Cell signaling
6 studies on Cell signaling — reviewed, translated, woven together.
Articles
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Research
- 2017
Complex mechanics of the heterogeneous extracellular matrix in cancer
Andrea Malandrino, Michael Mak, Roger D Kammd, Emad MoeendarbaryThis narrative review explores the complex role of the extracellular matrix (ECM), the non-cellular network that provides structural support to tissues. In solid tumors, the ECM becomes highly altered and complex, as ca…
- 2017
Structural and functional analysis of two small leucine-rich repeat proteoglycans, fibromodulin and chondroadherin
Patricia Paracuellos, Sebastian Kalamajski, Arkadiusz Bonnac, Dominique Bihanc, Richard W. Farndale, Erhard HohenesterFibromodulin and chondroadherin are small proteins that help organize the extracellular matrix. This study examined their 3D structure and how they interact with collagen. Researchers found that while their overall shap…
- 2015
Size Matters: Molecular Weight Specificity of Hyaluronan Effects in Cell Biology
Jaime M Cyphert, Carol S Trempus, Stavros GarantziotisThis narrative review summarizes current knowledge about hyaluronan, a molecule whose biological effects are dependent on its size. Unlike many other molecules, hyaluronan's signaling properties are determined not by ch…
- 2013
Cell-to-cell signaling through light: just a ghost of chance?
Ondřej Kučera, Michal CifraThis paper examines the physical feasibility of cell-to-cell communication via weak light signals, often referred to as biophotons. The researchers analyze whether electromagnetic signaling is possible when considering…
- 2004
Protection from Fluorescein Isothiocyanate-Induced Fibrosis in IL-13-Deficient, but Not IL-4-Deficient, Mice Results from Impaired Collagen Synthesis by Fibroblasts
Jill E Kolodsick, Galen B Toews, Claudia Jakubzick, Cory Hogaboam, Thomas A Moore, Andrew McKenzie, Carol A Wilke, Cara…In this animal study, researchers investigated the drivers of lung fibrosis in mice. The team compared mice genetically deficient in the immune molecules IL-4, IL-13, or both. Results showed that mice lacking IL-13 were…
- 2004
Fibroblasts form a body-wide cellular network
Helene M Langevin, Carson J Cornbrooks, Douglas J TaatjesIn this mouse study, researchers investigated how cells called fibroblasts connect to one another within loose connective tissue. Using various microscopy techniques, they found that fibroblasts form an extensive, web-l…
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