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The Fascia Guide

Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

2,804
studies
602
top-graded
2,783
with plain-language summary
TopicAllfascia233extracellular matrix51hyaluronan46inflammation40Connective tissue39mechanotransduction36collagen32Vitamin C31Manual Therapy30acupuncture24
GradeAll1A+++41A++21A+42A++++1A+++317A++236A+84A435
YearAll yearsSince 2020Since 2015Since 2010With summary
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Showing 1–3 of 3 studieshyaluronanSince 2020
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  1. A++
    2023

    Functional organization of extracellular hyaluronan, CD44 and RHAMM

    Mary K Cowman, Eva A Turley

    In this comprehensive review, the authors explore how hyaluronan (HA) and its receptors, CD44 and RHAMM, organize the space immediately surrounding cells. In healthy tissue, these components maintain a stable environmen…

    hyaluronanCD44extracellular matrixRHAMMpericellular matrix
  2. A+++
    2022

    Hyaluronan homeostasis and its role in pain and muscle stiffness

    Adam Amir, Soo Kim, Antonio Stecco, Michael P Jankowski, Preeti Raghavan

    This narrative review explores the role of hyaluronan (HA) in the musculoskeletal system. HA is a key component of the extracellular matrix in muscles and fascia, where it normally functions as a lubricant and shock abs…

    hyaluronanpainmuscle stiffness
  3. A
    2020

    A Hyaluronan-binding Peptide (P15-1) Reduces inflammatory and catabolic events in IL-1beta-treated human articular chondrocytes

    Claire Shortt, Leonard G Luyt, Eva A Turley, Mary K Cowman, Thorsten Kirsch

    Inflammation in osteoarthritis drives cartilage degradation. In this laboratory study, researchers investigated whether a peptide (P15-1) combined with hyaluronan (HA) could protect human cartilage cells in a simulated…

    hyaluronaninflammationchondrocytesP15-1IL-1beta