Research.
Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.
We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.
- A+++2020
Antiviral Mechanisms of Vitamin C: A Short Communication Consensus Report
Michael J Gonzalez, Jorge R Miranda-Massari, Jose R Rodriguez, Victor Marcial-Vega, Miguel J Berdiel, Jorge Duconge, St…This 2020 publication is a consensus report from a large group of authors, summarizing agreed-upon points regarding vitamin C. Based on the title, the report details the various mechanisms by which vitamin C may exert a…
Vitamin CAscorbic acidantiviral effects - A+++2020
Overview of the possible role of vitamin C in management of COVID-19
Anis Abobaker, Aboubaker Alzwi, Alsalheen Hamed A AlraiedIn this 2020 review, the authors examine the possible role of vitamin C in managing COVID-19. They note that the body's vitamin C levels often drop during an acute infection due to increased metabolic demands. Because v…
Vitamin CCOVID-19SARS-CoV-2Beneficial effectsManagement - A2020
A new clinical trial to test high-dose vitamin C in patients with COVID-19
Anitra C CarrThis 2020 entry by Anitra C. Carr announces a new clinical trial. The study was designed to investigate the effects of high-dose vitamin C on patients with COVID-19. As this is only a title entry, no details about the s…
Vitamin CCOVID-19corona virushigh-dose C - A+++2020
Continuous Ascorbate Infusions in the Management of Patients with Advanced Colon Cancer
Nina MikirovaThis study analyzed data from a previous clinical trial involving 17 patients with late-stage colon cancer. The patients received continuous intravenous infusions of vitamin C (ascorbate) over 6-8 weeks. Researchers fou…
Vitamin CAscorbic acidcolon cancer - A+++2020
Is the VITAMINS RCT indicating potential redundancy between corticosteroids and vitamin C?
Anitra C CarrKnown only by its title, this article appears to be a commentary or analysis of a randomized controlled trial (RCT) known as VITAMINS. The title poses a question about whether there might be a "redundancy," or overlappi…
Vitamin Ccorticosteroidsstress respons - A2019
High-dose vitamin C suppresses the invasion and metastasis of breast cancer cells via inhibiting epithelial-mesenchymal transition
Ling-Hui Zeng, Qing-Mei Wang, Lin-Yi Feng, Yu-Dun Ke, Qian-Zi Xu, An-Yi Wei, Chong Zhang, Rong-Biao YingThis study on breast cancer cells in the lab and in mice explored how different doses of vitamin C affect cancer cell behavior. Researchers found that low and medium doses of vitamin C seemed to encourage cancer cells t…
Breast cancermetastasisTGF-β1Vitamin C - A+++2019
Vitamin C administration in the critically ill: a summary of recent meta-analyses
Anitra C CarrThis 2019 publication is a summary of recent meta-analyses on the topic of vitamin C administration for critically ill patients. As the full text has not yet been reviewed, a detailed summary of its findings is not avai…
Vitamin CAscorbic acidsepsis - A+++2018
Evidence is stronger than you think: a meta-analysis of vitamin C use in patients with sepsis
Jing LiThis commentary presents a meta-analysis of research on using vitamin C to treat sepsis. It builds upon two previous reviews by pooling their data for a combined statistical analysis. The aggregated results indicated a…
meta-analysisVitamin CAscorbic acidsepsisSevere sepsis - A++2018
Ascorbic acid in cancer treatment: let the phoenix fly
Niraj Shenoy, Edward Creagan, Thomas Witzig, Mark LevineThis review article discusses the renewed interest in Vitamin C (ascorbic acid) as a potential anti-cancer agent. When administered intravenously, Vitamin C can reach much higher concentrations in the body than when tak…
cancerVitamin Cascorbatepharmacokinetics - A++2017
Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes
