fibroblast
22 studies on fibroblast — reviewed, translated, woven together.
Articles
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Research
- 2020
Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts
Torsten Lowin, Ren Tingting, Julia Zurmahr, Tim Classen, Matthias Schneider, Georg PongratzThis laboratory study investigated how cannabidiol (CBD) affects synovial fibroblasts, the cells responsible for joint destruction in rheumatoid arthritis. Researchers found that CBD can reduce the viability of these ce…
- 2018
New Proposal to Define the Fascial System
Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Roberto Castagna, Beatrice Sacconi, Paul MazzuccoIn this proposal, the authors suggest a new definition for the fascial system, noting that a universally accepted one does not yet exist. They argue for including the epidermis (the outer layer of skin) based on functio…
- 2017
The indeterminable resilience of the fascial system
Bruno Bordoni, Fabiola Marelli, Bruno Morabito, Beatrice SacconiThis commentary proposes a model of fascia not as layers, but as a network of polyhedral microvacuoles of connective tissue. These structures connect the body's systems and can change shape in response to tension, allow…
- 2015
Understanding Fibroblasts in Order to Comprehend the Osteopathic Treatment of the Fascia
Bruno Bordoni, Emiliano ZanierIn this review paper, the authors argue that understanding fibroblasts is essential for comprehending and applying osteopathic treatment of the fascia. As the foundational cells of connective tissue, fibroblasts have ma…
- 2014
Fascia—Current knowledge and future directions in physiatry: Narrative review
E H Kwong, T W FindleyIn this 2014 narrative review, the authors discuss fascia from the perspective of physiatry, or rehabilitation medicine. They note that while fascia is part of the body's connective tissue, its definition is unclear in…
- 2014
Crosstalk between fibroblasts and inflammatory cells
S Van Linthout, K Miteva, C TschöpeThis narrative review describes how fibroblasts, traditionally seen as passive cells that produce extracellular matrix, are increasingly understood as active key players in the immune system. The authors provide an over…
- 2013
Fascia Research Congress Evidence from the 100 year perspective of Andrew Taylor Still
Thomas W Findley, Mona ShalwalaThis review paper examines research from the first three International Fascia Research Congresses through the perspective of Andrew Taylor Still, the founder of osteopathic medicine. Over a century ago, Still described…
- 2013
Cellular Control of Connective Tissue Matrix Tension
H M Langevin, M Nedergaard, A HoweThis review article explores how fibroblasts, the cells within connective tissue, actively help regulate tissue tension. Traditionally, the mechanical properties of connective tissue have been attributed to its passive…
- 2012
The role of stromal cells in the persistence of chronic inflammation
A J Naylor, A Filer, C D BuckleyThis review article explores why chronic inflammation often persists in specific anatomical locations. The authors highlight that stromal cells, particularly the fibroblasts that define a tissue's architecture, are like…
- 2011
Fibroblasts and Myofibroblasts: What are we talking about?
