sensory Cells
Jamis McGrath, Benjamin J PerrinThis study describes how the sensory cells in our ears get their specific shape. These cells have bundles of tiny hair-like structures called stereocilia, arranged like a staircase in rows of decreasing height. The proc…
Podcast
- Ep. 0-8
Episode on the basic principles of well-being
Your guide to the guide All episodes are available on Spotify, iTunes, and on the web here All of these episodes are about the basic principles of well-being. Life and flow are the foundation of well…
- Ep. 067
67. Mechanotransduction – what happens in the body when we move?
It may sound complex, but new research on Mechanotransduction shows how the body uses movement to initiate chemical processes, cell division, and restructuring – in other words, how movement can crea…