Anitra C Carr, Patrice C Rosengrave, Simone Bayer, Steve Chambers, Jan Mehrtens, Geoff M ShawThis study investigated vitamin C levels in 44 critically ill patients in an intensive care unit (ICU). Researchers found that most patients had low vitamin C levels (hypovitaminosis C), and one-third were severely defi…
Vitamin CsepsisIntensive careHypovitaminosis CCritical illness - A+2017
Effects of vitamin C supplementation on glycaemic control: a systematic review and meta-analysis of randomised controlled trials
A W Ashor, A D Werner, J Lara, N D Willis, J C Mathers, M SiervoThis systematic review and meta-analysis compiled data from 22 randomized controlled trials to assess the effect of vitamin C supplementation on glycemic control. Overall, the researchers found no significant effect on…
Vitamin Cinsulin resistensglycaemic control - A++2015
Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross-sectional associations with insulin resistance and glycaemia in 9-10 year-old children
A S Donin, J E Dent, C M Nightingale, N Sattar, C G Owen, A R Rudnicka, M R Perkin, A M Stephen, S A Jebb, D G Cook, P…This cross-sectional study of over 2000 children in the UK examined the relationship between vitamin C and risk factors for type 2 diabetes. Researchers found that higher levels of vitamin C in the blood were associated…
Vitamin Cinsulin resistensglycaemiadiabetes type 2 - A+++2013
Vitamin C Is an Essential Factor on the Anti-viral Immune Responses through the Production of Interferon-α/β at the Initial Stage of Influenza A Virus (H3N2) Infection
Yejin Kim, Hyemin Kim, Seyeon Bae, Jiwon Choi, Sun Young Lim, Naeun Lee, Joo Myung Kong, Young-il Hwang, Jae Seung Kang…This animal study investigated how vitamin C affects the immune response to influenza A virus (H3N2). Researchers used mice that, like humans, cannot synthesize their own vitamin C. When these mice were made vitamin C-d…
immune responseVitamin Cantiviralinfluenza Ainterferon alfa/beta - A+2013
Local vitamin-C Injection Reduced Tendon Adhesion in a Chicken Model of Flexor Digitorum Profundus Tendon Injury
Leung-Kim Hung, Sai-Chuen Fu, Yuk-Wa Lee, Tsui-Yu Mok, Kai-Ming ChanThis animal study investigated whether vitamin C could reduce scar tissue formation after a tendon injury. Researchers injured a flexor tendon in chickens and then injected either vitamin C or a saline solution at the s…
Vitamin Chealing tendonadhesion - B2013
Vitamin C further improves the protective effect of glucagon-like peptide-1 on acute hypoglycemia-induced oxidative stress, inflammation, and endothelial dysfunction in type 1 diabetes
ANTONIO CERIELLO, ANNA NOVIALS, EMILIO ORTEGA, SILVIA CANIVELL, LUCIA LA SALA, GEMMA PUJADAS, LOREDANA BUCCIARELLI, MAU…Acute low blood sugar (hypoglycemia) in people with type 1 diabetes can cause oxidative stress, inflammation, and damage to the lining of blood vessels. This study investigated whether the hormone GLP-1 and vitamin C co…
Oxidative stressdiabetesVitamin C - A++2013
Vitamin C in Disease Prevention and Cure: An Overview
Shailja Chambial, Shailendra Dwivedi, Kamla Kant Shukla, Placheril J John, Praveen SharmaThis narrative review provides an overview of Vitamin C's many roles in the body. It is essential for developing and maintaining connective tissues, and plays a key part in bone formation, wound healing, and gum health.…
cancerdiabetesVitamin CImmunityinfertility - A2013
Human skeletal muscle ascorbate is highly responsive to changes in vitamin C intake and plasma concentrations
Anitra C Carr, Stephanie M Bozonet, Juliet M Pullar, Jeremy W Simcock, Margreet C M VissersThis study investigated how vitamin C intake affects its concentration in human skeletal muscle. Researchers gave 36 men either half a kiwifruit or two kiwifruits daily for six weeks, as kiwifruit is a rich source of vi…
Vitamin Cascorbate - A2011
The Genetics of Vitamin C Loss in Vertebrates