Jennifer Baum, Heather S DuffyThis 2011 narrative review explores the roles of fibroblasts and myofibroblasts, two key cell types in the heart's connective tissue. Once considered static, research indicates these cells are dynamic and play an active…
- 2011
Fascia Research from a Clinician/Scientist’s Perspective
Thomas W FindleyIn this perspective piece, a clinician-scientist summarizes exciting areas in fascia research. The article describes the fascial network as a body-wide system that connects individual cells and shares loads with muscles…
- 2011
Why does chronic inflammation persist: An unexpected role for fibroblasts
C D BuckleyThis 2011 review explores why chronic inflammation persists. Traditionally, research has focused on immune cells, but this text highlights the crucial role that stromal cells, particularly fibroblasts, play in sustainin…
- 2011
Fibroblast cytoskeletal remodeling contributes to connective tissue tension
H M Langevin, N A Bouffard, J R Fox, B M Palmer, J Wu, J C Iatridis, W D Barnes, G J Badger, A K HoweThe mechanical properties of connective tissue, such as its elasticity and resistance, have traditionally been attributed to its non-cellular matrix. This study investigated the role of fibroblasts, the cells residing w…
- 2009
From mechanotransduction to extracellular matrix gene expression in fibroblasts
Matthias Chiquet, Laurent Gelman, Roman Lutz, Silke MaierThis 2009 review article explores how connective tissue cells, or fibroblasts, sense and respond to mechanical forces from their environment. Cells attach to the surrounding extracellular matrix via adhesion contacts, w…
- 2009
From mechanical loading to collagen synthesis, structural changes and function in human tendon
Michael Kjær, H Langberg, K Heinemeier, M L Bayer, Mette Hansen, L Holm, S Doessing, M Kongsgaard, M R Krogsgaard, S P…This review article outlines how tendons adapt to mechanical loading from exercise. The research indicates that loading increases the synthesis and turnover of collagen, the protein that gives tendons their strength. Th…
- 2008
Differential effects of hyaluronan and its fragments on fibroblasts: Relation to wound healing
Maha David-Raoudi, Frederic Tranchepain, Brigitte Deschrevel, Jean-Claude Vincent, Patrick Bogdanowicz, Karim Boumedien…This lab study investigated how hyaluronan (HA) of different molecular sizes affects human fibroblast cells, which are key to wound healing. Researchers exposed fibroblasts to native HA and two smaller fragments. All th…
- 2006
Subcutaneous Tissue Fibroblast Cytoskeletal Remodeling Induced by Acupuncture: Evidence for a Mechanotransduction-Based Mechanism
Helene M Langevin, Nicole A Bouffard, Gary J Badger, David L Churchill, Alan K HoweIn this mouse tissue study, researchers investigated how rotating an acupuncture needle affects fibroblasts in the connective tissue under the skin. They found that rotation caused the fibroblasts to actively change sha…
- 2006
Fibroblast spreading induced by connective tissue stretch involves intracellular redistribution of a- and b-actin
Helene M Langevin, Kirsten N Storch, Marilyn J Cipolla, Sheryl L White, Thomas R Buttolph, Douglas J TaatjesResearchers investigated how fibroblasts, the primary cells in connective tissue, respond to mechanical stretching. In this ex vivo study, they stretched samples of subcutaneous tissue for 30 minutes and observed change…
- 2005
Cell–Matrix Entanglement and Mechanical Anchorage of Fibroblasts in Three-dimensional Collagen Matrices
H Jiang, F GrinnellResearchers studied how fibroblasts, a key connective tissue cell, behave within a three-dimensional collagen matrix that mimics body tissues. They found the cells' ability to engulf particles (phagocytosis) was reduced…
- 2005
A stromal address code defined by fibroblasts
G Parsonage, A D Filer, O Haworth, G B Nash, G E Rainger, M Salmon, C D BuckleyThis 2005 review article explores how immune cells (leukocytes) navigate within the body's tissues. The authors propose that fibroblasts create a "stromal address code" that acts as a local guidance system. This code di…
- 2004
Protection from Fluorescein Isothiocyanate-Induced Fibrosis in IL-13-Deficient, but Not IL-4-Deficient, Mice Results from Impaired Collagen Synthesis by Fibroblasts
Jill E Kolodsick, Galen B Toews, Claudia Jakubzick, Cory Hogaboam, Thomas A Moore, Andrew McKenzie, Carol A Wilke, Cara…In this animal study, researchers investigated the drivers of lung fibrosis in mice. The team compared mice genetically deficient in the immune molecules IL-4, IL-13, or both. Results showed that mice lacking IL-13 were…
- 1996
Effects of continuous and Intermittent forces on human fibroblasts in vitro
Aldo Carano, Giuseppe SicilianiThis in vitro study investigated how human connective tissue cells (fibroblasts) respond to different types of mechanical force. Researchers grew fibroblasts on flexible membranes and subjected them to either continuous…
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