hyaluronan
46 studies on hyaluronan — reviewed, translated, woven together.
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Research
- 2023
Immediate Effects of Extracorporeal Shock Wave Therapy in Fascial Fibroblasts: An In Vitro Study, 2022
Carmelo Pirri, Caterina Fede, Lucia Petrelli, Enrico De Rose, Carlo Biz, Diego Guidolin, Raffaele De Caro, Carla SteccoThis laboratory study (in vitro) investigated how extracorporeal shock wave therapy (ESWT) affects human fascial fibroblasts. Researchers found that immediately following treatment, the cells began producing small vesic…
- 2023
Functional organization of extracellular hyaluronan, CD44 and RHAMM
Mary K Cowman, Eva A TurleyIn this comprehensive review, the authors explore how hyaluronan (HA) and its receptors, CD44 and RHAMM, organize the space immediately surrounding cells. In healthy tissue, these components maintain a stable environmen…
- 2022
Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory, 2019
Ramesh C Gupta, Rajiv Lall, Ajay Srivastava, Anita SinhaThis narrative review summarizes the roles of hyaluronic acid (HA), a substance naturally found in many body tissues, especially joint cartilage and synovial fluid. HA is crucial for joint lubrication and the shock-abso…
- 2022
Hyaluronan homeostasis and its role in pain and muscle stiffness
Adam Amir, Soo Kim, Antonio Stecco, Michael P Jankowski, Preeti RaghavanThis narrative review explores the role of hyaluronan (HA) in the musculoskeletal system. HA is a key component of the extracellular matrix in muscles and fascia, where it normally functions as a lubricant and shock abs…
- 2020
A Hyaluronan-binding Peptide (P15-1) Reduces inflammatory and catabolic events in IL-1beta-treated human articular chondrocytes
Claire Shortt, Leonard G Luyt, Eva A Turley, Mary K Cowman, Thorsten KirschInflammation in osteoarthritis drives cartilage degradation. In this laboratory study, researchers investigated whether a peptide (P15-1) combined with hyaluronan (HA) could protect human cartilage cells in a simulated…
- 2019
Hyaluronic Acid: Molecular Mechanisms and Therapeutic Trajectory
Ramesh C Gupta, Rajiv Lall, Ajay Srivastava, Anita SinhaThis narrative review explores hyaluronic acid (HA), a naturally occurring substance found in connective tissues and synovial fluid. HA is essential for joint lubrication and viscoelasticity, but its concentration and m…
- 2019
TMEM2: a missing link in hyaluronan catabolism identified?
Yu Yamaguchi, Hayato Yamamoto, Yuki Tobisawa, Fumitoshi IrieHyaluronan (HA) is a large molecule in our connective tissues that is broken down and replaced very quickly. Scientists have long understood that large HA molecules are first chopped into smaller pieces on the surface o…
- 2019
Quantifying muscle glycosaminoglycan levels in patients with post-stroke muscle stiffness using T1p MRI
Rajiv G Menon, Preeti Raghavan, Ravinder R RegatteThis study is the first to quantify the amount of hyaluronan, a key component for gliding movements within fascia. Researchers measured hyaluronan in tissue samples from various human anatomical sites and found that the…
- 2019
Evaluation of hyaluronan content in areas of densification compared to adjacent areas of fascia
E J Hughes, K McDermott, M F FunkThis entry is currently a title only, so a full summary is not available. Based on the title, the researchers appear to have evaluated and compared the hyaluronan content in areas of fascial densification with the conte…
- 2018
Elevated expression of hyaluronan synthase 2 associates with decreased survival in diffusely infiltrating astrocytomas
Mari Valkonen, Hannu Haapasalo, Kirsi Rilla, Kristiina Tyynelä-Korhonen, Ylermi Soini , Sanna Pasonen-SeppänenAstrocytomas are the most common type of brain tumor in adults. In this retrospective study, researchers investigated hyaluronan, a key component of the brain's extracellular matrix, and its related enzymes in 163 tumor…
- 2018
The Fasciacytes- A New Cell Devoted To Fascial Gliding Regulation