Guy Drouin, Jean-Rémi Godin, Benoît PagéThis narrative review explores why some vertebrate species, including humans, cannot produce their own Vitamin C. The inability to synthesize this crucial nutrient, important for collagen and antioxidant functions, stem…
BiosynthesisVitamin CAscorbic acidGLO geneL-gulono-gamma-lactone oxidase - A2008
Anti-angiogenic effect of high doses of ascorbic acid
Nina A Mikirova, Thomas E Ichim, Neil H RiordanThis laboratory study investigated how high doses of ascorbic acid (vitamin C) affect the formation of new blood vessels, a process called angiogenesis. Researchers exposed several types of human endothelial cells, incl…
AngiogenesisVitamin CAscorbic acid - A2007
Intra-articular injection of a nutritive mixture solution protects articular cartilage from osteoarthritic progression induced by anterior cruciate ligament transection in mature rabbits: a randomized controlled trial
Yoo-Sin Park, Si-Woong Lim, Il-Hoon Lee, Tae-Jin Lee, Jong-Sung Kim, Jin Soo HanIn this animal study, researchers investigated if injecting a simple nutrient solution could protect knee cartilage in rabbits with induced osteoarthritis. The solution, containing glucose, amino acids, and vitamin C, w…
nutritionosteoarthritisVitamin Cascorbateintra articular - A+2005
Nutraceutical Therapies for Degenerative Joint Diseases: A Critical Review
ROBERT GOGGS, ANNE VAUGHAN-THOMAS, PETER D CLEGG, STUART D CARTER, JOHN F INNES, ALI MOBASHERI, MEHDI SHAKIBAEI, WOLFGA…This 2005 critical review examines the role of nutrition in managing degenerative joint diseases like osteoarthritis. The authors suggest that while nutritional factors are crucial for cartilage health, dietary programs…
articular cartilagenutritionosteoarthritisnutraceuticalVitamin C - A2003
Vitamin C, respiratory infections and the immune system
Harri HemiläThis 2003 publication by Harri Hemilä explores the relationship between Vitamin C, respiratory infections, and immune system function. As only the title is available, specific conclusions regarding the study's exact res…
Vitamin CAscorbic acid - A1994
Glutathione-Ascorbic Acid Antioxidant System in Animals
Alton MeisterThis 1994 publication by Alton Meister discusses the biochemical interaction between glutathione and ascorbic acid (Vitamin C) within animal antioxidant systems. As the source material is limited to the title, the summa…
Vitamin CAscorbic acidantioxidantanimals - A++1990
Immunological evidence for the accumulation of lipoprotein(a) in the atherosclerotic lesion of the hypoascorbemic guinea pig
M Rath, L PaulingThis animal study investigated the link between vitamin C, a specific cholesterol particle called Lipoprotein(a) or Lp(a), and atherosclerosis. Researchers found that guinea pigs, which like humans cannot produce their…
Vitamin CAscorbic acidAtherosclerosis - A1978
Supplemental ascorbate in the supportive treatment of cancer: Reevaluation of prolongation of survival times in terminal human cancer
EWAN CAMERON, LINUS PAULINGThis study compared the survival times of 100 terminal cancer patients who received supplemental ascorbate (vitamin C) with 1000 matched control patients who did not. The ascorbate-treated group was found to have a mean…
cancerVitamin Cascorbate - A++1978
Ascorbic acid status in idiopathic hemochromatosis
P Brissot, Y Deugnier, A Le Treut, F Regnouard, M Simon, M BourelThis study investigated Vitamin C (ascorbic acid) levels in patients with idiopathic hemochromatosis, a condition characterized by excessive iron accumulation. The results showed that untreated patients had significantl…
Vitamin Ciron overloadHemochromatosis - A++1975
SYNTHESIS AND SOME MAJOR FUNCTIONS OF VITAMIN C IN ANIMALS
I B Chatterjee, A K Majumder, B K Nandi, N SubramanianVitamin C, or ascorbic acid, is essential for most living things, but some animals, including humans, cannot produce it themselves. Historically, determining an animal's ability to synthesize Vitamin C required feeding…
StressVitamin Csyntesisanimalhistamin