Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
Antiviral Mechanisms of Vitamin C: A Short Communication Consensus Report
This 2020 publication is a consensus report from a large group of authors, summarizing agreed-upon points regarding vitamin C. Based on the title, the report details the various mechanisms by which vitamin C may exert a…
Overview of the possible role of vitamin C in management of COVID-19
In this 2020 review, the authors examine the possible role of vitamin C in managing COVID-19. They note that the body's vitamin C levels often drop during an acute infection due to increased metabolic demands. Because v…
A new clinical trial to test high-dose vitamin C in patients with COVID-19
This 2020 entry by Anitra C. Carr announces a new clinical trial. The study was designed to investigate the effects of high-dose vitamin C on patients with COVID-19. As this is only a title entry, no details about the s…
Continuous Ascorbate Infusions in the Management of Patients with Advanced Colon Cancer
This study analyzed data from a previous clinical trial involving 17 patients with late-stage colon cancer. The patients received continuous intravenous infusions of vitamin C (ascorbate) over 6-8 weeks. Researchers fou…
Is the VITAMINS RCT indicating potential redundancy between corticosteroids and vitamin C?
Known only by its title, this article appears to be a commentary or analysis of a randomized controlled trial (RCT) known as VITAMINS. The title poses a question about whether there might be a "redundancy," or overlappi…
High-dose vitamin C suppresses the invasion and metastasis of breast cancer cells via inhibiting epithelial-mesenchymal transition
This study on breast cancer cells in the lab and in mice explored how different doses of vitamin C affect cancer cell behavior. Researchers found that low and medium doses of vitamin C seemed to encourage cancer cells t…
Vitamin C administration in the critically ill: a summary of recent meta-analyses
This 2019 publication is a summary of recent meta-analyses on the topic of vitamin C administration for critically ill patients. As the full text has not yet been reviewed, a detailed summary of its findings is not avai…
Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis
This commentary presents a meta-analysis of research on using vitamin C to treat sepsis. It builds upon two previous reviews by pooling their data for a combined statistical analysis. The aggregated results indicated a…
Ascorbic acid in cancer treatment: let the phoenix fly
This review article discusses the renewed interest in Vitamin C (ascorbic acid) as a potential anti-cancer agent. When administered intravenously, Vitamin C can reach much higher concentrations in the body than when tak…
Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes
This study investigated vitamin C levels in 44 critically ill patients in an intensive care unit (ICU). Researchers found that most patients had low vitamin C levels (hypovitaminosis C), and one-third were severely defi…
Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials
This systematic review and meta-analysis compiled data from 22 randomized controlled trials to assess the effect of vitamin C supplementation on glycemic control. Overall, the researchers found no significant effect on…
Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin resistance and glycaemia in 9-10 year-old children
This cross-sectional study of over 2000 children in the UK examined the relationship between vitamin C and risk factors for type 2 diabetes. Researchers found that higher levels of vitamin C in the blood were associated…
Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection
This animal study investigated how vitamin C affects the immune response to influenza A virus (H3N2). Researchers used mice that, like humans, cannot synthesize their own vitamin C. When these mice were made vitamin C-d…
Local vitamin-C Injection Reduced Tendon Adhesion in a Chicken Model of Flexor Digitorum Profundus Tendon Injury
This animal study investigated whether vitamin C could reduce scar tissue formation after a tendon injury. Researchers injured a flexor tendon in chickens and then injected either vitamin C or a saline solution at the s…
Vitamin C further improves the protective effect of glucagon-like peptide-1 on acute hypoglycemia-induced oxidative stress, inflammation, and endothelial dysfunction in type 1 diabetes
Acute low blood sugar (hypoglycemia) in people with type 1 diabetes can cause oxidative stress, inflammation, and damage to the lining of blood vessels. This study investigated whether the hormone GLP-1 and vitamin C co…
Vitamin C in Disease Prevention and Cure: An Overview
This narrative review provides an overview of Vitamin C's many roles in the body. It is essential for developing and maintaining connective tissues, and plays a key part in bone formation, wound healing, and gum health.…
Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations
This study investigated how vitamin C intake affects its concentration in human skeletal muscle. Researchers gave 36 men either half a kiwifruit or two kiwifruits daily for six weeks, as kiwifruit is a rich source of vi…
The Genetics of Vitamin C Loss in Vertebrates
This narrative review explores why some vertebrate species, including humans, cannot produce their own Vitamin C. The inability to synthesize this crucial nutrient, important for collagen and antioxidant functions, stem…
Anti-angiogenic effect of high doses of ascorbic acid
This laboratory study investigated how high doses of ascorbic acid (vitamin C) affect the formation of new blood vessels, a process called angiogenesis. Researchers exposed several types of human endothelial cells, incl…
Intra-articular injection of a nutritive mixture solution protects articular cartilage from osteoarthritic progression induced by anterior cruciate ligament transection in mature rabbits: a randomized controlled trial
In this animal study, researchers investigated if injecting a simple nutrient solution could protect knee cartilage in rabbits with induced osteoarthritis. The solution, containing glucose, amino acids, and vitamin C, w…
Nutraceutical Therapies for Degenerative Joint Diseases: A Critical Review
This 2005 critical review examines the role of nutrition in managing degenerative joint diseases like osteoarthritis. The authors suggest that while nutritional factors are crucial for cartilage health, dietary programs…
Vitamin C, respiratory infections and the immune system
This 2003 publication by Harri Hemilä explores the relationship between Vitamin C, respiratory infections, and immune system function. As only the title is available, specific conclusions regarding the study's exact res…
Glutathione-Ascorbic Acid Antioxidant System in Animals
This 1994 publication by Alton Meister discusses the biochemical interaction between glutathione and ascorbic acid (Vitamin C) within animal antioxidant systems. As the source material is limited to the title, the summa…
Immunological evidence for the accumulation of lipoprotein(a) in the atherosclerotic lesion of the hypoascorbemic guinea pig
This animal study investigated the link between vitamin C, a specific cholesterol particle called Lipoprotein(a) or Lp(a), and atherosclerosis. Researchers found that guinea pigs, which like humans cannot produce their…
Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer
This study compared the survival times of 100 terminal cancer patients who received supplemental ascorbate (vitamin C) with 1000 matched control patients who did not. The ascorbate-treated group was found to have a mean…
Ascorbic acid status in idiopathic hemochromatosis
This study investigated Vitamin C (ascorbic acid) levels in patients with idiopathic hemochromatosis, a condition characterized by excessive iron accumulation. The results showed that untreated patients had significantl…
SYNTHESIS AND SOME MAJOR FUNCTIONS OF VITAMIN C IN ANIMALS
Vitamin C, or ascorbic acid, is essential for most living things, but some animals, including humans, cannot produce it themselves. Historically, determining an animal's ability to synthesize Vitamin C required feeding…