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The Fascia Guide

Research.

Every peer-reviewed study on fascia in one place — graded for strength of evidence, summarised in plain language for clinicians, researchers, and curious patients.

We grade studies from A to 1A+++ using the Fascia Research Database rubric — 1A+++ is the strongest.

2,804
studies
602
top-graded
2,783
with plain-language summary
TopicAllfascia233extracellular matrix51hyaluronan46inflammation40Connective tissue39mechanotransduction36collagen32Vitamin C31Manual Therapy30acupuncture24
GradeAll1A+++41A++21A+42A++++1A+++317A++236A+84A435
YearAll yearsSince 2020Since 2015Since 2010With summary
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Showing 1–3 of 3 studiesextracellular matrixSince 2020
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  1. A++
    2023

    Functional organization of extracellular hyaluronan, CD44 and RHAMM

    Mary K Cowman, Eva A Turley

    In this comprehensive review, the authors explore how hyaluronan (HA) and its receptors, CD44 and RHAMM, organize the space immediately surrounding cells. In healthy tissue, these components maintain a stable environmen…

    hyaluronanCD44extracellular matrixRHAMMpericellular matrix
  2. A++
    2020

    The Structure and Role of Intramuscular Connective Tissue in Muscle Function

    Peter P Purslow

    This narrative review analyzes the microscopic structure of intramuscular connective tissue—endomysium, perimysium, and epimysium—and its role in muscle function. Rather than acting simply as a container, this connectiv…

    extracellular matrixMusclecollagenmechanotransductionperimysium
  3. A
    2020

    Feeling Things Out: Bidirectional Signaling of the Cell–ECM Interface, Implications in the Mechanobiology of Cell Spreading, Migration, Proliferation, and Differentiation

    Andrew E Miller, Ping Hu, Thomas H Barker

    This narrative review describes how cells and their surrounding environment, the extracellular matrix (ECM), constantly communicate with each other. This communication involves physical cues from the ECM being translate…

    extracellular matrixstiffnesscytoskeletonmechanotransduction