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The Fascia Guide

Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

2,804
studies
602
top-graded
2,783
with plain-language summary
TopicAllfascia233extracellular matrix51hyaluronan46inflammation40Connective tissue39mechanotransduction36collagen32Vitamin C31Manual Therapy30acupuncture24
GradeAll1A+++41A++21A+42A++++1A+++317A++236A+84A435
YearAll yearsSince 2020Since 2015Since 2010With summary
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Showing 1–5 of 5 studiesmechanotransductionSince 2020
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  1. A++
    2021

    Mechanosensitive Ion Channel Piezo1 Activated by Matrix Stiffness Regulates Oxidative Stress-Induced Senescence and Apoptosis in Human Intervertebral Disc Degeneration

    Bingjin Wang, Wencan Ke, Kun Wang, Gaocai Li, Liang Ma, Saideng Lu, Qian Xiang, Zhiwei Liao, Rongjin Luo, Yu Song, Wenb…

    This study investigates how the mechanical environment of the intervertebral disc influences cellular health during disc degeneration. Researchers found that as the central part of the disc (nucleus pulposus) becomes st…

    mechanotransductionOxidative stressPiezo1Ion channel
  2. A++
    2020

    Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk

    Lijun Wang, Xiuling You, Sutada Lotinun, Lingli Zhang, Nan Wu, Weiguo Zou

    This study using mouse models investigates how the protein PIEZO1 acts as a mechanical sensor in the skeleton to regulate bone mass. Researchers found that a deficiency of PIEZO1 in bone-forming cells (osteoblasts) lead…

    mechanotransductionpiezobone homeostasis
  3. A++
    2020

    The Structure and Role of Intramuscular Connective Tissue in Muscle Function

    Peter P Purslow

    This narrative review analyzes the microscopic structure of intramuscular connective tissue—endomysium, perimysium, and epimysium—and its role in muscle function. Rather than acting simply as a container, this connectiv…

    extracellular matrixMusclecollagenmechanotransductionperimysium
  4. A
    2020

    Feeling Things Out: Bidirectional Signaling of the Cell–ECM Interface, Implications in the Mechanobiology of Cell Spreading, Migration, Proliferation, and Differentiation

    Andrew E Miller, Ping Hu, Thomas H Barker

    This narrative review describes how cells and their surrounding environment, the extracellular matrix (ECM), constantly communicate with each other. This communication involves physical cues from the ECM being translate…

    extracellular matrixstiffnesscytoskeletonmechanotransduction
  5. C
    2020

    Endothelial mechanobiology

    Ming He, Marcy Martin, Traci Marin, Zhen Chen, Brendan Gongol

    This narrative review explores how the cells lining our blood vessels, called endothelial cells, respond to the mechanical forces of blood flow. It describes two main patterns: smooth, pulsatile flow in straight vessels…

    mechanotransductionmechanpbiologyendothelial cellsvasculatory disease