Carla Stecco, Caterina Fede, Veronica Macchi, Andrea Porzionato, Lucia Petrelli, Carlo Biz, Robert Stern, Raffaele De C…Researchers have identified a new type of cell within fascia, which they have named "fasciacytes." This study presents evidence that these specialized cells are responsible for producing hyaluronan, a key component of t…
- 2017
Hyaluronan as a therapeutic target in human diseases
Jiurong Liang, Dianhua Jiang, Paul W NobleThis narrative review explores the role of hyaluronan, a major component of the extracellular matrix involved in tissue injury and repair. Its function varies significantly with its size; fragmented hyaluronan can promo…
- 2016
Hyaluronan concentration and size distribution in human knee synovial fluid: variations with age and cartilage degeneration
Michele M Temple-Wong, Shuwen Ren, Phu Quach, Bradley C Hansen, Albert C Chen, Akihiko Hasegawa, Darryl D D’Lima, Jim K…This study investigated how the lubricant hyaluronan in knee joint fluid changes with age and cartilage wear. Researchers analyzed synovial fluid from human donors aged 23 to 91 without diagnosed osteoarthritis. They fo…
- 2016
Fascial Manipulation® for chronic aspecific low back pain: a single blinded randomized controlledtrial.
Mirco Branchini, Francesca Lopopolo, Ernesto Andreoli, Ivano Loreti, Aurélie M Marchand, Antonio SteccoThis randomized controlled trial compared Fascial Manipulation® combined with standard physiotherapy to physiotherapy alone for patients with chronic non-specific low back pain. The group receiving Fascial Manipulation®…
- 2015
Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology
Jaime M Cyphert, Carol S Trempus, Stavros GarantziotisThis narrative review summarizes current knowledge about hyaluronan, a molecule whose biological effects are dependent on its size. Unlike many other molecules, hyaluronan's signaling properties are determined not by ch…
- 2015
Hyaluronan, inflammation and breast cancer progression
Katryn L Schwertfeger, Mary K Cowman, Patrick G Telmer, Eva A Turley, James B McCarthyThis narrative review explores the link between inflammation, the tissue component hyaluronan (HA), and breast cancer progression. Cancer cells and surrounding host cells can create an inflamed microenvironment that hel…
- 2015
Hyaluronan Regulates Bone Morphogenetic Protein-7- dependent Prevention and Reversal of Myofibroblast Phenotype
Adam C Midgley, Lucy Duggal, Robert Jenkins, Vincent Hascall, Robert Steadman, Aled O Phillips, Soma MeranThis study on human lung fibroblasts investigated how a protein called BMP7 might counteract fibrosis. Researchers found that BMP7 can prevent and even reverse the formation of myofibroblasts, which are cells that contr…
- 2015
Platelet hyaluronidase-2: an enzyme that translocates to the surface upon activation to function in extracellular matrix degradation
Sami Albeiroti, Katayoun Ayasoufi, [...], Carol A de la MottePlatelets play a key role in responding to tissue injury. This study explores how they interact with hyaluronan, a major component of the extracellular matrix that is involved in inflammation. Researchers demonstrated t…
- 2015
Hyaluronan Controls the Deposition of Fibronectin and Collagen and Modulates TGF-β1 Induction of Lung Myofibroblasts
Stephen P Evanko, Susan Potter-Perigo, Loreen J Petty, Gail A Workman, Thomas N WightThis study investigated how hyaluronan (HA), a key component of the extracellular matrix, influences the formation of myofibroblasts—cells involved in tissue scarring and fibrosis. Researchers observed that while HA lev…
- 2015
The content and size of hyaluronan in biological fluids and tissues
Mary K Cowman, Hong-Gee Lee, Kathryn L Schwertfeger, James B McCarthy,, Eva A TurleyHyaluronan is a simple sugar polymer found throughout the body's tissues and fluids. It is typically produced as a very large, high-molecular-mass molecule. This narrative review notes that during processes like inflamm…
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